Injection of ropivacaine into the subarachnoid changes the ultrastructure and proteome of the rat spinal cord

Xenobiotica

Volumn 43, Issue 10, 2013, Pages 908-914

  Li, Lin ^a   Zhang, Tiezheng ^b   Diao, Yugang ^b   Wang, Junke ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

^b GENERAL HOSPITAL OF NORTHERN THEATER COMMAND   (China)

Author keywords

Local anesthesia; Neurotoxicity; Proteomics; Ropivacaine; Two dimensional electrophoresis

Indexed keywords

HEAT SHOCK PROTEIN 27; MYELIN; MYELIN BASIC PROTEIN; PROTEOME; PYRUVATE DEHYDROGENASE; ROPIVACAINE; VOLTAGE DEPENDENT ANION CHANNEL 2;

ANIMAL EXPERIMENT; ARTICLE; CELL NUCLEUS MEMBRANE; CONTROLLED STUDY; DORSAL ROOT; DOWN REGULATION; MALE; MASS SPECTROMETRY; MITOCHONDRIAL MEMBRANE; MYELINATED NERVE; NEUROTOXICITY; NONHUMAN; RAT; ROUGH ENDOPLASMIC RETICULUM; SPINAL CORD; SUBARACHNOID SPACE; TRANSMISSION ELECTRON MICROSCOPY; TWO DIMENSIONAL ELECTROPHORESIS; ULTRASTRUCTURE;

AMIDES; ANESTHETICS, LOCAL; ANIMALS; DNA-BINDING PROTEINS; DRUG ADMINISTRATION ROUTES; HSP27 HEAT-SHOCK PROTEINS; INJECTIONS; MALE; MYELIN BASIC PROTEIN; PROTEOME; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD; SUBARACHNOID SPACE; TRANSCRIPTION FACTORS; VOLTAGE-DEPENDENT ANION CHANNEL 2;

EID: 84884236837     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2013.782454     Document Type: Article

References (30)

1. Chabbouh T, Lentschener C, Zuber M, et al. (2005). Persistent cauda equina syndrome with no identifiable facilitating condition after an uneventful single spinal administration of 0.5% hyperbaric bupivacaine. Anesth Analg 106:1847-8 (Pubitemid 41720650)
2. Daugaard M, Rohde M, Ja?a?ttela? M. (2007). The heat shock protein 70 family: highly homologous proteins with overlapping and distinct functions. FEBS Lett 58:3702-10 (Pubitemid 47081009)
3. Eisenach JC, Yaksh TL. (2002). Safety in numbers: how do we study toxicity of spinal analgestics? Anesthesiology 97:1047-9 (Pubitemid 35265553)
4. Fassoulaki A, Chatziara V, Melemeni A, et al. (2008). Preoperative gabapentin: the effect on ropivacaine subarachnoid block and hemodynamics. Anesth Analg 106:334-8
5. Guryay D, Karaege GT, Katircioglu K, et al. (2008). The effects of an epidural infusion of ropivacaine versus saline on sensory block after spinal anesthesia. Reg Anesth Pain Med 33:217-21 (Pubitemid 351545850)
6. Hirayama A, Oka A, Ito M, et al. (2003). Myelin transcription factor 1 (MyT1) immunoreactivity in infants with periventricular leukomalacia. Dev Brain Res 140:85-92 (Pubitemid 36084339)
7. Khaw KS, Ngan Kee WD, Wong EL, et al. (2001). Spinal ropivacaine for cesarean section: a dose-finding study. Anesthesiology 95:1346-50 (Pubitemid 33126744)
8. Kitagawa N, Oda M, Totoki T. (2004). Possible mechanism of irreversible nerve injury caused by local anesthetics. Anesthesiology 100:962-7
9. Lamers KJ, Vos P, Verbeek MM, et al. (2003). Protein S-100, neuronspecific enolase (NSE), Myelin basic protein (MBP) in cerebrospinal fluid (CSF) and blood of neurological patients. Brain Res Bull 6: 261-5
10. Lee YY, Ngan Kee WD, Chang HK, et al. (2007). Spinal ropivacaine for lower limb surgery: a dose-response study. Anesth Analg 105:520-3 (Pubitemid 47196438)
11. Li HJ, Bao SY, Xu Y, et al. (2005). Expression and its significance of MyT1 in the brain of epileptic rats induced by lithium chloridepilocarpin. J Clin Neurol 18:130-2
12. Li X, Mertens-Talcott SU, Zhang S, et al. (2010). MicroRNA-27a indirectly regulates estrogen receptor a expression and hormone responsiveness in MCF-7 breast cancer cells. Endocrinology 151: 2462-73
13. Lirk P, Haller I, Colvin HP, et al. (2008). In vitro, inhibition of mitogenactivated protein kinase pathways protects against bupivacaine and ropivacaine-induced neurotoxicity. Anesth Analg 106:1456-64 (Pubitemid 351571076)
14. Loo CC, Irestedt L. (1999). Caudal equine syndrome after spinal anaesthesia with hyperbaric 5% lidocaine: a review of six cases of caudal equine syndrome reported to the Swedish Pharmaceutical Insurance 1993-1997 Acta Anaesth Scand 43:371-9 (Pubitemid 29186102)
15. Malinovsky JM, Charles F, Baudrimont M, et al. (2002). Intrathecal ropivacaine in rabbits: pharmacodynamic and neurotoxicologic study. Anesthesiology 97:429-35 (Pubitemid 34847757)
16. Nagdyman N, Ko?men W, Ko HK, et al. (2001) Early biochemical indicators of hypoxic-ischemic encephalopathy after birth asphyxia. Pediatr Res 49:502-5
17. Prins JM, Brooks DM, Thompson CM, Lurie DI. (2010). Chronic low-level Pb exposure during development decreases the expression of the voltage-dependent anion channel in auditory neurons of the brainstem. Neurotoxicology 31:662-73
18. Rigler ML, Drasner K, Krejcie TC, et al. (1991). Cauda equina syndrome after continuous spinal anesthesia. Anesth Analg 72:275-81
19. Sakura S, Kirihara Y, Muguruma T, et al. (2005). The comparative neurotoxicity of intrathecal lidocaine and bupivacaine in rats. Anesth Analg 101:541-7 (Pubitemid 41045242)
20. Sun ZH, Xu XP, Song ZB, et al. (2012). Repeated intrathecal administration of ropivacaine causes neurotoxicity in rats. Anaesth Intensive Care 40:825-31
21. Takenami T, Wang G, Nara Y, et al. (2012). Intrathecally administered ropivacaine is less neurotoxic than procaine, bupivacaine, and levobupivacaine in a rat spinal model. Can J Anaesth 59:456-65
22. Takenami T, Yagishita S, Asato F, et al. (2002). Intrathecal lidocaine causes posterior root axonal degeneration near entry into the spinal cord in rats. Reg Anesth Pain Med 27:58-67 (Pubitemid 34093281)
23. Takenami T, Yagishita S, Murase S, et al. (2005). Neurotoxicity of intrathecally administered bupivacaine involves the posterior roots/posterior white matter and is milder than lidocaine in rats. Reg Anesth Pain Med 30:464-72 (Pubitemid 44437078)
24. Tanaka S, Sakai A, Kimura K, et al. (2008). Proteomic analysis of the basic proteins in 5-fluorouracil resistance of human colon cancer cell line using the radical-free and highly reducing method of twodimensional polyacrylamide gel electrophoresis. Int J Control 33: 361-70
25. Williams KL, Rahimtula M, Mearow KM. (2006). Heat shock protein 27 is involved in neurite extension and branching of dorsal root ganglion neurons in vitro. J Neurosci Res 84:716-23 (Pubitemid 44366673)
26. Yaksh TL, Rudy TA. (1976). Chronic catherization of the spinal subarachnoid space. Physiol Behav 17:1031-6 (Pubitemid 8063691)
27. Yamashita A, Matsumoto M, Matsumoto S, et al. (2003). A comparison of the neurotoxic effects on the spinal cord of tetracaine, lidocaine, bupivacaine, and ropivacaine administered intrathecally in rabbits. Anesth Analog 97:512-19 (Pubitemid 36899758)
28. Yang SH, Guo QL, Wang YC. (2008). Alterations of myelin basic protein concentration in the plasma and ultrastructure in the spinal cord after continuous intrathecal ropivacaine injection in rats. J Cent South Univ (Med Sci) 33:527-32
29. Zaric D, Pace NL. (2009). Transient neurologic symptoms (TNS) following spinal anaesthesia with lidocaine versus other local anaesthetics. Cochrane Database Syst Rev 2:CD003006
30. Zhong Z, Qulian G, Yuan Z, et al. (2009). Repeated intrathecal administration of ropivacaine causes neurotoxicity in rats. Anaesth Intensive Care 37:929-36.