Exploring Anti-Bacterial Compounds against Intracellular Legionella

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  Harrison, Christopher F ^a   Kicka, Sébastien ^b   Trofimov, Valentin ^b   Berschl, Kathrin ^a   Ouertatani Sakouhi, Hajer ^b   Ackermann, Nikolaus ^a   Hedberg, Christian ^c   Cosson, Pierre ^b   Soldati, Thierry ^b   Hilbi, Hubert ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF GENEVA   (Switzerland)

^c MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMPICILLIN; ANTIINFECTIVE AGENT; BREFELDIN A; ENZYME INHIBITOR; GENTAMICIN; GREEN FLUORESCENT PROTEIN; KANAMYCIN; LATRUNCULIN B; NEOMYCIN; NOCODAZOLE; PACLITAXEL; PALMOSTATIN B; PALMOSTATIN M; RAS PROTEIN; THIOL ESTER HYDROLASE; UNCLASSIFIED DRUG;

ACANTHAMOEBA CASTELLANII; AMOEBA (GENUS); ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ANTIBIOTIC THERAPY; ARTICLE; BACTERIAL GENE; BACTERIAL GROWTH; BACTERIAL REPRODUCTION; BACTERIAL SURVIVAL; BACTERIAL VIRULENCE; CELL DIVISION; CELLULAR DISTRIBUTION; CHEMICAL MODIFICATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSKELETON; DEPALMITOYLATION; DICTYOSTELIUM DISCOIDEUM; DRUG CYTOTOXICITY; DRUG TARGETING; ENZYME LOCALIZATION; GENE DELETION; GROWTH INHIBITION; HOST CELL; IC 50; INTRACELLULAR BACTERIUM; LEGIONELLA; LEGIONELLA PNEUMOPHILA; LEGIONNAIRE DISEASE; MACROPHAGE; MICROBIAL DEGRADATION; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; MYCOBACTERIUM; NONHUMAN; PALMITOYLATION; PATHOGENESIS; PHAGOCYTOSIS; PNEUMONIA; PROTEIN SYNTHESIS; SPECIES CONSERVATION; TREATMENT OUTCOME;

ANIMALS; ANTI-BACTERIAL AGENTS; CELL LINE; GREEN FLUORESCENT PROTEINS; HUMANS; INHIBITORY CONCENTRATION 50; INTRACELLULAR SPACE; LEGIONELLA PNEUMOPHILA; MICE; MICROBIAL SENSITIVITY TESTS; MOLECULAR WEIGHT; MYCOBACTERIUM; PROPIOLACTONE; SPECIES SPECIFICITY; SULFONES;

EID: 84884168974     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0074813     Document Type: Article

References (54)

1. Hilbi H, Hoffmann C, Harrison CF, (2011) Legionella spp. outdoors: colonization, communication and persistence. Environ Microbiol Rep 3: 286-296. doi:10.1111/j.1758-2229.2011.00247.x. PubMed: 23761274.
2. Newton HJ, Ang DK, van Driel IR, Hartland EL, (2010) Molecular pathogenesis of infections caused by Legionella pneumophila. Clin Microbiol Rev 23: 274-298. doi:10.1128/CMR.00052-09. PubMed: 20375353.
3. Greub G, Raoult D, (2004) Microorganisms resistant to free-living amoebae. Clin Microbiol Rev 17: 413-433. doi:10.1128/CMR.17.2.413-433.2004. PubMed: 15084508.
4. Isberg RR, O'Connor TJ, Heidtman M, (2009) The Legionella pneumophila replication vacuole: making a cosy niche inside host cells. Nat Rev Microbiol 7: 13-24. doi:10.1038/nrmicro1967. PubMed: 19011659.
5. Hubber A, Roy CR, (2010) Modulation of host cell function by Legionella pneumophila type IV effectors. Annu Rev Cell Dev Biol 26: 261-283. doi:10.1146/annurev-cellbio-100109-104034. PubMed: 20929312.
6. Hilbi H, Haas A, (2012) Secretive bacterial pathogens and the secretory pathway. Traffic 13: 1187-1197. doi:10.1111/j.1600-0854.2012.01344.x. PubMed: 22340894.
7. Nash TW, Libby DM, Horwitz MA, (1984) Interaction between the Legionnaires' disease bacterium (Legionella pneumophila) and human alveolar macrophages. Influence of antibody, lymphokines, and hydrocortisone. J Clin Invest 74: 771-782. doi:10.1172/JCI111493. PubMed: 6470140.
8. García MT, Jones S, Pelaz C, Millar RD, Abu Kwaik Y, (2007) Acanthamoeba polyphaga resuscitates viable non-culturable Legionella pneumophila after disinfection. Environ Microbiol 9: 1267-1277. doi:10.1111/j.1462-2920.2007.01245.x. PubMed: 17472639.
9. Taylor M, Ross K, Bentham R, (2009) Legionella, protozoa, and biofilms: interactions within complex microbial systems. Microb Ecol 58: 538-547. doi:10.1007/s00248-009-9514-z. PubMed: 19365668.
10. Vildé JL, Dournon E, Rajagopalan P, (1986) Inhibition of Legionella pneumophila multiplication within human macrophages by antimicrobial agents. Antimicrob Agents Chemother 30: 743-748. doi:10.1128/AAC.30.5.743. PubMed: 3492176.
11. Barker J, Scaife H, Brown MR, (1995) Intraphagocytic growth induces an antibiotic-resistant phenotype of Legionella pneumophila. Antimicrob Agents Chemother 39: 2684-2688. doi:10.1128/AAC.39.12.2684. PubMed: 8593002.
12. Pedro-Botet L, Yu VL, (2006) Legionella: macrolides or quinolones? Clin Microbiol Infect 12 (Suppl 3):: 25-30. doi:10.1111/j.1469-0691.2006.01528.x. PubMed: 16669926.
13. Alix E, Mukherjee S, Roy CR, (2011) Subversion of membrane transport pathways by vacuolar pathogens. J Cell Biol 195: 943-952. doi:10.1083/jcb.201105019. PubMed: 22123831.
14. Payne DJ, Gwynn MN, Holmes DJ, Pompliano DL, (2007) Drugs for bad bugs: confronting the challenges of antibacterial discovery. Nat Rev Drug Discov 6: 29-40. doi:10.1038/nrd2201. PubMed: 17159923.
15. Clatworthy AE, Pierson E, Hung DT, (2007) Targeting virulence: a new paradigm for antimicrobial therapy. Nat Chem Biol 3: 541-548. doi:10.1038/nchembio.2007.24. PubMed: 17710100.
16. Cegelski L, Marshall GR, Eldridge GR, Hultgren SJ, (2008) The biology and future prospects of antivirulence therapies. Nat Rev Microbiol 6: 17-27. doi:10.1038/nrmicro1818. PubMed: 18079741.
17. LaSarre B, Federle MJ, (2013) Exploiting quorum sensing to confuse bacterial pathogens. Microbiol Mol Biol Rev 77: 73-111. doi:10.1128/MMBR.00046-12. PubMed: 23471618.
18. Imperi F, Massai F, Ramachandran Pillai C, Longo F, Zennaro E, et al. (2013) New life for an old drug: the anthelmintic drug niclosamide inhibits Pseudomonas aeruginosa quorum sensing. Antimicrob Agents Chemother 57: 996-1005. doi:10.1128/AAC.01952-12. PubMed: 23254430.
19. Tiaden A, Spirig T, Weber SS, Brüggemann H, Bosshard R, et al. (2007) The Legionella pneumophila response regulator LqsR promotes host cell interactions as an element of the virulence regulatory network controlled by RpoS and LetA. Cell Microbiol 9: 2903-2920. doi:10.1111/j.1462-5822.2007.01005.x. PubMed: 17614967.
20. Weber S, Dolinsky S, Hilbi H, (2013) Interactions of Legionella effector proteins with host phosphoinositide lipids. Methods Mol Biol 954: 367-380. doi:10.1007/978-1-62703-161-5_23. PubMed: 23150409.
21. Tiaden AN, Kessler A, Hilbi H, (2013) Analysis of Legionella infection by flow cytometry. Methods Mol Biol 954: 233-249. doi:10.1007/978-1-62703-161-5_14. PubMed: 23150400.
22. Watts DJ, Ashworth JM, (1970) Growth of myxameobae of the cellular slime mould Dictyostelium discoideum in axenic culture. Biochem J 119: 171-174. PubMed: 5530748.
23. Segal G, Shuman HA, (1998) Intracellular multiplication and human macrophage killing by Legionella pneumophila are inhibited by conjugal components of IncQ plasmid RSF1010. Mol Microbiol 30: 197-208. doi:10.1046/j.1365-2958.1998.01054.x. PubMed: 9786196.
24. Hales LM, Shuman HA, (1999) The Legionella pneumophila rpoS gene is required for growth within Acanthamoeba castellanii. J Bacteriol 181: 4879-4889. PubMed: 10438758.
25. Dietrich C, Heuner K, Brand BC, Hacker J, Steinert M, (2001) Flagellum of Legionella pneumophila positively affects the early phase of infection of eukaryotic host cells. Infect Immun 69: 2116-2122. doi:10.1128/IAI.69.4.2116-2122.2001. PubMed: 11254565.
26. Rusch M, Zimmermann TJ, Bürger M, Dekker FJ, Görmer K, et al. (2011) Identification of acyl protein thioesterases 1 and 2 as the cellular targets of the Ras-signaling modulators palmostatin B and M. Angew Chem Int Ed Engl 50: 9838-9842. doi:10.1002/anie.201102967. PubMed: 21905186.
27. Hedberg C, Dekker FJ, Rusch M, Renner S, Wetzel S, et al. (2011) Development of highly potent inhibitors of the Ras-targeting human acyl protein thioesterases based on substrate similarity design. Angew Chem Int Ed Engl 50: 9832-9837. doi:10.1002/anie.201102965. PubMed: 21905185.
28. Hagedorn M, Soldati T, (2007) Flotillin and RacH modulate the intracellular immunity of Dictyostelium to Mycobacterium marinum infection. Cell Microbiol 9: 2716-2733. doi:10.1111/j.1462-5822.2007.00993.x. PubMed: 17587329.
29. Hagedorn M, Rohde KH, Russell DG, Soldati T, (2009) Infection by tubercular mycobacteria is spread by nonlytic ejection from their amoeba hosts. Science 323: 1729-1733. doi:10.1126/science.1169381. PubMed: 19325115.
30. Li XH, Zeng YL, Gao Y, Zheng XC, Zhang QF, et al. (2010) The ClpP protease homologue is required for the transmission traits and cell division of the pathogen Legionella pneumophila. BMC Microbiol 10: 54. doi:10.1186/1471-2180-10-54. PubMed: 20167127.
31. O'Connor TJ, Adepoju Y, Boyd D, Isberg RR, (2011) Minimization of the Legionella pneumophila genome reveals chromosomal regions involved in host range expansion. Proc Natl Acad Sci U S A 108: 14733-14740. doi:10.1073/pnas.1111678108. PubMed: 21873199.
32. Zhang JH, Chung TD, Oldenburg KR, (1999) A simple statistical parameter for use in evaluation and validation of high throughput screening assays. J Biomol Screen 4: 67-73. doi:10.1177/108705719900400206. PubMed: 10838414.
33. De Muylder G, Ang KK, Chen S, Arkin MR, Engel JC, et al. (2011) A screen against Leishmania intracellular amastigotes: comparison to a promastigote screen and identification of a host cell-specific hit. PLoS Negl Trop. Drosophila Inf Serv 5: e1253.
34. Steinert M, Heuner K, (2005) Dictyostelium as host model for pathogenesis. Cell Microbiol 7: 307-314. doi:10.1111/j.1462-5822.2005.00493.x. PubMed: 15679834.
35. Ragaz C, Pietsch H, Urwyler S, Tiaden A, Weber SS, et al. (2008) The Legionella pneumophila phosphatidylinositol-4 phosphate-binding type IV substrate SidC recruits endoplasmic reticulum vesicles to a replication-permissive vacuole. Cell Microbiol 10: 2416-2433. doi:10.1111/j.1462-5822.2008.01219.x. PubMed: 18673369.
36. Weber SS, Ragaz C, Hilbi H, (2009) The inositol polyphosphate 5-phosphatase OCRL1 restricts intracellular growth of Legionella, localizes to the replicative vacuole and binds to the bacterial effector LpnE. Cell Microbiol 11: 442-460. doi:10.1111/j.1462-5822.2008.01266.x. PubMed: 19021631.
37. Li Z, Solomon JM, Isberg RR, (2005) Dictyostelium discoideum strains lacking the RtoA protein are defective for maturation of the Legionella pneumophila replication vacuole. Cell Microbiol 7: 431-442. doi:10.1111/j.1462-5822.2004.00472.x. PubMed: 15679845.
38. Weber SS, Ragaz C, Reus K, Nyfeler Y, Hilbi H, (2006) Legionella pneumophila exploits PI(4)P to anchor secreted effector proteins to the replicative vacuole. PLOS Pathog 2: e46. doi:10.1371/journal.ppat.0020046. PubMed: 16710455.
39. Horwitz MA, Silverstein SC, (1983) Intracellular multiplication of Legionnaires' disease bacteria (Legionella pneumophila) in human monocytes is reversibly inhibited by erythromycin and rifampin. J Clin Invest 71: 15-26. doi:10.1172/JCI110744. PubMed: 6848556.
40. Avison MB, Simm AM, (2002) Sequence and genome context analysis of a new molecular class D N2-lactamase gene from Legionella pneumophila. J Antimicrob Chemother 50: 331-338. doi:10.1093/jac/dkf135. PubMed: 12205057.
41. Takemura H, Yamamoto H, Kunishima H, Ikejima H, Hara T, et al. (2000) Evaluation of a human monocytic cell line THP-1 model for assay of the intracellular activities of antimicrobial agents against Legionella pneumophila. J Antimicrob Chemother 46: 589-594. doi:10.1093/jac/46.4.589. PubMed: 11020257.
42. Bacheson MA, Friedman HM, Benson CE, (1981) Antimicrobial susceptibility of intracellular Legionella pneumophila. Antimicrob Agents Chemother 20: 691-692. doi:10.1128/AAC.20.5.691. PubMed: 7325633.
43. Lippincott-Schwartz J, Yuan LC, Bonifacino JS, Klausner RD, (1989) Rapid redistribution of Golgi proteins into the ER in cells treated with brefeldin A: evidence for membrane cycling from Golgi to ER. Cell 56: 801-813. doi:10.1016/0092-8674(89)90685-5. PubMed: 2647301.
44. Macia E, Ehrlich M, Massol R, Boucrot E, Brunner C, et al. (2006) Dynasore, a cell-permeable inhibitor of dynamin. Dev Cell 10: 839-850. doi:10.1016/j.devcel.2006.04.002. PubMed: 16740485.
45. Stechmann B, Bai S-K, Gobbo E, Lopez R, Merer G, et al. (2010) Inhibition of retrograde transport protects mice from lethal ricin challenge. Cell 141: 231-242. doi:10.1016/j.cell.2010.01.043. PubMed: 20403321.
46. El Sayed KA, Youssef DT, Marchetti D, (2006) Bioactive natural and semisynthetic latrunculins. J Nat Prod 69: 219-223. doi:10.1021/np050372r. PubMed: 16499319.
47. Gersch M, List A, Groll M, Sieber SA, (2012) Insights into structural network responsible for oligomerization and activity of bacterial virulence regulator caseinolytic protease P (ClpP) protein. J Biol Chem 287: 9484-9494. doi:10.1074/jbc.M111.336222. PubMed: 22291011.
48. Gersch M, Gut F, Korotkov VS, Lehmann J, Böttcher T, et al. (2013) The mechanism of caseinolytic (ClpP) protease inhibition. Angew Chem Int Ed Engl 52: 3009-3014. doi:10.1002/anie.201204690. PubMed: 23361916.
49. Ollinger J, O'Malley T, Kesicki EA, Odingo J, Parish T, (2012) Validation of the essential ClpP protease in Mycobacterium tuberculosis as a novel drug target. J Bacteriol 194: 663-668. doi:10.1128/JB.06142-11. PubMed: 22123255.
50. Albert-Weissenberger C, Cazalet C, Buchrieser C, (2007) Legionella pneumophila- a human pathogen that co-evolved with fresh water protozoa. Cell Mol Life Sci 64: 432-448. doi:10.1007/s00018-006-6391-1. PubMed: 17192810.
51. Philips JA, Ernst JD, (2012) Tuberculosis pathogenesis and immunity. Annu Rev Pathol 7: 353-384. doi:10.1146/annurev-pathol-011811-132458. PubMed: 22054143.
52. Rusch M, Zimmermann TJ, Bürger M, Dekker FJ, Görmer K, et al. (2011) Identification of acyl protein thioesterases 1 and 2 as the cellular targets of the Ras-signaling modulators palmostatin B and M. Angew Chem Int Ed Engl 50: 9838-9842. doi:10.1002/anie.201102967. PubMed: 21905186.
53. Kolch W, (2002) Ras/Raf signalling and emerging pharmacotherapeutic targets. Expert Opin Pharmacother 3: 709-718. doi:10.1517/14656566.3.6.709. PubMed: 12036410.
54. Hoffmann C, Finsel I, Hilbi H, (2013) Pathogen vacuole purification from Legionella-infected amoeba and macrophages. Methods Mol Biol 954: 309-321. doi:10.1007/978-1-62703-161-5_18. PubMed: 23150404.