Orexin receptor antagonists in development for Insomnia and CNS disorders

Annual Reports in Medicinal Chemistry

Volumn 48, Issue , 2013, Pages 73-87

  Kuduk, Scott D ^a   Winrow, Christopher J ^a   Coleman, Paul J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Almorexant; Antagonist; GPCR; Hypocretin; Insomnia; Orexin; Receptor; Sleep; Suvorexant; Wakefulness

Indexed keywords

1 (2 METHYL 6 BENZOXAZOLYL) 3 (1,5 NAPHTHYRIDIN 4 YL)UREA; ALMOREXANT; BENZOFURAN DERIVATIVE; CENTRAL NERVOUS SYSTEM AGENTS; G PROTEIN COUPLED RECEPTOR; GSK 1059865; JNJ 10397049; OREXIN 1 RECEPTOR; OREXIN 2 RECEPTOR; OREXIN RECEPTOR ANTAGONIST; SB 108424; SB 649868; SIMVASTATIN; SUVOREXANT; UNCLASSIFIED DRUG;

ANXIETY; ARTICLE; HUMAN; INSOMNIA; LOCOMOTION; MOOD DISORDER; NEUROLOGIC DISEASE; PAIN; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PHASE 3 CLINICAL TRIAL (TOPIC); REM SLEEP; SLEEP TIME; SLEEP WAKING CYCLE; SOMNOLENCE; STRUCTURE ACTIVITY RELATION; WAKEFULNESS;

EID: 84884169080     PISSN: 00657743     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-417150-3.00006-5     Document Type: Chapter

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