Screening for stability and compatibility conditions of recombinant human epidermal growth factor for parenteral formulation: Effect of pH, buffers, and excipients

International Journal of Pharmaceutics

Volumn 452, Issue 1-2, 2013, Pages 52-62

  Santana, Héctor ^a   González, Yaima ^a   Campana, Patricia Targon ^b   Noda, Jesús ^a   Amarantes, Odalys ^a   Itri, Rosangela ^b   Beldarraín, Alejandro ^c   Páez, Rolando ^a  

^a CENTER FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Cuba)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c Central Office for Scientific Pole   (Cuba)

Author keywords

Epidermal growth factor; Excipients compatibility; Formulation; Solution stability

Indexed keywords

ACETIC ACID; BUFFER; CITRIC ACID; EXCIPIENT; GAMMA UROGASTRONE; HISTIDINE; MACROGOL; PHOSPHATE; POLYSORBATE; RECOMBINANT EPIDERMAL GROWTH FACTOR; RECOMBINANT HUMAN EPIDERMAL GROWTH FACTOR; SUCCINIC ACID; TROMETAMOL; UNCLASSIFIED DRUG;

ARTICLE; BIOCOMPATIBILITY; CIRCULAR DICHROISM; CONCENTRATION (PARAMETERS); CONFORMATIONAL TRANSITION; DEAMINATION; DRUG SCREENING; DRUG STABILITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FREEZE THAWING; GEL PERMEATION CHROMATOGRAPHY; HIGH TEMPERATURE; HUMAN; IONIC STRENGTH; ISOELECTRIC POINT; LIGHT SCATTERING; OXIDATION; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN STABILITY; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ZETA POTENTIAL;

EID: 84884210379     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2013.04.054     Document Type: Article

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