Mirtazapine, a mixed-profile serotonin agonist/antagonist, suppresses sleep apnea in the rat

American Journal of Respiratory and Critical Care Medicine

Volumn 160, Issue 6, 1999, Pages 1824-1829

  Carley, David W ^a,b   Radulovacki, Miodrag ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b M/C 787 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUOXETINE; MIRTAZAPINE; PAROXETINE; SEROTONIN RECEPTOR; SEROTONIN RECEPTOR AFFECTING AGENT; TRYPTOPHAN;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; LUNG MINUTE VOLUME; MALE; NONHUMAN; NONREM SLEEP; PRIORITY JOURNAL; RAT; SEROTONIN RELEASE; SLEEP APNEA SYNDROME; SLEEP STAGE;

EID: 0033429421     PISSN: 1073449X     EISSN: None     Source Type: Journal    
DOI: 10.1164/ajrccm.160.6.9902090     Document Type: Article

References (35)

1. Schmidt, H. 1982. L-Tryptophan in the treatment of impaired respiration during sleep. Bull. Eur. Physiol. Respir. 19:625-629.
2. Hanzel, D., N. Proia, and D. Hudgel. 1991. Response of obstructive sleep apnea to fluoxetine and protriptyline. Chest 100:416-421.
3. Kraiczi, H., J. Hedner, P. Dahlöf, H. Ejnell, and J. Carlson. 1999. Effect of serotonin uptake inhibition on breathing during sleep and daytime symptoms in obstructive sleep apnea. Sleep 22:61-67.
4. Veasey, S., K. Panckeri, P. Fenik, and A. Pack. 1997. A novel serotonergic compound reduces sleep disordered breathing in the English bulldog. Sleep Res. 26:A529.
5. DeVane, C. 1998. Differential pharmacology of newer antidepressants. J. Clin. Psychiatry 59(Suppl. 20):85-93.
6. McNicholas, W. 1998. Implications of pathophysiology for management of the obstructive sleep apnoea syndrome. Monaldi Arch. Chest Dis. 53:524-529.
7. Lugaresi, E., G. Coccagna, and M. Mantovani. 1978. Hypersomnia with periodic apneas. In E. Weitzman, editor. Advances in Sleep Research. Spectrum Publications, New York. 68-70.
8. Carley, D., S. Trbovic, D. Monti, and M. Radulovacki. 1995. Effects of sleep fragmentation and clonidine administration on apnea in the rat. Res. Commun. Biol. Psychol. Psychiatr. 20:95-111.
9. Horner, R., D. Brooks, L. Kozar, S. Tse, and E. Phillipson. 1995. Immediate effects of arousal from sleep on cardiac autonomic outflow in the absence of breathing in dogs. J. Appl. Physiol. 79:151-162.
10. Milhorn, D., F. Eldridge, and T. Waldrop. 1980. Prolonged stimulation of respiration by endogenous central serotonin. Respir. Physiol. 42:171-188.
11. Fenik, V., L. Kubin, S. Okabe, A. Pack, and R. Davies. 1997. Differential sensitivity of laryngeal and pharyngeal motoneurons to intophoretic application of serotonin. Neuroscience 81:873-885.
12. Martin-Body, R., and H. Grundy. 1985. Effects of neurotoxin-induced brainstem lesions on the respiratory responses of conscious rats. Clin. Exp. Pharmacol. Physiol. 12:427-437.
13. Matsumoto, S. 1981. Effects of carotid body chemoreceptor stimulation by 5-HT on phrenic nerve activity and ventilation in the rabbit. Arch. Int. Pharmacodyn. Ther. 254:282-292.
14. Yoshioka, M., Y. Goda, H. Togashi, M. Matsumoto, and H. Saito. 1992. Pharmacological characterization of 5-hydroxytryptamine-induced apnea in the rat. J. Pharmacol. Exp. Ther. 260:917-924.
15. Carley, D., and M. Radulovacki. 1999. Role of peripheral serotonin in the regulation of central sleep apneas in rats. Chest 115:1397-1401.
16. Radulovacki, M., S. Trbovic, and D. Carley. 1998. Serotonin 5-HT3 receptor antagonist GR38032F suppresses sleep apnea in rats. Sleep 21:131-136.
17. Mendelson, W., J. Martin, and D. Rapoport. 1990. Effects of buspirone on sleep and respiration. Am. Rev. Respir. Dis. 141:1527-1530.
18. Mendelson, W., M. Maczaj, and J. Holt. 1991. Buspirone administration to sleep apnea patients. J. Clin. Psychopharmacol. 11:71-72.
19. deBoer, T. 1996. The pharmacologic profile of mirtazapine. J. Clin. Psychiatr. 57(Suppl. 4):19-25.
20. Ruigt, G., B. Kemp, C. Groenhout, and H. Kamphuisen. 1990. Effect of the antidepressant Org 3770 on human sleep. Eur. J. Clin. Pharmacol. 38:551-554.
21. Epstein, R., M. Epstein, G. Haddad, and R. Mellins. 1980. Practical implementation of the barometric method for measurement of tidal volume. J. Appl. Physiol. 49:1107-1115.
22. Christon, J., D. Carley, D. Monti, and M. Radulovacki. 1996. Effects of inspired gas on sleep-related apnea in the rat. J. Appl. Physiol. 80:2102-2107.
23. Önal, E., and M. Lopata. 1982. Periodic breathing and the pathogenesis of occlusive sleep apneas. Am. Rev. Respir. Dis. 126:676-680.
24. Badr, M., J. Grossman, and S. Weber. 1994. Treatment of refractory sleep apnea with supplemental carbon dioxide. Am. J. Respir. Crit. Care Med. 150:561-564.
25. 2 on Cheyne-Stokes respiration in congestive heart failure. Sleep 17:61-68.
26. Hudgel, D., C. Hendricks, and A. Dadley. 1988. Alteration in obstructive apnea pattern induced by changes in oxygen and carbon-dioxide concentrations. Am. Rev. Respir. Dis. 138:16-19.
27. Carley, D. W., S. Trbovic, and M. Radulovacki. 1996. Hydralazine reduces elevated sleep apnea index in spontaneously hypertensive (SHR) rats to equivalence with normotensive Wistar-Kyoto rats. Sleep 19:363-366.
28. Lavie, P., R. Ben-Yousef, and A. Rubin. 1984. Prevalence of sleep apnea syndrome among patients with essential hypertension. Am. Heart J. 108:373-376.
29. Mayer, J., U, Weichler, M. B. Herres, H. Schneider, U. Marx, and J. H. Peter. 1990. Influence of metoprolol and cilazapril on blood pressure and on sleep apnea activity. J. Cardiovasc. Pharmacol. 16:952-961.
30. Carley, D. W., and D. C. Shannon. 1988. Relative stability of human respiration during progressive hypoxia. J. Appl. Physiol. 65:1389-1399.
31. Gordon, M. 1972. Animal Physiology: Principles and Adaptations. MacMillan Limited, New York.
32. Schmidt-Nielsen, K. 1990. Animal Physiology: Adaptation and Environment, 4th ed. Cambridge University Press, Cambridge.
33. Veasey, S., K. Panckeri, E. Hoffman, A. Pack, and J. Hendricks. 1996. The effects of serotonin antagonists in an animal model of sleep-disordered breathing. Am. J. Respir. Crit. Care Med. 153:776-786.
34. Rose, D., J. Khater-Boidin, P. Toussaint, and B. Duron. 1995. Central effects of 5-HT on respiratory and hypoglossal activities in the adult cat. Respir. Physiol. 101:59-69.
35. Slamowitz, D., S. Shea, J. Edward, T. Akahoshi, and D. White. 1998. Serotonergic and cholinergic influences on pharyngeal muscles (abstract). Sleep 21:104A.