Cellular kinetics of perivascular MSC precursors

Stem Cells International

Volumn , Issue , 2013, Pages

  Chen, William C W ^a,b   Park, Tea Soon ^c   Murray, Iain R ^d,e   Zimmerlin, Ludovic ^c   Lazzari, Lorenza ^f   Huard, Johnny ^a,g   Péault, Bruno ^d,e,h  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b PA 15260   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^g MCGOWAN INSTITUTE FOR REGENERATIVE MEDICINE   (United States)

^h UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

5' NUCLEOTIDASE; CD146 ANTIGEN; ENDOGLIN; HERMES ANTIGEN; THY 1 ANTIGEN;

ADIPOSE DERIVED STEM CELL; ANGIOGENESIS; ANTIGEN EXPRESSION; BLOOD VESSEL; BONE MARROW CELL; CELL ACTIVATION; CELL ACTIVITY; CELL ADHESION; CELL COMPOSITION; CELL CULTURE; CELL FUNCTION; CELL HOMING; CELL HYPOXIA; CELL INTERACTION; CELL KINETICS; CELL MIGRATION; CELL REGENERATION; CELL SUBPOPULATION; CELLULAR DISTRIBUTION; ENDOTHELIAL PROGENITOR CELL; ENGRAFTMENT; GESTATIONAL AGE; HEMATOPOIETIC STEM CELL; HUMAN; MESENCHYMAL STEM CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMA CELL; MULTIPOTENT STEM CELL; MUSCLE REGENERATION; NONHUMAN; PERICYTE; PHENOTYPE; PLACENTA; PRIORITY JOURNAL; REGENERATIVE MEDICINE; REVIEW; SKELETAL MUSCLE; STEM CELL; TISSUE REGENERATION; TISSUE REPAIR; UMBILICAL CORD; VASCULARIZATION;

EID: 84884243077     PISSN: None     EISSN: 16879678     Source Type: Journal    
DOI: 10.1155/2013/983059     Document Type: Review

References (213)

1. Bruder S. P., Gazit D., Passi-Even L., Bab I., Caplan A. I., Osteochondral differentiation and the emergence of stage-specific osteogenic cell-surface molecules by bone marrow cells in diffusion chambers. Bone and Mineral 1990 11 2 141 151 2-s2.0-0025007284 10.1016/0169-6009(90)90054-J
2. Zuk P. A., Zhu M., Mizuno H., Huang J., Futrell J. W., Katz A. J., Benhaim P., Lorenz H. P., Hedrick M. H., Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Engineering 2001 7 2 211 228 2-s2.0-0035067539 10.1089/107632701300062859
3. Caplan A. I., Dennis J. E., Mesenchymal stem cells as trophic mediators. Journal of Cellular Biochemistry 2006 98 5 1076 1084 2-s2.0-33746424373 10.1002/jcb.20886
4. García-Castro J., Trigueros C., Madrenas J., Pérez- Simón J. A., Rodriguez R., Menendez P., Mesenchymal stem cells and their use as cell replacement therapy and disease modelling tool. Journal of Cellular and Molecular Medicine 2008 12 6B 2552 2565 2-s2.0-58149462473 10.1111/j.1582-4934.2008.00516.x
5. Prasongchean W., Ferretti P., Autologous stem cells for personalised medicine. New Biotechnology 2012 29 6 641 650
6. Steinert A. F., Rackwitz L., Gilbert F., Noth U., Tuan R. S., Concise review: the clinical application of mesenchymal stem cells for musculoskeletal regeneration: current status and perspectives. Stem Cells Translational Medicine 2012 1 3 237 247
7. Wu L., Cai X., Zhang S., Karperien M., Lin Y., Regeneration of articular cartilage by adipose tissue derived mesenchymal stem cells: perspectives from stem cell biology and molecular medicine. Journal of Cellular Physiology 2013 228 5 938 944
8. Jackson W. M., Nesti L. J., Tuan R. S., Potential therapeutic applications of muscle-derived mesenchymal stem and progenitor cells. Expert Opinion on Biological Therapy 2010 10 4 505 517 2-s2.0-77949464076 10.1517/14712591003610606
9. Chen C. W., Huard J., Péault B., Xiao Y., Mesenchymal stem cells and cardiovascular repair. Mesenchymal Stem Sells 2011 New York, NY, USA Nova Science Publishers
10. Jackson W. M., Nesti L. J., Tuan R. S., Concise review: clinical translation of wound healing therapies based on mesenchymal stem cells. Stem Cells Translational Medicine 2012 1 1 44 50
11. Pontikoglou C., Deschaseaux F., Sensebé L., Papadaki H. A., Bone marrow mesenchymal stem cells: biological properties and their role in hematopoiesis and hematopoietic stem cell transplantation. Stem Cell Reviews and Reports 2011 7 3 569 589 2-s2.0-79960290734 10.1007/s12015-011-9228-8
12. Reinders M. E. J., Rabelink T. J., de Fijter J. W., The role of mesenchymal stromal cells in chronic transplant rejection after solid organ transplantation. Current Opinion in Organ Transplantation 2013 18 1 44 50 10.1097/MOT.0b013e32835c2939
13. Wang L., Zhao Y., Shi S., Interplay between mesenchymal stem cells and lymphocytes: implications for immunotherapy and tissue regeneration. Journal of Dental Research 2012 91 11 1003 1010
14. Bernardo M. E., Fibbe W. E., Safety and efficacy of mesenchymal stromal cell therapy in autoimmune disorders. Annals of the New York Academy of Sciences 2012 1266 1 107 117
15. Meirelles L. D. S., Caplan A. I., Nardi N. B., In search of the in vivo identity of mesenchymal stem cells. Stem Cells 2008 26 9 2287 2299 2-s2.0-55049092713 10.1634/stemcells.2007-1122
16. Pevsner-Fischer M., Levin S., Zipori D., The origins of mesenchymal stromal cell heterogeneity. Stem Cell Reviews and Reports 2011 7 3 560 568 2-s2.0-79960315546 10.1007/s12015-011-9229-7
17. Chen C.-W., Corselli M., Péault B., Huard J., Human blood-vessel-derived stem cells for tissue repair and regeneration. Journal of Biomedicine and Biotechnology 2012 2012 9 2-s2.0-84858143597 10.1155/2012/597439 597439
18. Sacchetti B., Funari A., Michienzi S., Di Cesare S., Piersanti S., Saggio I., Tagliafico E., Ferrari S., Robey P. G., Riminucci M., Bianco P., Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment. Cell 2007 131 2 324 336 2-s2.0-35348921682 10.1016/j.cell.2007.08.025
19. Tavazoie M., van der Veken L., Silva-Vargas V., Louissaint M., Colonna L., Zaidi B., Garcia-Verdugo J. M., Doetsch F., A specialized vascular niche for adult neural stem cells. Cell Stem Cell 2008 3 3 279 288 2-s2.0-50849102656 10.1016/j.stem.2008.07.025
20. Shi S., Gronthos S., Perivascular niche of postnatal mesenchymal stem cells in human bone marrow and dental pulp. Journal of Bone and Mineral Research 2003 18 4 696 704 2-s2.0-0042306316
21. Tang W., Zeve D., Suh J. M., Bosnakovski D., Kyba M., Hammer R. E., Tallquist M. D., Graff J. M., White fat progenitor cells reside in the adipose vasculature. Science 2008 322 5901 583 586 2-s2.0-53549130485 10.1126/science.1156232
22. Tavian M., Zheng B., Oberlin E., Crisan M., Sun B., Huard J., Peault B., The vascular wall as a source of stem cells. Annals of the New York Academy of Sciences 2005 1044 41 50 2-s2.0-22044436702 10.1196/annals.1349.006
23. Crisan M., Yap S., Casteilla L., Chen C.-W., Corselli M., Park T. S., Andriolo G., Sun B., Zheng B., Zhang L., Norotte C., Teng P.-N., Traas J., Schugar R., Deasy B. M., Badylak S., Buhring H.-J., Giacobino J.-P., Lazzari L., Huard J., Péault B., A perivascular origin for mesenchymal stem cells in multiple human organs. Cell Stem Cell 2008 3 3 301 313 2-s2.0-50849139576 10.1016/j.stem.2008.07.003
24. Corselli M., Chen C. W., Sun B., Yap S., Rubin J. P., Péault B., The tunica adventitia of human arteries and veins as a source of mesenchymal stem cells. Stem Cells and Development 2012 21 8 1299 1308
25. Zheng B., Cao B., Crisan M., Sun B., Li G., Logar A., Yap S., Pollett J. B., Drowley L., Cassino T., Gharaibeh B., Deasy B. M., Huard J., Péault B., Prospective identification of myogenic endothelial cells in human skeletal muscle. Nature Biotechnology 2007 25 9 1025 1034 2-s2.0-34948857869 10.1038/nbt1334
26. Ballas C. B., Zielske S. P., Gerson S. L., Adult bone marrow stem cells for cell and gene therapies: implications for greater use. Journal of Cellular Biochemistry 2002 38 20 28 2-s2.0-0036362219
27. Chao H., Hirschi K. K., Hemato-vascular origins of endothelial progenitor cells? Microvascular Research 2010 79 3 169 173 2-s2.0-77952097368 10.1016/j.mvr.2010.02.003
28. Choi Y.-H., Kurtz A., Stamm C., Mesenchymal stem cells for cardiac cell therapy. Human Gene Therapy 2011 22 1 3 17 2-s2.0-79951880790 10.1089/hum.2010.211
29. Russell K. C., Phinney D. G., Lacey M. R., Barrilleaux B. L., Meyertholen K. E., O'Connor K. C., In vitro high-capacity assay to quantify the clonal heterogeneity in trilineage potential of mesenchymal stem cells reveals a complex hierarchy of lineage commitment. Stem Cells 2010 28 4 788 798 2-s2.0-77950991204 10.1002/stem.312
30. Van R. L. R., Bayliss C. E., Roncari D. A. K., Cytological and enzymological characterization of adult human adipocyte precursors in culture. Journal of Clinical Investigation 1976 58 3 699 704 2-s2.0-0017133796
31. Dardick I., Poznanski W. J., Waheed I., Setterfield G., Ultrastructural observations on differentiating human preadipocytes cultured in vitro. Tissue and Cell 1976 8 3 561 571 2-s2.0-0017151728 10.1016/0040-8166(76)90013-6
32. Zuk P. A., Zhu M., Ashjian P., De Ugarte D. A., Huang J. I., Mizuno H., Alfonso Z. C., Fraser J. K., Benhaim P., Hedrick M. H., Human adipose tissue is a source of multipotent stem cells. Molecular Biology of the Cell 2002 13 12 4279 4295 2-s2.0-18744373595 10.1091/mbc.E02-02-0105
33. Daher S. R., Johnstone B. H., Phinney D. G., March K. L., Adipose stromal/stem cells: basic and translational advances: the IFATS collection. Stem Cells 2008 26 10 2664 2665 2-s2.0-55049130440 10.1634/stemcells.2008-0927
34. Dominici M., Le Blanc K., Mueller I., Slaper-Cortenbach I., Marini F. C., Krause D. S., Deans R. J., Keating A., Prockop D. J., Horwitz E. M., Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 2006 8 4 315 317 2-s2.0-33747713246 10.1080/14653240600855905
35. Mitchell J. B., McIntosh K., Zvonic S., Garrett S., Floyd Z. E., Kloster A., Di Halvorsen Y., Storms R. W., Goh B., Kilroy G., Wu X., Gimble J. M., Immunophenotype of human adipose-derived cells: temporal changes in stromal-associated and stem cell-associated markers. Stem Cells 2006 24 2 376 385 2-s2.0-33746868358 10.1634/stemcells.2005-0234
36. Civin C. I., Strauss L. C., Brovall C., Antigenic analysis of hematopoiesis. III. A hematopoietic progenitor cell surface antigen defined by a monoclonal antibody raised against KG-1a cells. Journal of Immunology 1984 133 1 157 165 2-s2.0-0021250078
37. Asahara T., Murohara T., Sullivan A., Silver M., Van Der Zee R., Li T., Witzenbichler B., Schatteman G., Isner J. M., Isolation of putative progenitor endothelial cells for angiogenesis. Science 1997 275 5302 964 967 2-s2.0-0031019745 10.1126/science.275.5302.964
38. Sengenès C., Lolmède K., Zakaroff-Girard A., Busse R., Bouloumié A., Preadipocytes in the human subcutaneous adipose tissue display distinct features from the adult mesenchymal and hematopoietic stem cells. Journal of Cellular Physiology 2005 205 1 114 122 2-s2.0-24344448623 10.1002/jcp.20381
39. Zimmerlin L., Donnenberg V. S., Pfeifer M. E., Meyer E. M., Péault B., Rubin J. P., Donnenberg A. D., Stromal vascular progenitors in adult human adipose tissue. Cytometry A 2010 77 1 22 30 2-s2.0-74049104475 10.1002/cyto.a.20813
40. Suga H., Matsumoto D., Eto H., Inoue K., Aoi N., Kato H., Araki J., Yoshimura K., Functional implications of CD34 expression in human adipose-derived stem/progenitor cells. Stem Cells and Development 2009 18 8 1201 1209 2-s2.0-67650811823 10.1089/scd.2009.0003
41. Lin C.-S., Xin Z.-C., Deng C.-H., Ning H., Lin G., Lue T. F., Defining adipose tissue-derived stem cells in tissue and in culture. Histology and Histopathology 2010 25 6 807 815 2-s2.0-77953395031
42. Lin G., Garcia M., Ning H., Banie L., Guo Y.-L., Lue T. F., Lin C.-S., Defining stem and progenitor cells within adipose tissue. Stem Cells and Development 2008 17 6 1053 1063 2-s2.0-57049136677 10.1089/scd.2008.0117
43. Li H., Zimmerlin L., Marra K. G., Donnenberg V. S., Donnenberg A. D., Rubin J. P., Adipogenic potential of adipose stem cell subpopulations. Plastic and Reconstructive Surgery 2011 128 3 663 672
44. Spalding K. L., Arner E., Westermark P. O., Bernard S., Buchholz B. A., Bergmann O., Blomqvist L., Hoffstedt J., Näslund E., Britton T., Concha H., Hassan M., Rydén M., Frisén J., Arner P., Dynamics of fat cell turnover in humans. Nature 2008 453 7196 783 787 2-s2.0-44849132591 10.1038/nature06902
45. Witkowska-Zimny M., Wrobel E., Perinatal sources of mesenchymal stem cells: wharton's jelly, amnion and chorion. Cellular and Molecular Biology Letters 2011 16 3 493 514 2-s2.0-80052500026 10.2478/s11658-011-0019-7
46. Taghizadeh R. R., Cetrulo K. J., Cetrulo C. L., Wharton's Jelly stem cells: future clinical applications. Placenta 2011 32 4 S311 S315 2-s2.0-80052434885 10.1016/j.placenta.2011.06.010
47. Troyer D. L., Weiss M. L., Concise review: wharton's Jelly-derived cells are a primitive stromal cell population. Stem Cells 2008 26 3 591 599 2-s2.0-43049151898 10.1634/stemcells.2007-0439
48. Kumar V., Fausto N., Abbas A., Robbins and cotran pathologic basis of disease. Blood Vessels 2004 7th chapter 11 Philadelphia, Pa, USA Saunders
49. Cossu G., Bianco P., Mesoangioblasts: vascular progenitors for extravascular mesodermal tissues. Current Opinion in Genetics and Development 2003 13 5 537 542 2-s2.0-0141561864 10.1016/j.gde.2003.08.001
50. Galli D., Innocenzi A., Staszewsky L., Zanetta L., Sampaolesi M., Bai A., Martinoli E., Carlo E., Balconi G., Fiordaliso F., Chimenti S., Cusella G., Dejana E., Cossu G., Latini R., Mesoangioblasts, vessel-associated multipotent stem cells, repair the infarcted heart by multiple cellular mechanisms: a comparison with bone marrow progenitors, fibroblasts, and endothelial cells. Arteriosclerosis, Thrombosis, and Vascular Biology 2005 25 4 692 697 2-s2.0-20144387678 10.1161/01.ATV.0000156402.52029.ce
51. Armulik A., Abramsson A., Betsholtz C., Endothelial/pericyte interactions. Circulation Research 2005 97 6 512 523 2-s2.0-25444463573 10.1161/01.RES.0000182903.16652.d7
52. von Tell D., Armulik A., Betsholtz C., Pericytes and vascular stability. Experimental Cell Research 2006 312 5 623 629 2-s2.0-33344468704 10.1016/j.yexcr.2005.10.019
53. Rucker H. K., Wynder H. J., Thomas W. E., Cellular mechanisms of CNS pericytes. Brain Research Bulletin 2000 51 5 363 369 2-s2.0-0034010980 10.1016/S0361-9230(99)00260-9
54. Dore-Duffy P., LaManna J. C., Physiologic angiodynamics in the brain. Antioxidants and Redox Signaling 2007 9 9 1363 1371 2-s2.0-34547916146 10.1089/ars.2007.1713
55. Kuhnert F., Tam B. Y. Y., Sennino B., Gray J. T., Yuan J., Jocson A., Nayak N. R., Mulligan R. C., McDonald D. M., Kuo C. J., Soluble receptor-mediated selective inhibition of VEGFR and PDGFR β signaling during physiologic and tumor angiogenesis. Proceedings of the National Academy of Sciences of the United States of America 2008 105 29 10185 10190 2-s2.0-48249099658 10.1073/pnas.0803194105
56. Lindahl P., Johansson B. R., Levéen P., Betsholtz C., Pericyte loss and microaneurysm formation in PDGF-B-deficient mice. Science 1997 277 5323 242 245 2-s2.0-0030756325 10.1126/science.277.5323.242
57. Majesky M. W., Dong X. R., Hoglund V., Mahoney W. M. Jr., Daum G., The adventitia: a dynamic interface containing resident progenitor cells. Arteriosclerosis, Thrombosis, and Vascular Biology 2011 31 7 1530 1539 2-s2.0-79959763975 10.1161/ATVBAHA.110.221549
58. Hu Y., Xu Q., Adventitial biology: differentiation and function. Arteriosclerosis, Thrombosis, and Vascular Biology 2011 31 7 1523 1529 2-s2.0-79959768257 10.1161/ATVBAHA.110.221176
59. Tang Z., Wang A., Yuan F., Yan Z., Liu B., Chu J. S., Helms J. A., Li S., Differentiation of multipotent vascular stem cells contributes to vascular diseases. Nature Communications 2012 3, article 875 10.1038/ncomms1867
60. Hu Y., Zhang Z., Torsney E., Afzal A. R., Davison F., Metzler B., Xu Q., Abundant progenitor cells in the adventitia contribute to atheroscleroses of vein grafts in ApoE-deficient mice. Journal of Clinical Investigation 2004 113 9 1258 1265 2-s2.0-2342563875 10.1172/JCI200419628
61. Shi Y., O'Brien J. E. Jr., Fard A., Mannion J. D., Wang D., Zalewski A., Adventitial myofibroblasts contribute to neointimal formation in injured porcine coronary arteries. Circulation 1996 94 7 1655 1664 2-s2.0-0029784055
62. Oparil S., Chen S.-J., Chen Y.-F., Durand J. N., Allen L., Thompson J. A., Estrogen attenuates the adventitial contribution to neointima formation in injured rat carotid arteries. Cardiovascular Research 1999 44 3 608 614 2-s2.0-0033462232 10.1016/S0008-6363(99)00240-0
63. Crisan M., Huard J., Zheng B., Sun B., Yap S., Logar A., Giacobino J. P., Casteilla L., Péault B., Purification and culture of human blood vessel-associated progenitor cells. Current Protocols in Stem Cell Biology 2007 John Wiley and Sons
64. Dellavalle A., Sampaolesi M., Tonlorenzi R., Tagliafico E., Sacchetti B., Perani L., Innocenzi A., Galvez B. G., Messina G., Morosetti R., Li S., Belicchi M., Peretti G., Chamberlain J. S., Wright W. E., Torrente Y., Ferrari S., Bianco P., Cossu G., Pericytes of human skeletal muscle are myogenic precursors distinct from satellite cells. Nature Cell Biology 2007 9 3 255 267 2-s2.0-33847414019 10.1038/ncb1542
65. Campagnolo P., Cesselli D., Al Haj Zen A., Beltrami A. P., Kränkel N., Katare R., Angelini G., Emanueli C., Madeddu P., Human adult vena saphena contains perivascular progenitor cells endowed with clonogenic and proangiogenic potential. Circulation 2010 121 15 1735 1745 2-s2.0-77951476043 10.1161/CIRCULATIONAHA.109.899252
66. Tilki D., Hohn H.-P., Ergün B., Rafii S., Ergün S., Emerging biology of vascular wall progenitor cells in health and disease. Trends in Molecular Medicine 2009 15 11 501 509 2-s2.0-70449413790 10.1016/j.molmed.2009. 09.004
67. Zengin E., Chalajour F., Gehling U. M., Ito W. D., Treede H., Lauke H., Weil J., Reichenspurner H., Kilic N., Ergün S., Vascular wall resident progenitor cells: a source for postnatal vasculogenesis. Development 2006 133 8 1543 1551 2-s2.0-33646673174 10.1242/dev.02315
68. Okada M., Payne T. R., Zheng B., Oshima H., Momoi N., Tobita K., Keller B. B., Phillippi J. A., Péault B., Huard J., Myogenic endothelial cells purified from human skeletal muscle improve cardiac function after transplantation into infarcted myocardium. Journal of the American College of Cardiology 2008 52 23 1869 1880 2-s2.0-56349134139 10.1016/j.jacc.2008.07.064
69. Zheng B., Chen C. W., Li G., Thompson S. D., Poddar M., Péault B., Huard J., Isolation of myogenic stem cells from cultures of cryopreserved human skeletal muscle. Cell transplantation 2012 21 6 1087 1093
70. Park T. S., Gavina M., Chen C.-W., Sun B., Teng P.-N., Huard J., Deasy B. M., Zimmerlin L., Péault B., Placental perivascular cells for human muscle regeneration. Stem Cells and Development 2011 20 3 451 463 2-s2.0-79952162050 10.1089/scd.2010.0354
71. Montemurro T., Andriolo G., Montelatici E., Weissmann G., Crisan M., Colnaghi M. R., Rebulla P., Mosca F., Péault B., Lazzari L., Differentiation and migration properties of human foetal umbilical cord perivascular cells: potential for lung repair. Journal of Cellular and Molecular Medicine 2011 15 4 796 808 2-s2.0-79955675427 10.1111/j.1582-4934.2010.01047.x
72. Zebardast N., Lickorish D., Davies J. E., Human umbilical cord perivascular cells (HUCPVC): a mesenchymal cell source for dermal wound healing. Organogenesis 2010 6 4 197 203 2-s2.0-77956420291 10.4161/org.6.4.12393
73. Carvalho M. M., Teixeira F. G., Reis R. L., Sousa N., Salgado A. J., Mesenchymal stem cells in the umbilical cord: phenotypic characterization, secretome and applications in central nervous system regenerative medicine. Current Stem Cell Research and Therapy 2011 6 3 221 228 2-s2.0-80051723431 10.2174/157488811796575332
74. Jauniaux E., Burton G. J., Moscoso G. J., Hustin J., Development of the early human placenta: a morphometric study. Placenta 1991 12 3 269 276 2-s2.0-0025880716
75. Bárcena A., Kapidzic M., Muench M. O., Gormley M., Scott M. A., Weier J. F., Ferlatte C., Fisher S. J., The human placenta is a hematopoietic organ during the embryonic and fetal periods of development. Developmental Biology 2009 327 1 24 33 2-s2.0-59649120870 10.1016/j.ydbio.2008.11.017
76. Demir R., Kaufmann P., Castellucci M., Erbengi T., Kotowski A., Fetal vasculogenesis and angiogenesis in human placental villi1. Acta Anatomica 1989 136 3 190 203 2-s2.0-0024789635
77. Wareing M., Effects of oxygenation and luminal flow on human placenta chorionic plate blood vessel function. Journal of Obstetrics and Gynaecology Research 2012 38 1 185 191 2-s2.0-84856294086 10.1111/j.1447-0756.2011.01666.x
78. Jones C. J. P., Desoye G., A new possible function for placental pericytes. Cells Tissues Organs 2011 194 1 76 84 2-s2.0-79959380406 10.1159/000322394
79. Castrechini N. M., Murthi P., Gude N. M., Erwich J. J. H. M., Gronthos S., Zannettino A., Brennecke S. P., Kalionis B., Mesenchymal stem cells in human placental chorionic villi reside in a vascular Niche. Placenta 2010 31 3 203 212 2-s2.0-76749150934 10.1016/j.placenta.2009.12.006
80. Maier C. L., Shepherd B. R., Yi T., Pober J. S., Explant outgrowth, propagation and characterization of human pericytes. Microcirculation 2010 17 5 367 380 2-s2.0-77954344357 10.1111/j.1549-8719.2010.00038.x
81. Péault B., Rudnicki M., Torrente Y., Cossu G., Tremblay J. P., Partridge T., Gussoni E., Kunkel L. M., Huard J., Stem and progenitor cells in skeletal muscle development, maintenance, and therapy. Molecular Therapy 2007 15 5 867 877 2-s2.0-34247236574 10.1038/mt.sj.6300145
82. Deasy B. M., Li Y., Huard J., Tissue engineering with muscle-derived stem cells. Current Opinion in Biotechnology 2004 15 5 419 423 2-s2.0-4644240054 10.1016/j.copbio.2004.08.004
83. Sampaolesi M., Blot S., D'Antona G., Granger N., Tonlorenzi R., Innocenzi A., Mognol P., Thibaud J.-L., Galvez B. G., Barthélémy I., Perani L., Mantero S., Guttinger M., Pansarasa O., Rinaldi C., Cusella De Angelis M. G., Torrente Y., Bordignon C., Bottinelli R., Cossu G., Mesoangioblast stem cells ameliorate muscle function in dystrophic dogs. Nature 2006 444 7119 574 579 2-s2.0-33845257119 10.1038/nature05282
84. Cao B., Zheng B., Jankowski R. J., Kimura S., Ikezawa M., Deasy B., Cummins J., Epperly M., Qu-Petersen Z., Huard J., Muscle stem cells differentiate into haematopoietic lineages but retain myogenic potential. Nature Cell Biology 2003 5 7 640 646 2-s2.0-0038726091 10.1038/ncb1008
85. Oshima H., Payne T. R., Urish K. L., Sakai T., Ling Y., Gharaibeh B., Tobita K., Keller B. B., Cummins J. H., Huard J., Differential myocardial infarct repair with muscle stem cells compared to myoblasts. Molecular Therapy 2005 12 6 1130 1141 2-s2.0-28444464004 10.1016/j.ymthe.2005.07.686
86. Uezumi A., Fukada S.-I., Yamamoto N., Takeda S., Tsuchida K., Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle. Nature Cell Biology 2010 12 2 143 152 2-s2.0-75949130333 10.1038/ncb2014
87. Pusztaszeri M. P., Seelentag W., Bosman F. T., Immunohistochemical expression of endothelial markers CD31, CD34, von Willebrand factor, and Fli-1 in normal human tissues. Journal of Histochemistry and Cytochemistry 2006 54 4 385 395 2-s2.0-33645123097 10.1369/jhc.4A6514.2005
88. James A. W., Zara J. N., Corselli M., Askarinam A., Zhou A. M., Hourfar A., Nguyen A., Megerdichian S., Asatrian G., Pang S., Stoker D., Zhang X., Wu B., Ting K., Péault B., Soo C., An abundant perivascular source of stem cells for bone tissue engineering. Stem Cells Translational Medicine 2012 1 9 673 684
89. James A. W., Zara J. N., Zhang X., Askarinam A., Goyal R., Chiang M., Yuan W., Chang L., Corselli M., Shen J., Pang S., Stoker D., Wu B., Ting K., Péault B., Soo C., Perivascular stem cells: a prospectively purified mesenchymal stem cell population for bone tissue engineering. Stem Cells Translational Medicine 2012 1 6 510 519
90. Waller E. K., Olweus J., Lund-Johansen F., Huang S., Nguyen M., Guo-G. R., Terstappen L., The "common stem cell" hypothesis reevaluated: human fetal bone marrow contains separate populations of hematopoietic and stromal progenitors. Blood 1995 85 9 2422 2435 2-s2.0-0028946863
91. Waller E. K., Huang S., Terstappen L., Changes in the growth properties of CD34+, CD38- bone marrow progenitors during human fetal development. Blood 1995 86 2 710 718 2-s2.0-0029072589
92. Simmons D. J., Seitz P., Kidder L., Klein G. L., Waeltz M., Gundberg C. M., Tabuchi C., Yang C., Zhang R. W., Partial characterization of rat marrow stromal cells. Calcified Tissue International 1991 48 5 326 334 2-s2.0-0025730633
93. Kaiser S., Hackanson B., Follo M., Mehlhorn A., Geiger K., Ihorst G., Kapp U., BM cells giving rise to MSC in culture have a heterogeneous CD34 and CD45 phenotype. Cytotherapy 2007 9 5 439 450 2-s2.0-34548570285 10.1080/14653240701358445
94. Kopher R. A., Penchev V. R., Islam M. S., Hill K. L., Khosla S., Kaufman D. S., Human embryonic stem cell-derived CD34+ cells function as MSC progenitor cells. Bone 2010 47 4 718 728 2-s2.0-77956407150 10.1016/j.bone.2010.06.020
95. Barbet R., Peiffer I., Hatzfeld A., Charbord P., Hatzfeld J. A., Comparison of gene expression in human embryonic stem cells, hESC-derived mesenchymal stem cells and human mesenchymal stem cells. Stem Cells International 2011 2011 9 2-s2.0-81555207180 10.4061/2011/368192 368192
96. Vodyanik M. A., Yu J., Zhang X., Tian S., Stewart R., Thomson J. A., Slukvin I. I., A mesoderm-derived precursor for mesenchymal stem and endothelial cells. Cell Stem Cell 2010 7 6 718 729 2-s2.0-78649647544 10.1016/j.stem.2010. 11.011
97. Dar A., Domev H., Ben-Yosef O., Tzukerman M., Zeevi-Levin N., Novak A., Germanguz I., Amit M., Itskovitz-Eldor J., Multipotent vasculogenic pericytes from human pluripotent stem cells promote recovery of murine ischemic limb. Circulation 2012 125 1 87 99 2-s2.0-84855407739 10.1161/CIRCULATIONAHA.111. 048264
98. Traktuev D. O., Merfeld-Clauss S., Li J., Kolonin M., Arap W., Pasqualini R., Johnstone B. H., March K. L., A population of multipotent CD34-positive adipose stromal cells share pericyte and mesenchymal surface markers, reside in a periendothelial location, and stabilize endothelial networks. Circulation Research 2008 102 1 77 85 2-s2.0-37849026091 10.1161/CIRCRESAHA.107.159475
99. Yamanishi H., Fujiwara S., Soma T., Perivascular localization of dermal stem cells in human scalp. Experimental Dermatology 2012 21 1 78 80 2-s2.0-83455250603 10.1111/j.1600-0625.2011.01407.x
100. Zimmerlin L., Donnenberg V. S., Donnenberg A. D., Rare event detection and analysis in flow cytometry: bone marrow mesenchymal stem cells, breast cancer stem/progenitor cells in malignant effusions, and pericytes in disaggregated adipose tissue. Methods in Molecular Biology 2011 699 251 273 2-s2.0-79956290081
101. Zimmerlin L., Donnenberg V. S., Rubin J. P., Donnenberg A. D., Mesenchymal markers on human adipose stem/progenitor cells. Cytometry A 2012 83 1 134 140
102. Zimmerlin L., Donnenberg V. S., Donnenberg A. D., Pericytes: a universal adult tissue stem cell? Cytometry A 2012 81 1 12 14 2-s2.0-83855160794 10.1002/cyto.a.21168
103. Yoshimura K., Shigeura T., Matsumoto D., Sato T., Takaki Y., Aiba-Kojima E., Sato K., Inoue K., Nagase T., Koshima I., Gonda K., Characterization of freshly isolated and cultured cells derived from the fatty and fluid portions of liposuction aspirates. Journal of Cellular Physiology 2006 208 1 64 76 2-s2.0-33744929131 10.1002/jcp.20636
104. Covas D. T., Panepucci R. A., Fontes A. M., Silva W. A. Jr., Orellana M. D., Freitas M. C. C., Neder L., Santos A. R. D., Peres L. C., Jamur M. C., Zago M. A., Multipotent mesenchymal stromal cells obtained from diverse human tissues share functional properties and gene-expression profile with CD146+ perivascular cells and fibroblasts. Experimental Hematology 2008 36 5 642 654 2-s2.0-42249092647 10.1016/j.exphem.2007.12.015
105. Zannettino A. C. W., Paton S., Arthur A., Khor F., Itescu S., Gimble J. M., Gronthos S., Multipotential human adipose-derived stromal stem cells exhibit a perivascular phenotype in vitro and in vivo. Journal of Cellular Physiology 2008 214 2 413 421 2-s2.0-37349030439 10.1002/jcp.21210
106. Maumus M., Peyrafitte J.-A., D'Angelo R., Fournier-Wirth C., Bouloumié A., Casteilla L., Sengenès C., Bourin P., Native human adipose stromal cells: localization, morphology and phenotype. International Journal of Obesity 2011 35 9 1141 1153 2-s2.0-80052732753 10.1038/ijo.2010.269
107. Astori G., Vignati F., Bardelli S., Tubio M., Gola M., Albertini V., Bambi F., Scali G., Castelli D., Rasini V., Soldati G., Moccetti T., 'In vitro' and multicolor phenotypic characterization of cell subpopulations identified in fresh human adipose tissue stromal vascular fraction and in the derived mesenchymal stem cells. Journal of Translational Medicine 2007 5, article 55 2-s2.0-38349076518 10.1186/1479-5876-5-55
108. Sahin A. O., Buitenhuis M., Molecular mechanisms underlying adhesion and migration of hematopoietic stem cells. Cell Adhesion and Migration 2012 6 1 39 48 2-s2.0-84860371869 10.4161/cam.6.1.18975
109. Augello A., Kurth T. B., de Bari C., Mesenchymal stem cells: a perspective from in vitro cultures to in vivo migration and niches. European Cells and Materials 2010 20 121 133 2-s2.0-77957133737
110. Kang S. K., Shin I. S., Ko M. S., Jo J. Y., Ra J. C., Journey of mesenchymal stem cells for homing: atrategies to enhance efficacy and safety of stem cell therapy. Stem Cells International 2012 2012 11 342968 10.1155/2012/342968
111. Armulik A., Genové G., Betsholtz C., Pericytes: developmental, physiological, and pathological perspectives, problems, and promises. Developmental Cell 2011 21 2 193 215 2-s2.0-79961230399 10.1016/j.devcel.2011. 07.001
112. Arthur A., Zannettino A., Panagopoulos R., Koblar S. A., Sims N. A., Stylianou C., Matsuo K., Gronthos S., EphB/ephrin-B interactions mediate human MSC attachment, migration and osteochondral differentiation. Bone 2011 48 3 533 542 2-s2.0-79751533475 10.1016/j.bone.2010.10.180
113. Foo S. S., Turner C. J., Adams S., Compagni A., Aubyn D., Kogata N., Lindblom P., Shani M., Zicha D., Adams R. H., Ephrin-B2 controls cell motility and adhesion during blood-vessel-wall assembly. Cell 2006 124 1 161 173 2-s2.0-30344440869 10.1016/j.cell.2005.10.034
114. Stark K., Eckart A., Haidari S., Capillary and arteriolar pericytes attract innate leukocytes exiting through venules and "instruct" them with pattern-recognition and motility programs. Nature Immunology 2013 14 1 41 51
115. Bordon Y., Cell migration: pericytes: route planners. Nature Reviews Immunology 2013 13 1 5
116. Hellström M., Kalén M., Lindahl P., Abramsson A., Betsholtz C., Role of PDGF-B and PDGFR- β in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse. Development 1999 126 14 3047 3055 2-s2.0-0032768156
117. Enge M., Bjarnegård M., Gerhardt H., Gustafsson E., Kalén M., Asker N., Hammes H.-P., Shani M., Fässler R., Betsholtz C., Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy. EMBO Journal 2002 21 16 4307 4316 2-s2.0-18544366585 10.1093/emboj/cdf418
118. Abramsson A., Lindblom P., Betsholtz C., Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors. Journal of Clinical Investigation 2003 112 8 1142 1151 2-s2.0-0345798150 10.1172/JCI200318549
119. Ejaz S., Importance of pericytes and mechanisms of pericyte loss during diabetes retinopathy. Diabetes, Obesity and Metabolism 2008 10 1 53 63 2-s2.0-37349105431 10.1111/j.1463-1326.2007.00795.x
120. le Blanc K., Immunomodulatory effects of fetal and adult mesenchymal stem cells. Cytotherapy 2003 5 6 485 489 2-s2.0-0347600715 10.1080/14653240310003611
121. Ware L. B., Matthay M. A., Keratinocyte and hepatocyte growth factors in the lung: roles in lung development, inflammation, and repair. The American Journal of Physiology 2002 282 5 L924 L940 2-s2.0-0036080893
122. Curley G. F., Hayes M., Ansari B., Shaw G., Ryan A., Barry F., O'Brien T., O'Toole D., Laffey J. G., Mesenchymal stem cells enhance recovery and repair following ventilator-induced lung injury in the rat. Thorax 2012 67 6 496 501 2-s2.0-81355160880 10.1136/thoraxjnl-2011-201059
123. Chen C.-W., Montelatici E., Crisan M., Corselli M., Huard J., Lazzari L., Péault B., Perivascular multi-lineage progenitor cells in human organs: regenerative units, cytokine sources or both? Cytokine and Growth Factor Reviews 2009 20 5-6 429 434 2-s2.0-70849089712 10.1016/j.cytogfr.2009.10.014
124. Takeoka M., Ward W. F., Pollack H., Kamp D. W., Panos R. J., KGF facilitates repair of radiation-induced DNA damage in alveolar epithelial cells. The American Journal of Physiology 1997 272 6 L1174 L1180 2-s2.0-0030785751
125. Strem B. M., Hicok K. C., Zhu M., Wulur I., Alfonso Z., Schreiber R. E., Fraser J. K., Hedrick M. H., Multipotential differentiation of adipose tissue-derived stem cells. Keio Journal of Medicine 2005 54 3 132 141 2-s2.0-27544482446 10.2302/kjm.54.132
126. Matsumoto D., Sato K., Gonda K., Takaki Y., Shigeura T., Sato T., Aiba-Kojima E., Iizuka F., Inoue K., Suga H., Yoshimura K., Cell-assisted lipotransfer: supportive use of human adipose-derived cells for soft tissue augmentation with lipoinjection. Tissue Engineering 2006 12 12 3375 3382 2-s2.0-33845945858 10.1089/ten.2006.12.3375
127. van Pham P., Bui K. H.-T., Ngo D. Q., Khuat L. T., Phan N. K., Transplantation of nonexpanded adipose stromal vascular fraction and platelet-rich plasma for articular cartilage injury treatment in mice model. Journal of Medical Engineering 2013 2013 7 832396 10.1155/2013/832396
128. Cai L., Johnstone B. H., Cook T. G., Tan J., Fishbein M. C., Chen P.-S., March K. L., IFATS collection: human adipose tissue-derived stem cells induce angiogenesis and nerve sprouting following myocardial infarction, in conjunction with potent preservation of cardiac function. Stem Cells 2009 27 1 230 237 2-s2.0-59849115616 10.1634/stemcells.2008-0273
129. Kim U., Shin D.-G., Park J.-S., Kim Y.-J., Park S.-I., Moon Y.-M., Jeong K.-S., Homing of adipose-derived stem cells to radiofrequency catheter ablated canine atrium and differentiation into cardiomyocyte-like cells. International Journal of Cardiology 2011 146 3 371 378 2-s2.0-78951494233 10.1016/j.ijcard. 2009.07.016
130. Banas A., Teratani T., Yamamoto Y., Tokuhara M., Takeshita F., Osaki M., Kawamata M., Kato T., Okochi H., Ochiya T., IFATS collection: in vivo therapeutic potential of human adipose tissue mesenchymal stem cells after transplantation into mice with liver injury. Stem Cells 2008 26 10 2705 2712 2-s2.0-53949120786 10.1634/stemcells.2008-0034
131. Kim D. H., Je C. M., Sin J. Y., Jung J. S., Effect of partial hepatectomy on in vivo engraftment after intravenous administration of human adipose tissue stromal cells in mouse. Microsurgery 2003 23 5 424 431 2-s2.0-0142182585 10.1002/micr.10178
132. Kim Y. M., Choi Y. S., Choi J. W., Park Y. H., Koo B. S., Roh H.-J., Rha K.-S., Effects of systemic transplantation of adipose tissue-derived stem cells on olfactory epithelium regeneration. Laryngoscope 2009 119 5 993 999 2-s2.0-66349129278 10.1002/lary.20187
133. Xing W., Zhimei D., Liming Z., Dongni F., Gang W., Yongzheng H., Jiangning T., Lee W.-H., Hampel H., Dodel R., Johnstone B. H., March K. L., Farlow M. R., Yansheng D., IFATS collection: the conditioned media of adipose stromal cells protect against hypoxia-ischemia-induced brain damage in neonatal rats. Stem Cells 2009 27 2 478 488 2-s2.0-62549156690 10.1634/stemcells.2008- 0333
134. Cho K.-S., Park H.-K., Park H.-Y., Jin S. J., Jeon S.-G., Kim Y.-K., Hwan J. R., IFATS collection: immunomodulatory effects of adipose tissue-derived stem cells in an allergic rhinitis mouse model. Stem Cells 2009 27 1 259 265 2-s2.0-59849120888 10.1634/stemcells.2008-0283
135. Sacerdote P., Niada S., Franchi S., Arrigoni E., Rossi A., Yenagi V., de Girolamo L., Panerai A. E., Brini A. T., Systemic administration of human adipose-derived stem cells reverts nociceptive hypersensitivity in an experimental model of neuropathy. Stem Cells and Development 2013 22 8 1252 1263 10.1089/scd.2012.0398
136. Marconi S., Castiglione G., Turano E., Bissolotti G., Angiari S., Farinazzo A., Constantin G., Bedogni G., Bedogni A., Bonetti B., Human adipose-derived mesenchymal stem cells systemically injected promote peripheral nerve regeneration in the mouse model of sciatic crush. Tissue Engineering A 2012 18 11-12 1264 1272
137. Levi B., James A. W., Nelson E. R., Hu S., Sun N., Peng M., Wu J., Longaker M. T., Studies in adipose-derived stromal cells: migration and participation in repair of cranial injury after systemic injection. Plastic and Reconstructive Surgery 2011 127 3 1130 1140 2-s2.0-79952744344 10.1097/PRS.0b013e3182043712
138. Vieira N. M., Valadares M., Zucconi E., Secco M., Bueno Jr C. R., Brandalise V., Assoni A., Gomes J., Landini V., Andrade T., Caetano H. V., Vainzof M., Zatz M., Human adipose-derived mesenchymal stromal cells injected systemically into GRMD dogs without immunosuppression are able to reach the host muscle and express human dystrophin. Cell Transplantation 2012 21 7 1407 1417
139. Vieira N. M., Bueno C. R. Jr., Brandalise V., Moraes L. V., Zucconi E., Secco M., Suzuki M. F., Camargo M. M., Bartolini P., Brum P. C., Vainzof M., Zatz M., SJL dystrophic mice express a significant amount of human muscle proteins following systemic delivery of human adipose-derived stromal cells without immunosuppression. Stem Cells 2008 26 9 2391 2398 2-s2.0-55049097324 10.1634/stemcells.2008-0043
140. Baek S. J., Kang S. K., Ra J. C., In vitro migration capacity of human adipose tissue-derived mesenchymal stem cells reflects their expression of receptors for chemokines and growth factors. Experimental and Molecular Medicine 2011 43 10 596 603 2-s2.0-80055062477 10.3858/emm.2011.43.10.069
141. Garrovo C., Bergamin N., Bates D., Cesselli D., Beltrami A. P., Lorenzon A., Ferrari R., Alberto Beltrami C., Lorusso V., Biffi S., In vivo tracking of murine adipose tissue-derived multipotent adult stem cells and ex vivo cross-validation. International Journal of Molecular Imaging 2013 2013 13 426961 10.1155/2013/426961
142. Kakudo N., Kushida S., Suzuki K., Ogura T., Notodihardjo P. V., Hara T., Kusumoto K., Effects of transforming growth factor-beta1 on cell motility, collagen gel contraction, myofibroblastic differentiation, and extracellular matrix expression of human adipose-derived stem cell. Human Cell 2012 25 4 87 95
143. Baraniak P. R., McDevitt T. C., Stem cell paracrine actions and tissue regeneration. Regenerative Medicine 2010 5 1 121 143 2-s2.0-77649285139 10.2217/rme.09.74
144. Casteilla L., Planat-Benard V., Laharrague P., Cousin B., Adipose-derived stromal cells: their identity and uses in clinical trials, an update. World Journal of Stem Cells 2011 3 4 25 33
145. Lee S. H., Jin S. Y., Song J. S., Seo K. K., Cho K. H., Paracrine effects of adipose-derived stem cells on keratinocytes and dermal fibroblasts. Annals of Dermatology 2012 24 2 136 143 2-s2.0-84860625707 10.5021/ad.2012.24.2.136
146. Hu L., Zhao J., Liu J., Gong N., Chen L., Effects of adipose stem cell-conditioned medium on the migration of vascular endothelial cells, fibroblasts and keratinocytes. Experimental and Therapeutic Medicine 2013 5 3 701 706
147. Collawn S. S., Sanjib Banerjee N., de la Torre J., Vasconez L., Chow L. T., Adipose-derived stromal cells accelerate wound healing in an organotypic raft culture model. Annals of Plastic Surgery 2012 68 5 501 504 2-s2.0-84859709756 10.1097/SAP.0b013e31823b69fc
148. Moon K. M., Park Y. H., Lee J. S., Chae Y. B., Kim M. M., Kim D. S., Kim B. W., Nam S. W., Lee J. H., The effect of secretory factors of adipose-derived stem cells on human keratinocytes. International Journal of Molecular Sciences 2012 13 1 1239 1257
149. Fu X., Fang L., Li H., Li X., Cheng B., Sheng Z., Adipose tissue extract enhances skin wound healing. Wound Repair and Regeneration 2007 15 4 540 548 2-s2.0-34447641482 10.1111/j.1524-475X.2007.00262.x
150. Karnoub A. E., Dash A. B., Vo A. P., Sullivan A., Brooks M. W., Bell G. W., Richardson A. L., Polyak K., Tubo R., Weinberg R. A., Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature 2007 449 7162 557 563 2-s2.0-34948896045 10.1038/nature06188
151. Nakamizo A., Marini F., Amano T., Khan A., Studeny M., Gumin J., Chen J., Hentschel S., Vecil G., Dembinski J., Andreef M., Lang F. F., Human bone marrow-derived mesenchymal stem cells in the treatment of gliomas. Cancer Research 2005 65 3307 3318 2-s2.0-33745228408 10.1158/0008-5472.CAN-66-11-COR1
152. Pendleton C., Li Q., Chesler D. A., Yuan K., Guerrero-Cazares H., Quinones-Hinojosa A., Mesenchymal stem cells derived from adipose tissue vs bone marrow: in vitro comparison of their tropism towards gliomas. PLoS ONE 2013 8 3 e58198
153. Lamfers M., Idema S., van Milligen F., Schouten T., van der Valk P., Vandertop P., Dirven C., Noske D., Homing properties of adipose-derived stem cells to intracerebral glioma and the effects of adenovirus infection. Cancer Letters 2009 274 1 78 87 2-s2.0-57749113504 10.1016/j.canlet.2008.08.035
154. Kucerova L., Altanerova V., Matuskova M., Tyciakova S., Altaner C., Adipose tissue-derived human mesenchymal stem cells mediated prodrug cancer gene therapy. Cancer Research 2007 67 13 6304 6313 2-s2.0-34447132890 10.1158/0008-5472.CAN-06-4024
155. Cavarretta I. T., Altanerova V., Matuskova M., Kucerova L., Culig Z., Altaner C., Adipose tissue-derived mesenchymal stem cells expressing prodrug-converting enzyme inhibit human prostate tumor growth. Molecular Therapy 2010 18 1 223 231 2-s2.0-74149088471 10.1038/mt.2009.237
156. Muehlberg F. L., Song Y.-H., Krohn A., Pinilla S. P., Droll L. H., Leng X., Seidensticker M., Ricke J., Altman A. M., Devarajan E., Liu W., Arlinghaus R. B., Alt E. U., Tissue-resident stem cells promote breast cancer growth and metastasis. Carcinogenesis 2009 30 4 589 597 2-s2.0-64349103828 10.1093/carcin/bgp036
157. Pinilla S., Alt E., Abdul Khalek F. J., Jotzu C., Muehlberg F., Beckmann C., Song Y.-H., Tissue resident stem cells produce CCL5 under the influence of cancer cells and thereby promote breast cancer cell invasion. Cancer Letters 2009 284 1 80 85 2-s2.0-69049098045 10.1016/j.canlet.2009.04.013
158. Sun B., Roh K.-H., Park J.-R., Lee S.-R., Park S.-B., Jung J.-W., Kang S.-K., Lee Y.-S., Kang K.-S., Therapeutic potential of mesenchymal stromal cells in a mouse breast cancer metastasis model. Cytotherapy 2009 11 3 289 298 2-s2.0-68049124516 10.1080/14653240902807026
159. Cousin B., Ravet E., Poglio S., De Toni F., Bertuzzi M., Lulka H., Touil I., André M., Grolleau J.-L., Péron J.-M., Chavoin J.-P., Bourin P., Pénicaud L., Casteilla L., Buscail L., Cordelier P., Adult stromal cells derived from human adipose tissue provoke pancreatic cancer cell death both in vitro and in vivo. PLoS ONE 2009 4 7 2-s2.0-67650869280 10.1371/journal.pone.0006278 e6278
160. Tottey S., Corselli M., Jeffries E. M., Londono R., Peault B., Badylak S. F., Extracellular matrix degradation products and low-oxygen conditions enhance the regenerative potential of perivascular stem cells. Tissue Engineering A 2011 17 1-2 37 44 2-s2.0-78650870346 10.1089/ten.tea.2010.0188
161. Annabi B., Lee Y.-T., Turcotte S., Naud E., Desrosiers R. R., Champagne M., Eliopoulos N., Galipeau J., Béliveau R., Hypoxia promotes murine bone-marrow-derived stromal cell migration and tube formation. Stem Cells 2003 21 3 337 347 2-s2.0-0038323916
162. Assoian R. K., Schwartz M. A., Coordinate signaling by integrins and receptor tyrosine kinases in the regulation of G1 phase cell-cycle progression. Current Opinion in Genetics and Development 2001 11 1 48 53 2-s2.0-0035253672 10.1016/S0959-437X(00)00155-6
163. Hunger-Glaser I., Fan R. S., Perez-Salazar E., Rozengurt E., PDGF and FGF induce focal adhesion kinase (FAK) phosphorylation at Ser-910: dissociation from Tyr-397 phosphorylation and requirement for ERK activation. Journal of Cellular Physiology 2004 200 2 213 222 2-s2.0-3042776220 10.1002/jcp.20018
164. Huang C., Jacobson K., Schaller M. D., MAP kinases and cell migration. Journal of Cell Science 2004 117 20 4619 4628 2-s2.0-7244231301 10.1242/jcs.01481
165. Rosová I., Dao M., Capoccia B., Link D., Nolta J. A., Hypoxic preconditioning results in increased motility and improved therapeutic potential of human mesenchymal stem cells. Stem Cells 2008 26 8 2173 2182 2-s2.0-55049084643 10.1634/stemcells.2007-1104
166. Neuss S., Becher E., Wöltje M., Tietze L., Jahnen-Dechent W., Functional expression of HGF and HGF receptor/c-met in adult human mesenchymal stem cells suggests a role in cell mobilization, tissue repair, and wound healing. Stem Cells 2004 22 3 405 414 2-s2.0-2942583980
167. Liu H., Xue W., Ge G., Luo X., Li Y., Xiang H., Ding X., Tian P., Tian X., Hypoxic preconditioning advances CXCR4 and CXCR7 expression by activating HIF-1 α in MSCs. Biochemical and Biophysical Research Communications 2010 401 4 509 515 2-s2.0-77958480787 10.1016/j.bbrc.2010.09.076
168. Chen C. W., Okada M., Proto J. D., Gao X., Human pericytes for ischemic heart repair. Stem Cells 2013 31 2 305 316
169. Katare R., Riu F., Mitchell K., Gubernator M., Campagnolo P., Cui Y., Fortunato O., Avolio E., Cesselli D., Beltrami A. P., Angelini G., Emanueli C., Madeddu P., Transplantation of human pericyte progenitor cells improves the repair of infarcted heart through activation of an angiogenic program involving micro-RNA-132. Circulation Research 2011 109 8 894 906 2-s2.0-80053561101 10.1161/CIRCRESAHA.111.251546
170. Dellavalle A., Maroli G., Covarello D., Azzoni E., Innocenzi A., Perani L., Antonini S., Sambasivan R., Brunelli S., Tajbakhsh S., Cossu G., Pericytes resident in postnatal skeletal muscle differentiate into muscle fibres and generate satellite cells. Nature Communications 2011 2 1, article 499 2-s2.0-80055059641 10.1038/ncomms1508
171. Pierro M., Ionescu L., Montemurro T., Vadivel A., Short-term, long-term and paracrine effect of human umbilical cord-derived stem cells in lung injury prevention and repair in experimental bronchopulmonary dysplasia. Thorax 2013 68 5 475 484
172. Corselli M., Chin C. J., Parekh C., Sahaghian A., Perivascular support of human hematopoietic stem/progenitor cells. Blood 2013 121 15 2891 2901
173. Zhang X., Péault B., Chen W., Li W., Corselli M., James A. W., Lee M., Siu R. K., Shen P., Zheng Z., Shen J., Kwak J., Zara J. N., Chen F., Zhang H., Yin Z., Wu B., Ting K., Soo C., The nell-1 growth factor stimulates bone formation by purified human perivascular cells. Tissue Engineering A 2011 17 19-20 2497 2509 2-s2.0-80053128558 10.1089/ten.tea.2010.0705
174. Chavakis E., Urbich C., Dimmeler S., Homing and engraftment of progenitor cells: a prerequisite for cell therapy. Journal of Molecular and Cellular Cardiology 2008 45 4 514 522 2-s2.0-54149103668 10.1016/j.yjmcc.2008.01.004
175. Lee R. H., Pulin A. A., Seo M. J., Kota D. J., Ylostalo J., Larson B. L., Semprun-Prieto L., Delafontaine P., Prockop D. J., Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6. Cell Stem Cell 2009 5 1 54 63 2-s2.0-67649171661 10.1016/j.stem.2009.05.003
176. Askarinam A., James A. W., Zara J. N., Goyal R., Corselli M., Pan A., Liang P., Chang L., Rackohn T., Stoker D., Zhang X., Ting K., Péault B., Soo C., Human perivascular stem cells show enhanced osteogenesis and vasculogenesis with nel-like molecule I protein. Tissue Engineering A 2013 19 11-12 1386 1397
177. Zhang X., Ting K., Bessette C. M., Culiat C. T., Sung S. J., Lee H., Chen F., Shen J., Wang J. J., Kuroda S., Soo C., Nell-1, a key functional mediator of Runx2, partially rescues calvarial defects in Runx2+/- mice. Journal of Bone and Mineral Research 2011 26 4 777 791 2-s2.0-79953036100 10.1002/jbmr.267
178. Kitaori T., Ito H., Schwarz E. M., Tsutsumi R., Yoshitomi H., Oishi S., Nakano M., Fujii N., Nagasawa T., Nakamura T., Stromal cell-derived factor 1/CXCR4 signaling is critical for the recruitment of mesenchymal stem cells to the fracture site during skeletal repair in a mouse model. Arthritis and Rheumatism 2009 60 3 813 823 2-s2.0-61649090805 10.1002/art.24330
179. Song N., Huang Y., Shi H., Yuan S., Ding Y., Song X., Fu Y., Luo Y., Overexpression of platelet-derived growth factor-BB increases tumor pericyte content via stromal-derived factor-1 α /CXCR4 axis. Cancer Research 2009 69 15 6057 6064 2-s2.0-68049140803 10.1158/0008-5472.CAN-08-2007
180. Chavakis E., Koyanagi M., Dimmeler S., Enhancing the outcome of cell therapy for cardiac repair: progress from bench to bedside and back. Circulation 2010 121 2 325 335 2-s2.0-74949106772 10.1161/CIRCULATIONAHA.109.901405
181. Stratman A. N., Schwindt A. E., Malotte K. M., Davis G. E., Endothelial-derived PDGF-BB and HB-EGF coordinately regulate pericyte recruitment during vasculogenic tube assembly and stabilization. Blood 2010 116 22 4720 4730 2-s2.0-78649455280 10.1182/blood-2010-05-286872
182. Stratman A. N., Malotte K. M., Mahan R. D., Davis M. J., Davis G. E., Pericyte recruitment during vasculogenic tube assembly stimulates endothelial basement membrane matrix formation. Blood 2009 114 24 5091 5101 2-s2.0-73949086144 10.1182/blood-2009-05-222364
183. Gerhardt H., Betsholtz C., Endothelial-pericyte interactions in angiogenesis. Cell and Tissue Research 2003 314 1 15 23 2-s2.0-0242405617 10.1007/s00441-003-0745-x
184. Díaz-Flores L., Gutiérrez R., Madrid J. F., Varela H., Valladares F., Acosta E., Martín-Vasallo P., Díaz-Flores L. Jr., Pericytes. Morphofunction, interactions and pathology in a quiescent and activated mesenchymal cell niche. Histology and Histopathology 2009 24 7 909 969 2-s2.0-68849128539
185. Sims D. E., The pericyte-A review. Tissue and Cell 1986 18 2 153 174 2-s2.0-0022567611
186. Gaengel K., Genové G., Armulik A., Betsholtz C., Endothelial-mural cell signaling in vascular development and angiogenesis. Arteriosclerosis, Thrombosis, and Vascular Biology 2009 29 5 630 638 2-s2.0-65249173169 10.1161/ATVBAHA.107.161521
187. Rajashekhar G., Traktuev D. O., Roell W. C., Johnstone B. H., Merfeld-Clauss S., van Natta B., IFATS collection: adipose stromal cell differentiation is reduced by endothelial cell contact and paracrine communication: role of canonical Wnt signaling. Stem Cells 2008 26 10 2674 2681
188. Saleh F. A., Whyte M., Ashton P., Genever P. G., Regulation of mesenchymal stem cell activity by endothelial cells. Stem Cells and Development 2011 20 3 391 403
189. Saleh F. A., Whyte M., Genever P. G., Effects of endothelial cells on human mesenchymal stem cell activity in a three-dimensional in vitro model. Journal of European Cells and Materials 2011 22 242 257
190. Xue Y., Xing Z., Hellem S., Arvidson K., Mustafa K., Endothelial cells influence the osteogenic potential of bone marrow stromal cells. BioMedical Engineering Online 2009 8, article 34
191. Kaigler D., Krebsbach P. H., West E. R., Horger K., Huang Y. C., Mooney D. J., Endothelial cell modulation of bone marrow stromal cell osteogenic potential. FASEB Journal 2005 19 6 665 667
192. Li H., Daculsi R., Grellier M., Bareille R., Bourget C., Amedee J., Role of neural-cadherin in early osteoblastic differentiation of human bone marrow stromal cells cocultured with human umbilical vein endothelial cells. The American Journal of Physiology 2010 299 2 422 430
193. Grellier M., Ferreira-Tojais N., Bourget C., Bareille R., Guillemot F., Amedee J., Role of vascular endothelial growth factor in the communication between human osteoprogenitors and endothelial cells. Journal of Cellular Biochemistry 2009 106 3 390 398
194. Meury T., Verrier S., Alini M., Human endothelial cells inhibit BMSC differentiation into mature osteoblasts in vitro by interfering with osterix expression. Journal of Cellular Biochemistry 2006 98 4 992 1006
195. Villars F., Guillotin B., Amedee T., Dutoya S., Bordenave L., Bareille R., Effect of HUVEC on human osteoprogenitor cell differentiation needs heterotypic gap junction communication. The American Journal of Physiology 2002 282 4 775 785
196. Villars F., Bordenave L., Bareille R., Amedee J., Effect of human endothelial cells on human bone marrow stromal cell phenotype: role of VEGF? Journal of Cellular Biochemistry 2000 79 4 672 685
197. Guillotin B., Bourget C., Remy-Zolgadri M., Bareille R., Fernandez P., Conrad V., Human primary endothelial cells stimulate human osteoprogenitor cell differentiation. Cellular Physiology and Biochemistry 2004 14 4-6 325 332
198. Ozerdem U., Stallcup W. B., Early contribution of pericytes to angiogenic sprouting and tube formation. Angiogenesis 2003 6 3 241 249 2-s2.0-1942504107 10.1023/B:AGEN.0000021401.58039.a9
199. Ozerdem U., Grako K. A., Dahlin-Huppe K., Monosov E., Stallcup W. B., NG2 proteoglycan is expressed exclusively by mural cells during vascular morphogenesis. Developmental Dynamics 2001 222 2 218 227 2-s2.0-0034796499 10.1002/dvdy.1200
200. Reynolds L. P., Grazul-Bilska A. T., Redmer D. A., Angiogenesis in the corpus luteum. Endocrine 2000 12 1 1 9 2-s2.0-0034030633
201. Enge M., Bjarnegård M., Gerhardt H., Gustafsson E., Kalén M., Asker N., Hammes H.-P., Shani M., Fässler R., Betsholtz C., Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy. EMBO Journal 2002 21 16 4307 4316 2-s2.0-18544366585 10.1093/emboj/cdf418
202. Hirschi K. K., Rohovsky S. A., Beck L. H., Smith S. R., D'Amore P. A., Endothelial cells modulate the proliferation of mural cell precursors via platelet-derived growth factor-BB and heterotypic cell contact. Circulation Research 1999 84 3 298 305 2-s2.0-0032973230
203. Blocki A., Wang Y., Koch M., Peh P., Beyer S., Law P., Hui J., Raghunath M., Not all MSCs can act as pericytes: functional in vitro assays to distinguish pericytes from other mesenchymal stem cells in angiogenesis. Stem Cells and Development 2013 22 17
204. Corselli M., Chen C.-W., Crisan M., Lazzari L., Péault B., Perivascular ancestors of adult multipotent stem cells. Arteriosclerosis, Thrombosis, and Vascular Biology 2010 30 6 1104 1109 2-s2.0-77952888341 10.1161/ATVBAHA.109.191643
205. Ehninger A., Trumpp A., The bone marrow stem cell niche grows up: mesenchymal stem cells and macrophages move in. Journal of Experimental Medicine 2011 208 3 421 428 2-s2.0-79952724283 10.1084/jem.20110132
206. Ergün S., Tilki D., Klein D., Vascular wall as a reservoir for different types of stem and progenitor cells. Antioxidants and Redox Signaling 2011 15 4 981 995 2-s2.0-79960395669 10.1089/ars.2010.3507
207. Caplan A. I., All MSCs are pericytes? Cell Stem Cell 2008 3 3 229 230 2-s2.0-50849122983 10.1016/j.stem.2008.08.008
208. Müller A. M., Mehrkens A., Schäfer D. J., Jaquiery C., Güven S., Lehmicke M., Martinetti R., Farhadi I., Jakob M., Scherberich A., Martin I., Towards an intraoperative engineering of osteogenic and vasculogenic grafts from the stromal vascular fraction of human adipose tissue. European Cells and Materials 2010 19 127 135 2-s2.0-77950654904
209. Marthiens V., Kazanis I., Moss L., Long K., Ffrench-Constant C., Adhesion molecules in the stem cell niche: more than just staying in shape? Journal of Cell Science 2010 123 10 1613 1622 2-s2.0-77952347589 10.1242/jcs.054312
210. Kirton J. P., Wilkinson F. L., Canfield A. E., Alexander M. Y., Dexamethasone downregulates calcification-inhibitor molecules and accelerates osteogenic differentiation of vascular pericytes: implications for vascular calcification. Circulation Research 2006 98 10 1264 1272 2-s2.0-33745003972 10.1161/01.RES.0000223056.68892.8b
211. Mathews S., Bhonde R., Gupta P. K., Totey S., Extracellular matrix protein mediated regulation of the osteoblast differentiation of bone marrow derived human mesenchymal stem cells. Differentiation 2012 84 2 185 192
212. Ranganath S. H., Levy O., Inamdar M. S., Karp J. M., Harnessing the mesenchymal stem cell secretome for the treatment of cardiovascular disease. Cell Stem Cell 2012 10 3 244 258 2-s2.0-84857838864 10.1016/j.stem.2012.02.005
213. Takada I., Kouzmenko A. P., Kato S., PPAR- γ signaling crosstalk in mesenchymal stem cells. PPAR Research 2010 2010 6 2-s2.0-77956797254 10.1155/2010/341671 341671