Use of genomic data in risk assessment case study: II. Evaluation of the dibutyl phthalate toxicogenomic data set

Toxicology and Applied Pharmacology

Volumn 271, Issue 3, 2013, Pages 349-362

  Euling, Susan Y ^a   White, Lori D ^b,f   Kim, Andrea S ^a,g   Sen, Banalata ^b,f   Wilson, Vickie S ^c   Keshava, Channa ^a   Keshava, Nagalakshmi ^a   Hester, Susan ^c   Ovacik, Meric A ^d   Ierapetritou, Marianthi G ^d   Androulakis, Ioannis P ^d   Gaido, Kevin W ^e  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^d UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

^e CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^f NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^g ALLERGAN INC   (United States)

Author keywords

Development; Male reproduction; Phthalate syndrome; Phthalates; Risk assessment; Testicular dysgenesis syndrome; Testosterone; Toxicogenomic

Indexed keywords

CHOLESTEROL; LIPID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PHTHALIC ACID DIBUTYL ESTER; STEROL; TESTOSTERONE;

ARTICLE; CELL ADHESION; CELL METABOLISM; GENE EXPRESSION; HUMAN; IMMEDIATE EARLY GENE; IN VIVO STUDY; MALE; RISK ASSESSMENT; SIGNAL TRANSDUCTION; TESTIS;

AGD; ANOGENITAL DISTANCE; BBP; BENZYL BUTYL PHTHALATE; DBP; DEG; DEHP; DEP; DEVELOPMENT; DI-(2-ETHYLHEXYL) PHTHALATE; DIBUTYL PHTHALATE; DIETHYL PHTHALATE; DIFFERENTIALLY-EXPRESSED GENE; DIMETHYL PHTHALATE; DIOCTYL TERE-PHTHALATE; DIPENTYL PHTHALATE; DMP; DOTP; DPP; EST; EXPRESSED SEQUENCE TAG; FALSE DISCOVERY RATE; FDR; GD; GENE ONTOLOGY; GESTATION DAY; GO; INSL3; INSULIN-LIKE 3; INTEGRATED RISK INFORMATION SYSTEM; IRIS; LC; LEYDIG CELLS; LOAEL; LOEL; LOWEST OBSERVED ADVERSE EFFECT LEVEL; LOWEST OBSERVED EFFECT LEVEL; MALE REPRODUCTION; MAQC; MICROARRAY QUALITY CONTROL PROJECT; MOA; MODE OF ACTION; NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; NIEHS; NO OBSERVED ADVERSE EFFECT LEVEL; NO OBSERVED EFFECT LEVEL; NOAEL; NOEL; PCA; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR; PHTHALATE SYNDROME; PHTHALATES; PPAR; PRINCIPAL COMPONENT ANALYSIS; REM; REVERSE TRANSCRIPTION-POLYMERASE CHAIN REACTION; RISK ASSESSMENT; ROSETTA ERROR MODEL; RT-PCR; SCIENCE TO ACHIEVE RESULTS; SD; SIGNAL-TO-NOISE RATIO; SNR; SPRAGUE-DAWLEY; STAR; T; TESTICULAR DYSGENESIS SYNDROME; TESTOSTERONE; TOXICOGENOMIC; U.S. ENVIRONMENTAL PROTECTION AGENCY; US EPA; WD; WEIGHT-OF-EVIDENCE; WOE; WOLFFIAN DUCT;

ANIMALS; DIBUTYL PHTHALATE; ENVIRONMENTAL POLLUTANTS; GENE EXPRESSION REGULATION; GENOMICS; MALE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PLASTICIZERS; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RISK ASSESSMENT; TESTIS;

RATTUS; WOLFFIA;

EID: 84883740500     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2011.06.014     Document Type: Article

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