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Volumn 12, Issue 1, 2010, Pages 17-23

Clinical development and perspectives of CIMAvax EGF, cuban vaccine for non-small-cell lung cancer therapy

Author keywords

Cancer vaccines; EGF receptor; Epidermal growth factor; Immunotherapy; Lung cancer; Non small cell lung carcinoma; Vaccine therapy

Indexed keywords

ALUMINUM HYDROXIDE; ANTINEOPLASTIC AGENT; CANCER VACCINE; CIMAVAX EGF VACCINE; CYCLOPHOSPHAMIDE; CYTOKINE ANTIBODY; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR ANTIBODY; IMMUNOLOGICAL ADJUVANT; MONTANIDE ISA 51; NEISSERIA MENINGITIDIS P64K; UNCLASSIFIED DRUG;

EID: 77649229271     PISSN: 15557960     EISSN: 15273172     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (79)

References (51)
  • 1
    • 68649090499 scopus 로고    scopus 로고
    • Trends in Cuba's Cancer Incidence (1990 to 2003) and Mortality (1990 to 2007)
    • Galán Y, Fernández L, Torres P, García M. Trends in Cuba's Cancer Incidence (1990 to 2003) and Mortality (1990 to 2007). MEDICC Review. 2009;11(3):19-26.
    • (2009) MEDICC Review , vol.11 , Issue.3 , pp. 19-26
    • Galán, Y.1    Fernández, L.2    Torres, P.3    García, M.4
  • 3
    • 38349179704 scopus 로고    scopus 로고
    • Connecting immunology research to public health: Cuban biotechnology
    • Lage A. Connecting immunology research to public health: Cuban biotechnology. Nature Immunology. 2008;9(2):109-12.
    • (2008) Nature Immunology , vol.9 , Issue.2 , pp. 109-112
    • Lage, A.1
  • 4
    • 68649087885 scopus 로고    scopus 로고
    • Transforming Cancer Indicators Begs Bold New Strategies from Biotechnology
    • Lage A. Transforming Cancer Indicators Begs Bold New Strategies from Biotechnology. MEDICC Review. 2009;11(3):8-12.
    • (2009) MEDICC Review , vol.11 , Issue.3 , pp. 8-12
    • Lage, A.1
  • 5
    • 70350571213 scopus 로고    scopus 로고
    • Immunotherapy in the landscape of new targeted treatments for nonsmall cell lung cancer
    • Dec;
    • Gerard C, Debruyne C. Immunotherapy in the landscape of new targeted treatments for nonsmall cell lung cancer. Mol Oncol. 2009 Dec;3(5-6):409-24.
    • (2009) Mol Oncol , vol.3 , Issue.5-6 , pp. 409-424
    • Gerard, C.1    Debruyne, C.2
  • 7
    • 68949213744 scopus 로고    scopus 로고
    • Predictive value of EGFR and HER2 overexpression in advanced non-small-cell lung cancer
    • Aug;
    • Hirsch FR, Varella-García M, Cappuzzo F. Predictive value of EGFR and HER2 overexpression in advanced non-small-cell lung cancer. Oncogene. 2009 Aug;28 Suppl 1:S32-7.
    • (2009) Oncogene , vol.28 , Issue.SUPPL. 1
    • Hirsch, F.R.1    Varella-García, M.2    Cappuzzo, F.3
  • 8
    • 34247860903 scopus 로고    scopus 로고
    • Cancer Vaccines for Hormone/Growth Factor Immune Deprivation: A Feasible Approach for Cancer Treatment
    • May;
    • González G, Lage A. Cancer Vaccines for Hormone/Growth Factor Immune Deprivation: A Feasible Approach for Cancer Treatment. Curr Cancer Drug Targets. 2007 May;7(3):229-41.
    • (2007) Curr Cancer Drug Targets , vol.7 , Issue.3 , pp. 229-241
    • González, G.1    Lage, A.2
  • 9
    • 0023230566 scopus 로고
    • Prognostic significance of the receptor for epidermal growth factor in human mammary carcinoma
    • May-Jun;
    • Macías A, Azavedo E, Hägerström T, Klintenberg C, Pérez R, Skoog L. Prognostic significance of the receptor for epidermal growth factor in human mammary carcinoma. Anticancer Res. 1987 May-Jun;7(3 Pt B):459-64.
    • (1987) Anticancer Res , vol.7 , Issue.3 PART B , pp. 459-464
    • Macías, A.1    Azavedo, E.2    Hägerström, T.3    Klintenberg, C.4    Pérez, R.5    Skoog, L.6
  • 10
    • 0037429652 scopus 로고    scopus 로고
    • ErbB-targeted therapeutic approaches in human cancer
    • Mar 10;
    • Arteaga CL. ErbB-targeted therapeutic approaches in human cancer. Exp Cell Res. 2003 Mar 10;284(1):122-30.
    • (2003) Exp Cell Res , vol.284 , Issue.1 , pp. 122-130
    • Arteaga, C.L.1
  • 11
    • 0041386348 scopus 로고    scopus 로고
    • Targeting epidermal growth factor receptor signaling: Early results and future trends in oncology
    • Lage A, Crombet T, González G. Targeting epidermal growth factor receptor signaling: early results and future trends in oncology. Ann Med. 2003;35(5):327-36.
    • (2003) Ann Med , vol.35 , Issue.5 , pp. 327-336
    • Lage, A.1    Crombet, T.2    González, G.3
  • 12
    • 0021226547 scopus 로고
    • Epidermal growth factor receptors in human breast cancer
    • Sep;
    • Pérez R, Pascual M, Macías A, Lage A. Epidermal growth factor receptors in human breast cancer. Breast Cancer Res Treat. 1984 Sep;4(3):189-93.
    • (1984) Breast Cancer Res Treat , vol.4 , Issue.3 , pp. 189-193
    • Pérez, R.1    Pascual, M.2    Macías, A.3    Lage, A.4
  • 13
    • 0030497413 scopus 로고    scopus 로고
    • Induction of immune recognition of self-epidermal growth factor (EGF): Effect on EGF biodistribution and tumor growth
    • González G, Sánchez B, Suárez E, Beausoleil I, Perez O, Lastre M, et al. Induction of immune recognition of self-epidermal growth factor (EGF): effect on EGF biodistribution and tumor growth. Vac Res. 1996;5(4):233-44.
    • (1996) Vac Res , vol.5 , Issue.4 , pp. 233-244
    • González, G.1    Sánchez, B.2    Suárez, E.3    Beausoleil, I.4    Perez, O.5    Lastre, M.6
  • 14
    • 0030711671 scopus 로고    scopus 로고
    • Induction of immune recognition of self-epidermal growth factor II: Characterization of the antibody immune response and the use of a fusion protein
    • González G, Pardo OL, Sánchez B, García JL, Beausoleil I, Marinello P, et al. Induction of immune recognition of self-epidermal growth factor II: characterization of the antibody immune response and the use of a fusion protein. Vac Res. 1997;6(2):91-100.
    • (1997) Vac Res , vol.6 , Issue.2 , pp. 91-100
    • González, G.1    Pardo, O.L.2    Sánchez, B.3    García, J.L.4    Beausoleil, I.5    Marinello, P.6
  • 15
    • 0031775979 scopus 로고    scopus 로고
    • A novel cancer vaccine composed of human-recombinant epidermal growth factor linked to a carrier protein: Report of a pilot clinical trial
    • Apr;
    • González G, Crombet T, Catalá M, Mirabal V, Hernández JC, González Y, et al. A novel cancer vaccine composed of human-recombinant epidermal growth factor linked to a carrier protein: report of a pilot clinical trial. Ann Oncol. 1998 Apr;9(4):431-5.
    • (1998) Ann Oncol , vol.9 , Issue.4 , pp. 431-435
    • González, G.1    Crombet, T.2    Catalá, M.3    Mirabal, V.4    Hernández, J.C.5    González, Y.6
  • 16
    • 49149127726 scopus 로고    scopus 로고
    • Increased EGFR Gene Copy Number Detected by Fluorescent In Situ Hybridization Predicts Outcome in Non-Small-Cell Lung Cancer Patients Treated With Cetuximab and Chemotherapy
    • Jul 10;
    • Hirsch FR, Herbst RS, Olsen C, Chansky K, Crowley J, Kelly K, et al. Increased EGFR Gene Copy Number Detected by Fluorescent In Situ Hybridization Predicts Outcome in Non-Small-Cell Lung Cancer Patients Treated With Cetuximab and Chemotherapy. J Clin Oncol. 2008 Jul 10;26(20):3351-7.
    • (2008) J Clin Oncol , vol.26 , Issue.20 , pp. 3351-3357
    • Hirsch, F.R.1    Herbst, R.S.2    Olsen, C.3    Chansky, K.4    Crowley, J.5    Kelly, K.6
  • 17
    • 12244304887 scopus 로고    scopus 로고
    • Epidermal growth factor-based cancer vaccine for non-small-cell lung cancer therapy
    • Mar;
    • González G, Crombet T, Torres F, Catalá M, Alfonso L, Osorio M, et al. Epidermal growth factor-based cancer vaccine for non-small-cell lung cancer therapy. Ann Oncol. 2003 Mar;14(3):461-6.
    • (2003) Ann Oncol , vol.14 , Issue.3 , pp. 461-466
    • González, G.1    Crombet, T.2    Torres, F.3    Catalá, M.4    Alfonso, L.5    Osorio, M.6
  • 18
    • 1642378018 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory T cells suppress tumor immunity but are sensitive to cyclophosphamide which allows immunotherapy of established tumors to be curative
    • Feb;
    • Ghiringhelli F, Larmonier N, Schmitt E, Parcellier A, Cathelin D, Garrido C, et al. CD4+CD25+ regulatory T cells suppress tumor immunity but are sensitive to cyclophosphamide which allows immunotherapy of established tumors to be curative. Eur J Immunol. 2004 Feb;34(2):336-44.
    • (2004) Eur J Immunol , vol.34 , Issue.2 , pp. 336-344
    • Ghiringhelli, F.1    Larmonier, N.2    Schmitt, E.3    Parcellier, A.4    Cathelin, D.5    Garrido, C.6
  • 19
    • 0037093209 scopus 로고    scopus 로고
    • Antitumor effects in mice of low-dose (metronomic) cyclophosphamide administered continuously through the drinking water
    • May 15;
    • Man S, Bocci G, Francia G, Green SK, Jothy S, Hanahan D, et al. Antitumor effects in mice of low-dose (metronomic) cyclophosphamide administered continuously through the drinking water. Cancer Res. 2002 May 15;62(10):2731-5.
    • (2002) Cancer Res , vol.62 , Issue.10 , pp. 2731-2735
    • Man, S.1    Bocci, G.2    Francia, G.3    Green, S.K.4    Jothy, S.5    Hanahan, D.6
  • 20
    • 33847041123 scopus 로고    scopus 로고
    • Therapeutic vaccination with epidermal growth factor (EGF) in advanced lung cancer: Analysis of pooled data from three clinical trials
    • Jan-Feb;
    • González G, Crombet T, Neninger E, Viada C, Lage A. Therapeutic vaccination with epidermal growth factor (EGF) in advanced lung cancer: analysis of pooled data from three clinical trials. Hum Vaccin. 2007 Jan-Feb;3(1):8-13.
    • (2007) Hum Vaccin , vol.3 , Issue.1 , pp. 8-13
    • González, G.1    Crombet, T.2    Neninger, E.3    Viada, C.4    Lage, A.5
  • 21
    • 77649216831 scopus 로고    scopus 로고
    • Treatment of NSCLC Patients with an EGF-Based Cancer Vaccine: Report of a Phase I trial
    • Feb;
    • Crombet T, Neninger E, Catalá M, García B, Leonard I, Martínez L, et al. Treatment of NSCLC Patients with an EGF-Based Cancer Vaccine: report of a Phase I trial. Cancer Biol Ther. 2006 Feb;5(2):130-40.
    • (2006) Cancer Biol Ther , vol.5 , Issue.2 , pp. 130-140
    • Crombet, T.1    Neninger, E.2    Catalá, M.3    García, B.4    Leonard, I.5    Martínez, L.6
  • 22
    • 1342294725 scopus 로고    scopus 로고
    • Immunopharmacologic analysis of an autologous, hapten-modified human melanoma vaccine
    • Feb 1;
    • Berd D, Sato T, Maguire HC Jr, Kairys J, Mastrangelo MJ. Immunopharmacologic analysis of an autologous, hapten-modified human melanoma vaccine. J Clin Oncol. 2004 Feb 1;22(3):403-15.
    • (2004) J Clin Oncol , vol.22 , Issue.3 , pp. 403-415
    • Berd, D.1    Sato, T.2    Maguire Jr, H.C.3    Kairys, J.4    Mastrangelo, M.J.5
  • 23
    • 29044437924 scopus 로고    scopus 로고
    • Multiple-site DNA vaccination enhances immune responses in mice
    • Jan 16;
    • Gardiner DF, Huang Y, Basu S, Leung L, Song Y, Chen Z, et al. Multiple-site DNA vaccination enhances immune responses in mice. Vaccine. 2006 Jan 16;24(3):287-92.
    • (2006) Vaccine , vol.24 , Issue.3 , pp. 287-292
    • Gardiner, D.F.1    Huang, Y.2    Basu, S.3    Leung, L.4    Song, Y.5    Chen, Z.6
  • 24
    • 33645225168 scopus 로고    scopus 로고
    • Aucouturier J, Ascarateil S, Dupuis L. The use of oil adjuvants in therapeutic vaccines. Vaccine. 2006 Apr 12;24 Suppl 2:S2-44-5.
    • Aucouturier J, Ascarateil S, Dupuis L. The use of oil adjuvants in therapeutic vaccines. Vaccine. 2006 Apr 12;24 Suppl 2:S2-44-5.
  • 25
    • 29044433581 scopus 로고    scopus 로고
    • Therapeutic cancer vaccines: At midway between immunology and pharmacology
    • Dec;
    • Lage A, Pérez R, Fernández LE. Therapeutic cancer vaccines: at midway between immunology and pharmacology. Curr Cancer Drug Targets. 2005 Dec;5(8):611-27.
    • (2005) Curr Cancer Drug Targets , vol.5 , Issue.8 , pp. 611-627
    • Lage, A.1    Pérez, R.2    Fernández, L.E.3
  • 26
    • 0035854484 scopus 로고    scopus 로고
    • Regulation of the immune response by antigen
    • Jul 13;
    • Zinkernagel RM, Hengartner H. Regulation of the immune response by antigen. Science. 2001 Jul 13;293(5528):251-3.
    • (2001) Science , vol.293 , Issue.5528 , pp. 251-253
    • Zinkernagel, R.M.1    Hengartner, H.2
  • 27
    • 0032564659 scopus 로고    scopus 로고
    • Antigen localization and migration in immunity and tolerance
    • Dec 24;
    • Starzl TE, Zinkernagel RM. Antigen localization and migration in immunity and tolerance. N Engl J Med. 1998 Dec 24;339(26):1905-13.
    • (1998) N Engl J Med , vol.339 , Issue.26 , pp. 1905-1913
    • Starzl, T.E.1    Zinkernagel, R.M.2
  • 29
    • 48849094983 scopus 로고    scopus 로고
    • Priming and boosting determinants on the antibody response to an Epidermal Growth Factor-based cancer vaccine
    • Aug 26;
    • Rodríguez PC, González I, González A, Avellanet J, López A, Pérez R, et al. Priming and boosting determinants on the antibody response to an Epidermal Growth Factor-based cancer vaccine. Vaccine. 2008 Aug 26;26(36):4647-54.
    • (2008) Vaccine , vol.26 , Issue.36 , pp. 4647-4654
    • Rodríguez, P.C.1    González, I.2    González, A.3    Avellanet, J.4    López, A.5    Pérez, R.6
  • 30
    • 0034614637 scopus 로고    scopus 로고
    • The Hallmarks of cancer
    • Review, Jan 7;
    • Hanahan D, Weinberg RA. The Hallmarks of cancer. Cell. 2000 Jan 7;100(1):57-70. Review.
    • (2000) Cell , vol.100 , Issue.1 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 32
    • 44449147036 scopus 로고    scopus 로고
    • Tumor Cell Metabolism: Cancer's Achilles' Heel
    • Review, Jun;
    • Kroemer G, Pouyssegur J. Tumor Cell Metabolism: Cancer's Achilles' Heel. Cancer Cell. 2008 Jun;13(6):472-82. Review.
    • (2008) Cancer Cell , vol.13 , Issue.6 , pp. 472-482
    • Kroemer, G.1    Pouyssegur, J.2
  • 33
    • 47949096781 scopus 로고    scopus 로고
    • Cancer-related inflammation
    • Review, Jul 24;
    • Mantovani A, Allavena P, Sica A, Balkwill F. Cancer-related inflammation. Nature. 2008 Jul 24;454(7203):436-44. Review.
    • (2008) Nature , vol.454 , Issue.7203 , pp. 436-444
    • Mantovani, A.1    Allavena, P.2    Sica, A.3    Balkwill, F.4
  • 34
    • 58149231380 scopus 로고    scopus 로고
    • Inflaming Metastasis
    • Jan 1;
    • Mantovani A. Inflaming Metastasis. Nature. 2009 Jan 1;457(7225):36-7.
    • (2009) Nature , vol.457 , Issue.7225 , pp. 36-37
    • Mantovani, A.1
  • 35
    • 24944478531 scopus 로고    scopus 로고
    • Leveraging the activity of tumor vaccines with citotoxic chemotherapy
    • Sep 15;
    • Emens LA, Jaffee EM. Leveraging the activity of tumor vaccines with citotoxic chemotherapy. Cancer Res. 2005 Sep 15;65(18):8059-64.
    • (2005) Cancer Res , vol.65 , Issue.18 , pp. 8059-8064
    • Emens, L.A.1    Jaffee, E.M.2
  • 36
    • 34547786479 scopus 로고    scopus 로고
    • Development of psoriasis after B cell depletion with rituximab
    • Aug;
    • Dass S, Vital EM, Emery P. Development of psoriasis after B cell depletion with rituximab. Arthritis Rheum. 2007 Aug;56(8):2715-8.
    • (2007) Arthritis Rheum , vol.56 , Issue.8 , pp. 2715-2718
    • Dass, S.1    Vital, E.M.2    Emery, P.3
  • 37
  • 38
    • 0242329379 scopus 로고    scopus 로고
    • On combining antineoplastic drugs with tumor vaccines
    • Nov;
    • Terando A, Mulé JJ. On combining antineoplastic drugs with tumor vaccines. Cancer Immunol Immunother. 2003 Nov;52(11):680-5.
    • (2003) Cancer Immunol Immunother , vol.52 , Issue.11 , pp. 680-685
    • Terando, A.1    Mulé, J.J.2
  • 39
    • 0038307758 scopus 로고    scopus 로고
    • Immunomodulation in cancer therapeutics
    • Review, Aug;
    • Ehrke MJ. Immunomodulation in cancer therapeutics. Int Immunopharmacol. 2003 Aug;3(8):1105-19. Review.
    • (2003) Int Immunopharmacol , vol.3 , Issue.8 , pp. 1105-1119
    • Ehrke, M.J.1
  • 40
    • 0020051506 scopus 로고
    • Suppression of human B lymphocyte function by cyclophosphamide
    • Jun;
    • Cupps TR, Edgar LC, Fauci AS. Suppression of human B lymphocyte function by cyclophosphamide. J Immunol. 1982 Jun;128(6):2453-7.
    • (1982) J Immunol , vol.128 , Issue.6 , pp. 2453-2457
    • Cupps, T.R.1    Edgar, L.C.2    Fauci, A.S.3
  • 41
    • 33847197174 scopus 로고    scopus 로고
    • Evidence accumulating in support of cancer vaccines combined with chemotherapy: A pragmatic review of past and present efforts
    • Oct;
    • Sinkovics JG, Horvath JC. Evidence accumulating in support of cancer vaccines combined with chemotherapy: a pragmatic review of past and present efforts. Int J Oncol. 2006 Oct;29(4):765-77.
    • (2006) Int J Oncol , vol.29 , Issue.4 , pp. 765-777
    • Sinkovics, J.G.1    Horvath, J.C.2
  • 42
    • 65549127347 scopus 로고    scopus 로고
    • Combining an EGF-based cancer vaccine with chemotherapy in advanced nonsmall cell lung cancer
    • Jan;
    • Neninger E, Verdecia BG, Crombet T, Viada C, Pereda S, Leonard I, et al. Combining an EGF-based cancer vaccine with chemotherapy in advanced nonsmall cell lung cancer. J Immunother. 2009 Jan;32(1):92-9.
    • (2009) J Immunother , vol.32 , Issue.1 , pp. 92-99
    • Neninger, E.1    Verdecia, B.G.2    Crombet, T.3    Viada, C.4    Pereda, S.5    Leonard, I.6
  • 43
    • 61849137236 scopus 로고    scopus 로고
    • Chemotherapy induced transient B-cell depletion boosts antibody-forming cells expansion driven by an epidermal growth factor-based cancer vaccine
    • Apr 6;
    • Montero E, Valdés M, Avellanet J, López A, Pérez R, Lage A. Chemotherapy induced transient B-cell depletion boosts antibody-forming cells expansion driven by an epidermal growth factor-based cancer vaccine. Vaccine. 2009 Apr 6;27(16):2230-9.
    • (2009) Vaccine , vol.27 , Issue.16 , pp. 2230-2239
    • Montero, E.1    Valdés, M.2    Avellanet, J.3    López, A.4    Pérez, R.5    Lage, A.6
  • 45
    • 38949193901 scopus 로고    scopus 로고
    • Effective Inhibition of the Epidermal Growth Factor/Epidermal Growth Factor Receptor Binding by Anti-Epidermal Growth Factor Antibodies Is Related to Better Survival in Advanced Non Small-Cell Lung Cancer Patients Treated with the Epidermal Growth Factor Cancer Vaccine
    • Feb 1;
    • García B, Neninger E, de la Torre A, Leonard I, Martínez R, Viada C, et al. Effective Inhibition of the Epidermal Growth Factor/Epidermal Growth Factor Receptor Binding by Anti-Epidermal Growth Factor Antibodies Is Related to Better Survival in Advanced Non Small-Cell Lung Cancer Patients Treated with the Epidermal Growth Factor Cancer Vaccine. Clin Cancer Res. 2008 Feb 1;14(3):840-6.
    • (2008) Clin Cancer Res , vol.14 , Issue.3 , pp. 840-846
    • García, B.1    Neninger, E.2    de la Torre, A.3    Leonard, I.4    Martínez, R.5    Viada, C.6
  • 46
    • 77649211546 scopus 로고    scopus 로고
    • CIMAvax EGF® Conjugado químico de Factor de Crecimiento Epidérmico humano recombinante acoplado a la proteína recombinante rP64K, Número de Registro B- 08- 063- L03- C, Centro de Inmunología Molecular (CIM, Cuba. Centro para el Control de la Calidad de los Medicamentes CECMED, Havana, Cuba; 2008 June 12
    • CIMAvax EGF® Conjugado químico de Factor de Crecimiento Epidérmico humano recombinante acoplado a la proteína recombinante rP64K, Número de Registro B- 08- 063- L03- C, Centro de Inmunología Molecular (CIM), Cuba. Centro para el Control de la Calidad de los Medicamentes (CECMED). Havana, Cuba; 2008 June 12.
  • 47
    • 77649210978 scopus 로고    scopus 로고
    • Rodríguez G, González G, Crombet T, Lage A. CIMAvax EGF Development and Manufacturing. Biopharm International. 2008 Oct;Suppl 1:S36-42.
    • Rodríguez G, González G, Crombet T, Lage A. CIMAvax EGF Development and Manufacturing. Biopharm International. 2008 Oct;Suppl 1:S36-42.
  • 48
    • 34447136106 scopus 로고    scopus 로고
    • Cancer Vaccines: Moving Beyond Current Paradigms
    • Jul 1;
    • Schlom J, Arlen PM, Gulley JL. Cancer Vaccines: Moving Beyond Current Paradigms. Clin Cancer Res. 2007 Jul 1;13(13):3776-82.
    • (2007) Clin Cancer Res , vol.13 , Issue.13 , pp. 3776-3782
    • Schlom, J.1    Arlen, P.M.2    Gulley, J.L.3
  • 49
    • 33845993628 scopus 로고    scopus 로고
    • A Clinical Development Paradigm for Cancer Vaccines and Related Biologics
    • Jan;
    • Hoos A, Parmiani G, Hege K, Sznol M, Loibner H, Eggermont A, et al. A Clinical Development Paradigm for Cancer Vaccines and Related Biologics. J Immunother. 2007 Jan;30(1):1-15.
    • (2007) J Immunother , vol.30 , Issue.1 , pp. 1-15
    • Hoos, A.1    Parmiani, G.2    Hege, K.3    Sznol, M.4    Loibner, H.5    Eggermont, A.6
  • 50
    • 34447287767 scopus 로고    scopus 로고
    • Consequences of delayed treatment effects on analysis of time-to-event endpoints
    • Fine GD. Consequences of delayed treatment effects on analysis of time-to-event endpoints. Drug Inf J. 2007;41(4):535-9.
    • (2007) Drug Inf J , vol.41 , Issue.4 , pp. 535-539
    • Fine, G.D.1
  • 51
    • 72449127534 scopus 로고    scopus 로고
    • Therapeutic vaccines in metastatic castration-resistant prostate cancer: Principles in clinical trial design
    • Oct 27;
    • Madan RA, Mohebtash M, Schlom J, Gulley JL. Therapeutic vaccines in metastatic castration-resistant prostate cancer: principles in clinical trial design. Expert Opin Biol Ther. 2009 Oct 27;10(1):1-10.
    • (2009) Expert Opin Biol Ther , vol.10 , Issue.1 , pp. 1-10
    • Madan, R.A.1    Mohebtash, M.2    Schlom, J.3    Gulley, J.L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.