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Volumn 114, Issue 11, 2013, Pages 2595-2602

Activation of the PI3K/Akt pathway by oxidative stress mediates high glucose-induced increase of adipogenic differentiation in primary rat osteoblasts

Author keywords

Adipogenic Differentiation; High Glucose; Osteogenic Differentiation; Oxidative Stress; PI3K Akt

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ACETIC ACID DERIVATIVE; ACETYLCYSTEINE; ALKALINE PHOSPHATASE; COLLAGEN TYPE 1; FAT DROPLET; FATTY ACID BINDING PROTEIN 4; GLUCOSE; OSTEOCALCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SCAVENGER; TRANSCRIPTION FACTOR RUNX2;

EID: 84884237242     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.24607     Document Type: Article
Times cited : (85)

References (25)
  • 2
    • 23044460463 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase is required for human adipocyte differentiation in culture
    • Aubin D, Gagnon A, Sorisky A,. 2005. Phosphoinositide 3-kinase is required for human adipocyte differentiation in culture. Int J Obes 29: 1006-1009.
    • (2005) Int J Obes , vol.29 , pp. 1006-1009
    • Aubin, D.1    Gagnon, A.2    Sorisky, A.3
  • 3
    • 0035155069 scopus 로고    scopus 로고
    • Glucose-induced inhibition of in vitro bone mineralization
    • Balint E, Szabo P, Marshall C, Sprague S,. 2001. Glucose-induced inhibition of in vitro bone mineralization. Bone 28: 21-28.
    • (2001) Bone , vol.28 , pp. 21-28
    • Balint, E.1    Szabo, P.2    Marshall, C.3    Sprague, S.4
  • 4
    • 33748946364 scopus 로고    scopus 로고
    • Chronic hyperglycemia modulates osteoblast gene expression through osmotic and non-osmotic pathways
    • Botolin S, McCabe LR,. 2006. Chronic hyperglycemia modulates osteoblast gene expression through osmotic and non-osmotic pathways. J Cell Biochem 99: 411-424.
    • (2006) J Cell Biochem , vol.99 , pp. 411-424
    • Botolin, S.1    McCabe, L.R.2
  • 5
    • 33845883071 scopus 로고    scopus 로고
    • Bone loss and increased bone adiposity in spontaneous and pharmacologically induced diabetic mice
    • Botolin S, McCabe LR,. 2007. Bone loss and increased bone adiposity in spontaneous and pharmacologically induced diabetic mice. Endocrinology 148: 198-205.
    • (2007) Endocrinology , vol.148 , pp. 198-205
    • Botolin, S.1    McCabe, L.R.2
  • 6
    • 23044440774 scopus 로고    scopus 로고
    • Increased bone adiposity and peroxisomal proliferator-activated receptor-γ2 expression in type i diabetic mice
    • Botolin S, Faugere MC, Malluche H, Orth M, Meyer R, McCabe LR,. 2005. Increased bone adiposity and peroxisomal proliferator-activated receptor-γ2 expression in type I diabetic mice. Endocrinology 146: 3622-3631.
    • (2005) Endocrinology , vol.146 , pp. 3622-3631
    • Botolin, S.1    Faugere, M.C.2    Malluche, H.3    Orth, M.4    Meyer, R.5    McCabe, L.R.6
  • 8
    • 42549148447 scopus 로고    scopus 로고
    • Hesperetin attenuates the highly reducing sugar-triggered inhibition of osteoblast differentiation
    • Choi EM, Kim YH,. 2008. Hesperetin attenuates the highly reducing sugar-triggered inhibition of osteoblast differentiation. Cell Biol Toxicol 24: 225-231.
    • (2008) Cell Biol Toxicol , vol.24 , pp. 225-231
    • Choi, E.M.1    Kim, Y.H.2
  • 9
    • 34548103553 scopus 로고    scopus 로고
    • Hyperglycemia enhances adipogenic induction of lipid accumulation: Involvement of extracellular signal-regulated protein kinase 1/2, phosphoinositide 3-kinase/Akt, and peroxisome proliferator-activated receptor γ signaling
    • Chuang CC, Yang RS, Tsai KS, Ho FM, Liu SH,. 2007. Hyperglycemia enhances adipogenic induction of lipid accumulation: involvement of extracellular signal-regulated protein kinase 1/2, phosphoinositide 3-kinase/Akt, and peroxisome proliferator-activated receptor γ signaling. Endocrinology 148: 4267-4275.
    • (2007) Endocrinology , vol.148 , pp. 4267-4275
    • Chuang, C.C.1    Yang, R.S.2    Tsai, K.S.3    Ho, F.M.4    Liu, S.H.5
  • 10
    • 82055165899 scopus 로고    scopus 로고
    • High glucose concentrations alter the biomineralization process in human osteoblastic cells
    • García-Hernández A, Arzate H, Gil-Chavarría I, Rojo R, Moreno-Fierros L,. 2011. High glucose concentrations alter the biomineralization process in human osteoblastic cells. Bone 50: 276-288.
    • (2011) Bone , vol.50 , pp. 276-288
    • García-Hernández, A.1    Arzate, H.2    Gil-Chavarría, I.3    Rojo, R.4    Moreno-Fierros, L.5
  • 11
    • 33645409010 scopus 로고    scopus 로고
    • Effects of glucose and its modulation by insulin and estradiol on BMSC differentiation into osteoblastic lineages
    • Gopalakrishnan V, Vignesh R, Arunakaran J, Aruldhas M, Srinivasan N,. 2006. Effects of glucose and its modulation by insulin and estradiol on BMSC differentiation into osteoblastic lineages. Biochem Cell Biol 84: 93-101.
    • (2006) Biochem Cell Biol , vol.84 , pp. 93-101
    • Gopalakrishnan, V.1    Vignesh, R.2    Arunakaran, J.3    Aruldhas, M.4    Srinivasan, N.5
  • 12
    • 67349135645 scopus 로고    scopus 로고
    • Role of oxidative stress in diabetic bone disorder
    • Hamada Y, Fujii H, Fukagawa M,. 2009a. Role of oxidative stress in diabetic bone disorder. Bone 45: 35-38.
    • (2009) Bone , vol.45 , pp. 35-38
    • Hamada, Y.1    Fujii, H.2    Fukagawa, M.3
  • 13
    • 63449095873 scopus 로고    scopus 로고
    • Thioredoxin-1 overexpression in transgenic mice attenuates streptozotocin-induced diabetic osteopenia: A novel role of oxidative stress and therapeutic implications
    • Hamada Y, Fujii H, Kitazawa R, Yodoi J, Kitazawa S, Fukagawa M,. 2009b. Thioredoxin-1 overexpression in transgenic mice attenuates streptozotocin- induced diabetic osteopenia: a novel role of oxidative stress and therapeutic implications. Bone 44: 936-941.
    • (2009) Bone , vol.44 , pp. 936-941
    • Hamada, Y.1    Fujii, H.2    Kitazawa, R.3    Yodoi, J.4    Kitazawa, S.5    Fukagawa, M.6
  • 17
    • 84884261823 scopus 로고    scopus 로고
    • Effect of insulin on prohibitin in the osteogenic differentiation of rat's mandibular bone marrow stromal cells in high glucose
    • Li Y, Liu H, Lv Y, Wang D,. 2012. Effect of insulin on prohibitin in the osteogenic differentiation of rat's mandibular bone marrow stromal cells in high glucose. Shanghai J Stomatol 21: 526-530.
    • (2012) Shanghai J Stomatol , vol.21 , pp. 526-530
    • Li, Y.1    Liu, H.2    Lv, Y.3    Wang, D.4
  • 18
    • 0029891232 scopus 로고    scopus 로고
    • Expression of a constitutively activated form of protein kinase B (c-Akt) in 3T3-L1 preadipose cells causes spontaneous differentiation
    • Magun R, Burgering B, Coffer P, Pardasani D, Lin Y, Chabot J, Sorisky A,. 1996. Expression of a constitutively activated form of protein kinase B (c-Akt) in 3T3-L1 preadipose cells causes spontaneous differentiation. Endocrinology 137: 3590-3593.
    • (1996) Endocrinology , vol.137 , pp. 3590-3593
    • Magun, R.1    Burgering, B.2    Coffer, P.3    Pardasani, D.4    Lin, Y.5    Chabot, J.6    Sorisky, A.7
  • 19
    • 36849045166 scopus 로고    scopus 로고
    • Understanding the pathology and mechanisms of type i diabetic bone loss
    • McCabe LR,. 2007. Understanding the pathology and mechanisms of type I diabetic bone loss. J Cell Biochem 102: 1343-1357.
    • (2007) J Cell Biochem , vol.102 , pp. 1343-1357
    • McCabe, L.R.1
  • 20
    • 0344736959 scopus 로고    scopus 로고
    • Diabetes mellitus: Does it affect bone
    • Schwartz AV,. 2003. Diabetes mellitus: does it affect bone ? Calcif Tissue Int 73: 515-519.
    • (2003) Calcif Tissue Int , vol.73 , pp. 515-519
    • Schwartz, A.V.1
  • 21
    • 35848959474 scopus 로고    scopus 로고
    • Diabetes mellitus, bone mineral density, and fracture risk
    • Strotmeyer ES, Cauley JA,. 2007. Diabetes mellitus, bone mineral density, and fracture risk. Curr Opin Endocrinol Diab Obes 14: 429-435.
    • (2007) Curr Opin Endocrinol Diab Obes , vol.14 , pp. 429-435
    • Strotmeyer, E.S.1    Cauley, J.A.2
  • 23
    • 77951297831 scopus 로고    scopus 로고
    • High glucose stimulates adipogenic and inhibits osteogenic differentiation in MG-63 cells through cAMP/protein kinase A/extracellular signal-regulated kinase pathway
    • Wang W, Zhang X, Zheng J, Yang J,. 2010. High glucose stimulates adipogenic and inhibits osteogenic differentiation in MG-63 cells through cAMP/protein kinase A/extracellular signal-regulated kinase pathway. Mol Cell Biochem 338: 115-122.
    • (2010) Mol Cell Biochem , vol.338 , pp. 115-122
    • Wang, W.1    Zhang, X.2    Zheng, J.3    Yang, J.4
  • 24
    • 3743152831 scopus 로고    scopus 로고
    • Inhibition of adipose differentiation by phosphatidylinositol 3-kinase inhibitors
    • Xia X, Serrero G,. 1999. Inhibition of adipose differentiation by phosphatidylinositol 3-kinase inhibitors. J Cell Physiol 178: 9-16.
    • (1999) J Cell Physiol , vol.178 , pp. 9-16
    • Xia, X.1    Serrero, G.2
  • 25
    • 77956228665 scopus 로고    scopus 로고
    • Metformin reverses the deleterious effects of high glucose on osteoblast function
    • Zhen D, Chen Y, Tang X,. 2010. Metformin reverses the deleterious effects of high glucose on osteoblast function. J Diabetes Complications 24: 334-344.
    • (2010) J Diabetes Complications , vol.24 , pp. 334-344
    • Zhen, D.1    Chen, Y.2    Tang, X.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.