Ligand selectivity for the acetylcholine binding site of the rat α4β2 and α3β4 nicotinic subtypes investigated by molecular docking

Journal of Medicinal Chemistry

Volumn 48, Issue 16, 2005, Pages 5123-5130

  Bisson, William H ^a   Scapozza, Leonardo ^b   Westera, Gerrit ^a   Mu, Linjing ^a   Schubiger, P A ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

3 (2 AZETIDINYLMETHOXY)PYRIDINE; 3 METHYL 5 (1 METHYL 2 PYRROLIDINYL)ISOXAZOLE; A 84543; A 98795; ACETYLCHOLINE; AMINE; AMPHIBIAN VENOM; EPIBATIDINE; LIGAND; LYSINE; N METHYL DECHLOROEPIBATIDINE; NICOTINE; NICOTINE DERIVATIVE; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR ALPHA3BETA4; NICOTINIC RECEPTOR ALPHA4BETA2; RECEPTOR SUBTYPE; TRYPTOPHAN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SPECIFICITY; DRUG STRUCTURE; ENANTIOMER; ENERGY TRANSFER; FEMALE; GANGLION; HYDROGEN BOND; MALE; MOLECULAR MODEL; MOUSE; NERVE CELL; NONHUMAN; PROTEIN DOMAIN; RAT; SEQUENCE HOMOLOGY;

ACETYLCHOLINE; ANIMALS; AZETIDINES; BICYCLO COMPOUNDS, HETEROCYCLIC; BINDING SITES; BINDING, COMPETITIVE; BRAIN; CELL LINE; CRYSTALLOGRAPHY, X-RAY; HYDROGEN BONDING; ISOXAZOLES; LIGANDS; MICE; MODELS, MOLECULAR; NERVE TISSUE PROTEINS; OOCYTES; PYRIDINES; PYRROLIDINES; RATS; RECEPTORS, NICOTINIC; SNAILS; STEREOISOMERISM; THERMODYNAMICS; XENOPUS;

EID: 23444452103     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm040881a     Document Type: Article

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