메뉴 건너뛰기




Volumn 4, Issue 7, 2013, Pages 1093-1102

STAT6-mediated BCL6 repression in primary mediastinal B-cell lymphoma (PMBL)

Author keywords

BCL6; Intratumoral heterogeneity; PMBL; pSTAT6

Indexed keywords

JANUS KINASE; JANUS KINASE 2; PROTEIN BCL 6; SMALL INTERFERING RNA; STAT6 PROTEIN;

EID: 84884260608     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.1149     Document Type: Article
Times cited : (32)

References (52)
  • 5
    • 0023212344 scopus 로고
    • Mediastinal lymphoma of clear cell type is a tumor corresponding to terminal steps of B cell differentiation.
    • Moller P, Moldenhauer G, Momburg F, Lammler B, Eberlein-Gonska M, Kiesel S, Dorken B. Mediastinal lymphoma of clear cell type is a tumor corresponding to terminal steps of B cell differentiation. Blood. 1987; 69: 1087-1095.
    • (1987) Blood. , vol.69 , pp. 1087-1095
    • Moller, P.1    Moldenhauer, G.2    Momburg, F.3    Lammler, B.4    Eberlein-Gonska, M.5    Kiesel, S.6    Dorken, B.7
  • 6
    • 33644987681 scopus 로고    scopus 로고
    • Absence of the JAK2 V617F activating mutation in classical Hodgkin lymphoma and primary mediastinal B-cell lymphoma.
    • Melzner I, Weniger MA, Menz CK, Moller P. Absence of the JAK2 V617F activating mutation in classical Hodgkin lymphoma and primary mediastinal B-cell lymphoma. Leukemia. 2006; 20: 157-158.
    • (2006) Leukemia. , vol.20 , pp. 157-158
    • Melzner, I.1    Weniger, M.A.2    Menz, C.K.3    Moller, P.4
  • 8
    • 15244350510 scopus 로고    scopus 로고
    • Biallelic mutation of SOCS-1 impairs JAK2 degradation and sustains phospho-JAK2 action in the MedB-1 mediastinal lymphoma line
    • Melzner I, Bucur A.J, Bruderlein S, Dorsch K, Hasel C, Barth TF, Leithauser F, Moller P. Biallelic mutation of SOCS-1 impairs JAK2 degradation and sustains phospho-JAK2 action in the MedB-1 mediastinal lymphoma line. Blood. 2005; 105: 2535-2542.
    • (2005) Blood , vol.105 , pp. 2535-2542
    • Melzner, I.1    Bucur, A.J.2    Bruderlein, S.3    Dorsch, K.4    Hasel, C.5    Barth, T.F.6    Leithauser, F.7    Moller, P.8
  • 11
    • 0034811146 scopus 로고    scopus 로고
    • Expression of bcl-6 and CD10 in primary mediastinal large B-cell lymphoma: evidence for derivation from germinal center B cells?
    • De Leval L, Ferry JA, Falini B, Shipp M, Harris N L. Expression of bcl-6 and CD10 in primary mediastinal large B-cell lymphoma: evidence for derivation from germinal center B cells? Am. J. Surg. Pathol. 2001; 25; 1277-1282.
    • (2001) Am. J. Surg. Pathol , vol.25 , pp. 1277-1282
    • De Leval, L.1    Ferry, J.A.2    Falini, B.3    Shipp, M.4    Harris, N.L.5
  • 12
    • 4644221781 scopus 로고    scopus 로고
    • Primary mediastinal B-cell lymphoma: hypermutation of the BCL6 gene targets motifs different from those in diffuse large B-cell and follicular lymphomas.
    • Malpeli G, Barbi S, Moore PS, Scardoni M, Chilosi M, Scarpa A, Menestrina F. Primary mediastinal B-cell lymphoma: hypermutation of the BCL6 gene targets motifs different from those in diffuse large B-cell and follicular lymphomas. Haematologica. 2004; 89:1091-1099.
    • (2004) Haematologica. , vol.89 , pp. 1091-1099
    • Malpeli, G.1    Barbi, S.2    Moore, P.S.3    Scardoni, M.4    Chilosi, M.5    Scarpa, A.6    Menestrina, F.7
  • 17
    • 33744507087 scopus 로고    scopus 로고
    • Primary mediastinal large B-cell lymphoma: a single-center study of clinicopathologic characteristics.
    • Kolonic SO, Dzebro S, Kusec R, Planinc-Peraica A, Dominis M, Jaksic B. Primary mediastinal large B-cell lymphoma: a single-center study of clinicopathologic characteristics. Int.J.Hematol. 2006; 83: 331-336.
    • (2006) Int.J.Hematol. , vol.83 , pp. 331-336
    • Kolonic, S.O.1    Dzebro, S.2    Kusec, R.3    Planinc-Peraica, A.4    Dominis, M.5    Jaksic, B.6
  • 21
    • 79955574671 scopus 로고    scopus 로고
    • Transcriptional regulation by STAT6.
    • Goenka S, Kaplan MH. Transcriptional regulation by STAT6. Immunol.Res. 2011; 50: 87-96.
    • (2011) Immunol.Res. , vol.50 , pp. 87-96
    • Goenka, S.1    Kaplan, M.H.2
  • 22
    • 0030901289 scopus 로고    scopus 로고
    • Control of inflammation, cytokine expression, and germinal center formation by BCL-6.
    • Dent AL, Shaffer AL, Yu X, Allman D, Staudt LM. Control of inflammation, cytokine expression, and germinal center formation by BCL-6. Science 1997; 276: 589-592.
    • (1997) Science , vol.276 , pp. 589-592
    • Dent, A.L.1    Shaffer, A.L.2    Yu, X.3    Allman, D.4    Staudt, L.M.5
  • 23
    • 33846187999 scopus 로고    scopus 로고
    • STAT5 represses BCL6 expression by binding to a regulatory region frequently mutated in lymphomas.
    • Walker SR, Nelson EA, Frank DA. STAT5 represses BCL6 expression by binding to a regulatory region frequently mutated in lymphomas. Oncogene. 2007; 26:224-233.
    • (2007) Oncogene. , vol.26 , pp. 224-233
    • Walker, S.R.1    Nelson, E.A.2    Frank, D.A.3
  • 24
    • 0038243177 scopus 로고    scopus 로고
    • Mutations of the BCL6 proto-oncogene disrupt its negative autoregulation in diffuse large B-cell lymphoma.
    • Pasqualucci L, Migliazza A, Basso K, Houldsworth J, Chaganti RS, Dalla-Favera R. Mutations of the BCL6 proto-oncogene disrupt its negative autoregulation in diffuse large B-cell lymphoma. Blood. 2003; 101: 2914-2923.
    • (2003) Blood. , vol.101 , pp. 2914-2923
    • Pasqualucci, L.1    Migliazza, A.2    Basso, K.3    Houldsworth, J.4    Chaganti, R.S.5    Dalla-Favera, R.6
  • 26
    • 77951249046 scopus 로고    scopus 로고
    • ZEB1 and CtBP form a repressive complex at a distal promoter element of the BCL6 locus.
    • Papadopoulou V, Postigo A, Sanchez-Tillo E, Porter AC, Wagner SD. ZEB1 and CtBP form a repressive complex at a distal promoter element of the BCL6 locus. Biochem.J. 2010; 427: 541-550.
    • (2010) Biochem.J. , vol.427 , pp. 541-550
    • Papadopoulou, V.1    Postigo, A.2    Sanchez-Tillo, E.3    Porter, A.C.4    Wagner, S.D.5
  • 29
    • 0034640404 scopus 로고    scopus 로고
    • A gain-of-function mutation in STAT6.
    • Daniel C, Salvekar A, Schindler U. A gain-of-function mutation in STAT6. J.Biol.Chem. 2000; 275: 14255-14259.
    • (2000) J.Biol.Chem. , vol.275 , pp. 14255-14259
    • Daniel, C.1    Salvekar, A.2    Schindler, U.3
  • 30
    • 77955949060 scopus 로고    scopus 로고
    • BCL6: master regulator of the germinal center reaction and key oncogene in B cell lymphomagenesis.
    • Basso K, Dalla-Favera R. BCL6: master regulator of the germinal center reaction and key oncogene in B cell lymphomagenesis. Adv.Immunol. 2010; 105: 193-210.
    • (2010) Adv.Immunol. , vol.105 , pp. 193-210
    • Basso, K.1    Dalla-Favera, R.2
  • 31
    • 78649986973 scopus 로고    scopus 로고
    • The role of BCL6 in lymphomas and routes to therapy
    • Wagner SD, Ahearne M, Ferrigno P.K. The role of BCL6 in lymphomas and routes to therapy. Br.J.Haematol. 2011; 152: 3-12.
    • (2011) Br.J.Haematol , vol.152 , pp. 3-12
    • Wagner, S.D.1    Ahearne, M.2    Ferrigno, P.K.3
  • 32
    • 0037025173 scopus 로고    scopus 로고
    • Cancer. Addiction to oncogenes--the Achilles heal of cancer
    • Weinstein IB. Cancer. Addiction to oncogenes--the Achilles heal of cancer. Science. 2002; 297: 63-64.
    • (2002) Science. , vol.297 , pp. 63-64
    • Weinstein, I.B.1
  • 34
    • 0036467533 scopus 로고    scopus 로고
    • Cutting edge: STAT6 serves as a positive and negative regulator of gene expression in IL-4-stimulated B lymphocytes.
    • Schroder AJ, Pavlidis P, Arimura A, Capece D, Rothman PB. Cutting edge: STAT6 serves as a positive and negative regulator of gene expression in IL-4-stimulated B lymphocytes. J.Immunol. 2002; 168: 996-1000.
    • (2002) J.Immunol. , vol.168 , pp. 996-1000
    • Schroder, A.J.1    Pavlidis, P.2    Arimura, A.3    Capece, D.4    Rothman, P.B.5
  • 42
    • 80052673612 scopus 로고    scopus 로고
    • The molecular pathogenesis of primary mediastinal large B-cell lymphoma.
    • Steidl C, Gascoyne RD. The molecular pathogenesis of primary mediastinal large B-cell lymphoma. Blood. 2011;118: 2659-2669.
    • (2011) Blood. , vol.118 , pp. 2659-2669
    • Steidl, C.1    Gascoyne, R.D.2
  • 43
    • 0034066072 scopus 로고    scopus 로고
    • Disorders in cell circuitry during multistage carcinogenesis: the role of homeostasis.
    • Weinstein IB. Disorders in cell circuitry during multistage carcinogenesis: the role of homeostasis. Carcinogenesis. 2000; 21: 857-864.
    • (2000) Carcinogenesis. , vol.21 , pp. 857-864
    • Weinstein, I.B.1
  • 44
    • 33746961739 scopus 로고    scopus 로고
    • Mechanisms of disease: Oncogene addiction--a rationale for molecular targeting in cancer therapy.
    • Weinstein IB, Joe AK. Mechanisms of disease: Oncogene addiction--a rationale for molecular targeting in cancer therapy. Nat.Clin.Pract.Oncol. 2006; 3: 448-457.
    • (2006) Nat.Clin.Pract.Oncol. , vol.3 , pp. 448-457
    • Weinstein, I.B.1    Joe, A.K.2
  • 45
    • 78649251520 scopus 로고    scopus 로고
    • The origins and implications of intratumor heterogeneity.
    • Michor F, Polyak K. The origins and implications of intratumor heterogeneity. Cancer Prev.Res.(Phila). 2010; 3:1361-1364.
    • (2010) Cancer Prev.Res.(Phila). , vol.3 , pp. 1361-1364
    • Michor, F.1    Polyak, K.2
  • 46
    • 33750437419 scopus 로고    scopus 로고
    • First among equals: the cancer cell hierarchy
    • Ichim CV, Wells RA. First among equals: the cancer cell hierarchy. Leuk.Lymphoma. 2006; 47:, 2017-2027.
    • (2006) Leuk.Lymphoma , vol.47 , pp. 2017-2027
    • Ichim, C.V.1    Wells, R.A.2
  • 48
    • 84875884456 scopus 로고    scopus 로고
    • Cellular heterogeneity and molecular evolution in cancer.
    • Almendro V, Marusyk A, Polyak,K. Cellular heterogeneity and molecular evolution in cancer. Annu.Rev.Pathol. 2013; 8: 277-302.
    • (2013) Annu.Rev.Pathol. , vol.8 , pp. 277-302
    • Almendro, V.1    Marusyk, A.2    Polyak, K.3
  • 50
    • 8644227858 scopus 로고    scopus 로고
    • Epigenetic silencing of the immunoglobulin heavy-chain gene in classical Hodgkin lymphoma-derived cell lines contributes to the loss of immunoglobulin expression.
    • Ushmorov A, Ritz O, Hummel M, Leithauser F, Moller P, Stein H, Wirth T. Epigenetic silencing of the immunoglobulin heavy-chain gene in classical Hodgkin lymphoma-derived cell lines contributes to the loss of immunoglobulin expression. Blood. 2004; 104: 3326-3334.
    • (2004) Blood. , vol.104 , pp. 3326-3334
    • Ushmorov, A.1    Ritz, O.2    Hummel, M.3    Leithauser, F.4    Moller, P.5    Stein, H.6    Wirth, T.7
  • 51
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.
    • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001; 25: 402-408.
    • (2001) Methods. , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 52
    • 17344392308 scopus 로고    scopus 로고
    • A new mathematical model for relative quantification in real-time RT-PCR
    • Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 2001; 29: e45.
    • (2001) Nucleic Acids Res , vol.29 , pp. 45
    • Pfaffl, M.W.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.