Pharmacological characterisation of the orexin receptor subtype mediating postsynaptic excitation in the rat dorsal raphe nucleus

Neuropharmacology

Volumn 46, Issue 8, 2004, Pages 1168-1176

  Soffin, Ellen M ^a   Gill, Catherine H ^a   Brough, Stephen J ^a   Jerman, Jeff C ^a   Davies, Ceri H ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Brain slices; Dorsal raphe nucleus; Electrophysiology; Hypocretin; Orexin; Orexin receptors

Indexed keywords

1 (2 METHYLBENZOXAZOL 6 YL) 3 [1,5]NAPHTHYRIDIN 4 YLUREA; BRAIN RECEPTOR; OREXIN 1 RECEPTOR; OREXIN 2 RECEPTOR; OREXIN A; OREXIN B; OREXIN RECEPTOR; PEPTIDE DERIVATIVE; RECEPTOR SUBTYPE; SB 334867 A; SB 668875 DM; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ANIMAL TISSUE; ARTICLE; BRAIN ELECTROPHYSIOLOGY; BRAIN SLICE; CENTRAL NERVOUS SYSTEM; CHO CELL; CONTROLLED STUDY; DEPOLARIZATION; DORSAL RAPHE NUCLEUS; DRUG POTENCY; EXCITATION; LOCUS CERULEUS; MALE; MONOAMINE NERVE CELL; NERVE CELL; NERVE CELL STIMULATION; NERVE CONDUCTION; NONHUMAN; NORADRENERGIC NERVE; POSTSYNAPTIC MEMBRANE; POSTSYNAPTIC POTENTIAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; RAT; SEROTONINERGIC NERVE CELL;

ANIMALS; BENZOXAZOLES; CHO CELLS; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY POSTSYNAPTIC POTENTIALS; MALE; RAPHE NUCLEI; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NEUROPEPTIDE; UREA;

EID: 1942468742     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2004.02.014     Document Type: Article

References (27)

1. Asahi, S., Egashira, S.-I., Matsuda, M., Iwaasa, H., Kanatani, A., Ohkubo, M., Ihara, M., Sakurai, T., Morishima, H., 2000. Structure-activity relationship studies on the novel neuropeptide orexin. In: N. Fujii (Ed.), Proceedings of the 36th Symposium on Japanese Peptide Symposium. Japanese Peptide Society, Kyoto, pp. 37-40.
2. Bingham S., Davey P.T., Babbs A.J., Irving E.A., Sammons M.J., Wyles M., Jeffrey P., Cutler L., Riba I., Johns A., Porter R.A., Upton N., Hunter A.J., Parsons A.A. Orexin-A, an hypothalamic peptide with analgesic properties. Pain. 92:(1-2):2001;81-90.
3. Brough S.J., Jerman J.C., Porter R., Martin J., Pilleux J.P., Smart D. Pharmacological characterization of orexin receptor subtype selective ligands. British Journal of Pharmacology. 134:2001;41.
4. Brown R.E., Sergeeva O., Eriksson K.S., Haas H.L. Orexin A excites serotonergic neurons in the dorsal raphe nucleus of the rat. Neuropharmacology. 40:(3):2001;457-459.
5. Brown R.E., Sergeeva O., Eriksson K.S., Haas H.L. Convergent excitation of dorsal raphe serotonin neurons by multiple arousal systems (orexin/hypocretin, histamine and noradrenaline). The Journal of Neuroscience. 22:(20):2002;8850-8859.
6. Burlet S., Tyler C.J., Leonard C.S. Direct and indirect excitation of laterodorsal tegmental neurons by hypocretin/orexin peptides: implications for wakefulness and narcolepsy. The Journal of Neuroscience. 22:(7):2002;2862-2872.
7. De Lecea L., Kilduff T.S., Peyron C., Gao X.-B., Foye P.E., Danielson P.E., Fukuhara C., Battenberg E.L.F., Gautvik V.T., Bartlett F.S. II, Frankel W.N., Van den Pol A.N., Bloom F.E., Gautvik K.M., Sutcliffe J.G. The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proceedings of the National Academy of Sciences, USA. 95:1998;322-327.
8. Eriksson K.S., Sergeeva O., Brown R.E., Haas H.L. Orexin/hypocretin excites the histaminergic neurons of the tuberomammillary nucleus. The Journal of Neuroscience. 21:(23):2001;9273-9279.
9. Greco M.A., Shiromani P.J. Hypocretin receptor protein and mRNA expression in the dorsolateral pons of rats. Molecular Brain Research. 88:2001;176-182.
10. Hagan J.J., Leslie R.A., Patel S., Evans M.L., Wattam T.A., Holmes S., Benham C.D., Taylor S.G., Routledge C., Hemmati P., Munton R.P., Ashmeade T.E., Shah A.S., Hatcher J.P., Hatcher P.D., Jones D.N., Smith M.I., Piper D.C., Hunter A.J., Porter R.A., Upton N. Orexin A activates locus coeruleus cell firing and increases arousal in the rat. Proceedings of the National Academy of Sciences, USA. 96:(19):1999;10911-10916.
11. Haynes A.C., Jackson B., Chapman H., Tadayyon M., Johns A., Porter R.A., Arch J.R. A selective orexin-1 receptor antagonist reduces food consumption in male and female rats. Regulatory Peptides. 96:(1-2):2000;45-51.
12. Hervieu G.J., Cluderay J.E., Harrison D.C., Roberts J.C., Leslie R.A. Gene expression and protein distribution of the orexin-1 receptor in the rat brain and spinal cord. Neuroscience. 103:(3):2001;777-797.
13. Horvath T.L., Peyron C., Diano S., Ivanov A., Aston-Jones G., Kilduff T.S., Van den Pol A.N. Hypocretin (orexin) activation and synaptic innervation of the locus coeruleus noradrenergic system. Journal of Comparative Neurology. 415:(2):1999;145-159.
14. Ivanov A., Aston-Jones G. Hypocretin/orexin depolarizes and decreases potassium conductance in locus coeruleus neurons. Neuroreport. 11:(8):2000;1755-1758.
15. Korotkova T., Eridsson K.S., Haas H.L., Brown R.E. Selective excitation of GABAergic neurons in the substantia nigra of the rat by orexin/hypocretin in vitro. Regulatory Peptides. 104:2002;83-89.
16. Liu R.-J., Van den Pol A., Aghajanian G.K. Hypocretins regulate serotonin neurons in the dorsal raphe nucleus by excitatory direct and inhibitory indirect actions. The Journal of Neuroscience. 22:(21):2002;9453-9464.
17. Marcus J.N., Aschkenasi C.J., Lee C.E., Chemelli R.M., Saper C.B., Yanagisawa M., Elmquist J.K. Differential expression of orexin receptors 1 and 2 in the rat brain. Journal of Comparative Neurology. 435:2001;6-25.
18. Peyron C., Tighe D.K., Van den Pol A.N., De Lecea L., Heller H.C., Sutcliffe J.G., Kilduff T.S. Neurons containing hypocretin (Orexin) project to multiple neuronal systems. Journal of Neuroscience. 18:1998;9996-10015.
19. Piper D.C., Upton N., Smith M.I., Hunter A.J. The novel brain neuropeptide, orexin-A, modulates the sleep-wake cycle of rats. European Journal of Neuroscience. 12:2000;726-730.
20. Sakurai T., Amemiya A., Ishii M., Matsuzaki I., Chemilli R.M., Tanaka H., Clay Williams S., Richardson J.A., Kozlowski G.P., Wilson S., Arch J.R.S., Buckingham R.E., Haynes A.C., Carr S.A., Annan R.S., Mcnulty D.E., Liu W.S., Terret J.A., Elshourbagy N.A., Bergsma D.J., Yanagisawa M. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviour. Cell. 92:1998;573-585.
21. Samson W.K., Gosnell B., Chang J.K., Resch Z.T., Murphy T.C. Cardiovascular regulatory actions of the hypocretins in brain. Brain Research. 831:1999;248-253.
22. Smart D., Sabido-David C., Brough S.J., Jewitt F., Johns A., Porter R.A., Jerman J.C. SB-334867-A: the first selective orexin-1 receptor antagonist. British Journal of Pharmacology. 132:(6):2001;1179-1182.
23. Soffin E.M., Evans M.L., Gill C.H., Harries M.H., Benham C.D., Davies C.H. SB-334867-A antagonises orexin mediated excitation in the locus coeruleus. Neuropharmacology. 42:2002;127-133.
24. i using the fluometric imaging plate reader (FLIPR). Lambert D.G. Calcium Signalling Protocols. 1999;125-136 Humana Press, New Jersey.
25. Trivedi P., Yu H., Macneil D.J., Van der Ploeg L.H.T., Guan X.M. Distribution of orexin receptor mRNA in the rat brain. FEBS Letters. 438:1998;71-75.
26. Vandermaelen C.P., Aghajanian G.K. Electrophysiological and pharmacological characterization of serotonergic dorsal raphe neurons recorded extracellularly and intracellularly in rat brain slices. Brain Research. 289:1983;109-119.
27. Yamanaka A., Tsujino N., Funahashi H., Honda K., Guan J.-L., Wang Q.-P., Tominaga M., Goto K., Shioda S., Sakurai T. Orexins activate histaminergic neurons via the orexin 2 receptor. Biochemical and Biophysical Research Communications. 290:2002;1237-1245.