Heterozygosity for an inactivating mutation in low-density lipoprotein-related receptor 6 (Lrp6) increases osteoarthritis severity in mice after ligament and meniscus injury

Osteoarthritis and Cartilage

Volumn 21, Issue 10, 2013, Pages 1576-1585

  Joiner, D M ^a   Less, K D ^a   Van Wieren, E M ^a   Hess, D ^a,b   Williams, B O ^a  

^a VAN ANDEL RESEARCH INSTITUTE   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

Ligament; Low density lipoprotein related receptor 6 (LRP6); Meniscus; Osteoarthritis; Wnt catenin signaling

Indexed keywords

BETA CATENIN; CYCLIN D1; GELATINASE B; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; ARTICULAR CARTILAGE; BONE DEVELOPMENT; CELL FUNCTION; CELL PROLIFERATION; CHONDROGENESIS; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME ACTIVITY; GENE EXPRESSION; HETEROZYGOSITY; HISTOPATHOLOGY; KNEE LIGAMENT INJURY; KNEE MENISCUS RUPTURE; LOSS OF FUNCTION MUTATION; MALE; MICRO-COMPUTED TOMOGRAPHY; MOUSE; NONHUMAN; OSTEOARTHRITIS; OSTEOBLAST; OSTEOPHYTE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; TRABECULAR BONE; WNT SIGNALING PATHWAY;

LIGAMENT; LOW-DENSITY LIPOPROTEIN-RELATED RECEPTOR 6 (LRP6); MENISCUS; OSTEOARTHRITIS; WNT/Β-CATENIN SIGNALING;

ANIMALS; ARTHRITIS, EXPERIMENTAL; BETA CATENIN; CARTILAGE, ARTICULAR; HETEROZYGOTE; LIGAMENTS, ARTICULAR; LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-6; MALE; MENISCI, TIBIAL; MICE; MICE, MUTANT STRAINS; MUTATION; OSTEOARTHRITIS; TIBIA; WNT SIGNALING PATHWAY;

EID: 84884164406     PISSN: 10634584     EISSN: 15229653     Source Type: Journal    
DOI: 10.1016/j.joca.2013.05.019     Document Type: Article

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