Innate lung defenses and compromised Pseudomonas aeruginosa clearance in the malnourished mouse model of respiratory infections in cystic fibrosis

Infection and Immunity

Volumn 68, Issue 4, 2000, Pages 2142-2147

  Yu, H ^a   Nasr, S Z ^a   Deretic, V ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 10;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL COLONIZATION; CYSTIC FIBROSIS; CYTOKINE PRODUCTION; DISEASE PREDISPOSITION; HOST RESISTANCE; MALNUTRITION; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; RESPIRATORY TRACT INFECTION;

ADMINISTRATION, INHALATION; ANIMALS; CHEMOTACTIC FACTORS; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; CYTOKINES; DISEASE MODELS, ANIMAL; GENOTYPE; INTERFERON TYPE II; INTERLEUKIN-10; INTESTINES; LUNG; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MONOKINES; NEUTROPHILS; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NITRITES; PEROXIDASE; PROTEIN-ENERGY MALNUTRITION; PSEUDOMONAS AERUGINOSA; RESPIRATORY TRACT INFECTIONS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0034104818     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.68.4.2142-2147.2000     Document Type: Article

References (41)

1. Abman, S. H., F. J. Accurso, and C. M. Bowman. 1986. Persistent morbidity and mortality of protein calorie malnutrition in young infants with cystic fibrosis. J. Pediatr. Gastroenterol. Nutr. 5:393-396.
2. Alemzadeh, R., L. Upchurch, and V. McCarthy. 1998. Anabolic effects of growth hormone treatment in young children with cystic fibrosis. J. Am. Coll. Nutr. 17:419-424.
3. Benabdeslam, H., I. Garcia, G. Bellon, R. Gilly, and A. Revol. 1998. Biochemical assessment of the nutritional status of cystic fibrosis patients with pancreatic enzyme extracts. Am. J. Clin. Nutr. 67:817-818.
4. Biwersi, J., and A. S. Verkman. 1994. Functions of CFTR other than as a plasma membrane chloride channel, p. 155-171. In J. A. Dodge, D. J. H. Brock, and J. H. Widdicombe (ed.), Cystic fibrosis-current topics, vol. 2. John Wiley & Sons Ltd., Chichester, England.
5. Bonfield, T. L., J. R. Panuska, M. W. Konstan, K. A. Hillard, J. B. Hillard, H. Ghnaim, and M. Berger. 1995. Inflammatory cytokines in cystic fibrosis lungs. Am. J. Respir. Crit. Care Med. 152:2111-2118.
6. Booth, I. W. 1991. The nutritional consequences of gastrointestinal disease in adolescence. Acta Paediatr. Scand. Suppl. 373:91-102.
7. Borowitz, D. 1994. Pathophysiology of gastrointestinal complications of cystic fibrosis. Semin. Respir. Crit. Care Med. 15:391-401.
8. Buret, A., M. L. Dunkley, G. Pang, R. L. Clancy, and A. W. Cripps. 1994. Pulmonary immunity to Pseudomonas aeruginosa in intestinally immunized rats roles of alveolar macrophages, tumor necrosis factor alpha, and interleukin-1 alpha. Infect. Immun. 62:5335-5343.
9. Chan, J., Y. Tian, K. E. Tanaka, M. S. Tsang, K. Yu, P. Salgame, D. Carroll, Y. Kress, R. Teitelbaum, and B. R. Bloom. 1996. Effects of protein calorie malnutrition on tuberculosis in mice. Proc. Natl. Acad. Sci. USA 93:14857-14861.
10. Collins, F. S. 1992. Cystic fibrosis: molecular biology and therapeutic implications. Science 256:774-779.
11. FitzSimmons, S. C. 1993. The changing epidemiology of cystic fibrosis. J. Pediatr. 122:1-9.
12. Goldman, M. J., G. M. Anderson, E. D. Stolzenberg, U. P. Kari, M. Zasloff, and J. M. Wilson. 1997. Human ß-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis. Cell 88:553-560.
13. Gosselin, D., J. DeSanctis, M. Boule, E. Skamene, C. Matouk, and D. Radzioch. 1995. Role of tumor necrosis factor alpha in innate resistance to mouse pulmonary infection with Pseudomonas aeruginosa. Infect. Immun. 63:3272-3278.
14. Gosselin, D., M. M. Stevenson, E. A. Cowley, U. Griesenbach, D. H. Eidelman, M. Boule, M. F. Tam, G. Kent, E. Skamene, L. C. Tsui, and D. Radzioch. 1998. Impaired ability of Cftr knockout mice to control lung infection with Pseudomonas aeruginosa. Am. J. Respir. Crit. Care Med. 157: 1253-1262.
15. Govan, J. R. W., and V. Deretic. 1996. Microbial pathogenesis in cystic fibrosis: mucoid Pseudomonas aeruginosa and Burkholderia cepacia. Microbiol. Rev. 60:539-574.
16. Greenberger, M. J., R. M. Strieter, S. L. Kunkel, J. M. Danforth, L. L. Laichalk, D. C. McGillicuddy, and T. J. Standiford. 1996. Neutralization of macrophage inflammatory protein-2 attenuates neutrophil recruitment and bacterial clearance in murine Klebsiella pneumoniae. J. Infect. Dis. 173: 159-165.
17. Hobden, J. A., S. A. Masinick, R. P. Barrett, and L. D. Hazlett. 1997. Proinflammatory cytokine deficiency and pathogenesis of Pseudomonas aeruginosa keratitis in aged mice. Infect. Immun. 65:2754-2758.
18. Holt, T. L., L. C. Ward, P. J. Francis, A. Isles, W. G. Cooksley, and R. W. Shepherd. 1985. Whole body protein turnover in malnourished cystic fibrosis patients and its relationship to pulmonary disease. Am. J. Clin. Nutr. 41: 1061-1066.
19. Kelley, T. J., and M. L. Drumm. 1998. Inducible nitric oxide synthase expression is reduced in cystic fibrosis murine and human airway epithelial cells. J. Clin. Investig. 102:1200-1207.
20. Kent, G., R. Iles, C. E. Bear, L. Huan, U. Griesenbach, C. McKerlie, H. Frndova, C. Ackerley, D. Gosselin, D. Razioch, H. O'Brodovich, L. Tsui, M. Buchwald, and A. K. Tanswell. 1997. Lung disease in mice with cystic fibrosis. J. Clin. Investig. 100:3060-3069.
21. Kerem, E., B. Corey, and B.-S. Kerem, et al. 1989. Clinical and genetic comparisons of patients with cystic fibrosis with or without meconium ileus. J. Pediatr. 114:767-773.
22. Khan, T. Z., J. S. Wagener, T. Bost, J. Martinez, F. J. Accurso, and D. W. H. Riches. 1995. Early pulmonary inflammation in infants with cystic fibrosis. Am. J. Respir. Crit. Care Med. 151:1075-1082.
23. Konstan, M. W., and M. Berger. 1993. Infection and inflammation of the lung in cystic fibrosis, p. 219-276. In P. B. Davis (ed.), Cystic fibrosis, vol. 64. Marcel Dekker, Inc., New York, N.Y.
24. Kraemer, R., A. Rudeberg, B. Hadorn, and E. Rossi. 1978. Relative underweight in cystic fibrosis and its prognostic value. Acta Paediatr. Scand. 67: 33-37.
25. Lai, H. C., M. R. Kosorok, S. A. Sondel, S. T. Chen, S. C. FitzSimmons, C. G. Green, G. Shen, S. Walker, and P. M. Farrell. 1998. Growth status in children with cystic fibrosis based on the national cystic fibrosis patient registry data: evaluation of various criteria used to identify malnutrition. J. Pediatr. 132:478-485.
26. Landon, C., J. A. Kerner, R. Castillo, L. Adams, R. Whalen, and N. J. Lewiston. 1981. Oral correction of essential fatty acid deficiency in cystic fibrosis. JPEN J. Parenter. Enteral Nutr. 5:501-504.
27. Meng, Q. H., D. R. Springall, A. E. Bishop, K. Morgan, T. J. Evans, S. Habib, D. C. Gruenert, K. M. Gyi, M. E. Hodson, M. H. Yacoub, and J. M. Polak. 1998. Lack of inducible nitric oxide synthase in bronchial epithelium: a possible mechanism of susceptibility to infection in cystic fibrosis. J. Pathol. 184:323-331.
28. Mornet, E., J. L. Serre, and M. E. A. Farrall. 1988. Genetic differences between cystic fibrosis with and without meconium ileus. Lancet i:376-378.
29. Pedersen, S. S., T. Jensen, T. Pressler, N. Hoiby, and K. Rosendal. 1986. Does centralized treatment of cystic fibrosis increase the risk of Pseudomonas aeruginosa infection? Acta Paediatr. Scand. 75:840-845.
30. Pencharz, P., and P. Durie. 1993. Nutritional management of cystic fibrosis. Annu. Rev. Nutr. 13:111-136.
31. Pier, G. B., M. Grout, T. S. Zaidi, J. C. Olsen, L. G. Johnson, J. R. Yankaska, and J. B. Goldberg. 1996. Role of mutant CFTR in hypersusceptibility of cystic fibrosis patients to lung infections. Science 271:64-67.
32. Roulet, M. 1994. Protein-energy malnutrition in cystic fibrosis patients. Acta Pediatr. Suppl. 395:43-48.
33. Roulet, M., P. Frascarolo, I. Rappaz, and M. Pilet. 1997. Essential fatty acid deficiency in well nourished young cystic fibrosis patients. Eur. J. Pediatr. 156:952-956.
34. Schall, T. J. 1994. The chemokines, p. 419-460. In A. W. Thomson (ed.), The cytokine handbook, 2nd ed. Academic Press, San Diego, Calif.
35. Schmal, H., T. P. Shanley, M. L. Jones, H. P. Friedl, and P. A. Ward. 1995. Role for macrophage inflammatory protein-2 in lipopolysaccharide-induced lung injury in rats. J. Immunol. 156:1963-1972.
36. Smith, J. J., S. M. Travis, E. P. Greenberg, and M. J. Welsh. 1996. Cystic fibrosis airway epithelia fail to kill bacteria because of abnormal airway surface fluid. Cell 85:1-20.
37. Snouwaert, J. N., K. K. Brigman, A. M. Latour, N. N. Malouf, R. C. Boucher, O. Smithies, and B. H. Koller. 1992. An animal model for cystic fibrosis made by gene targeting. Science 257:1083-1088.
38. van Buren, C. T., F. B. Rudolph, A. Kulkarni, R. Pizzini, W. C. Fanslow, and S. Kumar. 1990. Reversal of immunosuppression induced hy a protein-free diet: comparison of nucleotides, fish oil, and arginine. Crit. Care Med. 18: S114-S117.
39. Yu, H., M. Hanes, C. E. Chrisp, J. C. Boucher, and V. Deretic. 1998. Microbial pathogenesis in cystic fibrosis: pulmonary clearance of mucoid Pseudumonas aeruginosa and inflammation in a mouse model of repeated repiratory challenge. Infect. Immun. 66:280-288.
40. Zar, H., L. Saiman, L. Quittell, and A. Prince. 1995. Binding of Pseudamonas aeruginosa to respiratory epithelial cells from patients with various mutations in the cystic fibrosis transmembrane regulator. J. Pediatr. 126:230-233.
41. Zhou, L., C. R. Dey, S. E. Wert, M. D. DuVall, R. A. Frizzell, and J. A. Whitsett. 1994. Correction of lethal intestinal defect in a mouse model of cystic fibrosis by human CFTR. Science 266:1705-1708.