Pathway modeling of microarray data: A case study of pathway activity changes in the testis following in utero exposure to dibutyl phthalate (DBP)

Toxicology and Applied Pharmacology

Volumn 271, Issue 3, 2013, Pages 386-394

  Ovacik, Meric A ^a   Sen, Banalata ^b,f   Euling, Susan Y ^c   Gaido, Kevin W ^d   Ierapetritou, Marianthi G ^a   Androulakis, Ioannis P ^a,e  

^a The State University of New Jersey   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^d CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^e RUTGERS UNIVERSITY   (United States)

^f NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Dibutyl Phthalate (DBP); Microarray data; Pathway analysis; Singular value decomposition (SVD); Time course

Indexed keywords

CHOLESTEROL; PHTHALIC ACID DIBUTYL ESTER; STEROID; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; DECOMPOSITION; DEVELOPMENTAL TOXICITY; FEMALE; FETUS; GENE EXPRESSION; GENE REPRESSION; GENETIC ANALYSIS; MALE; MALE GENITAL SYSTEM; MICROARRAY ANALYSIS; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PRENATAL DRUG EXPOSURE; RAT; REPRODUCTIVE TOXICITY; SIGNAL TRANSDUCTION; STEROIDOGENESIS; TESTIS DEVELOPMENT; TESTOSTERONE SYNTHESIS;

DBP; DEG; DIBUTYL PHTHALATE; DIBUTYL PHTHALATE (DBP); DIFFERENTIALLY EXPRESSED GENES; GENE-SET ENRICHMENT ANALYSIS; GSEA; KEGG; KYOTO ENCYCLOPEDIA OF GENES AND GENOMES; MICROARRAY DATA; ORA; OVER-REPRESENTATION ANALYSIS; PA; PAL; PATHWAY ACTIVITY; PATHWAY ACTIVITY LEVEL; PATHWAY ANALYSIS; SINGULAR VALUE DECOMPOSITION; SINGULAR VALUE DECOMPOSITION (SVD); SVD; TIME COURSE;

ANIMALS; DATABASES, GENETIC; DIBUTYL PHTHALATE; ENVIRONMENTAL POLLUTANTS; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MALE; MATERNAL-FETAL EXCHANGE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PLASTICIZERS; PREGNANCY; RATS; TESTIS;

RATTUS;

EID: 84883742339     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2010.09.008     Document Type: Article

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