Methylglyoxal Induces Platelet Hyperaggregation and Reduces Thrombus Stability by Activating PKC and Inhibiting PI3K/Akt Pathway

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  Hadas, Karin ^a   Randriamboavonjy, Voahanginirina ^a   Elgheznawy, Amro ^a   Mann, Alexander ^b   Fleming, Ingrid ^a  

^a GOETHE UNIVERSITY   (Germany)

^b Endokrinologikum Frankfurt   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BETA3 INTEGRIN; CALCIUM ION; COLLAGEN; FERRIC CHLORIDE; FIBRONECTIN; METHYLGLYOXAL; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE C;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM CELL LEVEL; CAROTID ARTERY INJURY; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETIC PATIENT; ENZYME ACTIVATION; ENZYME INHIBITION; EX VIVO STUDY; FEMALE; HUMAN; HUMAN CELL; INCUBATION TIME; MALE; MOUSE; NONHUMAN; PATHOGENESIS; SIGNAL TRANSDUCTION; THROMBOCYTE ADHESION; THROMBOCYTE AGGREGATION; THROMBOCYTE DYSFUNCTION; THROMBOCYTE FUNCTION; THROMBUS; WESTERN BLOTTING;

ADULT; ANIMALS; BLOOD PLATELETS; CALCIUM; CELL DEGRANULATION; CELL MEMBRANE; COLLAGEN; ENZYME ACTIVATION; FEMALE; HUMANS; INTEGRIN BETA3; MALE; MICE; MICE, INBRED C57BL; MYOSIN LIGHT CHAINS; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PLATELET ADHESIVENESS; PLATELET AGGREGATION; PROTEIN KINASE C; PROTO-ONCOGENE PROTEINS C-AKT; PYRUVALDEHYDE; THROMBIN; THROMBOSIS;

EID: 84884156458     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0074401     Document Type: Article

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