Delayed bone regeneration and low bone mass in a rat model of insulin-resistant type 2 diabetes mellitus is due to impaired osteoblast function

American Journal of Physiology - Endocrinology and Metabolism

Volumn 301, Issue 6, 2011, Pages

  Hamann, Christine ^a   Goettsch, Claudia ^a   Mettelsiefen, Jan ^a   Henkenjohann, Veit ^a   Rauner, Martina ^a   Hempel, Ute ^b   Bernhardt, Ricardo ^b   Fratzl Zelman, Nadja ^c   Roschger, Paul ^c   Rammelt, Stefan ^a,d   Günther, Klaus Peter ^a,d   Hofbauer, Lorenz C ^a,d  

^a UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^c HANUSCH HOSPITAL   (Austria)

^d CENTER FOR REGENERATIVE THERAPIES DRESDEN   (Germany)

Author keywords

Bone defect; Bone matrix mineralization; Bone regeneration; Osteoblast; Osteoclast; Type 2 diabetes mellitus

Indexed keywords

ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN 2; INSULIN; OSTEOCALCIN; OSTEOPONTIN; TRANSCRIPTION FACTOR RUNX2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOCHEMISTRY; BONE DEFECT; BONE DENSITY; BONE DEVELOPMENT; BONE MASS; CELL DIFFERENTIATION; CONTROLLED STUDY; DELAYED BONE REGENERATION; FEMUR; INSULIN RESISTANCE; LUMBAR SPINE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OSTEOBLAST; OSTEOBLASTOGENESIS; PRIORITY JOURNAL; RAT; TRABECULAR BONE; ZUCKER DIABETIC FATTY RAT;

ANIMALS; BONE AND BONES; BONE DENSITY; BONE REGENERATION; CALCIFICATION, PHYSIOLOGIC; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; DOWN-REGULATION; FEMUR; INSULIN RESISTANCE; MALE; ORGAN SIZE; OSTEOBLASTS; RATS; RATS, ZUCKER; TIME FACTORS;

EID: 82355163201     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00378.2011     Document Type: Article

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