Cordyceps mycelia extract decreases portal hypertension in rats with dimethylnitrosamine-induced liver cirrhosis: A study on its histological basis

Journal of Chinese Integrative Medicine

Volumn 6, Issue 11, 2008, Pages 1136-1144

  Wang, Xian Bo ^a   Liu, Ping ^a   Tang, Zhi Peng ^a   Li, Feng Hua ^a   Liu, Cheng Hai ^a   Hu, Yi Yang ^a   Xu, Lie Ming ^a  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Cordyceps mycelia extract; Liver cirrhosis; Liver sinusoidal endothelial cells; Portal hypertension; Rat

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN TYPE 1; COLLAGEN TYPE 4; CORDYCEPS MYCELIA EXTRACT; DIMETHYLNITROSAMINE; HERMES ANTIGEN; HYALURONIC ACID; LAMININ; PLANT EXTRACT; UNCLASSIFIED DRUG; VON WILLEBRAND FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORDYCEPS; CORDYCEPS MYCELIA; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LIVER CIRRHOSIS; LIVER SINUSOID; MESENTERIC VEIN; NONHUMAN; PORTAL HYPERTENSION; PORTAL VEIN BLOOD PRESSURE; PROTEIN EXPRESSION; RADIOIMMUNOASSAY; RAT; VEIN DIAMETER; WISTAR RAT;

ANIMALS; CORDYCEPS; DIMETHYLNITROSAMINE; DRUGS, CHINESE HERBAL; HYPERTENSION, PORTAL; LIVER CIRRHOSIS, EXPERIMENTAL; PORTAL VEIN; RATS; RATS, WISTAR;

EID: 56849108059     PISSN: 16721977     EISSN: None     Source Type: Journal    
DOI: 10.3736/jcim20081107     Document Type: Article

References (15)

1. Shimamoto T, Mori Y, Takagi H, et al. Experimental studies on morphological changes of microcirculation of DMN-induced liver cirrhosis after normothermic ischemia with charge-coupled device microscope. J Gastroenterol Hepatol. 2003; 18(9): 1071-1075.
2. Sakamoto M, Ueno T, Nakamura T, et al. Improvement of portal hypertension and hepatic blood flow in cirrhotic rats by oestrogen. Eur J Clin Invest. 2005; 35(3): 220-225.
3. Wang XB, Liu P, Tang ZP, et al. Role of injury and phenotype shift of liver sinusoidal endothelial cells in the development of portal hypertension of cirrhosis in rats. Zhongguo Bing Li Sheng Li Za Zhi. 2005; 21(9): 1811-1816. Chinese with abstract in English.
4. Wang XB, Liu P, Tang ZP, et al. Role of hepatic stellate cells activation in development of portal hypertension of dimethylnitrosamine-induced liver cirrhosis in rats. Zhongguo Zhong Xi Yi Jie He Xiao Hua Za Zhi. 2005; 13 (4): 211-214. Chinese with abstract in English.
5. Wang XB, Liu P, Tang ZP, et al. Study on the mechanisms of development of sinusoidal capillarization. Zhonghua Xiao Hua Za Zhi. 2004; 24 (5): 289-292. Chinese with abstract in English.
6. Li FH, Liu P, Xiong WG, et al. Effects of Cordyceps sinensis on dimethylnitrosamine-induced liver fibrosis in rats. Zhong Xi Yi Jie He Xue Bao. 2006; 4(5): 514-517. Chinese with abstract in English.
7. Casu A, Canepa M, Nanni G. Perisinusoidal stellate cells or Ito cells and their role in hepatic fibrosis. Pathologica. 1994; 86(5): 467-499.
8. Rockey DC. Hepatic fibrosis, stellate cells, and portal hypertension. Clin Liver Dis. 2006; 10(3): 459-479, vii-viii.
9. Reynaert H, Thompson MG, Thomas T, et al. Hepatic stellate cells: role in microcirculation and pathophysiology of portal hypertension. Gut. 2002; 50(4): 571-581.
10. Bataller R, Brenner DA. Liver fibrosis. J Clin Invest. 2005; 115(2): 209-218.
11. Oda M, Han JY, Nakamura M. Endothelial cell dysfunction in microvasculature: relevance to disease processes. Clin Hemorheol Microcirc. 2000; 23(2-4): 199-211.
12. Wang XB, Liu P, Tang ZP, et al. Dynamic changes of pressure of portal vein in development of liver fibrosis induced by dimethylnitrosamine in rats. Shi Jie Hua Ren Xiao Hua Za Zhi. 2002; 10(4): 401-405. Chinese with abstract in English.
13. Satoh T, Ichida T, Matsuda Y, et al. Interaction between hyaluronan and CD44 in the development of dimethylnitrosamine-induced liver cirrhosis. J Gastroenterol Hepatol. 2000; 15(4): 402-411.
14. Albornoz L, Alvarez D, Otaso JC, et al. Von Willebrand factor could be an index of endothelial dysfunction in patients with cirrhosis: relationship to degree of liver failure and nitric oxide levels. J Hepatol. 1999; 30(3): 451-455.
15. George J, Tsutsumi M, Takase S. Expression of hyaluronic acid in N-nitrosodimethylamine induced hepatic fibrosis in rats. Int J Biochem Cell Biol. 2004; 36(2): 307-319.