Mechanotransduction in bone tissue: The A214V and G171V mutations in Lrp5 enhance load-induced osteogenesis in a surface-selective manner

Bone

Volumn 51, Issue 3, 2012, Pages 459-465

  Niziolek, Paul J ^a,b   Warman, Matthew L ^c,d   Robling, Alexander G ^a,e  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b PURDUE UNIVERSITY   (United States)

^c BOSTON CHILDREN S HOSPITAL   (United States)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^e Indiana University Purdue University Indianapolis   (United States)

Author keywords

HBM; Loading; Lrp5; Mechanotransduction; Osteoporosis; Wnt

Indexed keywords

ADULT ANIMAL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AXIAL TIBIAL LOADING; BONE CELL; BONE DEVELOPMENT; CONTROLLED STUDY; CORTICAL BONE; GENE; IN VIVO STUDY; KNOCKOUT MOUSE; LRP5 GENE; MALE; MECHANICAL STIMULATION; MECHANOTRANSDUCTION; MISSENSE MUTATION; MOUSE; NONHUMAN; PERIOSTEUM; WILD TYPE; WNT SIGNALING PATHWAY;

AMINO ACID SUBSTITUTION; ANIMALS; LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-5; MALE; MECHANOTRANSDUCTION, CELLULAR; MICE; MICE, TRANSGENIC; MUTATION; OSTEOGENESIS; PERIOSTEUM; SURFACE PROPERTIES; TIBIA; WEIGHT-BEARING;

EID: 84864772292     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2012.05.023     Document Type: Article

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