Hypocretin-1 potentiates NMDA receptor-mediated somatodendritic secretion from locus ceruleus neurons

Journal of Neuroscience

Volumn 28, Issue 12, 2008, Pages 3202-3208

  Chen, Xiao Wei ^a,b   Mu, Yu ^b,c   Huang, Hong Ping ^b   Guo, Ning ^b   Zhang, Bo ^b   Fan, Shuang Yi ^a   Xiong, Jia Xiang ^a   Wang, Shi Rong ^b   Xiong, Wei ^b   Huang, Wei ^a,b   Liu, Tao ^b   Zheng, Liang Hong ^b   Zhang, Claire Xi ^b   Li, Li Huan ^c   Yu, Zheng Ping ^a   Hu, Zhi An ^a   Zhou, Zhuan ^b  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b PEKING UNIVERSITY   (China)

^c FUWAI HOSPITAL   (China)

Author keywords

Amperometry; Hypocretin; Locus ceruleus; NMDA; Noradrenaline; Somatic secretion

Indexed keywords

1 (2 METHYL 6 BENZOXAZOLYL) 3 (1,5 NAPHTHYRIDIN 4 YL)UREA; 2 AMINO 5 PHOSPHONOVALERIC ACID; BISINDOLYLMALEIMIDE; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NORADRENALIN; OREXIN A; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C;

AMPEROMETRY; ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG INHIBITION; DRUG POTENTIATION; LOCUS CERULEUS; NONHUMAN; NORADRENALIN RELEASE; PRIORITY JOURNAL; RAT;

ACTION POTENTIALS; ANIMALS; ANIMALS, NEWBORN; CALCIUM; DENDRITES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ELECTRIC STIMULATION; ENZYME INHIBITORS; EXCITATORY AMINO ACID AGONISTS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LOCUS COERULEUS; N-METHYLASPARTATE; NEURONS; NEUROPEPTIDES; NEUROTRANSMITTER AGENTS; PATCH-CLAMP TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 41149102361     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4426-07.2008     Document Type: Article

References (33)

1. Borgland SL, Taha SA, Sarti F, Fields HL, Bonci A (2006) Orexin A in the VTA is critical for the induction of synaptic plasticity and behavioral sensitization to cocaine. Neuron 49:589-601.
2. Chen G, Gavin PF, Luo G, Ewing AG (1995) Observation and quantitation of exocytosis from the cell body of a fully developed neuron in Planorbis corneus. J Neurosci 15:7747-7755.
3. Chen X, Wang L, Zhou Y, Zheng LH, Zhou Z (2005) "Kiss-and-run" glutamate secretion in cultured and freshly isolated rat hippocampal astrocytes. J Neurosci 25:9236-9243.
4. Chen XK, Wang LC, Zhou Y, Cai Q, Prakriya M, Duan KL, Sheng ZH, Lingle C, Zhou Z (2005) Activation of GPCRs modulates quantal size in chromaffin cells through G(betagamma) and PKC. Nat Neurosci 8:1160-1168.
5. Dan Y, Song HJ, Poo MM (1994) Evoked neuronal secretion of false transmitters. Neuron 13:909-917.
6. de Lecea L, Kilduff TS, Peyron C, Gao X, Foye PE, Danielson PE, Fukuhara C, Battenberg EL, Gautvik VT, Bartlett II FS, Frankel WN, van den Pol AN, Bloom FE, Gautvik KM, Sutcliffe JG (1998) The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci USA 95:322-327.
7. Hagan JJ, Leslie RA, Patel S, Evans ML, Wattam TA, Holmes S, Benham CD, Taylor SG, Routledge C, Hemmati P, Munton RP, Ashmeade TE, Shah AS, Hatcher JP, Hatcher PD, Jones DN, Smith MI, Piper DC, Hunter AJ, Porter RA, et al. (1999) Orexin A activates locus coeruleus cell firing and increases arousal in the rat. Proc Natl Acad Sci USA 96:10911-10916.
8. Hirota K, Kushikata T, Kudo M, Kudo T, Lambert DG, Matsuki A (2001) Orexin A and B evoke noradrenaline release from rat cerebrocortical slices. Br J Pharmacol 134:1461-1466.
9. Horvath TL, Peyron C, Diano S, Ivanov A, Aston-Jones G, Kilduff TS, van Den Pol AN (1999) Hypocretin (orexin) activation and synaptic innervation of the locus coeruleus noradrenergic system. J Comp Neurol 415:145-159.
10. Huang HP, Wang SR, Yao W, Zhang C, Zhou Y, Chen XW, Zhang B, Xiong W, Wang LY, Zheng LH, Landry M, Hokfelt T, Xu ZQ, Zhou Z (2007) Long latency of evoked quantal transmitter release from somata of locus coeruleus neurons in rat pontine slices. Proc Natl Acad Sci USA 104:1401-1406.
11. Huang LY, Neher E (1996) Ca(2+)-dependent exocytosis in the somata of dorsal root ganglion neurons. Neuron 17:135-145.
12. Jaffe EH, Marty A, Schulte A, Chow RH (1998) Extrasynaptic vesicular transmitter release from the somata of substantia nigra neurons in rat midbrain slices. J Neurosci 18:3548-3553.
13. Kawa K (2004) Discrete but simultaneous release of adenine nucleotides and serotonin from mouse megakaryocytes as detected with patch- and carbon-fiber electrodes. Am J Physiol Cell Physiol 286:C119-C128.
14. Koh DS, Hille B (1997) Modulation by neurotransmitters of catecholamine secretion from sympathetic ganglion neurons detected by amperometry. Proc Natl Acad Sci USA 94:1506-1511.
15. Kohlmeier KA, Inoue T, Leonard CS (2004) Hypocretin/orexin peptide signaling in the ascending arousal system: elevation of intracellular calcium in the mouse dorsal raphe and laterodorsal tegmentum. J Neurophysiol 92:221-235.
16. Lan JY, Skeberdis VA, Jover T, Grooms SY, Lin Y, Araneda RC, Zheng X, Bennett MV, Zukin RS (2001) Protein kinase C modulates NMDA receptor trafficking and gating. Nat Neurosci 4:382-390.
17. Marcus JN, Aschkenasi CJ, Lee CE, Chemelli RM, Saper CB, Yanagisawa M, Elmquist JK (2001) Differential expression of orexin receptors 1 and 2 in the rat brain. J Comp Neurol 435:6-25.
18. Martin G, Fabre V, Siggins GR, de Lecea L (2002) Interaction of the hypocretins with neurotransmitters in the nucleus accumbens. Regul Pept 104:111-117.
19. Mendiguren A, Pineda J (2004) Cannabinoids enhance N-methyl- D-aspartate-induced excitation of locus coeruleus neurons by CB1 receptors in rat brain slices. Neurosci Lett 363:1-5.
20. Miyakawa H, Ross WN, Jaffe D, Callaway JC, Lasser-Ross N, Lisman JE, Johnston D (1992) Synaptically activated increases in Ca2+ concentration in hippocampal CA1 pyramidal cells are primarily due to voltage-gated Ca2+ channels. Neuron 9:1163-1173.
21. Rasmussen K (1995) The role of the locus coeruleus and N-methyl-D-aspartic acid (NMDA) and AMPA receptors in opiate withdrawal. Neuropsychopharmacology 13:295-300.
22. Sakurai T (2007) The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness. Nat Rev Neurosci 8:171-181.
23. Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richardson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, et al. (1998) Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92:573-585.
24. Smart D, Jerman JC, Brough SJ, Rushton SL, Murdock PR, Jewitt F, Elshourbagy NA, Ellis CE, Middlemiss DN, Brown F (1999) Characterization of recombinant human orexin receptor pharmacology in a Chinese hamster ovary cell-line using FLIPR. Br J Pharmacol 128:1-3.
25. Soffin EM, Evans ML, Gill CH, Harries MH, Benham CD, Davies CH (2002) SB-334867-A antagonises orexin mediated excitation in the locus coeruleus. Neuropharmacology 42:127-133.
26. Song CH, Chen XW, Xia JX, Yu ZP, Hu ZA (2006) Modulatory effects of hypocretin-1/orexin-A with glutamate and gamma-aminobutyric acid on freshly isolated pyramidal neurons from the rat prefrontal cortex. Neurosci Lett 399:101-105.
27. Uramura K, Funahashi H, Muroya S, Shioda S, Takigawa M, Yada T (2001) Orexin-a activates phospholipase C- and protein kinase C-mediated Ca2+ signaling in dopamine neurons of the ventral tegmental area. NeuroReport 12:1885-1889.
28. van den Pol AN, Gao XB, Obrietan K, Kilduff TS, Belousov AB (1998) Presynaptic and postsynaptic actions and modulation of neuroendocrine neurons by a new hypothalamic peptide, hypocretin/orexin. J Neurosci 18:7962-7971.
29. van den Pol AN, Ghosh PK, Liu RJ, Li Y, Aghajanian GK, Gao XB (2002) Hypocretin (orexin) enhances neuron activity and cell synchrony in developing mouse GFP-expressing locus coeruleus. J Physiol (Lond) 541:169-185.
30. Walling SG, Nutt DJ, Lalies MD, Harley CW (2004) Orexin-A infusion in the locus ceruleus triggers norepinephrine (NE) release and NE-induced long-term potentiation in the dentate gyrus. J Neurosci 24:7421-7426.
31. Xia J, Chen X, Song C, Ye J, Yu Z, Hu Z (2005) Postsynaptic excitation of prefrontal cortical pyramidal neurons by hypocretin-1/orexin A through the inhibition of potassium currents. J Neurosci Res 82:729-736.
32. Xu R, Roh SG, Gong C, Hernandez M, Ueta Y, Chen C (2003) Orexin-B augments voltage-gated L-type Ca(2+) current via protein kinase C-mediated signalling pathway in ovine somatotropes. Neuroendocrinology 77:141-152.
33. Yang B, Samson WK, Ferguson AV (2003) Excitatory effects of orexin-A on nucleus tractus solitarius neurons are mediated by phospholipase C and protein kinase C. J Neurosci 23:6215-6222.