Repeated intrathecal administration of ropivacaine causes neurotoxicity in rats

Anaesthesia and Intensive Care

Volumn 37, Issue 6, 2009, Pages 929-936

  Zhong, Z ^a   Qulian, G ^a   Yuan, Z ^a   Wangyuan, Z ^a   Zhihua, S ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Apoptosis; Intrathecal; Neurotoxicity; Ropivacaine; Subarachnoid

Indexed keywords

ROPIVACAINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BEHAVIOR CHANGE; BODY WEIGHT; CELL VACUOLE; CONTROLLED STUDY; CONVALESCENCE; DORSAL ROOT; DRUG SAFETY; ELECTRON MICROSCOPY; IMPLANTATION; INFLAMMATORY CELL; MALE; MECHANICAL STIMULATION; MOTOR PERFORMANCE; MYELIN SHEATH; NERVE FIBER; NEUROTOXICITY; NICK END LABELING; NOCICEPTIVE STIMULATION; NONHUMAN; PERCEPTIVE THRESHOLD; RAT;

EID: 74049134974     PISSN: 0310057X     EISSN: None     Source Type: Journal    
DOI: 10.1177/0310057x0903700612     Document Type: Article

References (24)

1. Zink W, Graf BM. The toxicity of local anesthetics: the place of ropivacaine and levobupivacaine. Curr Opin Anaesthesiol 2008; 21:645-650.
2. Yamashita A, Matsumoto M, Matsumoto S, Itoh M, Kawai K, Sakabe T. A comparison of the neurotoxic effects on the spinal cord of tetracaine, lidocaine, bupivacaine, and ropivacaine administered intrathecally in rabbits. Anesth Analg 2003; 97:512-519.
3. Schneider M, Ettlin T, Kaufmann M, Schumacher P, Urwyler A, Hampl K et al. Transient neurologic toxicity after hyperbaric subarachnoid anesthesia with 5% lidocaine. Anesth Analg 1993; 76:1154-1157.
4. Rigler ML, Drasner K, Krejcie TC, Yelich SJ, Scholnick FT, DeFontes J et al. Cauda equina syndrome after continuous spinal anesthesia. Anesth Analg 1991; 72:275-281.
5. Pollock JE. Neurotoxicity of intrathecal local anaesthetics and transient neurological symptoms. Best Pract Res Clin Anaesthesiol 2003; 17:471-484.
6. Radwan IAM, Saito S, Goto F. The neurotoxicity of local anesthetics on growing neurons: a comparative study of lidocaine, bupivacaine, mepivacaine, and ropivacaine. Anesth Analg 2002; 94:319-324.
7. Sakura S, Kirihara Y, Muguruma T, Kishimoto T, Saito Y. The comparative neurotoxicity of intrathecal lidocaine and bupivacaine in rats. Anesth Analg 2005; 101:541-547.
8. Kallio H, Snall E-VT, Kero MP, Rosenberg PH. A comparison of intrathecal plain solutions containing ropivacaine 20 or 15 mg versus bupivacaine 10 mg. Anesth Analg 2004; 99:713-717.
9. Luck JF, Fettes PDW, Wildsmith JAW. Spinal anaesthesia for elective surgery: a comparison of hyperbaric solutions of racemic bupivacaine, levobupivacaine, and ropivacaine. Br J Anaesth 2008; 101:705-710.
10. Qian XW, Chen XZ, Li DB. Low-dose ropivacaine-sufentanil spinal anaesthesia for caesarean delivery: a randomised trial. Int J Obstet Anesth 2008; 17:309-314.
11. de Jong RH. Ropivacaine neurotoxicity: a stab in the back? Anesthesiology 2001; 95:1531.
12. Al-Nasser B. Toxic effects of epidural analgesia with ropivacaine 0.2% in a diabetic patient. J Clin Anesth 2004; 16:220-223.
13. Ganapathy S, Sandhu HB, Stockall CA, Hurley D. Transient neurologic symptom (TNS) following intrathecal ropivacaine. Anesthesiology 2000; 93:1537-1539.
14. Denny NM, Selander DE. Continuous spinal anaesthesia. Br J Anaesth 1998; 81:590-597.
15. Schell RM, Brauer FS, Cole DJ, Applegate RL 2nd. Persistent sacral nerve root deficits after continuous spinal anaesthesia. Can J Anaesth 1991; 38:908-911.
16. 2+ content of spinal cord in rats.] Zhong Nan Da Xue Xue Bao Yi Xue Ban 2005; 30:88-91.
17. Johnson ME, Uhl CB, Spittler K-H, Wang H, Gores GJ. Mitochondrial injury and caspase activation by the local anesthetic lidocaine. Anesthesiology 2004; 101:1184-1194.
18. Yaksh TL, Rudy TA. Chronic catheterization of the spinal subarachnoid space. Physiol Behav 1976; 17:1031-1036.
19. Takenami T, Yagishita S, Murase S, Hiruma H, Kawakami T, Hoka S. Neurotoxicity of intrathecally administered bupivacaine involves the posterior roots/posterior white matter and is milder than lidocaine in rats. Reg Anesth Pain Med 2005; 30:464-472.
20. Malinovsky J-M, Charles F, Baudrimont M, Pereon Y, Le Corre P, Pinaud M et al. Intrathecal ropivacaine in rabbits: pharmacodynamic and neurotoxicologic study. Anesthesiology 2002; 97:429-435.
21. Rose F-X, Estebe J-P, Ratajczak M, Wodey E, Chevanne F, Dollo G et al. Epidural, intrathecal pharmacokinetics, and intrathecal bioavailability of ropivacaine. Anesth Analg 2007; 105:859-867.
22. Gordh T Jr, Post C, Olsson Y. Evaluation of the toxicity of subarachnoid clonidine, guanfacine, and a substance P-antagonist on rat spinal cord and nerve roots: light and electron microscopic observations after chronic intrathecal administration. Anesth Analg 1986; 65:1303-1311.
23. Svensson BA, Alari L, Post C. Repeated intrathecal injections of dezocine produce antinociception without evidence for neurotoxicity in the rat: a study of morphometric evaluation of spinal cord histology. Anesth Analg 1992; 75:392-399.
24. Boselli E, Duflo F, Debon R, Allaouchiche B, Chassard D, Thomas L et al. The induction of apoptosis by local anesthetics: a comparison between lidocaine and ropivacaine. Anesth Analg 2003; 96:755-756.