Inositol prevents folate-resistant neural tube defects in the mouse

Nature Medicine

Volumn 3, Issue 1, 1997, Pages 60-66

  Greene, Nicholas D E ^a   Copp, Andrew J ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

FOLIC ACID; INOSITOL; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; EMBRYO; MOUSE; NEURAL TUBE DEFECT; NONHUMAN; PRIORITY JOURNAL; SPINA BIFIDA;

ANIMALS; ARACHIDONIC ACID; EMBRYO; FEMALE; FOLIC ACID; GENE EXPRESSION REGULATION, DEVELOPMENTAL; INOSITOL; MALE; MICE; MICE, INBRED CBA; MICE, MUTANT STRAINS; NEURAL TUBE DEFECTS; PREGNANCY; PROTEIN KINASE C; RECEPTORS, RETINOIC ACID; TETRADECANOYLPHORBOL ACETATE; UP-REGULATION;

EID: 0031033593     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0197-60     Document Type: Article

References (11)

1. Smithells, R.W. et al. Apparent prevention of neural tube defects by periconceptional vitamin supplementation. Arch. Dis. Child. 56, 911-918 (1981).
2. Wald, N., Sneddon, J., Densem, J., Frost, C., Stone, R. & MRC Vitamin Study Research Group. Prevention of neural tube defects: Results of the Medical Research Council Vitamin Study. Lancet 338, 131-137 (1991).
3. Czeizel, A.E. & Dudás, I. Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. N. Engl. J. Med. 327, 1832-1835 (1992).
4. Seller, M.J. & Adinolfi, M. The curly tail mouse: An experimental model for human neural tube defects. Life Sci. 29, 1607-1615 (1981).
5. Letts, V.A., Schork, N.J., Copp, A.J., Bernfield, M. & Frankel, W.N. Mapping modifier genes for tail defects in curly tail mutant mice. Genomics 29, 719-724 (1995).
6. Seller, M.J. Vitamins, folic acid and the cause and prevention of neural tube defects. Ciba Found. Symp. 181, 161-173 (1994).
7. Van Straaten, H.W.M. et al. Dietary methionine does not reduce penetrance in curly tail mice but causes a phenotype-specific decrease in embryonic growth. J. Nutr. 125, 2733-2740 (1995).
8. Nishizuka, Y. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science 158, 607-613 (1992).
9. Cockroft, D.L. Changes with gestational age in the nutritional requirements of postimplantation rat embryos in culture. Teratology 38, 281-290 (1988).
10. Cockroft, D.L., Brook, F.A. & Copp, A.J. Inositol deficiency increases the susceptibility to neural tube defects of genetically predisposed (curly tail) mouse embryos in vitro. Teratology 45, 223-232 (1992).
11. Kucera, J. Rate and type of congenital anomalies among offspring of diabetic women. J. Reprod. Med. 7, 61-70 (1971).