Characterization of bacterial infections in allogeneic hematopoietic stem cell transplant recipients who received prophylactic levofloxacin with either penicillin or doxycycline

Mayo Clinic Proceedings

Volumn 85, Issue 8, 2010, Pages 711-718

  Therriault, Bridgette L ^a   Wilson, John W ^a   Barreto, Jason N ^a   Estes, Lynn L ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA LACTAM ANTIBIOTIC; DOXYCYCLINE; LEVOFLOXACIN; PENICILLIN V POTASSIUM; QUINOLINE DERIVED ANTIINFECTIVE AGENT;

ADULT; AGED; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ANTIBIOTIC PROPHYLAXIS; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL INFECTION; CLOSTRIDIUM DIFFICILE; COHORT ANALYSIS; COLITIS; FEMALE; FEVER; GRAM NEGATIVE INFECTION; GRAM POSITIVE INFECTION; HUMAN; INFECTION RATE; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; NEUTROPHIL; NONHUMAN; RECIPIENT; RETROSPECTIVE STUDY; VANCOMYCIN RESISTANT ENTEROCOCCUS;

EID: 77955157035     PISSN: 00256196     EISSN: None     Source Type: Journal    
DOI: 10.4065/mcp.2010.0006     Document Type: Article

References (26)

1. Cruciani M, Rampazzo R, Malena M, Lazzaini L, et al. Prophylaxis with fluoroquinolones for bacterial infections in neutropenic patients: a meta-analysis. Clin Infect Dis. 1996;23:795-805. (Pubitemid 26331127)
2. Engels EA, Lau J, Barza M. Efficacy of quinolone prophylaxis in neutropenic cancer patients: a meta-analysis. J Clin Oncol. 1998;16(3):1179- 1187.. (Pubitemid 28108756)
3. Cometta A, Calandta T, Bille J, et al. Escherichia coli resistant to fluoroquinolones in patients with cancer and neutropenia. N Engl J Med. 1994;330(17):1240-1241. (Pubitemid 24122001)
4. Bucaneve G, Micozzi A, Menichetti F, et al. Levofloxacin to prevent bacterial infection in patients with cancer and neutropenia. N Engl J Med. 2005;353(10):977-987.
5. Cullen M, Steven N, Billingham L, et al. Antibacterial prophylaxis after chemotherapy for solid tumors and lymphomas. N Engl J Med. 2005;353(10):988-998.
6. Imran H, Tleyjeh IM, Arndt CAS, et al. Fluoroquinolone prophylaxis in patients with neutropenia: a meta-analysis of randomized placebo-controlled trials. Eur J Clin Microbiol Infect Dis. 2008;27(1):53-63. (Pubitemid 350197874)
7. Segal BH, Freifeld AG, Baden LR, et.al. Prevention and treatment of cancer-related infections. J Natl Compr Canc Netw. 2008;6(2):122-174.
8. Centers for Disease Control and Prevention; Infectious Disease Society of America; American Society of Blood and Marrow Transplantation. Guidelines for preventing opportunistic infections among hematopoietic stem cell transplant recipients [published correction appears in MMWR Recomm Rep. 2004;14(19):396]. MMWR Recomm Rep. 2000;49(RR-10):1-125.
9. Hughes WT, Armstrong D, Bodey GP, et al. 2002 Guidelines for the use of antimicrobial agents in neutropenic patients with cancer. Clin Infect Dis. 2002;34(6):730-751.
10. Tomblyn M, Chiller, T, Einsele H, et al. Guidelines for preventing infectious complications among hematopoietic cell transplantation recipients: a global perspective. Biol Blood Marrow Transplant. 2009;15(10):1143-1238.
11. Cosgrove S. The relationship between antimicrobial resistance and patient outcomes: mortality, length of hospital stay, and healthcare costs. Clin Infect Dis. 2006;42(suppl 2):S82-S89.
12. Mikulska M, Del Bono V, Raiola AM, et al. Blood stream infections in allogeneic hematopoietic stem cell transplant recipients: reemergence of gram-negative rods and increasing antibiotic resistance. Biol Blood Marrow Transplant. 2009;15(1):47-53.
13. Poutsiaka DD, Price LL, Ucuzian A, Chan GW, Miller KB, Snydman DR. Blood stream infection after hematopoietic stem cell transplantation is associated with increased mortality. Bone Marrow Transplant. 2007;40(1):63-70. (Pubitemid 47018415)
14. Collin BA, Leather HL, Wingard JR, Ramphal R. Evolution, incidence and susceptibility of bacterial bloodstream isolates from 519 bone marrow transplant patients. Clin Infect Dis. 2000;33(7):947-953. (Pubitemid 32907094)
15. Ortega M, Rovira M, Almela M, et al. Bacterial and fungal bloodstream isolates from 796 hematopoietic stem cell transplant recipients between 1991 and 2000. Ann Hematol. 2005;84(1):40-47.
16. Kern WV, Andriof E, Oethinger M, Kern P, Hacker J, Marre R. Emergence of fluoroquinolone-resistant Escherichia coli at a cancer center. Antimicrob Agents Chemother. 1994;38(4):681-687. (Pubitemid 24114001)
17. Somolinos N, Arranz R, Del Rey MC, et al. Superinfections by Escherichia coli reistant to fluoroquinolones in immunocompromised patients. J Antimicrob Chemother. 1992;30(5):730-731. (Pubitemid 23009024)
18. Kern WV, Klose K, Jellen-Ritter AS, et al. Fluoroquinolone resistance of Eschericia coli at a cancer center: epidemiologic evolution and effects of discontinuing prophylactic fluoroquinolone use in neutropenic patients with leukemia. Eur J Clin Microbiol Infect Dis. 2005;24(2):111-118.
19. Frere P, Hermanne JP, Debouge MH, et al. Changing pattern of bacterial susceptibility to antibiotics in hematopoietic stem cell transplant recipients. Bone Marrow Transplant. 2002;29(7):589-594. (Pubitemid 34537719)
20. Rangaraj G, Granwehr BP, Jiang Y, et al. Perils of quinolone exposure in cancer patients. Cancer. 2010;116:967-973.
21. Oliveira A, de Souza M, Carvalho-Dias VMH, et al. Epidemiology of bacteremia and factors associated with multi-drug resistant gram-negative bacteremia in hematopoietic stem cell transplant recipients. Bone Marrow Transplant. 2007;39(12):775-781.
22. Henrichfreise B, Wiegand I, Pfister W, et al. Resistance mechanisms of multiresistant Pseudomonas aeruginosa strains from Germany and correlation with hypermutation. Antimicrob Agents Chemother. 2007;51(11):4062-4070. (Pubitemid 350057805)
23. Hocquet D, Muller A, Blanc K, et al. Relationship between antibiotic use and incidence of MexXY-OprM overproducers among clinical isolates of Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2008;52(3):1173-1175. (Pubitemid 351358410)
24. Weinstock D, Conlon M, Iovino C, et al. Colonization, bloodstream infection, and mortality caused by vancomycin-resistant Enterococcus early after allogeneic hematopoietic stem cell transplant. Biol Bone Marrow Transplant. 2007;13(5):615-621.
25. Zirakzadeh A, Gastineau DA, Mandrekar JN, et al. Vancomycin-resistant enterococcal colonization appears associated with increased mortality among hematopoietic stem cell transplant recipients. Bone Marrow Transplant. 2008; 41(4):385-392. (Pubitemid 351330734)
26. Loo V, Poirier L, Miller MA, et al. A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality. N Engl J Med. 2005;353(23):2442-2449.