Paracrine effects of adipose-derived stem cells on keratinocytes and dermal fibroblasts

Annals of Dermatology

Volumn 24, Issue 2, 2012, Pages 136-143

  Lee, Seung Ho ^a   Jin, Sang Yun ^a   Song, Jin Seok ^a,b   Seo, Kyle K ^a,b   Cho, Kwang Hyun ^a,b  

^a Dongguk University Ilsan Hospital   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

Adipose tissue; Fibroblasts; Keratinocytes; Mesenchymal stem cells; Wound healing

Indexed keywords

EID: 84860625707     PISSN: 10139087     EISSN: None     Source Type: Journal    
DOI: 10.5021/ad.2012.24.2.136     Document Type: Article

References (23)

1. Steeper R. A critical review of the aetiology of diabetic neuropathic ulcers. J Wound Care 2005;14:101-103.
2. Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999;284:143-147. (Pubitemid 29282067)
3. Deng W, Obrocka M, Fischer I, Prockop DJ. In vitro differentiation of human marrow stromal cells into early progenitors of neural cells by conditions that increase intracellular cyclic AMP. Biochem Biophys Res Commun 2001;282:148-152. (Pubitemid 32924357)
4. Fuchs S, Baffour R, Zhou YF, Shou M, Pierre A, Tio FO, et al. Transendocardial delivery of autologous bone marrow enhances collateral perfusion and regional function in pigs with chronic experimental myocardial ischemia. J Am Coll Cardiol 2001;37:1726-1732.
5. Wu Y, Chen L, Scott PG, Tredget EE. Mesenchymal stem cells enhance wound healing through differentiation and angiogenesis. Stem Cells 2007;25:2648-2659. (Pubitemid 47582758)
6. Chen L, Tredget EE, Wu PY, Wu Y. Paracrine factors of mesenchymal stem cells recruit macrophages and endothelial lineage cells and enhance wound healing. PLoS One 2008;3:e1886.
7. Zuk PA, Zhu M, Ashjian P, De Ugarte DA, Huang JI, Mizuno H, et al. Human adipose tissue is a source of multipotent stem cells. Mol Biol Cell 2002;13:4279-4295. (Pubitemid 35471185)
8. Izadpanah R, Trygg C, Patel B, Kriedt C, Dufour J, Gimble JM, et al. Biologic properties of mesenchymal stem cells derived from bone marrow and adipose tissue. J Cell Biochem 2006;99:1285-1297.
9. Nambu M, Kishimoto S, Nakamura S, Mizuno H, Yanagibayashi S, Yamamoto N, et al. Accelerated wound healing in healing-impaired db/db mice by autologous adipose tissuederived stromal cells combined with atelocollagen matrix. Ann Plast Surg 2009;62:317-321.
10. Park JS, Park WY, Cho KA, Kim DI, Jhun BH, Kim SR, et al. Down-regulation of amphiphysin-1 is responsible for reduced receptor-mediated endocytosis in the senescent cells. FASEB J 2001;15:1625-1627.
11. Moon MH, Kim SY, Kim YJ, Kim SJ, Lee JB, Bae YC, et al. Human adipose tissue-derived mesenchymal stem cells improve postnatal neovascularization in a mouse model of hindlimb ischemia. Cell Physiol Biochem 2006;17:279-290.
12. Singer AJ, Clark RA. Cutaneous wound healing. N Engl J Med 1999;341:738-746. (Pubitemid 29407375)
13. Lee EY, Xia Y, Kim WS, Kim MH, Kim TH, Kim KJ, et al. Hypoxia-enhanced wound-healing function of adipose-derived stem cells: increase in stem cell proliferation and up-regulation of VEGF and bFGF. Wound Repair Regen 2009;17:540-547.
14. Kim WS, Park BS, Sung JH, Yang JM, Park SB, Kwak SJ, et al. Wound healing effect of adipose-derived stem cells: a critical role of secretory factors on human dermal fibroblasts. J Dermatol Sci 2007;48:15-24.
15. Baum CL, Arpey CJ. Normal cutaneous wound healing: clinical correlation with cellular and molecular events. Dermatol Surg 2005;31:674-686. (Pubitemid 43093424)
16. Sarret Y, Woodley DT, Grigsby K, Wynn K, O'Keefe EJ. Human keratinocyte locomotion: the effect of selected cytokines. J Invest Dermatol 1992;98:12-16.
17. Bhora FY, Dunkin BJ, Batzri S, Aly HM, Bass BL, Sidawy AN, et al. Effect of growth factors on cell proliferation and epithelialization in human skin. J Surg Res 1995;59:236-244.
18. Ishimoto S, Ishibashi T, Bottaro DP, Kaga K. Direct application of keratinocyte growth factor, basic fibroblast growth factor and transforming growth factor-alpha during healing of tympanic membrane perforation in glucocorticoidtreated rats. Acta Otolaryngol 2002;122:468-473. (Pubitemid 34913424)
19. Werner S, Grose R. Regulation of wound healing by growth factors and cytokines. Physiol Rev 2003;83:835-870. (Pubitemid 36828927)
20. Yamaguchi Y, Crane S, Zhou L, Ochoa SM, Falanga V. Lack of co-ordinate expression of the alpha1 (I) and alpha1 (III) procollagen genes in fibroblast clonal cultures. Br J Dermatol 2000;143:1149-1153. (Pubitemid 32052748)
21. Montesano R, Orci L. Transforming growth factor beta stimulates collagen-matrix contraction by fibroblasts: implications for wound healing. Proc Natl Acad Sci USA 1988;85:4894-4897.
22. Clark RA, Folkvord JM, Hart CE, Murray MJ, McPherson JM. Platelet isoforms of platelet-derived growth factor stimulate fibroblasts to contract collagen matrices. J Clin Invest 1989;84:1036-1040. (Pubitemid 19228382)
23. Rehman J, Traktuev D, Li J, Merfeld-Clauss S, Temm-Grove CJ, Bovenkerk JE, et al. Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells. Circulation 2004;109:1292-1298. (Pubitemid 38372789)