Tear EGF concentration following corneal epithelial wound creation

Journal of Ocular Pharmacology and Therapeutics

Volumn 12, Issue 3, 1996, Pages 239-243

  Sheardown, Heather ^a,b   Cheng, Yu Ling ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR;

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORNEA EPITHELIUM; CORNEA INJURY; ENZYME LINKED IMMUNOSORBENT ASSAY; KERATECTOMY; LACRIMAL FLUID LEVEL; LACRIMAL GLAND; NONHUMAN; RABBIT; WOUND HEALING;

EID: 0029789160     PISSN: 10807683     EISSN: None     Source Type: Journal    
DOI: 10.1089/jop.1996.12.239     Document Type: Article

References (22)

1. van Setten, G.B. Epidermal growth factor in human tear fluid: increased release but decreased concentration during reflex tearing. Curr. Eye Res., 9.79-83, 1990.
2. Ohashi, Y., Motokura, M., Kinoshita, Y., Mano, T., Watanabe, H., Kinoshita, S., Manabe, R., Oshiden, K., and Yanaihara, C. Presence of human epidermal growth factor in human tears. Invest. Ophthalmol. Vis. Sci., 30:1879-1889, 1989.
3. van Setten, G.B., Tervo, T., Viinikka, L., Pesonen, K., Perheentupa, J., and Tarkkanen, A. Ocular disease leads to decreased concentrations of epidermal growth factor in the tear fluid. Curr. Eye Res., 10:523-527, 1991.
4. Parelman, J.J., Nicolson, M., and Pepose, J.S. Epidermal growth factor in human aqueous humor. Am. J. Ophthalmol., 109:603-604, 1990.
5. van Setten, G.B., Viinikka, L., and Tervo, T. Epidermal growth factor is a constant component of normal human tear fluid. Graefe's Arch. Clin. Exp. Ophthalmol., 227:184-187, 1989.
6. Ho, P.C., Davis, W.H., Elliot, J.H., and Cohen, S. Kinetics of corneal epithelial regeneration and epidermal growth factor. Invest. Ophthalmol. Vis. Sci., 13:804-809, 1974.
7. Stern, M.E., Brazzell, R.K., Beuerman, R.W., Aquavella, J.V., and Kirscher, S.E. The effects of human recombinant epidermal growth factor in epithelial wound healing. In Healing Processes in the Cornea, Crosson, C., Beuerman, R.W., and Kaufman, H.E., eds, Gulf Press, Houston, 1989, pp 69-78.
8. Leibowitz, H.M., Morello, S., Stern, M., and Kupferman, A. Effect of topically administered epidermal growth factor on corneal wound strength. Arch. Ophthalmol., 108:734-737, 1990.
9. Brazzell, R.K., Stern, M.E., Aquavella, J.V., and Baird, L. Human recombinant epidermal growth factor in experimental corneal wound healing. Invest. Ophthalmol. Vis. Sci., 32:3336-3340, 1991.
10. Sheardown, H., Wedge, C., Chou, L., Apel, R., Rootman, D.S., and Cheng, Y.-L. Continuous epidermal growth factor delivery in corneal epithelial wound healing. Invest. Ophthalmol. Vis. Sci., 34:3593-3600, 1993.
11. Beaubien, J., Boisjoly, H.M., Gagnon, P., and Guidoin, R. Mechanical properties of the rabbit cornea during wound healing after treatment with epidermal growth factor. Can. J. Ophthalmol., 29:61-65, 1994.
12. Grant, M.B., Khaw, P.T., Schultz, G.S., Adams, J.L., and Shimizu, R.W. Effects of epidermal growth factor, fibroblast growth factor, and transforming growth factor-β on corneal cell chemotaxis. Invest. Ophthalmol. Vis. Sci., 33:3292-3301, 1992.
13. Nishida, T., Nakamura, M., Murakami, J., Mishima, H., and Otori, T. Epidermal growth factor stimulates corneal epithelial cell attachment to fibronectin through a fibronectin receptor system. Invest. Ophthalmol. Vis. Sci., 33:2464-2469, 1992.
14. Mishima, H., Nakamura, M., Murakami, J., Nishida, T., and Otori, T. Transforming growth factor-β modulates effects of epidermal growth factor in corneal epithelial cells. Curr. Eye Res., 7:691-696, 1992.
15. Boisjoly, H., Laplante, C., Bernatchez, S.F., Salesse, C., Giasson, M., and Joly, M.-C. Effect of EGF, IL-1, and their combination on in vitro corneal epithelial wound closure and cell chemotaxis. Exp. Eye Res., 57:293-300, 1993.
16. Maurice, D.M. and Mishima, S. Ocular pharmacokinetics. In Pharmacology of the Eye, Sears, M.L. ed., Springer Verlag, Berlin, 1984, pp. 19-116.
17. van Setten, G.B., Tervo, T., Tervo, K., and Tarkkanen, A. Epidermal growth factor (EGF) in ocular fluids: presence, origin, and therapeutic considerations. Acta Ophthalmol., 70:54-59, 1992.
18. Mishima, S., Gasset, A., Klyce, S.D., and Baum, J.L. Determination of tear volume and tear flow. Invest. Ophthalmol., 5:264-276, 1966.
19. Wright, J.C. and Meger, G.E. A review of the Schirmer test for tear production. Arch. Ophthalmol., 67:564, 1962.
20. Chrai, S.S., Patton, T.F., Mehta, A., and Robinson, J.R. Lacrimal and instilled fluid dynamics in rabbit eyes. J. Pharm. Sci., 62:1112-1121, 1973.
21. Chrai, S.S., Makoid, M., Eriksen, S.P., and Robinson, J.R. Drop size and initial dosing frequency problems of topically applied ophthalmic drugs. J. Pharm. Sci., 63:333-338, 1974.
22. Davies, N.M., Farr, S.J., Hadgraft, J., and Kellaway, I.W. Evaluation of mucoadhesive polymers in ocular drug delivery. I. viscous solutions. Pharm. Res., 8:1039-1043, 1991.