Defective pulmonary innate immune responses post-stem cell transplantation; review and results from one model system

Frontiers in Immunology

Volumn 4, Issue MAY, 2013, Pages

  Domingo Gonzalez, Racquel ^a   Moore, Bethany B ^b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Alveolar macrophage; Eicosanoids; Hematopoietic stem cell transplantation; MicroRNA; Polymorphonuclear leukocytes; Prostaglandins E; Pulmonary complications; Scavenger receptors

Indexed keywords

CYCLOOXYGENASE 2; GAMMA INTERFERON; GRANULOCYTE COLONY STIMULATING FACTOR; ICOSANOID; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 3; MICRORNA; MICRORNA 155; PHOSPHATIDYLINOSITOL 3, 4, 5 TRISPHOSPHATE 3 PHOSPHATASE; PROSTAGLANDIN E2; SCAVENGER RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; BACTERIAL INFECTION; BONE MARROW TRANSPLANTATION; BRONCHIOLITIS OBLITERANS; CYTOMEGALOVIRUS INFECTION; GRAFT VERSUS HOST REACTION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; INFECTION SENSITIVITY; INNATE IMMUNITY; LUNG ALVEOLUS EPITHELIUM; LUNG ALVEOLUS MACROPHAGE; LUNG DISEASE; LUNG HEMORRHAGE; MOUSE MODEL; NEUTROPHIL; NONHUMAN; PHAGOCYTOSIS; RESPIRATORY DISTRESS SYNDROME; REVIEW; STREPTOCOCCUS PNEUMONIAE; VIRUS INFECTION; WHOLE BODY RADIATION;

EID: 84883756049     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2013.00126     Document Type: Review

References (107)

1. Afessa, B. (2001). Bronchiolitis obliterans and other late onset non-infectious pulmonary complications in hematopoietic stem cell transplantation. Bone Marrow Transplant. 28, 425-434. doi:10.1038/sj.bmt.1703142
2. Afessa, B., Abdulai, R. M., Kremers, W. K., Hogan, W. J., Litzow, M. R., and Peters, S. G. (2012). Risk factors and outcome of pulmonary complications after autologous hematopoietic stem cell transplanthematopoietic stem cell transplant complications. Chest 141, 442-450. doi:10.1378/chest.10-2889
3. Afessa, B., and Peters, S. G. (2006). Major complications following hematopoietic stem cell transplantation. Semin. Respir. Crit. Care Med. 27, 297-309. doi:10.1055/s-2006-945530
4. Aronoff, D. M., Canetti, C., and Peters-Golden, M. (2004). Prostaglandin E2 inhibits alveolar macrophage phagocytosis through an E-prostanoid 2 receptor-mediated increase in intracellular cyclic AMP. J. Immunol. 173, 559-565.
5. Aronoff, D. M., Canetti, C., Serezani, C. H., Luo, M., and Peters-Golden, M. (2005). Cutting edge: macrophage inhibition by cyclic AMP (cAMP): differential roles of protein kinase A and exchange protein directly activated by cAMP-1. J. Immunol. 174, 595-599.
6. Arredouani, M., Yang, Z., Ning, Y., Qin, G., Soininen, R., Tryggvason, K., et al. (2004). The scavenger receptor MARCO is required for lung defense against pneumococcal pneumonia and inhaled particles. J. Exp. Med. 200, 267-272. doi:10.1084/jem.20040731
7. Arredouani, M. S., Yang, Z., Imrich, A., Ning, Y., Qin, G., and Kobzik, L. (2006). The macrophage scavenger receptor SR-AI/II and lung defense against pneumococci and particles. Am. J. Respir. Cell Mol. Biol. 35, 474-478. doi:10.1165/rcmb.2006-0128OC
8. Asano-Mori, Y. (2010). Fungal infections after hematopoietic stem cell transplantation. Int. J. Hematol. 91, 576-587. doi:10.1007/s12185-010-0574-0
9. Aschan, J. (2007). Risk assessment in haematopoietic stem cell transplantation: conditioning. Best Pract. Res. Clin. Haematol. 20, 295-310. doi:10.1016/j.beha.2006.09.004
10. Bailie, M. B. (1996). Leukotriene-deficient mice manifest enhanced lethality from Klebsiella pneumonia in association with decreased alveolar macrophage phagocytic and bactericidal activities. J. Immunol. 157, 5221-5224.
11. Bala, S., Marcos, M., Kodys, K., Csak, T., Catalano, D., Mandrekar, P., et al. (1436). Up-regulation of microRNA-155 in macrophages contributes to increased tumor necrosis factor {alpha} (TNF{alpha}) production via increased mRNA half-life in alcoholic liver disease. J. Biol. Chem. 286, 1436-1444. doi:10.1074/jbc.M110.145870
12. Ballinger, M. N., Aronoff, D. M., McMillan, T. R., Cooke, K. R., Okiewicz, K., Toews, G. B., et al. (2006a). Critical role of prostaglandin E2 overproduction in impaired pulmonary host response following bone marrow transplantation. J. Immunol. 177, 5499-5508.
13. Ballinger, M. N., Paine, R. III, Serezani, C. H., Aronoff, D. M., Choi, E. S., Standiford, T. J., et al. (2006b). Role of granulocyte macrophage colony-stimulating factor during gram-negative lung infection with Pseudomonas aeruginosa. Am. J. Respir. Cell Mol. Biol. 34, 766-774. doi:10.1165/rcmb.2005-0246OC
14. Ballinger, M. N., Hubbard, L. L., McMillan, T. R., Toews, G. B., Peters-Golden, M., Paine, R. III, et al. (2008). Paradoxical role of alveolar macrophage-derived granulocyte-macrophage colony-stimulating factor in pulmonary host defense post-bone marrow transplantation. Am. J. Physiol. Lung Cell Mol. Physiol. 295, L114-L122. doi:10.1152/ajplung.00309.2007
15. Ballinger, M. N., McMillan, T. R., and Moore, B. B. (2007). Eicosanoid regulation of pulmonary innate immunity post-hematopoietic stem cell transplantation. Arch. Immunol. Ther. Exp. 55, 1-12. doi:10.1007/s00005-007-0001-2
16. Boeckh, M. (2003). Cytomegalovirus in hematopoietic stem cell transplant recipients: current status, known challenges, and future strategies. Biol. Blood Marrow Transplant. 9, 543-558. doi:10.1016/S1083-8791(03)00287-8
17. Boeckh, M. (2011). Complications, diagnosis, management, and prevention of CMV infections: current and future. Hematology Am. Soc. Hematol. Educ. Program 2011, 305-309. doi:10.1182/asheducation-2011.1.305
18. Bow, E. J. (2009). Invasive fungal infection in haematopoietic stem cell transplant recipients: epidemiology from the transplant physician's viewpoint. Mycopathologia 168, 283-297. doi:10.1007/s11046-009-9196-6
19. Canetti, C., Serezani, C. H., Atrasz, R. G., White, E. S., Aronoff, D. M., and Peters-Golden, M. (2007). Activation of phosphatase and tensin homolog on chromosome 10 mediates the inhibition of FcgammaR phagocytosis by prostaglandin E2 in alveolar macrophages. J. Immunol. 179, 8350-8356.
20. Cayeux, S. J., Beverly, P. C. L., Schulz, R., and Dorken, B. (1993). Elevated plasma prostaglandin E2 levels found in 14 patients undergoing autologous or stem cell transplantation. Bone Marrow Transplant. 12, 603-608.
21. Chandrasekar, P. H. (1995). Autopsy-identified infections among bone marrow transplant recipients: a clinico-pathologic study of 56 patients. Bone Marrow Transplantation Team. Bone Marrow Transplant. 16, 675-681.
22. Chen, C.-S., Boeckh, M., Seidel, K., Clark, J. G., Kansu, E., Madtes, D. K., et al. (2003). Incidence, risk factors, and mortality from pneumonia developing late after hematopoietic stem cell transplantation. Bone Marrow Transplant. 32, 515-522. doi:10.1038/sj.bmt.1704162
23. Chen, G. H., Reddy, R. C., Newstead, M. W., Tateda, K., Kyasapura, B. L., and Standiford, T. J. (2000). Intrapulmonary TNF gene therapy reverses sepsis-induced suppression of lung antibacterial host defense. J. Immunol. 165, 6496-6503.
24. Chen, K., and Rajewsky, N. (2007). The evolution of gene regulation by transcription factors and microRNAs. Nat. Rev. Genet. 8, 93-103. doi:10.1038/nrg1990
25. Coomes, S. M., Hubbard, L. L., and Moore, B. B. (2011). Impaired pulmonary immunity post-bone marrow transplant. Immunol. Res. 50, 78-86. doi:10.1007/s12026-010-8200-z
26. Coomes, S. M., Wilke, C. A., Moore, T. A., and Moore, B. B. (2010). Induction of TGF-beta 1, not regulatory T cells, impairs antiviral immunity in the lung following bone marrow transplant. J. Immunol. 184, 5130-5140. doi:10.4049/jimmunol.0901871
27. Copelan, E. A. (2006). Hematopoietic stem-cell transplantation. N. Engl. J. Med. 354, 1813-1826. doi:10.1056/NEJMra052638
28. Cordonnier, C. (1986). Pulmonary complications occurring after allogeneic bone marrow transplantation. A study of 130 consecutive transplanted patients. Cancer 58, 1047-1054. doi:10.1002/1097-0142(19860901)58:5<1047::AIDCNCR2820580512>3.0.CO;2-Y
29. Cruciani, M. (1996). Prophylaxis with fluoroquinolones for bacterial infections in neutropenic patients: a meta-analysis. Clin. Infect. Dis. 23, 795-805. doi:10.1093/clinids/23.4.795
30. Cutler, C. (2005). An overview of hematopoietic stem cell transplantation. Clin. Chest Med. 26, 517-527. doi:10.1016/j.ccm.2005.06.016
31. Domingo-Gonzalez, R. (2012). COX-2 expression is upregulated by DNA hypomethylation after hematopoietic stem cell transplantation. J. Immunol. 189, 4528-4536. doi:10.4049/jimmunol.1201116
32. Domingo-Gonzalez, R., Katz, S., Serezani, C., Moore, T., LeVine, A., and Moore, B. (2013). PGE2-induced changes in alveolar macrophage scavenger receptor profiles differentially alter phagocytosis of P. aeruginosa and S. aureus post-bone marrow transplant. J. Immunol. doi:10.4049/jimmunol.1203274 (in press)
33. Folco, G., and Murphy, R. C. (2006). Eicosanoid transcellular biosynthesis: from cell-cell interactions to in vivo tissue responses. Pharmacol. Rev. 58, 375-388. doi:10.1124/pr.58.3.8
34. Funk, C. D. (2001). Prostaglandins and leukotrienes: advances in eicosanoid biology. Science 294, 1871-1875. doi:10.1126/science.294.5548.1871
35. Gadish, M., Kletter, Y., Flidel, O., Nagler, A., Slavin, S., and Fabian, I. (1991). Effects of recombinant human granulocyte and granulocyte-macrophage colony-stimulating factors on neutrophil function following autologous bone marrow transplantation. Leuk. Res. 15, 1175-1182. doi:10.1016/0145-2126(91)90187-X
36. Giralt, S. (2005). Reduced-intensity conditioning regimens for hematologic malignancies: what have we learned over the last 10 years? Hematology Am. Soc. Hematol. Educ. Program 2005, 384-389. doi:10.1182/asheducation-2005.1.384
37. Gordon, S. B., and Read, R. C. (2002). Macrophage defences against respiratory tract infections. Br. Med. Bull. 61, 45-61. doi:10.1093/bmb/61.1.45
38. Gosselin, D. (1995). Role of tumor necrosis factor alpha in innate resistance to mouse pulmonary infection with Pseudomonas aeruginosa. Infect. Immun. 63, 3272-3278.
39. Gratwohl, A., Baldomero, H., Aljurf, M., Pasquini, M. C., Bouzas, L. F., Yoshimi, A., et al. (2010). Hematopoietic stem cell transplantation: a global perspective. JAMA 303, 1617-1624. doi:10.1001/jama.2010.491
40. Griese, M. (2000). Pulmonary complications after bone marrow transplantation in children: twenty-four years of experience in a single pediatric center. Pediatr. Pulmonol. 30, 393-401. doi:10.1002/1099-0496(200011)30:5<393::AIDPPUL5>3.0.CO;2-W
41. Gunzl, P., and Schabbauer, G. (2008). Recent advances in the genetic analysis of PTEN and PI3K innate immune properties. Immunobiology 213, 759-765. doi:10.1016/j.imbio.2008.07.028
42. Hakki, M., Limaye, A. P., Kim, H. W., Kirby, K. A., Corey, L., and Boeckh, M. (2007). Invasive Pseudomonas aeruginosa infections: high rate of recurrence and mortality after hematopoietic cell transplantation. Bone Marrow Transplant. 39, 687-693. doi:10.1038/sj.bmt.1705653
43. Harizi, H. (2002). Cyclooxygenase-2-issued prostaglandin e(2) enhances the production of endogenous IL-10, which down-regulates dendritic cell functions. J. Immunol. 168, 2255-2263.
44. He, L., and Hannon, G. J. (2004). MicroRNAs: small RNAs with a big role in gene regulation. Nat. Rev. Genet. 5, 522-531. doi:10.1038/nrg1415
45. He, L. K. (2001). The expression of cyclooxygenase and the production of prostaglandin E2 in neutrophils after burn injury and infection. J. Burn Care Rehabil. 22, 58-64. doi:10.1097/00004630-200101000-00012
46. Hubbard, L., Wilke, C., White, E., and Moore, B. P. T. E. N. (2011). Limits alveolar macrophage function against Pseudomonas aeruginosa following bone marrow transplantation. Am. J. Respir. Cell Mol. Biol. 45, 1050-1058. doi:10.1165/rcmb.2011-0079OC
47. Hubbard, L. L., Ballinger, M. N., Thomas, P. E., Wilke, C. A., Standiford, T. J., Kobayashi, K. S., et al. (2010). A role for IL-1 receptor-associated kinase-M in prostaglandin E2-induced immunosuppression post-bone marrow transplantation. J. Immunol. 184, 6299-6308. doi:10.4049/jimmunol.0902828
48. Hubbard, L. L., Ballinger, M. N., Wilke, C. A., and Moore, B. B. (2008). Comparison of conditioning regimens for alveolar macrophage reconstitution and innate immune function post bone marrow transplant. Exp. Lung Res. 34, 263-275. doi:10.1080/01902140802022518
49. Hubbard, N. E., Lee, S., Lim, D., and Erickson, K. L. (2001). Differential mRNA expression of prostaglandin receptor subtypes in macrophage activation. Prostaglandins Leukot. Essent. Fatty Acids 65, 287-294. doi:10.1054/plef.2001.0327
50. Jhunjhunwala, S., and Little, S. R. (2011). Microparticulate systems for targeted drug delivery to phagocytes. Cell 10, 2047-2048.
51. Kato, K., Cui, S., Kuick, R., Mineishi, S., Hexner, E., Ferrara, J. L., et al. (2010). Identification of stem cell transcriptional programs normally expressed in embryonic and neural stem cells in alloreactive CD8+ T cells mediating graft-versus-host disease. Biol. Blood Marrow Transplant. 16, 751-771. doi:10.1016/j.bbmt.2010.01.012
52. Kim, S. H., Kee, S. Y., Lee, D. G., Choi, S. M., Park, S. H., Kwon, J. C., et al. (2013). Infectious complications following allogeneic stem cell transplantation: reduced-intensity vs. myeloablative conditioning regimens. Transpl. Infect. Dis. 15, 49-59. doi:10.1111/tid.12003
53. Kobayashi, K. (2002). IRAK-M is a negative regulator of Toll-like receptor signaling. Cell 110, 191-202. doi:10.1016/S0092-8674(02)00827-9
54. Koh, A. Y. (2009). Inescapable need for neutrophils as mediators of cellular innate immunity to acute Pseudomonas aeruginosa pneumonia. Infect. Immun. 77, 5300-5310. doi:10.1128/IAI.00501-09
55. Kolb, H.-J. (2008). Graft-versus-leukemia effects of transplantation and donor lymphocytes. Blood 112, 4371-4383. doi:10.1182/blood-2008-03-077974
56. Kooguchi, K., Hashimoto, S., Kobayashi, A., Kitamura, Y., Kudoh, I., Wiener-Kronish, J., et al. (1998). Role of alveolar macrophages in initiation and regulation of inflammation in Pseudomonas aeruginosa pneumonia. Infect. Immun. 66, 3164-3169.
57. Körbling, M., and Anderlini, P. (2001). Peripheral blood stem cell versus bone marrow allotransplantation: does the source of hematopoietic stem cells matter? Blood 98, 2900-2908. doi:10.1182/blood.V98.10.2900
58. Kotloff, R., Ahya, V., and Crawford, S. W. (2004). Pulmonary complications of solid organ and hematopoietic stem cell transplantation. Am. J. Respir. Crit. Care Med. 170, 22-48. doi:10.1164/rccm.200309-1322SO
59. Kuronuma, K. (2004). Pulmonary surfactant protein A augments the phagocytosis of Streptococcus pneumoniae by alveolar macrophages through a casein kinase 2-dependent increase of cell surface localization of scavenger receptor A. J. Biol. Chem. 279, 21421-21430. doi:10.1074/jbc.M312490200
60. Li, Y., Jia, Y., Pichavant, M., Loison, F., Sarraj, B., Kasorn, A., et al. (2009). Targeted deletion of tumor suppressor PTEN augments neutrophil function and enhances host defense in neutropenia-associated pneumonia. Blood 113, 4930-4941. doi:10.1182/blood-2008-06-161414
61. Lim, D. H. (2006). Pulmonary complications after hematopoietic stem cell transplantation. J. Korean Med. Sci. 21, 406-411. doi:10.3346/jkms.2006.21.3.406
62. Little, M.-T., and Storb, R. (2002). History of haematopoietic stem-cell transplantation. Nat. Rev. Cancer 2, 231-238. doi:10.1038/nrc748
63. Ljungman, P. (2002). Prevention and treatment of viral infections in stem cell transplant recipients. Br. J. Haematol. 118, 44-57. doi:10.1046/j.1365-2141.2002.03515.x
64. Lorenz, E. (1951). Modification of irradiation injury in mice and guinea pigs by bone marrow injections. J. Natl. Cancer Inst. 12, 197-201.
65. MacKenzie, K. F., Clark, K., Naqvi, S., McGuire, V. A., Nöehren, G., Kristariyanto, Y., et al. (2012). PGE2 induces macrophage IL-10 production and a regulatory-like phenotype via a protein kinase A-SIK-CRTC3 pathway. J. Immunol. 190, 565-577. doi:10.4049/jimmunol.1202462
66. Mancuso, P. (2001). Leukotriene B4 augments neutrophil phagocytosis of Klebsiella pneumoniae. Infect. Immun. 69, 2011-2016. doi:10.1128/IAI.69.4.2011-2016.2001
67. Mancuso, P., Standiford, T. J., Marshall, T., and Peters-Golden, M. (1998). 5-Lipoxygenase reaction products modulate alveolar macrophage phagocytosis of Klebsiella pneumoniae. Infect. Immun. 66, 5140-5146.
68. Marr, K., Carter, R., Boeckh, M., Martin, P., and Corey, L. (2002). Invasive aspergillosis in allogeneic stem cell transplant recipients: changes in epidemiology and risk factors. Blood 100, 4358-4366. doi:10.1182/blood-2002-05-1496
69. Marr, K. A. (2012). Delayed opportunistic infections in hematopoietic stem cell transplantation patients: a surmountable challenge. Hematology Am. Soc. Hematol. Educ. Program 2012, 265-270. doi:10.1182/asheducation-2012.1.265
70. Martin, T. R., and Frevert, C. W. (2005). Innate immunity in the lungs. Proc. Am. Thorac. Soc. 2, 403-411. doi:10.1513/pats.200508-090JS
71. Ménard, G. (2000). Priming of alveolar macrophages by leukotriene D(4): potentiation of inflammation. Am. J. Respir. Cell Mol. Biol. 23, 572-577. doi:10.1165/ajrcmb.23.4.4152
72. Metcalf, J. P., Rennard, S. I., Reed, E. C., Haire, W. D., Sisson, J. H., Walter, T., et al. (1994). Corticosteroids as adjunctive therapy for diffuse alveolar hemorrhage associated with bone marrow transplantation. Am. J. Med. 96, 327-334. doi:10.1016/0002-9343(94)90062-0
73. Morissette, C., Skamene, E., and Gervais, F. (1995). Endobronchial inflammation following Pseudomonas aeruginosa infection in resistant and susceptible strains of mice. Infect. Immun. 63, 1718-1724.
74. Mosser, D. M. (2003). The many faces of macrophage activation. J. Leukoc. Biol. 73, 209-212. doi:10.1189/jlb.0602325
75. Nathan, C. (1991). Mechanisms and modulation of macrophage activation. Behring Inst. Mitt. 88, 200-207.
76. Ojielo, C., Cooke, K. R., Mancuso, P., Standiford, T. J., Olkiewicz, K. M., Cloutheir, S., et al. (2003). Defective phagocytosis and clearance of Pseudomonas aeruginosa in the lung following bone marrow transplantation. J. Immunol. 171, 4416-4424.
77. Palecanda, A., and Kobzik, L. (2001). Receptors for unopsonized particles: the role of alveolar macrophage scavenger receptors. Curr. Mol. Med. 1, 589-595. doi:10.2174/1566524013363384
78. Passweg, J. R. (2012). Hematopoietic stem cell transplantation: a review and recommendations for follow-up care for the general practitioner. Swiss. Med. Wkly. 142, w13696. doi:10.4414/smw.2012.13696
79. Peffault de Latour, R., Rocha, V., and Socie, G. (2013). Cord blood transplantation in aplastic anemia. Bone Marrow Transplant. 48, 201-202. doi:10.1038/bmt.2012.252
80. Peiser, L., Mukhopadhyay, S., and Gordon, S. (2002). Scavenger receptors in innate immunity. Curr. Opin. Immunol. 14, 123-128. doi:10.1016/S0952-7915(01)00307-7
81. Peters, W. P., Stuart, A., Affronti, M. L., Kim, C. S., and Coleman, R. E. (1988). Neutrophil migration is defective during recombinant human granulocyte-macrophage colony-stimulating factor infusion after autologous bone marrow transplantation in humans. Blood 72, 1310-1315.
82. Ramaprasad, C., Pouch, S., and Pitrak, D. L. (2010). Neutrophil function after bone marrow and hematopoietic stem cell transplant. Leuk. Lymphoma 51, 756-767. doi:10.3109/10428191003695678
83. Reddy, P., Maeda, Y., Liu, C., Krijanovski, O. I., Korngold, R., and Ferrara, J. L. (2005). A crucial role for antigen-presenting cells and alloantigen expression in graft-versus-leukemia responses. Nat. Med. 11, 1244-1249. doi:10.1038/nm1309
84. Roychowdhury, M. (2005). Pulmonary complications after bone marrow transplantation: an autopsy study from a large transplantation center. Arch. Pathol. Lab. Med. 129, 366-371.
85. Roziakova, L. (2011). Secondary malignancies after hematopoietic stem cell transplantation. Neoplasma 58, 1-8. doi:10.4149/neo_2011_01_1
86. Rubin, P., Johnston, C. J., Williams, J. P., McDonald, S., and Finkelstein, J. N. (1995). A perpetual cascade of cytokines postirradiation leads to pulmonary fibrosis. Int. J. Radiat. Oncol. Biol. Phys. 33, 99-109. doi:10.1016/0360-3016(95)00095-G
87. Sapru, K., Stotland, P. K., and Stevenson, M. M. (1999). Quantitative and qualitative differences in bronchoalveolar inflammatory cells in Pseudomonas aeruginosa-resistant and -susceptible mice. Clin. Exp. Immunol. 115, 103-109. doi:10.1046/j.1365-2249.1999.00762.x
88. Sayers, T. J. (1988). Effect of cytokines on polymorphonuclear neutrophil infiltration in the mouse. Prostaglandin- and leukotriene-independent induction of infiltration by IL-1 and tumor necrosis factor. J. Immunol. 141, 1670-1677.
89. Serezani, C. H., Aronoff, D. M., Jancar, S., Mancuso, P., and Peters-Golden, M. (2005). Leukotrienes enhance the bactericidal activity of alveolar macrophages against Klebsiella pneumoniae through the activation of NADPH oxidase. Blood 106, 1067-1075. doi:10.1182/blood-2004-08-3323
90. Soubani, A. O. (1996). Pulmonary complications of bone marrow transplantation. Chest 109, 1066-1077. doi:10.1378/chest.109.4.1066
91. Soubani, A. O., Miller, K. B., and Hassoun, P. M. (1996). Pulmonary complications of bone marrow transplantation. Chest 109, 1066-1077. doi:10.1378/chest.109.4.1066
92. Soubani, A. O., and Uberti, J. P. (2007). Bronchiolitis obliterans following haematopoietic stem cell transplantation. Eur. Respir. J. 29, 1007-1019. doi:10.1183/09031936.00052806
93. Subramanian, K. K., Jia, Y., Zhu, D., Simms, B. T., Jo, H., Hattori, H., et al. (2007). Tumor suppressor PTEN is a physiologic suppressor of chemoattractant-mediated neutrophil functions. Blood 109, 4028-4037. doi:10.1182/blood-2006-10-055319
94. Tarling, J. D., Lin, H. S., and Hsu, S. (1987). Self-renewal of pulmonary alveolar macrophages: evidence from radiation chimera studies. J. Leukoc. Biol. 42, 443-446.
95. Therriault, B. L. (2010). Characterization of bacterial infections in allogeneic hematopoietic stem cell transplant recipients who received prophylactic levofloxacin with either penicillin or doxycycline. Mayo Clin. Proc. 85, 711-718. doi:10.4065/mcp.2010.0006
96. Tomita, Y. (1994). Myelosuppressive conditioning is required to achieve engraftment of pluripotent stem cells contained in moderate doses of syngeneic bone marrow. Blood 83, 939-948.
97. Tse, W. (2008). New insights into cord blood stem cell transplantation. Curr. Opin. Hematol. 15, 279-284. doi:10.1097/MOH.0b013e328304ae2c
98. Versluys, A. B. (2010). Strong association between respiratory viral infection early after hematopoietic stem cell transplantation and the development of life-threatening acute and chronic alloimmune lung syndromes. Biol. Blood Marrow Transplant. 16, 782-791. doi:10.1016/j.bbmt.2009.12.534
99. Wang, Q. (2004). Neutrophils in innate immunity. Semin. Respir. Crit. Care Med. 25, 33-41. doi:10.1055/s-2004-822303
100. Whittle, A. T., Davis, M., Shovlin, C. L., Ganly, P. S., Haslett, C., and Greening, A. P. (2001). Alveolar macrophage activity and the pulmonary complications of haematopoietic stem cell transplantation. Thorax 56, 941-946. doi:10.1136/thorax.56.12.941
101. Wiltschke, C., Krainer, M., Nanut, M., Wagner, A., Linkesch, W., and Zielinski, C. C. (1995). In vivo administration of granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor increases neutrophil oxidative burst activity. J. Interferon Cytokine Res. 15, 249-253. doi:10.1089/jir.1995.15.249
102. Wingard, J. R., Hsu, J., and Hiemenz, J. W. (2010). Hematopoietic stem cell transplantation: an overview of infection risks and epidemiology. Infect. Dis. Clin. North Am. 24, 257-272. doi:10.1016/j.idc.2010.01.010
103. Winston, D. J., Territo, M. C., Ho, W. G., Miller, M. J., Gale, R. P., and Golde, D. W. (1982). Alveolar macrophage dysfunction in human bone marrow transplant recipients. Am. J. Med. 73, 859-866. doi:10.1016/0002-9343(82)90777-X
104. Wright, J. R. (2005). Immunoregulatory functions of surfactant proteins. Nat. Rev. Immunol. 5, 58-68. doi:10.1038/nri1528
105. Yang, S. (2000). Cyclophosphamide prevents systemic keratinocyte growth factor-induced up-regulation of surfactant protein A after allogeneic transplant in mice. Am. J. Respir. Crit. Care Med. 162, 1884-1890. doi:10.1164/ajrccm.162.5.2002053
106. Yu, H. (2000). Innate lung defenses and compromised Pseudomonas aeruginosa clearance in the malnourished mouse model of respiratory infections in cystic fibrosis. Infect. Immun. 68, 2142-2147. doi:10.1128/IAI.68.4.2142-2147.2000
107. Zimmerli, W., Zarth, A., Gratwohl, A., and Speck, B. (1991). Neutrophil function and pyogenic infections in bone marrow transplant recipients. Blood 77, 393-399.