The Design and In Vivo Evaluation of Engineered I-OnuI-Based Enzymes for HEG Gene Drive

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  Chan, Yuk Sang ^a   Takeuchi, Ryo ^b,c   Jarjour, Jordan ^d   Huen, David S ^a,f   Stoddard, Barry L ^b,c   Russell, Steven ^a,e  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b USA   (United States)

^c Northwest Genome Engineering Consortium   (United States)

^d Pregenen Inc   (United States)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^f UNIVERSITY OF WOLVERHAMPTON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ENDONUCLEASE; I ONUL ENDONUCLEASE; UNCLASSIFIED DRUG;

AGAP004734 GENE; ANOPHELES; ARTICLE; DOUBLE STRANDED DNA BREAK; DROSOPHILA; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ENGINEERING; ENZYME SPECIFICITY; GENE; GENE FREQUENCY; GENE INACTIVATION; GENETIC ENGINEERING; GENETIC MODEL; GENETIC RECOMBINATION; GENETIC VARIABILITY; GERMLINE STEM CELL; HOMING ENDONUCLEASE GENE DRIVE SYSTEM; IN VIVO STUDY; MUTAGENESIS; PROTEIN CLEAVAGE; REPORTER GENE; SEQUENCE HOMOLOGY;

ANIMALS; ANOPHELES; DEOXYRIBONUCLEASES, TYPE II SITE-SPECIFIC; DROSOPHILA MELANOGASTER; ENDODEOXYRIBONUCLEASES; GENE TARGETING; GENES, REPORTER; GENETIC ENGINEERING; GERM-LINE MUTATION; HOMOLOGOUS RECOMBINATION; INSECT PROTEINS; PEST CONTROL, BIOLOGICAL; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 84883808451     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0074254     Document Type: Article

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