Serotonin 5-HT3-receptor Antagonist GR 38032F Suppresses Sleep Apneas in Rats

Sleep

Volumn 21, Issue 2, 1998, Pages 131-136

  Radulovacki, Miodrag ^a   Trbovic, Sinisa M ^a   Carley, David W ^a  

^a UNIVERSITY OF ILLINOIS   (United States)

Author keywords

5 HT3; Central apneas; GR38032F; Rats; Receptor antagonist; Sleep

Indexed keywords

ONDANSETRON; SEROTONIN ANTAGONIST;

ANALYSIS OF VARIANCE; ANIMAL; ARTICLE; DRUG EFFECT; ELECTROENCEPHALOGRAPHY; ELECTROMYOGRAPHY; MALE; RAT; REM SLEEP; SLEEP APNEA SYNDROME; SPRAGUE DAWLEY RAT; TIME; WAKEFULNESS;

ANALYSIS OF VARIANCE; ANIMALS; ELECTROENCEPHALOGRAPHY; ELECTROMYOGRAPHY; MALE; ONDANSETRON; RATS; RATS, SPRAGUE-DAWLEY; SEROTONIN ANTAGONISTS; SLEEP APNEA SYNDROMES; SLEEP, REM; TIME FACTORS; WAKEFULNESS;

EID: 0032520418     PISSN: 01618105     EISSN: None     Source Type: Journal    
DOI: 10.1093/sleep/21.2.131     Document Type: Article

References (32)

1. Matsumoto S. Effects of carotid body chemoreceptor stimulation by 5-HT on PNA and ventilation in the rabbit. Arch Int Pharmacodyn Ther 1981; 254: 282-292.
2. Armstrong DJ, Kay IS. MDL 72222 (a 5-HT antagonist) antagonizes the pulmonary chemoreflexes evoked by phenylbiguanide in anaesthised rabbits. J Physiol (Lond.) 1985; 365: 104 P.
3. Bisgard GE, Mitchell RA, Herbert DA. Effects of dopamine, norepinephrine, and 5-hydoxytrytamine on the carotid body of the dog. Resp Physiol 1979; 37: 61-80.
4. Zucker IH, Cormish KG. Reflex cardiovascular and respiratory effects on serotonin in conscious and anaesthized dogs. Cire Res 1980; 47: 509-515.
5. Black AMS, Comroe JH Jr, Jacobs L. Species differences in carotid body response of the cat and dog to dopamine and serotonin. Am J Physiol 1972; 223: 1097-1102.
6. Jacobs L., Comroe JH Jr. Reflex apnea, bradycardia, and hypotension produced by serotonin in cats. Circ Res 1971; 29: 145-155.
7. Szereda-Przestaszewska M, Wypych B. Effects of vagal and laryngeal afferents on apnoeic response to serotonin in cats. Respir Physiol 1995; 101: 231-237.
8. Butler A, Hill JM, Ireland SJ, Jordan CC, Tyers MB. Pharmacological properties of GR38032F, a novel antagonist at 5-HT3 receptors. Br J Pharmacol 1988; 94: 397-412.
9. Hagan RM, Butler A, Hill JM, Jordan CC, Ireland SJ, Tyers MB. Effect of the 5-HT3 receptor antagonist, GR38032F, on responses to a neurokinin agonist into the ventral tegmental area of the rat brain. Eur J Pharmacol 1987; 138: 303-305.
10. Yoshioka M, Goda Y, Togashi H, Matsumoto M, Saito H. Pharmacological characterization of 5-hydroxtryptamine-induced apnea in the rat. J Pharmacol Exp Ther 1992; 260: 917-924.
11. Hilaire G, Marin D, Lajard AM, Monteau R. Changes in serotonin metabolism may elicit obstructive apnea in the newborn rat. J Physiol 1993; 466: 367-382.
12. Morin D. Compared effects of serotonin on the inspiratory activity of glossopharyngeal, vagal, hypoglossal and cervical motoneurons in neonatal rat brain stem-spinal chord preparations. Neurosci Lett 1993; 160: 61-64.
13. Mendelson WB, Martin JV, Perlis JM, Giesen H, Wagner R, Rapoport SI. Periodic cessation of respiratory effort during sleep in adult rats. Physiol Behav 1988; 43: 229-234.
14. Sato T, Saito H, Seto K, Takatsuji H. Sleep apneas and cardiac-arrhythmias in freely moving rats. Am J Physiol 1990; 259: R282-R287.
15. Monti D, Carley DW, Radulovacki M. Adenosine analogs modulate the incidence of sleep apneas in rats. Pharmacol Biochem Behav 1995; 51: 125-131.
16. Monti D, Carley DW, Radulovacki M. p-SPA, a peripheral adenosine A1 analogue, reduces sleep apneas in rats. Pharmacol Biochem Behav 1996; 53: 341-345.
17. Thomas AJ, Austin W, Friedman L, Strohl KP. A model of ventilatory instability induced in the unrestrained rat. J Appl Physiol 1992; 73: 1530-1536.
18. Thomas AJ, Friedman L, MacKenzie CN, Strohl KP. Modification of conditioned apneas in rats: evidence for cortical involvement. J Appl Physiol 1995; 78: 215-218.
19. Carley DW, Trbovic S, Radulovacki M. Hydralazine reduces elevated sleep apnea index in spontaneously hypertensive (SHR) rats to equivalence with normotensive Wistar-Kyoto rats. Sleep 1996; 19; 363-366.
20. Carley DW, Trbovic S, Radulovacki M. Effects of REM sleep deprivation on apnea in spontaneously hypertensive (SHR) and normotensive Wistar rats. Physiol Behav 1996; 59: 827-831.
21. Radulovacki M, Trbovic S, Carley DW. Acute hypotension reduces sleep apneas in Zucker lean and Zucker obese rats. Sleep 1996; 19: 767-773.
22. Christon J, Carley DW, Monti D, Radulovacki M. Effects of inspired gas on sleep-related apneas in the rat. J Appl Physiol 1996; 80: 2102-2107.
23. Benington J, Kodali S, Heller C. Scoring transition to REM sleep in rats based on the EEG phenomena of pre-REM sleep: An improved analysis of sleep structure. Sleep 1994; 17: 28-36.
24. Onal E. Central Sleep Apnea. Sem Resp Med 1988; 9: 547-552.
25. Hudgel DW, Hendricks L, Dadley A. Alteration in obstructive apnea pattern induced by changes in oxygen and carbon-dioxide inspired concentrations. Am Rev Respir Dis 1988; 138: 16-19.
26. Figg WD, Graham CL, Hak LJ, Dukes GE. Ondasetron: a novel antiemetic agent. S Med J 1993; 86: 497-502.
27. Simpson KH, Murphy P, Colthup PV, Whilen, P. Concentration of ondasetron in CSF following oral dosing in volunteers. Psychopharm 1992; 109: 497-498.
28. Kubin L, Tojima H. Davies RO, Pack AI. Serotonergic excitatory drive to hypoglossal neurones in the decerebrate cat. Neurosci Lett 1992; 139: 243-248.
29. Kubin L, Reignier C, Tojima H, Taguchi O, Pack AI, Davis OR. Changes in serotonin level in the hypoglossal nucleus region during carbachol-induced atonia. Brain Res 1994; 645: 291-302.
30. Veasey SC, Fornal CA, Metzler CW, Jacobs BL. Response of serotonergic caudal raphe neurons in relation to specific motor activities in freely moving cats. J Neurosci 1995; 152: 186-192.
31. Hudgel DW, Gordon EA, Meltzer HY. Abnormal serotonergic stimulation of cortisol production in obstructive sleep apnea. Am J Respir Crit Care Med 1995; 152: 186-192.
32. Veasey SC, Panckeri KA, Hoffman EA, Pack AI. Hendricks JC. The effects of serotonin antagonists in an animal model of sleep-disordered breathing. Am J Respir Crit Care Med 1996; 153: 776-786.