Downregulation of Nrf2/HO-1 pathway and activation of JNK/c-Jun pathway are involved in homocysteic acid-induced cytotoxicity in HT-22 cells

Toxicology Letters

Volumn 223, Issue 1, 2013, Pages 1-8

  Tan, Min ^a,b   Ouyang, Ying ^b   Jin, Minghua ^b   Chen, Meihui ^b   Liu, Peiqing ^b   Chao, Xiaojuan ^b   Chen, Ziwei ^b   Chen, Xiaohong ^b   Ramassamy, Charles ^c   Gao, Youheng ^a   Pi, Rongbiao ^b  

^a GUANGZHOU UNIVERSITY OF CHINESE MEDICINE   (China)

^b SUN YAT SEN UNIVERSITY   (China)

^c INRS INSTITUT ARMAND FRAPPIER   (Canada)

Author keywords

C Jun; Cytotoxicity; HO 1; Homocysteic acid; JNK; Nrf2

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CASPASE 3; GLUTATHIONE; HEME OXYGENASE 1; HOMOCYSTEIC ACID; PROTEIN BAX; PROTEIN BCL 2; PROTEIN C JUN; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR NRF2;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME INACTIVATION; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

C-JUN; CYTOTOXICITY; HO-1; HOMOCYSTEIC ACID; JNK; NRF2;

ANIMALS; ANTHRACENES; APOPTOSIS; CELL LINE; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; HEME OXYGENASE-1; HOMOCYSTEINE; MAP KINASE SIGNALING SYSTEM; MEMBRANE PROTEINS; MICE; MITOCHONDRIA; NEURONS; NEUROTOXICITY SYNDROMES; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES;

EID: 84884226784     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2013.08.011     Document Type: Article

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