Intrathecal lidocaine causes posterior root axonal degeneration near entry into the spinal cord in rats

Regional Anesthesia and Pain Medicine

Volumn 27, Issue 1, 2002, Pages 58-67

  Takenami, Tamie ^a   Yagishita, Saburo ^a   Asato, Fumio ^a   Arai, Masayasu ^a   Hoka, Sumio ^a  

^a KITASATO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Lidocaine; Local anesthetics; Neurotoxicity; Pathology; Posterior root; Spinal anesthesia

Indexed keywords

GLUCOSE; LIDOCAINE; LOCAL ANESTHETIC AGENT;

ANESTHESIA COMPLICATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DORSAL ROOT; LOCAL ANESTHESIA; NERVE FIBER DEGENERATION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; SPINAL ANESTHESIA; SPINAL CORD;

EID: 0036150357     PISSN: 10987339     EISSN: None     Source Type: Journal    
DOI: 10.1053/rapm.2002.27176     Document Type: Article

References (10)

1. Neurotoxicity of intrathecal local anesthetics in rabbits
2. Evaluation of neurotoxicity after subarachnoid injection of large volume of local anesthetic solutions
3. Neurological toxicity of the subarachnoid infusion of bupivacaine, lignocaine or 2-chloroprocaine in the rat
4. Comparative toxicity of glucose and lidocaine administered intrathecally in the rat
5. Neurotoxicity of intrathecally administered tetracaine commences at the posterior roots near entry into the spinal cord
6. Transient neurologic symptoms after spinal anesthesia: An epidemiologic study of 1,863 patients
7. Persistent sacral sensory deficit induced by intrathecal local anesthetic infusion in the rat
8. Chronic catheterization of the spinal subarachnoid space
9. Intrathecal catheterization in rat: Improved technique for morphologic analysis of drug-induced injury
10. The addition of 7.5% glucose does not alter the neurotoxicity of 5% lidocaine administered intrathecally in the rat