Discovery of [(2R,5R)-5-{[(5-Fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): A Dual Orexin Receptor Antagonist with Potent Sleep-Promoting Properties

ChemMedChem

Volumn 7, Issue 3, 2012, Pages 415-424

  Coleman, Paul J ^a   Schreier, John D ^a   Cox, Christopher D ^a   Breslin, Michael J ^a   Whitman, David B ^a   Bogusky, Michael J ^a   McGaughey, Georgia B ^a   Bednar, Rodney A ^a   Lemaire, Wei ^a   Doran, Scott M ^a   Fox, Steven V ^a   Garson, Susan L ^a   Gotter, Anthony L ^a   Harrell, C Meacham ^a   Reiss, Duane R ^a   Cabalu, Tamara D ^a   Cui, Donghui ^a   Prueksaritanont, Thomayant ^a   Stevens, Joanne ^a   Tannenbaum, Pamela L ^a   Ball, Richard G ^a   Stellabott, Joyce ^a   Young, Steven D ^a   Hartman, George D ^a   Winrow, Christopher J ^a   Renger, John J ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Insomnia; Medicinal chemistry; Neurotransmitters; Orexins; Receptors

Indexed keywords

[5 [[(5 FLUOROPYRIDIN 2 YL)OXY]METHYL] 2 METHYLPIPERIDIN 1 YL][5 METHYL 2 (PYRIMIDIN 2 YL)PHENYL]METHANONE; ALPHA METHYLPIPERIDINE CARBOXAMIDE; AMIDE; MK 6096; OREXIN 1 RECEPTOR; OREXIN 2 RECEPTOR; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; EXPERIMENTAL DOG; IN VIVO STUDY; INSOMNIA; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR OCCUPANCY;

ANIMALS; BRAIN; DOGS; DRUG DISCOVERY; HUMANS; HYPNOTICS AND SEDATIVES; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; PIPERIDINES; PROTEIN BINDING; PYRIDINES; RATS; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NEUROPEPTIDE; SLEEP; SLEEP INITIATION AND MAINTENANCE DISORDERS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; WAKEFULNESS;

EID: 84857757413     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201200025     Document Type: Article

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