Development of Novel 123I-Labeled Pyridyl Benzofuran Derivatives for SPECT Imaging of β-Amyloid Plaques in Alzheimer's Disease

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  Ono, Masahiro ^a   Cheng, Yan ^a   Kimura, Hiroyuki ^a   Watanabe, Hiroyuki ^a   Matsumura, Kenji ^a   Yoshimura, Masashi ^a   Iikuni, Shimpei ^a   Okamoto, Yoko ^a   Ihara, Masafumi ^a   Takahashi, Ryosuke ^a   Saji, Hideo ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

5 (5 IODOBENZOFURAN 2 YL) N METHYLPYRIDIN 2 AMINE I 125; 5 (5 IODOBENZOFURAN 2 YL) N,N DIMETHYLPYRIDIN 2 AMINE I 125; 5 (5 IODOBENZOFURAN 2 YL)PYRIDIN 2 AMINE I 125; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-42]; BENZOFURAN DERIVATIVE; IODINE 123; IODINE 125; PYRIDYL BENZOFURAN I 123; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA-PROTEIN (1-42); CONTRAST MEDIUM; DIAGNOSTIC AGENT; PEPTIDE FRAGMENT; PYRIDINE DERIVATIVE; RADIOACTIVE IODINE;

AGED; ALZHEIMER DISEASE; AMYLOID PLAQUE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOPSY; AUTORADIOGRAPHY; BINDING AFFINITY; BRAIN REGION; CONTROLLED STUDY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG STRUCTURE; EX VIVO STUDY; FEMALE; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; MALE; MOUSE; NONHUMAN; PROTEIN AGGREGATION; PROTEIN BINDING; RADIOACTIVITY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SPECT SCANNER; SUZUKI REACTION; TRANSGENIC MOUSE; WILD TYPE; ANIMAL; BRAIN; CHEMISTRY; METABOLISM; MICROTOMY; PATHOLOGY; SCINTISCANNING; TISSUE FIXATION;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; BENZOFURANS; BRAIN; CONTRAST MEDIA; HUMANS; IODINE RADIOISOTOPES; MALE; MICE; MICE, TRANSGENIC; MICROTOMY; PEPTIDE FRAGMENTS; PLAQUE, AMYLOID; PYRIDINES; TISSUE FIXATION; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 84884151794     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0074104     Document Type: Article

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