Activation of adenosine A2A receptors restores the altered cell-cycle machinery during impaired wound healing in genetically diabetic mice

Surgery

Volumn 149, Issue 2, 2011, Pages 253-261

  Altavilla, Domenica ^a   Squadrito, Francesco ^a   Polito, Francesca ^a   Irrera, Natasha ^a   Cal, Margherita ^b   Lo Cascio, Patrizia ^b   Galeano, Mariarosaria ^a   La Cava, Letizia ^a   Minutoli, Letteria ^a   Marini, Herbert ^a   Bitto, Alessandra ^a  

^a UNIVERSITY OF MESSINA   (Italy)

^b UNIVERSITY OF MESSINA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE A2A RECEPTOR; CYCLIN D1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 6; CYCLIN E; KI 67 ANTIGEN; POLYDEOXYRIBONUCLEOTIDE; PROTEIN P15; PROTEIN P16; PROTEIN P21; PROTEIN P27; CDK2 PROTEIN, MOUSE; CDK6 PROTEIN, MOUSE; CDKN1B PROTEIN, HUMAN; SIGNAL PEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG MECHANISM; FEMALE; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN INJURY; UPREGULATION; WESTERN BLOTTING; WOUND HEALING IMPAIRMENT; ANIMAL; C57BL MOUSE; CELL CYCLE; CELL PROLIFERATION; GRANULATION TISSUE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; WOUND HEALING;

ANIMALS; CELL CYCLE; CELL PROLIFERATION; CYCLIN D1; CYCLIN E; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE 6; DIABETES MELLITUS; FEMALE; GRANULATION TISSUE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, INBRED C57BL; POLYDEOXYRIBONUCLEOTIDES; RECEPTOR, ADENOSINE A2A; WOUND HEALING;

EID: 78751575958     PISSN: 00396060     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.surg.2010.04.024     Document Type: Article

References (40)

1. N. Singh, D.G. Armstrong, and B.A. Lipsky Preventing foot ulcers in patients with diabetes JAMA 293 2005 217 228
2. K.R. Jones, K. Fennie, and A. Lenihan Evidence-based management of chronic wounds Adv Skin Wound Care 20 2007 591 600
3. G.E. Reiber, and G.J. Raugi Preventing foot ulcers and amputations in diabetes Lancet 366 2005 1676 1677
4. M.G. Franz, M.C. Robson, D.L. Steed, A. Barbul, H. Brem, and D.M. Cooper Guidelines to aid healing of acute wounds by decreasing impediments of healing Wound Repair Regen 16 2008 723 748
5. Z.J. Liu, and O.C. Velazquez Hyperoxia, endothelial progenitor cell mobilization, and diabetic wound healing Antioxid Redox Signal 10 2008 1869 1882
6. S. Barrientos, O. Stojadinovic, M.S. Golinko, H. Brem, and M. Tomic-Canic Growth factors and cytokines in wound healing Wound Repair Regen 16 2008 585 601
7. D. Altavilla, A. Saitta, D. Cucinotta, M. Galeano, B. Deodato, and M. Colonna Inhibition of lipid peroxidation restores impaired vascular endothelial growth factor expression and stimulates wound healing and angiogenesis in the genetically diabetic mouse Diabetes 50 2001 667 674
8. M. Galeano, B. Deodato, D. Altavilla, D. Cucinotta, N. Arsic, and H. Marini Adeno-associated viral vector-mediated human vascular endothelial growth factor gene transfer stimulates angiogenesis and wound healing in the genetically diabetic mouse Diabetologia 46 2003 546 555
9. M. Galeano, D. Altavilla, D. Cucinotta, G.T. Russo, M. Cal, and A. Bitto Recombinant human erythropoietin stimulates angiogenesis and wound healing in the genetically diabetic mouse Diabetes 53 2004 2509 2517
10. W.Y. Chen, and A.A. Rogers Recent insights into the causes of chronic leg ulceration in venous diseases and implications on other types of chronic wounds Wound Repair Regen 15 2007 434 449
11. H. Brem, and M. Tomic-Canic Cellular and molecular basis of wound healing in diabetes J Clin Invest 117 2007 1219 1222
12. R. Blakytny, and E. Jude The molecular biology of chronic wounds and delayed healing in diabetes Diabet Med 23 2006 594 608
13. G. Sibbald, and K.Y. Woo The biology of chronic foot ulcers in persons with diabetes Diabetes Metab Res Rev 1 2008 25 30
14. D.G. Greenhalgh Wound healing and diabetes mellitus Clin Plast Surg 30 2003 37 45
15. S.V. Nolte, W. Xu, H.O. Rennekampff, and H.P. Rodemann Diversity of fibroblasts - a review on implications for skin tissue engineering Cells Tissues Organs 187 2008 165 176
16. M.S. Agren, and M. Werthén The extracellular matrix in wound healing: a closer look at therapeutics for chronic wounds Int J Low Extrem Wounds 6 2007 82 97
17. J.B. Acosta, D.G. Del Barco, D.C. Vera, W. Savigne, P. Lopez-Saura, and N.G. Guillen The pro-inflammatory environment in recalcitrant diabetic foot wounds Int Wound J 5 2008 530 539
18. G.G. Yegutkin Nucleotide- and nucleoside-converting ectoenzymes: important modulators of purinergic signalling cascade Biochim Biophys Acta 1783 2008 673 694
19. M.P. Rathbone, P.J. Middlemiss, J.W. Gysbers, S. DeForge, P. Costello, and R.F. Del Maestro Purine nucleosides and nucleotides stimulate proliferation of a wide range of cell types In Vitro Cell Dev Biol 28 1992 529 536
20. O. Muratore, G. Cattarini, S. Gianoglio, E.L. Tonoli, S.C. Sacc, and D. Ghiglione A human placental polydeoxyribonucleotide (PDRN) may promote the growth of human corneal fibroblasts and iris pigment epithelial cells in primary culture New Microbiol 26 2003 13 26
21. S. Thellung, T. Florio, A. Maragliano, G. Cattarini, and G. Schettini Polydeoxyribonucleotides enhance the proliferation of human skin fibroblasts: involvement of A2 purinergic receptor subtypes Life Sci 64 1999 1661 1674
22. D.J. Wang, N.N. Huang, and L.A. Heppel Extracellular ATP shows synergistic enhancement of DNA synthesis when combined with agents that are active in wound healing or as neurotransmitters Biochem Biophys Res Commun 166 1990 251 258
23. A.J. Chavan, B.E. Haley, D.B. Volkin, K.E. Marfia, A.M. Verticelli, and M.W. Bruner Interaction of nucleotides with acidic fibroblast growth factor (FGF-1) Biochemistry 33 1994 7193 7202
24. M.C. Montesinos, P. Gadangi, M. Longaker, J. Sung, J. Levine, and D. Nilsen Wound healing is accelerated by agonists of adenosine A2 (G alpha s-linked) receptors J Exp Med 186 1997 1615 1620
25. E.S. Chan, P. Fernandez, A.A. Merchant, M.C. Montesinos, S. Trzaska, and A. Desai Adenosine A2A receptors in diffuse dermal fibrosis: pathogenic role in human dermal fibroblasts and in a murine model of scleroderma Arthritis Rheum 54 2006 2632 2642
26. A. Bitto, M. Galeano, F. Squadrito, L. Minutoli, F. Polito, and J.F. Dye Polydeoxyribonucleotide improves angiogenesis and wound healing in experimental thermal injury Crit Care Med 36 2008 1594 1602
27. M. Galeano, A. Bitto, D. Altavilla, L. Minutoli, F. Polito, and M. Cal Polydeoxyribonucleotide stimulates angiogenesis and wound healing in the genetically diabetic mouse Wound Repair Regen 16 2008 208 217
28. M. Gharaee-Kermani, and S.H. Phan Role of cytokines and cytokine therapy in wound healing and fibrotic diseases Curr Pharm Des 7 2001 1083 1103
29. T.K. MacLachlan, N. Sang, and A. Giordano Cyclins, cyclin-dependent kinases and cdk inhibitors: implications in cell cycle control and cancer Crit Rev Eukaryot Gene Expr 5 1995 127 156
30. D.O. Morgan Principles of CDK regulation Nature 374 1995 131 134
31. R. Kittler, L. Pelletier, and F. Buchholz Systems biology of mammalian cell division Cell Cycle 7 2008 2123 2128
32. S.W. Blain Switching cyclin D-Cdk4 kinase activity on and off Cell Cycle 7 2008 892 898
33. D. Santamaria, and S. Ortega Cyclins and CDKS in development and cancer: lessons from genetically modified mice Front Biosci 11 2006 1164 1188
34. M. Malumbres, S. Ortega, and M. Barbacid Genetic analysis of mammaliancyclin-dependent kinases and their inhibitors Biol Chem 381 2000 827 838
35. A. Bitto, L. Minutoli, M.R. Galeano, D. Altavilla, F. Polito, and T. Fiumara Angiopoietin-1 gene transfer improves impaired wound healing in genetically diabetic mice without increasing VEGF expression Clin Sci 114 2008 707 718
36. P. Nurse A long twentieth century of the cell cycle and beyond Cell 100 2000 71 78
37. P. Nurse, Y. Masui, and L. Hartwell Understanding the cell cycle Nat Med 4 1998 1103 1106
38. J. Bartkova, B. Grøn, E. Dabelsteen, and J. Bartek Cell-cycle regulatory proteins in human wound healing Arch Oral Biol 48 2003 125 132
39. A. Bitto, F. Polito, D. Altavilla, L. Minutoli, A. Migliorato, and F. Squadrito Polydeoxyribonucleotide (PDRN) restores blood flow in an experimental model of peripheral artery occlusive disease J Vasc Surg 48 2008 1292 1300
40. D. Altavilla, A. Bitto, F. Polito, H. Marini, L. Minutoli, and V. Di Stefano Polydeoxyribonucleotide (PDRN): a safe approach to induce therapeutic angiogenesis in peripheral artery occlusive disease and in diabetic foot ulcers Cardiovasc Hematol Agents Med Chem 7 2009 313 321