SJL dystrophic mice express a significant amount of human muscle proteins following systemic delivery of human adipose-derived stromal cells without immunosuppression

Stem Cells

Volumn 26, Issue 9, 2008, Pages 2391-2398

  Vieira, Natássia M ^a   Bueno Jr , Carlos R ^a   Brandalise, Vanessa ^a   Moraes, Luciana V ^a   Zucconi, Eder ^a   Secco, Mariane ^a   Suzuki, Miriam F ^b   Camargo, Maristela M ^a   Bartolini, Paolo ^b   Brum, Patricia C ^a   Vainzof, Mariz ^a   Zatz, Mayana ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b INSTITUTO DE PESQUISAS ENERGÉTICAS E NUCLEARES   (Brazil)

Author keywords

Human adipose stromal cells; Muscular dystrophy; Therapy; Xenotransplantation

Indexed keywords

DYSFERLIN; MUSCLE PROTEIN;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL EXPANSION; CELL ISOLATION; CELL LINEAGE; CELL TRANSPLANTATION; CONTROLLED STUDY; DNA DETERMINATION; ENGRAFTMENT; FLOW CYTOMETRY; GENE DELETION; GRAFT SURVIVAL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOSUPPRESSIVE TREATMENT; LIMB GIRDLE MUSCULAR DYSTROPHY; MOTOR PERFORMANCE; MOUSE; MUSCLE WEAKNESS; NONHUMAN; PROTEIN EXPRESSION; SKIN GRAFT; STROMA CELL; SWISS JAMES LAMBERT MOUSE; WESTERN BLOTTING;

ANIMALIA; MURINAE; MUS;

EID: 55049097324     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1634/stemcells.2008-0043     Document Type: Article

References (36)

1. Gene table of monogenic neuromuscular disorders (nuclear genome only). Neurom Disord 2008;18:101-129.
2. Mahjneh I, Passos-Bueno MR, Zatz M et al. The phenotype of chromosome 2p-linked limb-girdle muscular dystrophy. Neuromuscul Disord 1996;6:483-490.
3. Liu J, Aoki M, Illa I et al. Dysferlin, a novel skeletal muscle gene, is mutated in Miyoshi myopathy and limb girdle muscular dystrophy. Nat Genet 1998;20:31-36.
4. Matsuda C, Aoki M, Hayashi YK et al. Dysferlin is a surface membrane-associated protein that is absent in Miyoshi myopathy. Neurology 1999;53:1119-1122.
5. Bittner RE, Anderson LV, Burkhardt E et al. Dysferlin deletion in SJL mice (SJL-Dysf) defines a natural model for limb girdle muscular dystrophy 2B. Nat Genet 1999;23:141-142.
6. Chelly J, Gilgenkrantz H, Lambert M et al. Effect of dystrophin gene deletions on mRNA levels and processing in Duchenne and Becker muscular dystrophies. Cell 1990;63:1239-1248.
7. Schultz E, McCormick KM. Skeletal muscle satellite cells. Rev Physiol Biochem Pharmacol 1994;123:213-257.
8. Heslop L, Morgan JE, Partridge TA. Evidence for a myogenic stem cell that is exhausted in dystrophic muscle. J Cell Sci 2000;113:2299-2308.
9. Laguens R. Satellite cells of skeletal muscle fibers in human progressive muscular dystrophy. Virchows Arch Pathol Anat Physiol Klin Med 1963;336:564-569.
10. Gronthos S, Mankani M, Brahim J et al. Postnatal human dental pulp stem cells DPSCs in vitro and in vivo. Proc Natl Acad Sci U S A 2000;97:13625-13630.
11. Zuk PA, Zhu M, Mizuno H et al. Multilineage cells from human adipose tissue: Implications for cell-based therapies. Tissue Eng 2001;7:211-228.
12. Gussoni E, Soneoka Y, Strickland CD et al. Dystrophin expression in the mdx mouse restored by stem cell transplantation. Nature 1999;401:390-394.
13. Sampaolesi M, Blot S, D'Antona G et al. Mesoangioblast stem cells ameliorate muscle function in dystrophic dogs. Nature 2006;444:574-579.
14. Secco M, Zucconi E, Vieira NM et al. Multipotent stem cells from umbilical cord: Cord is richer than blood! STEM CELLS 2008;26:146-150.
15. Chan J, Waddington SN, O'Donoghue K et al. Widespread distribution and muscle differentiation of human fetal mesenchymal stem cells after intrauterine transplantation in dystrophic mdx mouse. STEM CELLS 2007;25:875-884.
16. Kong KY, Ren J, Kraus M et al. Human umbilical cord blood cells differentiate into muscle in SJL muscular dystrophy mice. STEM CELLS 2004;22:981-993.
17. Salah-Mohellibi N, Millet G, André-Schmutz I et al. Bone marrow transplantation attenuates the myopathic phenotype of a muscular mouse model of spinal muscular atrophy. STEM CELLS 2006;24:2723-2732.
18. Vieira NM, Brandalise V, Zucconi E et al. Human multipotent adipose derived stem cells restore dystrophin expression of Duchenne skeletal muscle cells in vitro. Biol Cell 2008;100:231-241.
19. Rodriguez AM, Pisani D, Dechesne CA et al. Transplantation of a multipotent cell population from human adipose tissue induces dystrophin expression in the immunocompetent mdx mouse. J Exp Med 2005;201:1397-1405.
20. Di Rocco G, Iachininoto MG, Tritarelli A et al. Myogenic potential of adipose-tissue-derived cells. J Cell Sci 2006;119:2945-2952.
21. Mizuno H, Zuk PA, Zhu M et al. Myogenic differentiation by human processed lipoaspirate cells. Plast Reconstr Surg 2002;109:199-209.
22. Pelz O, Wu M, Nikolova T et al. Duplex polymerase chain reaction quantification of human cells in a murine background. STEM CELLS 2005;23:828-833.
23. Thanh LT, Neguyen TM, Helliwell TR et al. Characterization of revertant muscle fibers in Duchenne Muscular Dystrophy using exon-specific monoclonal antibodies against dystrophin. Am J Hum Genet 1995;56:725-731.
24. Kennel PF, Fonteneau P, Martin E et al. Electromyographical and motor performance studies in the pmn mouse model of neurodegenerative disease. Neurobiol Dis 1996;3:137-147.
25. Davies KE, Grounds MD. Treating muscular dystrophy with stem cells? Cell 2006;127:1304-1306.
26. Benchaouir R, Meregalli M, Farini A et al. Restoration of human dystrophin following transplantation of exon-skipping-engineered DMD patient stem cells into dystrophic mice. Cell Stem Cell 2007;1:646-657.
27. Karpati G, Zubrzycka-Gaarn EE, Carpenter S et al. Age-related conversion of dystrophin-negative to-positive fiber segments of skeletal but not cardiac muscle fibers in heterozygote mdx mice. J Neuropathol Exp Neurol 1990;49:96-105.
28. Leriche-Guérin K, Anderson LV, Wrogemann K et al. Dysferlin expression after normal myoblast transplantation in SCID and in SJL mice. Neuromuscul Disord 2002;12:167-173.
29. Partridge T, Morgan JE, Coulton RG et al. Conversion of mdx myofibres from dystrophin-negative to-positive by injection of normal myoblasts. Nature 1989;337:176-179.
30. Bachrach E, Perez AL, Choi YH et al. Muscle engraftment of myogenic progenitor cells following intraarterial transplantation. Muscle Nerve 2006;34:44-52.
31. Groshong JS, Spencer MJ, Bhattacharyya BJ et al. Calpain activation impairs neuromuscular transmission in a mouse model of the slow-channel myasthenic syndrome. J Clin Invest 2007;117:2903-2912.
32. Simon D, Seznec H, Gansmuller A et al. Friedreich ataxia mouse models with progressive cerebellar and sensory ataxia reveal autophagic neurodegeneration in dorsal root ganglia. J Neurosci 2004;24:1987-1995.
33. Yonemori F, Yamaguchi T, Yamada H et al. Evaluation of a motor deficit after chronic focal cerebral ischemia in rats. J Cereb Blood Flow Metab 1998;18:1099-1106.
34. Yañez R, Lamana ML, García-Castro J et al. Adipose tissue-derived mesenchymal stem cells have in vivo immunosuppressive properties applicable for the control of the graft-versus-host disease. STEM CELLS 2006;24:2582-2591.
35. Niemeyer P, Kornacker M, Mehlhorn A et al. Comparison of immunological properties of bone marrow stromal cells and adipose tissue-derived stem cells before and after osteogenic differentiation in vitro. Tissue Eng 2007;13:111-121.
36. Schäffler A, Büchler C. Concise review: Adipose tissue-derived stromal cells - basic and clinical implications for novel cell-based therapies. STEM CELLS 2007;25:818-827.