메뉴 건너뛰기




Volumn 118, Issue 10, 2011, Pages 2659-2669

The molecular pathogenesis of primary mediastinal large B-cell lymphoma

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPHOSPHAMIDE; DOXORUBICIN; ETOPOSIDE; HLA ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; JANUS KINASE 2; LACTATE DEHYDROGENASE; MYC PROTEIN; PREDNISONE; PROGRAMMED DEATH 1 LIGAND 1; PROGRAMMED DEATH 1 LIGAND 2; PROTEIN P16; PROTEIN P53; RITUXIMAB; STAT6 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 1; TRANSCRIPTION FACTOR REL; VINCRISTINE;

EID: 80052673612     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2011-05-326538     Document Type: Review
Times cited : (180)

References (99)
  • 4
    • 66049124247 scopus 로고    scopus 로고
    • TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B-cell lymphoma
    • Schmitz R, Hansmann ML, Bohle V, et al. TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B-cell lymphoma. J Exp Med. 2009;206(5):981-989.
    • (2009) J Exp Med. , vol.206 , Issue.5 , pp. 981-989
    • Schmitz, R.1    Hansmann, M.L.2    Bohle, V.3
  • 5
    • 0022490258 scopus 로고
    • Mediastinal diffuse large-cell lymphoma with sclerosis. A clinicopathologic study of 60 cases
    • Perrone T, Frizzera G, Rosai J. Mediastinal diffuse large-cell lymphoma with sclerosis: a clinicopathologic study of 60 cases. Am J Surg Pathol. 1986;10(3):176-191. (Pubitemid 16055156)
    • (1986) American Journal of Surgical Pathology , vol.10 , Issue.3 , pp. 176-191
    • Perrone, T.1    Frizzera, G.2    Rosai, J.3
  • 7
    • 57749171165 scopus 로고    scopus 로고
    • The biology of Hodgkin's lymphoma
    • Kuppers R. The biology of Hodgkin's lymphoma. Nat Rev Cancer. 2009;9(1):15-27.
    • (2009) Nat Rev Cancer. , vol.9 , Issue.1 , pp. 15-27
    • Kuppers, R.1
  • 10
    • 78049370405 scopus 로고    scopus 로고
    • Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma
    • Green MR, Monti S, Rodig SJ, et al. Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma. Blood. 2010;116(17):3268-3277.
    • (2010) Blood. , vol.116 , Issue.17 , pp. 3268-3277
    • Green, M.R.1    Monti, S.2    Rodig, S.J.3
  • 11
    • 79952816655 scopus 로고    scopus 로고
    • MHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancers
    • Steidl C, Shah SP, Woolcock BW, et al. MHC class II transactivator CIITA is a recurrent gene fusion partner in lymphoid cancers. Nature. 2011;471(7338):377-381.
    • (2011) Nature , vol.471 , Issue.7338 , pp. 377-381
    • Steidl, C.1    Shah, S.P.2    Woolcock, B.W.3
  • 12
    • 29844432120 scopus 로고    scopus 로고
    • Favorable outcome of primary mediastinal large B-cell lymphoma in a single institution: The British Columbia experience
    • DOI 10.1093/annonc/mdj030
    • Savage KJ, Al-Rajhi N, Voss N, et al. Favorable outcome of primary mediastinal large B-cell lymphoma in a single institution: the British Columbia experience. Ann Oncol. 2006;17(1):123-130. (Pubitemid 43033851)
    • (2006) Annals of Oncology , vol.17 , Issue.1 , pp. 123-130
    • Savage, K.J.1    Al-Rajhi, N.2    Voss, N.3    Paltiel, C.4    Klasa, R.5    Gascoyne, R.D.6    Connors, J.M.7
  • 13
    • 79952029773 scopus 로고    scopus 로고
    • Primary mediastinal B-cell lymphoma treated with CHOP-like chemotherapy with or without rituximab: Results of the Mabthera International Trial Group study
    • Rieger M, Osterborg A, Pettengell R, et al. Primary mediastinal B-cell lymphoma treated with CHOP-like chemotherapy with or without rituximab: results of the Mabthera International Trial Group study. Ann Oncol. 2011;22(3):664-670.
    • (2011) Ann Oncol. , vol.22 , Issue.3 , pp. 664-670
    • Rieger, M.1    Osterborg, A.2    Pettengell, R.3
  • 15
    • 79551675263 scopus 로고    scopus 로고
    • Clinical, pathological and genetic features of primary mediastinal large B-cell lymphomas and mediastinal gray zone lymphomas in children
    • Oschlies I, Burkhardt B, Salaverria I, et al. Clinical, pathological and genetic features of primary mediastinal large B-cell lymphomas and mediastinal gray zone lymphomas in children. Haematologica. 2011;96(2):262-268.
    • (2011) Haematologica. , vol.96 , Issue.2 , pp. 262-268
    • Oschlies, I.1    Burkhardt, B.2    Salaverria, I.3
  • 16
    • 79955015019 scopus 로고    scopus 로고
    • Impact of concordant and discordant bone marrow involvement on outcome in diffuse large B-cell lymphoma treated with R-CHOP
    • Sehn LH, Scott DW, Chhanabhai M, et al. Impact of concordant and discordant bone marrow involvement on outcome in diffuse large B-cell lymphoma treated with R-CHOP. J Clin Oncol. 2011;29(11):1452-1457.
    • (2011) J Clin Oncol. , vol.29 , Issue.11 , pp. 1452-1457
    • Sehn, L.H.1    Scott, D.W.2    Chhanabhai, M.3
  • 17
    • 27244432753 scopus 로고    scopus 로고
    • Primary mediastinal large B-cell lymphoma: Optimal therapy and prognostic factor analysis in 141 consecutive patients treated at Memorial Sloan Kettering from 1980 to 1999
    • Hamlin PA, Portlock CS, Straus DJ, et al. Primary mediastinal large B-cell lymphoma: optimal therapy and prognostic factor analysis in 141 consecutive patients treated at Memorial Sloan Kettering from 1980 to 1999. Br J Haematol. 2005;130(5):691-699.
    • (2005) Br J Haematol. , vol.130 , Issue.5 , pp. 691-699
    • Hamlin, P.A.1    Portlock, C.S.2    Straus, D.J.3
  • 19
    • 55249084185 scopus 로고    scopus 로고
    • Primary mediastinal large cell lymphoma (PMBL): Frontline treatment with autologous stem cell transplantation (ASCT). The GEL-TAMO experience
    • Rodriguez J, Conde E, Gutierrez A, et al. Primary mediastinal large cell lymphoma (PMBL): frontline treatment with autologous stem cell transplantation (ASCT). The GEL-TAMO experience. Hematol Oncol. 2008;26(3):171-178.
    • (2008) Hematol Oncol. , vol.26 , Issue.3 , pp. 171-178
    • Rodriguez, J.1    Conde, E.2    Gutierrez, A.3
  • 20
    • 78651334987 scopus 로고    scopus 로고
    • Comparative clinical and biological features of primary mediastinal B-cell lymphoma (PMBL) and mediastinal grey zone lymphoma (MGZL)
    • abstract
    • Dunleavy K, Pittaluga S, Tay K, et al. Comparative clinical and biological features of primary mediastinal B-cell lymphoma (PMBL) and mediastinal grey zone lymphoma (MGZL) [abstract]. ASH Annual Meeting Abstracts. 2009;114(22):106.
    • (2009) ASH Annual Meeting Abstracts , vol.114 , Issue.22 , pp. 106
    • Dunleavy, K.1    Pittaluga, S.2    Tay, K.3
  • 24
    • 79953879650 scopus 로고    scopus 로고
    • Methylation profiling of mediastinal gray zone lymphoma reveals a distinctive signature with elements shared by classical Hodgkin's lymphoma and primary mediastinal large B-cell lymphoma
    • Eberle FC, Rodriguez-Canales J, Wei L, et al. Methylation profiling of mediastinal gray zone lymphoma reveals a distinctive signature with elements shared by classical Hodgkin's lymphoma and primary mediastinal large B-cell lymphoma. Haematologica. 2011;96(4):558-566.
    • (2011) Haematologica. , vol.96 , Issue.4 , pp. 558-566
    • Eberle, F.C.1    Rodriguez-Canales, J.2    Wei, L.3
  • 25
    • 79955961315 scopus 로고    scopus 로고
    • The 2008 WHO classification of lymphoid neoplasms and beyond: Evolving concepts and practical applications
    • Campo E, Swerdlow SH, Harris NL, Pileri S, Stein H, Jaffe ES. The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications. Blood. 2011;117(19):5019-5032.
    • (2011) Blood. , vol.117 , Issue.19 , pp. 5019-5032
    • Campo, E.1    Swerdlow, S.H.2    Harris, N.L.3    Pileri, S.4    Stein, H.5    Jaffe, E.S.6
  • 26
    • 82555167094 scopus 로고    scopus 로고
    • Gray zone lymphoma: Chromosomal aberrations with immunophenotypic and clinical correlations
    • [published online ahead of print August 5, 2011] doi:10.1038/modpathol. 2011.116
    • Eberle FC, Salaverria I, Steidl C, et al. Gray zone lymphoma: chromosomal aberrations with immunophenotypic and clinical correlations [published online ahead of print August 5, 2011]. Mod Pathol. doi:10.1038/modpathol.2011.116.
    • Mod Pathol.
    • Eberle, F.C.1    Salaverria, I.2    Steidl, C.3
  • 29
    • 0034811146 scopus 로고    scopus 로고
    • Expression of bcl-6 and CD10 in primary mediastinal large B-cell lymphoma: Evidence for derivation from germinal center B cells?
    • DOI 10.1097/00000478-200110000-00008
    • De Leval L, Ferry JA, Falini B, Shipp M, Harris NL. Expression of bcl-6 and CD10 in primary mediastinal large B-cell lymphoma: evidence for derivation from germinal center B cells? Am J Surg Pathol. 2001;25(10):1277-1282. (Pubitemid 32917121)
    • (2001) American Journal of Surgical Pathology , vol.25 , Issue.10 , pp. 1277-1282
    • De Leval, L.1    Ferry, J.A.2    Falini, B.3    Shipp, M.4    Harris, N.L.5
  • 30
    • 0023212344 scopus 로고
    • Mediastinal lymphoma of clear cell type is a tumor corresponding to terminal steps of B cell differentiation
    • Moller P, Moldenhauer G, Momburg F, et al. Mediastinal lymphoma of clear cell type is a tumor corresponding to terminal steps of B cell differentiation. Blood. 1987;69(4):1087-1095. (Pubitemid 17080929)
    • (1987) Blood , vol.69 , Issue.4 , pp. 1087-1095
    • Moller, P.1    Moldenhauer, G.2    Momburg, F.3
  • 31
    • 0022485216 scopus 로고
    • The primary mediastinal clear cell lymphoma of B-cell type has variable defects in MHC antigen expression
    • Moller P, Lammler B, Herrmann B, Otto HF, Moldenhauer G, Momburg F. The primary mediastinal clear cell lymphoma of B-cell type has variable defects in MHC antigen expression. Immunology. 1986;59(3):411-417. (Pubitemid 16007092)
    • (1986) Immunology , vol.59 , Issue.3 , pp. 411-417
    • Moller, P.1    Lammler, B.2    Herrmann, B.3
  • 33
    • 0028899456 scopus 로고
    • Mediastinal large B-cell lymphoma: Clinical and immunohistological findings in 18 patients treated with different third-generation regimens
    • Falini B, Venturi S, Martelli M, et al. Mediastinal large B-cell lymphoma: clinical and immunohistological findings in 18 patients treated with different third-generation regimens. Br J Haematol. 1995;89(4):780-789.
    • (1995) Br J Haematol. , vol.89 , Issue.4 , pp. 780-789
    • Falini, B.1    Venturi, S.2    Martelli, M.3
  • 34
    • 0033490219 scopus 로고    scopus 로고
    • CD30 expression is common in mediastinal large B-cell lymphoma
    • Higgins JP, Warnke RA. CD30 expression is common in mediastinal large B-cell lymphoma. Am J Clin Pathol. 1999;112(2):241-247. (Pubitemid 30212541)
    • (1999) American Journal of Clinical Pathology , vol.112 , Issue.2 , pp. 241-247
    • Higgins, J.P.1    Warnke, R.A.2
  • 36
    • 0035525763 scopus 로고    scopus 로고
    • Isotype-switched immunoglobulin genes with a high load of somatic hypermutation and lack of ongoing mutational activity are prevalent in mediastinal B-cell lymphoma
    • Leithauser F, Bauerle M, Huynh MQ, Moller P. Isotype-switched immunoglobulin genes with a high load of somatic hypermutation and lack of ongoing mutational activity are prevalent in mediastinal B-cell lymphoma. Blood. 2001;98(9):2762-2770.
    • (2001) Blood. , vol.98 , Issue.9 , pp. 2762-2770
    • Leithauser, F.1    Bauerle, M.2    Huynh, M.Q.3    Moller, P.4
  • 37
    • 4644221781 scopus 로고    scopus 로고
    • Primary mediastinal B-cell lymphoma: Hypermutation of the BCL6 gene targets motifs different from those in diffuse large B-cell and follicular lymphomas
    • Malpeli G, Barbi S, Moore PS, et al. Primary mediastinal B-cell lymphoma: hypermutation of the BCL6 gene targets motifs different from those in diffuse large B-cell and follicular lymphomas. Haematologica. 2004;89(9):1091-1099. (Pubitemid 39295480)
    • (2004) Haematologica , vol.89 , Issue.9 , pp. 1091-1099
    • Malpeli, G.1    Barbi, S.2    Moore, P.S.3    Scardoni, M.4    Chilosi, M.5    Scarpa, A.6    Menestrina, F.7
  • 40
    • 0036230745 scopus 로고    scopus 로고
    • Mediastinal (thymic) large B-cell lymphoma: Where do we stand?
    • DOI 10.1016/S1470-2045(02)00714-3
    • Barth TF, Leithauser F, Joos S, Bentz M, Moller P. Mediastinal (thymic) large B-cell lymphoma: where do we stand? Lancet Oncol. 2002;3(4):229-234. (Pubitemid 34436659)
    • (2002) Lancet Oncology , vol.3 , Issue.4 , pp. 229-234
    • Barth, T.F.E.1    Leithauser, F.2    Joos, S.3    Bentz, M.4    Moller, P.5
  • 46
    • 36349002280 scopus 로고    scopus 로고
    • Further delineation of chromosomal consensus regions in primary mediastinal B-cell lymphomas: An analysis of 37 tumor samples using high-resolution genomic profiling (array-CGH)
    • DOI 10.1038/sj.leu.2404919, PII 2404919
    • Wessendorf S, Barth TF, Viardot A, et al. Further delineation of chromosomal consensus regions in primary mediastinal B-cell lymphomas: an analysis of 37 tumor samples using high-resolution genomic profiling (array-CGH). Leukemia. 2007;21(12):2463-2469. (Pubitemid 350148889)
    • (2007) Leukemia , vol.21 , Issue.12 , pp. 2463-2469
    • Wessendorf, S.1    Barth, T.F.E.2    Viardot, A.3    Mueller, A.4    Kestler, H.A.5    Kohlhammer, H.6    Lichter, P.7    Bentz, M.8    Dohner, H.9    Moller, P.10    Schwaenen, C.11
  • 51
    • 70350504882 scopus 로고    scopus 로고
    • TNFAIP3/A20 functions as a novel tumor suppressor gene in several subtypes of non-Hodgkin lymphomas
    • Honma K, Tsuzuki S, Nakagawa M, et al. TNFAIP3/A20 functions as a novel tumor suppressor gene in several subtypes of non-Hodgkin lymphomas. Blood. 2009;114(12):2467-2475.
    • (2009) Blood. , vol.114 , Issue.12 , pp. 2467-2475
    • Honma, K.1    Tsuzuki, S.2    Nakagawa, M.3
  • 52
    • 66549086135 scopus 로고    scopus 로고
    • The NF-κB negative regulator TNFAIP3 (A20) is inactivated by somatic mutations and genomic deletions in marginal zone lymphomas
    • Novak U, Rinaldi A, Kwee I, et al. The NF-κB negative regulator TNFAIP3 (A20) is inactivated by somatic mutations and genomic deletions in marginal zone lymphomas. Blood. 2009;113(20):4918-4921.
    • (2009) Blood. , vol.113 , Issue.20 , pp. 4918-4921
    • Novak, U.1    Rinaldi, A.2    Kwee, I.3
  • 53
    • 76749103364 scopus 로고    scopus 로고
    • A20 is targeted by promoter methylation, deletion and inactivating mutation in MALT lymphoma
    • Chanudet E, Huang Y, Ichimura K, et al. A20 is targeted by promoter methylation, deletion and inactivating mutation in MALT lymphoma. Leukemia. 2010;24(2):483-487.
    • (2010) Leukemia. , vol.24 , Issue.2 , pp. 483-487
    • Chanudet, E.1    Huang, Y.2    Ichimura, K.3
  • 54
    • 66649112854 scopus 로고    scopus 로고
    • Frequent inactivation of A20 in B-cell lymphomas
    • Kato M, Sanada M, Kato I, et al. Frequent inactivation of A20 in B-cell lymphomas. Nature. 2009;459(7247):712-716.
    • (2009) Nature. , vol.459 , Issue.7247 , pp. 712-716
    • Kato, M.1    Sanada, M.2    Kato, I.3
  • 55
    • 79955956764 scopus 로고    scopus 로고
    • A20 (TNFAIP3) genetic alterations in EBV-associated AIDS-related lymphoma
    • Giulino L, Mathew S, Ballon G, et al. A20 (TNFAIP3) genetic alterations in EBV-associated AIDS-related lymphoma. Blood. 2011;117(18):4852-4854.
    • (2011) Blood. , vol.117 , Issue.18 , pp. 4852-4854
    • Giulino, L.1    Mathew, S.2    Ballon, G.3
  • 56
    • 30444435983 scopus 로고    scopus 로고
    • Lack of IKBA coding region mutations in primary mediastinal large B-cell lymphoma and the host response subtype of diffuse large B-cell lymphoma [5]
    • DOI 10.1182/blood-2005-07-2827
    • Takahashi H, Feuerhake F, Monti S, Kutok JL, Aster JC, Shipp MA. Lack of IKBA coding region mutations in primary mediastinal large B-cell lymphoma and the host response subtype of diffuse large B-cell lymphoma. Blood. 2006;107(2):844-845. (Pubitemid 43076418)
    • (2006) Blood , vol.107 , Issue.2 , pp. 844-845
    • Takahashi, H.1    Feuerhake, F.2    Monti, S.3    Kutok, J.L.4    Aster, J.C.5    Shipp, M.A.6
  • 57
    • 70350500225 scopus 로고    scopus 로고
    • STATs in cancer inflamation and immunity: A leading role for STAT3
    • Yu H, Pardoll D, Jove R. STATs in cancer inflamation and immunity: a leading role for STAT3. Nat Rev Cancer. 2009;9(11):798-809.
    • (2009) Nat Rev Cancer. , vol.9 , Issue.11 , pp. 798-809
    • Yu, H.1    Pardoll, D.2    Jove, R.3
  • 58
    • 79551508997 scopus 로고    scopus 로고
    • Dynamic mathematical modeling of IL13-induced signaling in Hodgkin and primary mediastinal B-cell lymphoma allows prediction of therapeutic targets
    • Raia V, Schilling M, Bohm M, et al. Dynamic mathematical modeling of IL13-induced signaling in Hodgkin and primary mediastinal B-cell lymphoma allows prediction of therapeutic targets. Cancer Res. 2011;71(3):693-704.
    • (2011) Cancer Res. , vol.71 , Issue.3 , pp. 693-704
    • Raia, V.1    Schilling, M.2    Bohm, M.3
  • 59
    • 73949136303 scopus 로고    scopus 로고
    • Interleukin-13 stimulation of the mediastinal B-cell lymphoma cell line Karpas-1106P induces a phenotype resembling the Hodgkin lymphoma cell line L1236
    • Andersson E, Schain F, Sjoberg J, Bjorkholm M, Claesson HE. Interleukin-13 stimulation of the mediastinal B-cell lymphoma cell line Karpas-1106P induces a phenotype resembling the Hodgkin lymphoma cell line L1236. Exp Hematol. 2010;38(2):116-123.
    • (2010) Exp Hematol. , vol.38 , Issue.2 , pp. 116-123
    • Andersson, E.1    Schain, F.2    Sjoberg, J.3    Bjorkholm, M.4    Claesson, H.E.5
  • 60
    • 51649111684 scopus 로고    scopus 로고
    • Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways
    • Lenz G, Wright GW, Emre NC, et al. Molecular subtypes of diffuse large B-cell lymphoma arise by distinct genetic pathways. Proc Natl Acad Sci U S A. 2008;105(36):13520-13525.
    • (2008) Proc Natl Acad Sci U S A. , vol.105 , Issue.36 , pp. 13520-13525
    • Lenz, G.1    Wright, G.W.2    Emre, N.C.3
  • 61
    • 78650012116 scopus 로고    scopus 로고
    • Cooperative epigenetic modulation by cancer amplicon genes
    • Rui L, Emre NC, Kruhlak MJ, et al. Cooperative epigenetic modulation by cancer amplicon genes. Cancer Cell. 2010;18(6):590-605.
    • (2010) Cancer Cell. , vol.18 , Issue.6 , pp. 590-605
    • Rui, L.1    Emre, N.C.2    Kruhlak, M.J.3
  • 62
    • 33644888064 scopus 로고    scopus 로고
    • SOCS1: A potent and multifaceted regulator of cytokines and cell-mediated inflammation
    • DOI 10.1111/j.1399-0039.2005.00532.x
    • Davey GM, Heath WR, Starr R. SOCS1: a potent and multifaceted regulator of cytokines and cell-mediated inflammation. Tissue Antigens. 2006;67(1):1-9. (Pubitemid 43381210)
    • (2006) Tissue Antigens , vol.67 , Issue.1 , pp. 1-9
    • Davey, G.M.1    Heath, W.R.2    Starr, R.3
  • 64
    • 15244350510 scopus 로고    scopus 로고
    • Biallelic mutation SOCS-1 impairs JAK2 degradation and sustains phospho-JAK2 action in the MedB-1 mediastinal lymphoma line
    • DOI 10.1182/blood-2004-09-3701
    • Melzner I, Bucur AJ, Bruderlein S, et al. Biallelic mutation of SOCS-1 impairs JAK2 degradation and sustains phospho-JAK2 action in the MedB-1 mediastinal lymphoma line. Blood. 2005;105(6):2535-2542. (Pubitemid 40387056)
    • (2005) Blood , vol.105 , Issue.6 , pp. 2535-2542
    • Melzner, I.1    Bucur, A.J.2    Bruderlein, S.3    Dorsch, K.4    Hasel, C.5    Barth, T.F.E.6    Leithauser, F.7    Moller, P.8
  • 65
    • 36148989576 scopus 로고    scopus 로고
    • Somatic hypermutation of SOCS1 in lymphocyte-predominant Hodgkin lymphoma is accompanied by high JAK2 expression and activation of STAT6
    • DOI 10.1182/blood-2007-03-082511
    • Mottok A, Renne C, Willenbrock K, Hansmann ML, Brauninger A. Somatic hypermutation of SOCS1 in lymphocyte-predominant Hodgkin lymphoma is accompanied by high JAK2 expression and activation of STAT6. Blood. 2007;110(9):3387-3390. (Pubitemid 350106334)
    • (2007) Blood , vol.110 , Issue.9 , pp. 3387-3390
    • Mottok, A.1    Renne, C.2    Willenbrock, K.3    Hansmann, M.-L.4    Brauninger, A.5
  • 66
    • 73349141714 scopus 로고    scopus 로고
    • Inactivating SOCS1 mutations are caused by aberrant somatic hypermutation and restricted to a subset of B-cell lymphoma entities
    • Mottok A, Renne C, Seifert M, et al. Inactivating SOCS1 mutations are caused by aberrant somatic hypermutation and restricted to a subset of B-cell lymphoma entities. Blood. 2009;114(20):4503-4506.
    • (2009) Blood. , vol.114 , Issue.20 , pp. 4503-4506
    • Mottok, A.1    Renne, C.2    Seifert, M.3
  • 67
    • 33645233157 scopus 로고    scopus 로고
    • Biallelic deletion within 16p13.13 including SOCS-1 in Karpas1106P mediastinal B-cell lymphoma line is associated with delayed degradation of JAK2 protein
    • Melzner I, Weniger MA, Bucur AJ, et al. Biallelic deletion within 16p13.13 including SOCS-1 in Karpas1106P mediastinal B-cell lymphoma line is associated with delayed degradation of JAK2 protein. Int J Cancer. 2006;118(8):1941-1944.
    • (2006) Int J Cancer. , vol.118 , Issue.8 , pp. 1941-1944
    • Melzner, I.1    Weniger, M.A.2    Bucur, A.J.3
  • 68
    • 69849087246 scopus 로고    scopus 로고
    • Recurrent mutations of the STAT6 DNA binding domain in primary mediastinal B-cell lymphoma
    • Ritz O, Guiter C, Castellano F, et al. Recurrent mutations of the STAT6 DNA binding domain in primary mediastinal B-cell lymphoma. Blood. 2009;114(6):1236-1242.
    • (2009) Blood. , vol.114 , Issue.6 , pp. 1236-1242
    • Ritz, O.1    Guiter, C.2    Castellano, F.3
  • 69
    • 70449560746 scopus 로고    scopus 로고
    • STAT6 in PMBL: Pathogenic or passenger?
    • Frank DA. STAT6 in PMBL: pathogenic or passenger? Blood. 2009;114(6):1133-1134.
    • (2009) Blood. , vol.114 , Issue.6 , pp. 1133-1134
    • Frank, D.A.1
  • 70
    • 75749124332 scopus 로고    scopus 로고
    • Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin
    • Morin RD, Johnson NA, Severson TM, et al. Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin. Nat Genet. 2010;42(2):181-185.
    • (2010) Nat Genet. , vol.42 , Issue.2 , pp. 181-185
    • Morin, R.D.1    Johnson, N.A.2    Severson, T.M.3
  • 71
    • 79952430906 scopus 로고    scopus 로고
    • Inactivating mutations of acetyltransferase genes in B-cell lymphoma
    • Pasqualucci L, Dominguez-Sola D, Chiarenza A, et al. Inactivating mutations of acetyltransferase genes in B-cell lymphoma. Nature. 2011;471(7337):189-195.
    • (2011) Nature. , vol.471 , Issue.7337 , pp. 189-195
    • Pasqualucci, L.1    Dominguez-Sola, D.2    Chiarenza, A.3
  • 73
    • 70349975711 scopus 로고    scopus 로고
    • JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin
    • Dawson MA, Bannister AJ, Gottgens B, et al. JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin. Nature. 2009;461(7265):819-822.
    • (2009) Nature. , vol.461 , Issue.7265 , pp. 819-822
    • Dawson, M.A.1    Bannister, A.J.2    Gottgens, B.3
  • 75
    • 54049147790 scopus 로고    scopus 로고
    • Gene expression predicts overall survival in paraffin-embedded tissues of diffuse large B-cell lymphoma treated with R-CHOP
    • Rimsza LM, Leblanc ML, Unger JM, et al. Gene expression predicts overall survival in paraffin-embedded tissues of diffuse large B-cell lymphoma treated with R-CHOP. Blood. 2008;112(8):3425-3433.
    • (2008) Blood. , vol.112 , Issue.8 , pp. 3425-3433
    • Rimsza, L.M.1    Leblanc, M.L.2    Unger, J.M.3
  • 77
    • 80052654002 scopus 로고    scopus 로고
    • HLA-DR protein expression correlates with non-neoplastic T-cell infiltration and predicts survival in patients with primary mediastinal large B-cell lymphoma (PMBCL) treated with CHOP chemotherapy
    • abstract
    • Farinha P, Steidl C, Rimsza LM, Savage KJ, Connors JM, Gascoyne RD. HLA-DR protein expression correlates with non-neoplastic T-cell infiltration and predicts survival in patients with primary mediastinal large B-cell lymphoma (PMBCL) treated with CHOP chemotherapy [abstract]. ASH Annual Meeting Abstracts. 2009;114(22):133.
    • (2009) ASH Annual Meeting Abstracts , vol.114 , Issue.22 , pp. 133
    • Farinha, P.1    Steidl, C.2    Rimsza, L.M.3    Savage, K.J.4    Connors, J.M.5    Gascoyne, R.D.6
  • 79
    • 40849126992 scopus 로고    scopus 로고
    • + regulatory T cells with improved survival in germinal center-like diffuse large B-cell lymphoma, follicular lymphoma and classical Hodgkin's lymphoma
    • DOI 10.3324/haematol.11702
    • Tzankov A, Meier C, Hirschmann P, Went P, Pileri SA, Dirnhofer S. Correlation of high numbers of intratumoral FOXP3+ regulatory T cells with improved survival in germinal center-like diffuse large B-cell lymphoma, follicular lymphoma and classical Hodgkin's lymphoma. Haematologica. 2008;93(2):193-200. (Pubitemid 351397707)
    • (2008) Haematologica , vol.93 , Issue.2 , pp. 193-200
    • Tzankov, A.1    Meier, C.2    Hirschmann, P.3    Went, P.4    Pileri, S.A.5    Dirnhofer, S.6
  • 80
    • 0036022074 scopus 로고    scopus 로고
    • Hemizygous deletions in the HLA region account for loss of heterozygosity in the majority of diffuse large B-cell lymphomas of the testis and the central nervous system
    • DOI 10.1002/gcc.10093
    • Jordanova ES, Riemersma SA, Philippo K, Giphart-Gassler M, Schuuring E, Kluin PM. Hemizygous deletions in the HLA region account for loss of heterozygosity in the majority of diffuse large B-cell lymphomas of the testis and the central nervous system. Genes Chromosomes Cancer. 2002;35(1):38-48. (Pubitemid 34847867)
    • (2002) Genes Chromosomes and Cancer , vol.35 , Issue.1 , pp. 38-48
    • Jordanova, E.S.1    Riemersma, S.A.2    Philippo, K.3    Giphart-Gassler, M.4    Schuuring, E.5    Kluin, P.M.6
  • 81
    • 33646719056 scopus 로고    scopus 로고
    • Mechanisms and effects of loss of human leukocyte antigen class II expression in immune-privileged site-associated B-cell lymphoma
    • Booman M, Douwes J, Glas AM, et al. Mechanisms and effects of loss of human leukocyte antigen class II expression in immune-privileged site-associated B-cell lymphoma. Clin Cancer Res. 2006;12(9):2698-2705.
    • (2006) Clin Cancer Res. , vol.12 , Issue.9 , pp. 2698-2705
    • Booman, M.1    Douwes, J.2    Glas, A.M.3
  • 82
    • 0034669309 scopus 로고    scopus 로고
    • Extensive genetic alterations of the HLA region, including homozygous deletions of HLA class II genes in B-cell lymphomas arising in immune-privileged sites
    • Riemersma SA, Jordanova ES, Schop RF, et al. Extensive genetic alterations of the HLA region, including homozygous deletions of HLA class II genes in B-cell lymphomas arising in immune-privileged sites. Blood. 2000;96(10):3569-3577.
    • (2000) Blood , vol.96 , Issue.10 , pp. 3569-3577
    • Riemersma, S.A.1    Jordanova, E.S.2    Schop, R.F.3
  • 83
    • 66349135959 scopus 로고    scopus 로고
    • CIITA or RFX coding region loss of function mutations occur rarely in diffuse large B-cell lymphoma cases and cell lines with low levels of major histocompatibility complex class II expression
    • Rimsza LM, Chan WC, Gascoyne RD, et al. CIITA or RFX coding region loss of function mutations occur rarely in diffuse large B-cell lymphoma cases and cell lines with low levels of major histocompatibility complex class II expression. Haematologica. 2009;94(4):596-598.
    • (2009) Haematologica , vol.94 , Issue.4 , pp. 596-598
    • Rimsza, L.M.1    Chan, W.C.2    Gascoyne, R.D.3
  • 84
    • 0035064073 scopus 로고    scopus 로고
    • The bare lymphocyte syndrome and the regulation of MHC expression
    • DOI 10.1146/annurev.immunol.19.1.331
    • Reith W, Mach B. The bare lymphocyte syndrome and the regulation of MHC expression. Annu Rev Immunol. 2001;19:331-373. (Pubitemid 32368039)
    • (2001) Annual Review of Immunology , vol.19 , pp. 331-373
    • Reith, W.1    Mach, B.2
  • 85
    • 0034194473 scopus 로고    scopus 로고
    • CIITA is a transcriptional coactivator that is recruited to MHC class II promoters by multiple synergistic interactions with an enhanceosome complex
    • Masternak K, Muhlethaler-Mottet A, Villard J, Zufferey M, Steimle V, Reith W. CIITA is a transcriptional coactivator that is recruited to MHC class II promoters by multiple synergistic interactions with an enhanceosome complex. Genes Dev. 2000;14(9):1156-1166. (Pubitemid 30324428)
    • (2000) Genes and Development , vol.14 , Issue.9 , pp. 1156-1166
    • Masternak, K.1    Muhlethaler-Mottet, A.2    Villard, J.3    Zufferey, M.4    Steimle, V.5    Reith, W.6
  • 86
    • 0031569959 scopus 로고    scopus 로고
    • CIITA-Dependent and -Independent Class II MHC Expression Revealed by a Dominant Negative Mutant
    • Zhou H, Su HS, Zhang X, Douhan J III, Glimcher LH. CIITA-dependent and -independent class II MHC expression revealed by a dominant negative mutant. J Immunol. 1997;158(10):4741-4749. (Pubitemid 127483794)
    • (1997) Journal of Immunology , vol.158 , Issue.10 , pp. 4741-4749
    • Zhou, H.1    Su, H.S.2    Zhang, X.3    Douhan III, J.4    Glimcher, L.H.5
  • 87
    • 0030951017 scopus 로고    scopus 로고
    • Importance of acidic, proline/serine/threonine-rich, and GTP-binding regions in the major histocompatibility complex class II transactivator: Generation of transdominant-negative mutants
    • DOI 10.1073/pnas.94.6.2501
    • Chin KC, Li GG, Ting JP. Importance of acidic, proline/serine/threonine- rich, and GTP-binding regions in the major histocompatibility complex class II transactivator: generation of transdominant-negative mutants. Proc Natl Acad Sci U S A. 1997;94(6):2501-2506. (Pubitemid 27136904)
    • (1997) Proceedings of the National Academy of Sciences of the United States of America , vol.94 , Issue.6 , pp. 2501-2506
    • Chin, K.-C.1    Li, G.G.-X.2    Ting, J.P.-Y.3
  • 88
    • 0032530457 scopus 로고    scopus 로고
    • The MHC class II transactivator (CIITA) requires conserved leucine charged domains for interactions with the conserved W box promoter element
    • DOI 10.1093/nar/26.18.4128
    • Brown JA, Rogers EM, Boss JM. The MHC class II transactivator (CIITA) requires conserved leucine charged domains for interactions with the conserved W box promoter element. Nucleic Acids Res. 1998;26(18):4128-4136. (Pubitemid 28418369)
    • (1998) Nucleic Acids Research , vol.26 , Issue.18 , pp. 4128-4136
    • Brown, J.A.1    Rogers, E.M.2    Boss, J.M.3
  • 89
    • 0031571793 scopus 로고    scopus 로고
    • Activation and transdominant suppression of MHC class II and HLA-DMB promoters by a series of C-terminal class II transactivator deletion mutants
    • Chin KC, Li G, Ting JP. Activation and transdominant suppression of MHC class II and HLA-DMB promoters by a series of C-terminal class II transactivator deletion mutants. J Immunol. 1997;159(6):2789-2794. (Pubitemid 127681299)
    • (1997) Journal of Immunology , vol.159 , Issue.6 , pp. 2789-2794
    • Chin, K.-C.1    Li, G.2    Ting, J.P.-Y.3
  • 90
    • 33748493395 scopus 로고    scopus 로고
    • Epigenetic regulation during B cell differentiation controls CIITA promoter accessibility
    • Green MR, Yoon H, Boss JM. Epigenetic regulation during B cell differentiation controls CIITA promoter accessibility. J Immunol. 2006;177(6):3865-3873. (Pubitemid 44359921)
    • (2006) Journal of Immunology , vol.177 , Issue.6 , pp. 3865-3873
    • Green, M.R.1    Yoon, H.2    Boss, J.M.3
  • 95
    • 42449147063 scopus 로고    scopus 로고
    • PD-1-PD-1 ligand interaction contributes to immunosuppressive microenvironment of Hodgkin lymphoma
    • Yamamoto R, Nishikori M, Kitawaki T, et al. PD-1-PD-1 ligand interaction contributes to immunosuppressive microenvironment of Hodgkin lymphoma. Blood. 2008;111(6):3220-3224.
    • (2008) Blood. , vol.111 , Issue.6 , pp. 3220-3224
    • Yamamoto, R.1    Nishikori, M.2    Kitawaki, T.3
  • 97
    • 77956578834 scopus 로고    scopus 로고
    • MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: Rationale for treatment of NF-kappaB-dependent lymphoma
    • Milhollen MA, Traore T, Adams-Duffy J, et al. MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF-kappaB-dependent lymphoma. Blood. 2010;116(9):1515-1523.
    • (2010) Blood. , vol.116 , Issue.9 , pp. 1515-1523
    • Milhollen, M.A.1    Traore, T.2    Adams-Duffy, J.3
  • 98
    • 51649092609 scopus 로고    scopus 로고
    • Vorinostat inhibits STAT6-mediated TH2 cytokine and TARC production and induces cell death in Hodgkin lymphoma cell lines
    • Buglio D, Georgakis GV, Hanabuchi S, et al. Vorinostat inhibits STAT6-mediated TH2 cytokine and TARC production and induces cell death in Hodgkin lymphoma cell lines. Blood. 2008;112(4):1424-1433.
    • (2008) Blood. , vol.112 , Issue.4 , pp. 1424-1433
    • Buglio, D.1    Georgakis, G.V.2    Hanabuchi, S.3
  • 99
    • 77749279776 scopus 로고    scopus 로고
    • PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors
    • Curran MA, Montalvo W, Yagita H, Allison JP. PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors. Proc Natl Acad Sci U S A. 2010;107(9):4275-4280.
    • (2010) Proc Natl Acad Sci U S A. , vol.107 , Issue.9 , pp. 4275-4280
    • Curran, M.A.1    Montalvo, W.2    Yagita, H.3    Allison, J.P.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.