Relaxin favors the development of activated human T cells into Th1-like effectors

European Journal of Immunology

Volumn 29, Issue 7, 1999, Pages 2241-2247

  Piccinni, Marie Pierre ^a   Bani, Daniele ^a   Beloni, Lucio ^a   Manuelli, Cinzia ^a   Mavilia, Carmelo ^a   Vocioni, Franco ^b   Bigazzi, Mario ^c   Sacchi, Tatiana Bani ^a   Romagnani, Sergio ^a,d   Maggi, Enrico ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b Military Blood Bank   (Italy)

^c Prosperius Institute   (Italy)

^d Dipartimento di Medicina Interna   (Italy)

Author keywords

IFN ; IL 4; Pregnancy; Relaxin; T lymphocyte

Indexed keywords

CD4 ANTIGEN; GAMMA INTERFERON; MESSENGER RNA; RELAXIN;

ANTIGEN PRESENTING CELL; ARTICLE; CYTOKINE PRODUCTION; EFFECTOR CELL; HELPER CELL; HOMEOSTASIS; HUMAN; HUMAN CELL; LYMPHOCYTE CLONE; PREGNANCY; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ANIMALS; BASE SEQUENCE; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL LINE; CLONE CELLS; DNA PRIMERS; FEMALE; HUMANS; INTERFERON TYPE II; INTERLEUKIN-4; LYMPHOCYTE ACTIVATION; PREGNANCY; RELAXIN; RNA, MESSENGER; SWINE; T-LYMPHOCYTES; TETANUS TOXOID; TH1 CELLS; TH2 CELLS;

EID: 0033000845     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199907)29:07<2241::AID-IMMU2241>3.0.CO;2-E     Document Type: Article

References (34)

1. Mosmann, T. R. and Coffman, R. L., Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 1989. 7: 145-173.
2. Romagnani, S., Human Th1 and Th2: doubt no more. Immunol. Today 1991. 12: 256-257.
3. Maggi, E., Parronchi, P., Manetti, R., Simonelli, C., Piccinni, M.-P., Santoni-Rugiu, F., De Carli, M., Ricci, M. and Romagnani, S., Reciprocal regulatory role of IFN-γ and IL-4 on the in vitro development of human Th1 and Th2 cells. J. Immunol. 1992. 148: 2142-2147.
4. Manetti, R., Parronchi, P., Giudizi, M. G., Piccinni, M.-P., Maggi, E., Trinchieri, G. and Romagnani, S., Natural killer stimulatory factor (NKSF/IL-12) induces Th1-type specific immune responses and inhibits the development of IL-4 producing Th cells. J. Exp. Med. 1993. 177: 1199-1204.
5. Daynes, R. A., Meikle, A. W. and Araneo, B. A., Local active steroid hormones may facilitate compartimentalization of immunity by regulating the types of lymphokines produced by helper T cells. Res. Immunol. 1991. 142: 40-44.
6. Piccinni, M.-P., Giudizi, M. G., Biagiotti, R., Beloni, L., Giannarini, L., Sampognaro, S., Parronchi, P., Manetti, R., Livi, C., Romagnani, S. and Maggi, E., Progesterone favors the development of human T helper cells producing Th2-type cytokines and promotes both IL-4 production and membrane CD30 expression in established Th1 cells clones. J. Immunol. 1995. 155: 128-133.
7. Rook, G. A. W., Hernandez-Pando, R. and Lightman, S. L., Hormones, peripherally activated prohormones and regulation of the Th1/Th2 balance. Immunol. Today 1994. 15: 301-303.
8. Sherwood, O. D., Relaxin. In Knobil, E. and Neill, E. (Eds.) The physiology of reproduction. 2nd ed. Raven Press, New York 1994. pp 861-1010.
9. Bani, D., Relaxin: a pleiotropic hormone. Gen. Pharmacol. 1997. 28: 13-22.
10. Masini, E., Bani, D., Bigazzi, M., Mannaioni, P. F. and Bani Sacchi, T., Effects of RLX on mast cells. In vitro and in vivo studies in rats and in guinea pigs. J. Clin. Invest. 1994. 94: 1974-1980.
11. Bani, D., Bigazzi, M., Masini, E., Bani, G. and Bani Sacchi, T., Relaxin depresses platelet agregation. In vitro studies on isolated human and rabbit platelets. Lab. Invest. 1995. 73: 709-713.
12. Bani, D., Ballati, L., Masini, E., Bigazzi, M. and Bani-Sacchi, T., Relaxin Counteracts asthma-like reaction induced by inhaled antigen in sensitized in guinea pigs. Endocrinology 1997. 138: 1909-1915.
13. Bani, D., Masini, E., Bello, M. G., Bigazzi, M. and Bani Sacchi, T., Relaxin protects against myocardial injury caused by ischemia and reperfusion in rat heart. Am. J. Pathol. 1998. 152: 1367-1376.
14. Chang, M. H. and Main, E. K., Nuclear regulation of HLA class I genes in human trophoblast. Am. J. Reprod. Immunol. 1994. 32: 167-172.
15. Toder, V., Blank, M. and Nebel, L., Immunosuppressive effect of alpha-protein at different stages of pregnancy in human. Dev. Comp. Immunol. 1979. 3: 537-542.
16. Okamoto, N., Uchida, A., Takakura, K., Kariya, Y., Kanzaki, H., Rittinen, L., Koistinen, R., Seppälä, M. and Mori, T., Suppression by human placental protein 14 of natural killer cell activity. Am. J. Reprod. Immunol. 1991. 26: 137-142.
17. Del Prete, G. F., De Carli, M., Lamel, R. M., D'Elios, M. M., Daniel, K. C., Giusti, B., Abbate, R. and Romagnani, S., Th1 and Th2 T-helper cells exert opposite regulatory effects on procoagulant activity and tissue factor production by human monocytes. Blood 1995. 86: 250-257.
18. Wegmann, T. G., Lin, H., Guilbert, L. and Mosmann, T. R., Bidirectional cytokine interactions in the maternal-fetal relationship: Is successful pregnancy a Th2 phenomenon? Immunol. Today 1993. 14: 353-356.
19. Piccinni, M.-P. and Romagnani, S., Regulation of fetal allograft survival by hormone-controlled Th1- and Th2-type cytokines. Immunol. Res. 1996. 15: 141-150.
20. Piccinni, M.-P., Beloni, L., Livi, C., Maggi, E., Scarselli, G. F. and Romagnani, S., The maintenance of pregnancy is associated with predominance of Th2 type-cytokines. In Colarcurci, N. and Cardone, A. (Eds.) The embryo from gametogenesis to implanation. Giuseppe Nicola editor, Naples 1998, pp 177-180.
21. Piccinni, M.-P., Beloni, L., Livi, C. Maggi, E., Scarselli, G. F. and Romagnani, S., Defective production of both leukemia inhibitory factor and type 2 T-helper cytokines by decidual T cells in unexplained recurrent abortions. Nature Med. 1998. 4: 1020-1024.
22. Quagliarello, J., Szlachter, N., Niesselbaum, J. S., Schwarz, M. K., Steinetz, B. G. and Weiss, G., Serum relaxin and human chorionic gonadotropin concentrations in sponteneous abortion. Fertil. Steril. 1981. 36: 399-401.
23. Seki, K., Uesato, T., Tabei, T. and Kato, K., Serum relaxin and steroid hormones in spontaneous abortion. Acta Obstet. Gynecol. Scand. 1988. 67: 483-486.
24. Witt, B. R., Wolf, G. C., Wainwright, C. J., Johnston, P. D. and Thorneycroft, I. H., Relaxin, CA-125, progesterone, estradiol. Schwanfershaft protein, and human chorionic gonadotropin as predictors of outcome in threatened and nonthreatened pregnancy. Fertil. Steril. 1990. 53: 1029-1036.
25. Stewart, D. R., Overstreet, J. W., Celniker, C., Hass, D. L., Cragun, J. R., Boyess, S. P. and Lasley, B. L., Relation between hCG and relaxin secretion in normal pregnancy vs periimplantation spontaneous abortion. Clin. Endocrinol. 1993. 38: 379-385.
26. Romagnani, S., Regulation of Th2 development in allergy. Curr. Opin. Immunol. 1994. 6: 838-846.
27. D'Elios, M. M., Romagnani, P., Scaletti, C., Annunziato, F., Manghetti, M., Mavilia, C., Parronchi, P., Pupilli, C., Pizzolo, G., Maggi, E., Del Prete, G. F. and Romagnani, S., In vivo CD30 expression in human diseases with predominant activation of Th2-like T cells. J. Leukoc. Biol. 1997. 61: 539-544.
28. Mavilia, C., Scaletti, C., Romagnani, P., Carossino, A. M., Pignone, A., Emmi, L., Pupilli, C., Pizzolo, G., Maggi, E. and Romagnani, S., Type 2 helper T-cell predominance and high CD30 expression in systemic sclerosis. Am. J. Pathol. 1997. 151: 1751-1758.
29. Kahan, A., Amor, B., Menkes, J. C. and Stauch, G., Recombinant interferon gamma in the treatment of systemic sclerosis. Am. J. Med. 1989. 87: 273-277.
30. Seibold, J. R., Recombinant human relaxin in diffuse scleroderma. Arthritis Rheum. 1997. 40 (Suppl 1): (Abstract 557).
31. Seibold, J. R., Clements, P. J., Furst, D. E., Mayes, M. D., McCloskey, D. A., Moreland, L. W., White, B., Wigley, F. M., Rocco, S., Erikson, M., Hannigan, J. F., Sanders, M. E. and Amento, E. P., Safety and pharmacokinetics of recombinant human relaxin in systemic sclerosis. J. Rheum. 1998. 25: 302-307.
32. Sherwood, O. D. and O'Byrne, E. M., Purification and characterization of porcine relaxin. Arch. Biochem. Biophys. 1974. 60: 185-196.
33. Reinholt, R. B. and Fine, J., A technique for quantitative measurement of endotoxin in human plasma. Proc. Soc. Exp. Biol. Med. 1971. 137: 334-340.
34. Southern, E. M., Detection of specific sequence among DNA fragments by gel electrophoresis. J. Mol. Biol. 1975. 98: 503-517.