Adherent-invasive E. coli in Crohn disease: Bacterial "agent provocateur"

Journal of Clinical Investigation

Volumn 121, Issue 3, 2011, Pages 841-844

  Strober, Warren ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADHERENT INVASIVE ESCHERICHIA COLI; BACTERIAL CELL; BACTERIUM ADHERENCE; CLINICAL RESEARCH; COLON DISEASE; CROHN DISEASE; ENTEROINVASIVE ESCHERICHIA COLI; FIMBRIA; GENOME ANALYSIS; HOST; LYMPHOID TISSUE; NONHUMAN; NOTE; PATHOGENESIS; PEYER PATCH; PRIMARY INFECTION; PRIORITY JOURNAL;

ANIMALS; BACTERIAL ADHESION; CROHN DISEASE; EPITHELIAL CELLS; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTIONS; FIMBRIAE, BACTERIAL; HUMANS; INFLAMMATION; MICE; PEYER'S PATCHES; PHENOTYPE;

EID: 79952218748     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI46333     Document Type: Note

References (21)

1. Darfeuille-Michaud A, et al. High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn's disease. Gastroenterology. 2004;127(2):412-421. (Pubitemid 39091889)
2. Barnich N, Boudeau J, Claret L, Darfeuille-Michaud A. Regulatory and functional co-operation of flagella and type 1 pili in adhesive and invasive abilities of AIEC strain LF82 isolated from a patient with Crohn's disease. Mol Microbiol. 2003;48(3):781-794. (Pubitemid 36819062)
3. Barnich N, et al. CEACAM6 acts as a receptor for adherent-invasive E. coli, supporting ileal mucosa colonization in Crohn disease. J Clin Invest. 2007;117(6):1566-1574. (Pubitemid 46871341)
4. Carvalho FA, et al. Crohn's disease adherent-invasive Escherichia coli colonize and induce strong gut inflammation in transgenic mice expressing human CEACAM. J Exp Med. 2009;206(10):2179-2189.
5. Kleessen B, Kroesen J, Buhr HJ, Blaut M. Mucosal and invading bacteria in patients with inflammatory bowel disease compared with controls. Scand J Gastroenterol. 2002;37(9):1034-1041.
6. Glasser AL, Boudeau J, Barnich N, Perruchot MH, Columbel JF, Darfeuille-Michaud A. Adherent invasive Escherichia coli strains from patients with Crohn's disease survive and replicate within macrophages without inducing host cell death. Infect Immun. 2001;69(9):5529-5537. (Pubitemid 32786488)
7. Miquel S, et al. Complete genome sequence of Crohn's disease-associated adherent-invasive E. coli strain LF82. PLoS One. 2010;5(9):e12714.
8. Chassaing B, et al. Crohn disease-associated adherent-invasive E. coli bacteria target mouse and human Peyer's patches via long polar fimbriae. J Clin Invest. 2011;121(3):966-975.
9. Hase K, et al. Uptake through glycoprotein 2 of FimH(+) bacteria by M cells initiates mucosal immune response. Nature. 2009;462(7270):226-230.
10. Kleessen B, Kroesen AJ, Buhr HJ, Blaut M. Mucosal and invading bacteria in patients with inflammatory bowel disease compared with controls. Scand J Gastroenterol. 2002;37(9):1034-1041.
11. Simms LA, Doecke JD, Walsh MD, Huang N, Fowler EV, Radford-Smith GL. Reduced α-defensin expression is associated with inflammation and not NOD2 mutation status in ileal Crohn's disease. Gut. 2008;57(7):903-910. (Pubitemid 351919524)
12. Garrett W, et al. Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system. Cell. 2007;131(1):33-45. (Pubitemid 47505255)
13. Garrett WS, et al. Enterobacteriaceae act in concert with the gut microbiota to induce spontaneous and maternally transmitted colitis. Cell Host Microbe. 2010;8(3):292-300.
14. Barreau F, et al. Nod2 regulates the host response towards microflora by modulating T cell function and epithelia permeability in mouse Peyer's patches. Gut. 2009;59(2):207-217.
15. Lapaquette P, Glasser A-L, Huett A, Xavier RJ, Darfeuille-Michaud A. Crohn's disease-associated adherent-invasive E. coli are selectively favoured by impaired autophagy to replicate intracellularly. Cell Microbiol. 2010;12(1):99-113.
16. Cooney R, et al. NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation. Nat Med. 2010;16(1):90-97.
17. Strober W, Fuss IJ, Blumberg RS. The immunology of mucosal models of inflammation. Annu Rev Immunol. 2002;20:495-549. (Pubitemid 34293433)
18. Watanabe T, et al. Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis. J Clin Invest. 2008;118(2):545-559. (Pubitemid 351206545)
19. Strober W, Fuss IJ, Mannon P. The fundamental basis of inflammatory bowel disease. J Clin Invest. 2007;117(3):514-521. (Pubitemid 46348505)
20. Frank D, St. Amand AL, Feldman RA, Boedeker EC, Harpaz N, Pace NR. Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proc Natl Acad Sci U S A. 2007;104(34):13780-13785. (Pubitemid 350003397)
21. Takaishi H, et al. Imbalance in intestinal microflora constitution could be involved in the pathogenesis of inflammatory bowel disease. Int J Med Microbiol. 2008;298(5-6):463-472. (Pubitemid 351734793)