Rodent models of sleep apnea

Respiratory Physiology and Neurobiology

Volumn 188, Issue 3, 2013, Pages 355-361

  Davis, Eric M ^a   O'Donnell, Christopher P ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Breathing; Central sleep apnea; Intermittent hypoxia; Mice; Obstructive sleep apnea; Rats; Upper airway

Indexed keywords

AIRWAY OBSTRUCTION; BREATHING DISORDER; CHRONIC DISEASE; HYPERCAPNIA; INTERMITTENT HYPOXIA; NONHUMAN; PRIORITY JOURNAL; REVIEW; RODENT; SLEEP DISORDERED BREATHING;

BREATHING; CENTRAL SLEEP APNEA; INTERMITTENT HYPOXIA; MICE; OBSTRUCTIVE SLEEP APNEA; RATS; UPPER AIRWAY;

ANIMALS; ANOXIA; COGNITION; DISEASE MODELS, ANIMAL; MICE; RATS; RESPIRATORY SYSTEM; RODENTIA; SLEEP; SLEEP APNEA SYNDROMES; SLEEP APNEA, OBSTRUCTIVE;

EID: 84884208780     PISSN: 15699048     EISSN: 18781519     Source Type: Journal    
DOI: 10.1016/j.resp.2013.05.022     Document Type: Review

References (66)

1. Almendros I., Carreras A., Ramirez J., Montserrat J.M., Navajas D., Farre R. Upper airway collapse and reopening induce inflammation in a sleep apnoea model. European Respiratory Journal 2008, 32:399-404.
2. Almendros I., Farre R., Planas A.M., Torres M., Bonsignore M.R., Navajas D., Montserrat J.M. Tissue oxygenation in brain, muscle, and fat in a rat model of sleep apnea: differential effect of obstructive apneas and intermittent hypoxia. Sleep 2011, 34:1127-1133.
3. Amiel J., Laudier B., Attie-Bitach T., Trang H., de Pontual L., Gener B., Trochet D., Etchevers H., Ray P., Simonneau M., Vekemans M., Munnich A., Gaultier C., Lyonnet S. Polyalanine expansion and frameshift mutations of the paired-like homeobox gene PHOX2B in congenital central hypoventilation syndrome. Nature Genetics 2003, 33:459-461.
4. Berry R.B., Budhiraja R., Gottlieb D.J., Gozal D., Iber C., Kapur V.K., Marcus C.L., Mehra R., Parthasarathy S., Quan S.F., Redline S., Strohl K.P., Davidson Ward S.L., Tangredi M.M. Rules for scoring respiratory events in sleep: update of the 2007 AASM manual for the scoring of sleep and associated events, deliberations of the sleep apnea definitions task force of the american academy of sleep medicine. Journal of Clinical Sleep Medicine 2012, 8:597-619.
5. Brennick M.J., Pack A.I., Ko K., Kim E., Pickup S., Maislin G., Schwab R.J. Altered upper airway and soft tissue structures in the New Zealand Obese mouse. American Journal of Respiratory and Critical Care Medicine 2009, 179:158-169.
6. Campen M.J., Shimoda L.A., O'Donnell C.P. Acute and chronic cardiovascular effects of intermittent hypoxia in C57BL/6J mice. Journal of Applied Physiology 2005, 99:2028-2035.
7. Carley D.W., Berecek K., Videnovic A., Radulovacki M. Sleep-disordered respiration in phenotypically normotensive, genetically hypertensive rats. American Journal of Respiratory and Critical Care Medicine 2000, 162:1474-1479.
8. Carley D.W., Radulovacki M. Mirtazapine, a mixed-profile serotonin agonist/antagonist, suppresses sleep apnea in the rat. American Journal of Respiratory and Critical Care Medicine 1999, 160:1824-1829.
9. Carley D.W., Radulovacki M. Role of peripheral serotonin in the regulation of central sleep apneas in rats. Chest 1999, 115:1397-1401.
10. Carreras A., Wang Y., Gozal D., Montserrat J.M., Navajas D., Farre R. Non-invasive system for applying airway obstructions to model obstructive sleep apnea in mice. Respiratory Physiology & Neurobiology 2011, 175:164-168.
11. Chen L., Einbinder E., Zhang Q., Hasday J., Balke C.W., Scharf S.M. Oxidative stress and left ventricular function with chronic intermittent hypoxia in rats. American Journal of Respiratory and Critical Care Medicine 2005, 172:915-920.
12. Christon J., Carley D.W., Monti D., Radulovacki M. Effects of inspired gas on sleep-related apnea in the rat. Journal of Applied Physiology 1996, 80:2102-2107.
13. Decker M.J., Hue G.E., Caudle W.M., Miller G.W., Keating G.L., Rye D.B. Episodic neonatal hypoxia evokes executive dysfunction and regionally specific alterations in markers of dopamine signaling. Neuroscience 2003, 117:417-425.
14. Durand E., Dauger S., Pattyn A., Gaultier C., Goridis C., Gallego J. Sleep-disordered breathing in newborn mice heterozygous for the transcription factor Phox2b. American Journal of Respiratory and Critical Care Medicine 2005, 172:238-243.
15. Farkas G.A., Schlenker E.H. Pulmonary ventilation and mechanics in morbidly obese Zucker rats. American Journal of Respiratory and Critical Care Medicine 1994, 150:356-362.
16. Fenik P., Ogawa H., Veasey S.C. Hypoglossal nerve response to 5-HT3 drugs injected into the XII nucleus and vena cava in the rat. Sleep 2001, 24:871-878.
17. Fletcher E.C., Bao G., Miller C.C. Effect of recurrent episodic hypocapnic, eucapnic, and hypercapnic hypoxia on systemic blood pressure. Journal of Applied Physiology 1995, 78:1516-1521.
18. Fletcher E.C., Lesske J., Qian W., Miller C.C., Unger T. Repetitive, episodic hypoxia causes diurnal elevation of blood pressure in rats. Hypertension 1992, 19:555-561.
19. Friedman L., Haines A., Klann K., Gallaugher L., Salibra L., Han F., Strohl K.P. Ventilatory behavior during sleep among A/J and C57BL/6J mouse strains. Journal of Applied Physiology 2004, 97:1787-1795.
20. Gastaut H., Tassinari C.A., Duron B. Polygraphic study of the episodic diurnal and nocturnal (hypnic and respiratory) manifestations of the Pickwick syndrome. Brain Research 1966, 1:167-186.
21. Goridis C., Dubreuil V., Thoby-Brisson M., Fortin G., Brunet J.F. Phox2b, congenital central hypoventilation syndrome and the control of respiration. Seminars in Cell and Developmental Biology 2010, 21:814-822.
22. Gozal D., Daniel J.M., Dohanich G.P. Behavioral and anatomical correlates of chronic episodic hypoxia during sleep in the rat. Journal of Neuroscience 2001, 21:2442-2450.
23. Hamrahi H., Chan B., Horner R.L. On-line detection of sleep-wake states and application to produce intermittent hypoxia only in sleep in rats. Journal of Applied Physiology 2001, 90:2130-2140.
24. Han F., Subramanian S., Price E.R., Nadeau J., Strohl K.P. Periodic breathing in the mouse. Journal of Applied Physiology 2002, 92:1133-1140.
25. Hendricks J.C., Kline L.R., Kovalski R.J., O'Brien J.A., Morrison A.R., Pack A.I. The English bulldog: a natural model of sleep-disordered breathing. Journal of Applied Physiology 1987, 63:1344-1350.
26. Hernandez A.B., Kirkness J.P., Smith P.L., Schneider H., Polotsky M., Richardson R.A., Hernandez W.C., Schwartz A.R. Novel whole body plethysmography system for the continuous characterization of sleep and breathing in a mouse. Journal of Applied Physiology 2012, 112:671-680.
27. Hinojosa-Laborde C., Mifflin S.W. Sex differences in blood pressure response to intermittent hypoxia in rats. Hypertension 2005, 46:1016-1021.
28. Iiyori N., Alonso L.C., Li J., Sanders M.H., Garcia-Ocana A., O'Doherty R.M., Polotsky V.Y., O'Donnell C.P. Intermittent hypoxia causes insulin resistance in lean mice independent of autonomic activity. American Journal of Respiratory and Critical Care Medicine 2007, 175:851-857.
29. Joseph V., Pequignot J.M., Van Reeth O. Neurochemical perspectives on the control of breathing during sleep. Respiratory Physiology & Neurobiology 2002, 130:253-263.
30. Koo B.B., Strohl K.P., Gillombardo C.B., Jacono F.J. Ventilatory patterning in a mouse model of stroke. Respiratory Physiology & Neurobiology 2010, 172:129-135.
31. Li J., Thorne L.N., Punjabi N.M., Sun C.K., Schwartz A.R., Smith P.L., Marino R.L., Rodriguez A., Hubbard W.C., O'Donnell C.P., Polotsky V.Y. Intermittent hypoxia induces hyperlipidemia in lean mice. Circulation Research 2005, 97:698-706.
32. Macey P.M., Kumar R., Woo M.A., Valladares E.M., Yan-Go F.L., Harper R.M. Brain structural changes in obstructive sleep apnea. Sleep 2008, 31:967-977.
33. Marin J.M., Carrizo S.J., Vicente E., Agusti A.G. Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study. Lancet 2005, 365:1046-1053.
34. Mendelson W.B., Martin J.V., Perlis M., Giesen H., Wagner R., Rapoport S.I. Periodic cessation of respiratory effort during sleep in adult rats. Physiology and Behavior 1988, 43:229-234.
35. Morrell M.J., McRobbie D.W., Quest R.A., Cummin A.R., Ghiassi R., Corfield D.R. Changes in brain morphology associated with obstructive sleep apnea. Sleep Medicine 2003, 4:451-454.
36. Naghshin J., Rodriguez R.H., Davis E.M., Romano L.C., McGaffin K.R., O'Donnell C.P. Chronic intermittent hypoxia exposure improves left ventricular contractility in transgenic mice with heart failure. Journal of Applied Physiology 2012, 113:791-798.
37. Nakamura A., Fukuda Y., Kuwaki T. Sleep apnea and effect of chemostimulation on breathing instability in mice. Journal of Applied Physiology 2003, 94:525-532.
38. Nakamura A., Zhang W., Yanagisawa M., Fukuda Y., Kuwaki T. Vigilance state-dependent attenuation of hypercapnic chemoreflex and exaggerated sleep apnea in orexin knockout mice. Journal of Applied Physiology 2007, 102:241-248.
39. Nieto F.J., Peppard P.E., Young T., Finn L., Hla K.M., Farre R. Sleep-disordered breathing and cancer mortality: results from the Wisconsin sleep cohort study. American Journal of Respiratory and Critical Care Medicine 2012, 186:190-194.
40. Norton C.E., Jernigan N.L., Kanagy N.L., Walker B.R., Resta T.C. Intermittent hypoxia augments pulmonary vascular smooth muscle reactivity to NO: regulation by reactive oxygen species. Journal of Applied Physiology 2011, 111:980-988.
41. O'Donnell C., Schaub P., Haines C.D., Berkowitz A.S., Tankersley D.E., Schwartz C.G., Smith A.R.P.L. Leptin prevents respiratory depression in obesity. American Journal of Respiratory and Critical Care Medicine 1999, 159:1477-1484.
42. O'Donnell C.P., Schwartz A.R., Smith P.L., Robotham J.L., Fitzgerald R.S., Shirahata M. Reflex stimulation of renal sympathetic nerve activity and blood pressure in response to apnea. American Journal of Respiratory and Critical Care Medicine 1996, 154:1763-1770.
43. Park A.M., Suzuki Y.J. Effects of intermittent hypoxia on oxidative stress-induced myocardial damage in mice. Journal of Applied Physiology 2007, 102:1806-1814.
44. Polotsky M., Elsayed-Ahmed A.S., Pichard L., Harris C.C., Smith P.L., Schneider H., Kirkness J.P., Polotsky V., Schwartz A.R. Effects of leptin and obesity on the upper airway function. Journal of Applied Physiology 2012, 112:1637-1643.
45. Polotsky V.Y., Rubin A.E., Balbir A., Dean T., Smith P.L., Schwartz A.R., O'Donnell C.P. Intermittent hypoxia causes REM sleep deficits and decreases EEG delta power in NREM sleep in the C57BL/6J mouse. Sleep Medicine 2006, 7:7-16.
46. Punjabi N.M., Caffo B.S., Goodwin J.L., Gottlieb D.J., Newman A.B., O'Connor G.T., Rapoport D.M., Redline S., Resnick H.E., Robbins J.A., Shahar E., Unruh M.L., Samet J.M. Sleep-disordered breathing and mortality: a prospective cohort study. PLoS Medicine 2009, 6:e1000132.
47. Radulovacki M., Trbovic S., Carley D.W. Hypotension reduces sleep apneas in Zucker lean and Zucker obese rats. Sleep 1996, 19:767-773.
48. Radulovacki M., Trbovic S.M., Carley D.W. Serotonin 5-HT3-receptor antagonist GR 38032F suppresses sleep apneas in rats. Sleep 1998, 21:131-136.
49. Real C., Popa D., Seif I., Callebert J., Launay J.M., Adrien J., Escourrou P. Sleep apneas are increased in mice lacking monoamine oxidase A. Sleep 2007, 30:1295-1302.
50. Reinke C., Bevans-Fonti S., Drager L.F., Shin M.K., Polotsky V.Y. Effects of different acute hypoxic regimens on tissue oxygen profiles and metabolic outcomes. Journal of Applied Physiology 2011, 111:881-890.
51. Row B.W., Kheirandish L., Neville J.J., Gozal D. Impaired spatial learning and hyperactivity in developing rats exposed to intermittent hypoxia. Pediatric Research 2002, 52:449-453.
52. Row B.W., Liu R., Xu W., Kheirandish L., Gozal D. Intermittent hypoxia is associated with oxidative stress and spatial learning deficits in the rat. American Journal of Respiratory and Critical Care Medicine 2003, 167:1548-1553.
53. Rubin A.E., Polotsky V.Y., Balbir A., Krishnan J.A., Schwartz A.R., Smith P.L., Fitzgerald R.S., Tankersley C.G., Shirahata M., O'Donnell C.P. Differences in sleep-induced hypoxia between A/J and DBA/2J mouse strains. American Journal of Respiratory and Critical Care Medicine 2003, 168:1520-1527.
54. Salejee I., Tarasiuk A., Reder I., Scharf S.M. Chronic upper airway obstruction produces right but not left ventricular hypertrophy in rats. American Review of Respiratory Disease 1993, 148:1346-1350.
55. Sato T., Saito H., Seto K., Takatsuji H. Sleep apneas and cardiac arrhythmias in freely moving rats. American Journal of Physiology 1990, 259:R282-R287.
56. Savransky V., Nanayakkara A., Li J., Bevans S., Smith P.L., Rodriguez A., Polotsky V.Y. Chronic intermittent hypoxia induces atherosclerosis. American Journal of Respiratory and Critical Care Medicine 2007, 175:1290-1297.
57. Sood S., Liu X., Liu H., Horner R.L. Genioglossus muscle activity and serotonergic modulation of hypoglossal motor output in obese Zucker rats. Journal of Applied Physiology 2007, 102:2240-2250.
58. Stettner G.M., Huppke P., Brendel C., Richter D.W., Gartner J., Dutschmann M. Breathing dysfunctions associated with impaired control of postinspiratory activity in Mecp2-/y knockout mice. Journal of Physiology 2007, 579:863-876.
59. Stettner G.M., Zanella S., Hilaire G., Dutschmann M. 8-OH-DPAT suppresses spontaneous central apneas in the C57BL/6J mouse strain. Respiratory Physiology & Neurobiology 2008, 161:10-15.
60. Stornetta R.L., Moreira T.S., Takakura A.C., Kang B.J., Chang D.A., West G.H., Brunet J.F., Mulkey D.K., Bayliss D.A., Guyenet P.G. Expression of Phox2b by brainstem neurons involved in chemosensory integration in the adult rat. Journal of Neuroscience 2006, 26:10305-10314.
61. Tagaito Y., Polotsky V.Y., Campen M.J., Wilson J.A., Balbir A., Smith P.L., Schwartz A.R., O'Donnell C.P. A model of sleep-disordered breathing in the C57BL/6J mouse. Journal of Applied Physiology 2001, 91:2758-2766.
62. Tarasiuk A., Scharf S.M., Miller M.J. Effect of chronic resistive loading on inspiratory muscles in rats. Journal of Applied Physiology 1991, 70:216-222.
63. Veasey S.C., Davis C.W., Fenik P., Zhan G., Hsu Y.J., Pratico D., Gow A. Long-term intermittent hypoxia in mice: protracted hypersomnolence with oxidative injury to sleep-wake brain regions. Sleep 2004, 27:194-201.
64. Yaggi H.K., Concato J., Kernan W.N., Lichtman J.H., Brass L.M., Mohsenin V. Obstructive sleep apnea as a risk factor for stroke and death. New England Journal of Medicine 2005, 353:2034-2041.
65. Young J.K., Wu M., Manaye K.F., Kc P., Allard J.S., Mack S.O., Haxhiu M.A. Orexin stimulates breathing via medullary and spinal pathways. Journal of Applied Physiology 2005, 98:1387-1395.
66. Young T., Palta M., Dempsey J., Skatrud J., Weber S., Badr S. The occurrence of sleep-disordered breathing among middle-aged adults. New England Journal of Medicine 1993, 328:1230-1235.