Rapid HPLC analysis of the antiepileptic lamotrigine and its metabolites in human plasma

Journal of Separation Science

Volumn 30, Issue 14, 2007, Pages 2249-2255

  Saracino, Maria Addolorata ^a   Bugamelli, Francesca ^a   Conti, Matteo ^b   Amore, Mario ^c   Raggi, Maria Augusta ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b Laboratory of Clinical Pharmacology and Toxicology   (Italy)

^c UNIVERSITY OF PARMA   (Italy)

Author keywords

Biological fluids; DAD detection; Lamotrigine; Liquid chromatography; Metabolites

Indexed keywords

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLITES; METHANOL; PH; PRECIPITATION (CHEMICAL); PURIFICATION;

DIODE ARRAY DETECTION; GLUCURONIDE; LAMOTRIGINE; MELATONIN;

PLASMA (HUMAN);

ANTICONVULSIVE AGENT; BUFFER; CARBAMAZEPINE; CHLORPROMAZINE; CLOTIAPINE; CLOZAPINE; DRUG METABOLITE; ETHOSUXIMIDE; ETIRACETAM; FLUOXETINE; FLUVOXAMINE; GABAPENTIN; HALOPERIDOL; LAMOTRIGINE; LEVOMEPROMAZINE; MELATONIN; METHANOL; OLANZAPINE; OXCARBAZEPINE; PAROXETINE; PHENOBARBITAL; PHENYTOIN; PHOSPHATE; PRIMIDONE; QUETIAPINE; RISPERIDONE; TRIETHYLAMINE; UNINDEXED DRUG; VALPROIC ACID; VENLAFAXINE;

ACCURACY; ANALYTIC METHOD; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DIODE; DIODE ARRAY DETECTION; DRUG BLOOD LEVEL; DRUG ISOLATION; DRUG PURIFICATION; DRUG STRUCTURE; EPILEPSY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; PH; PRECIPITATION; PRIORITY JOURNAL;

ANTICONVULSANTS; BLOOD CHEMICAL ANALYSIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; SOLID PHASE EXTRACTION; TRIAZINES;

EID: 34848842728     PISSN: 16159306     EISSN: 16159314     Source Type: Journal    
DOI: 10.1002/jssc.200700110     Document Type: Article

References (22)

1. Bartoli, A., Guerrini, R., Belmonte, A., Alessandrini, M. G., Gatti, G., Perucca, E., Ther. Drug Monit. 1997, 19, 252-260.
2. Pucci, V., Raggi, M. A., Electrophoresis 2005, 26, 767-782.
3. Meldrum, B. S., Epilepsia 1996, 37, 4-11.
4. Ketter, T. A., Post, R. M., Theodore, W. H., Neurology 1999, 53, 53-67.
5. Ramsey, R. E., Pellock, J. M., Garnett, W. R., Sanchez, R. M., Valakas, A. M., Wargin, W. A., Lai, A. A., Hubbell, J., Chern, W. H., Allsup, T., Epilepsy Res. 1991, 10, 191-200.
6. Hussein, Z., Posner,J., Br. J. Clin. Pharmacol. 1997, 43, 457-464.
7. Sweetman, S. C., Martindale - The Complete Drug Reference, 34th Edn., Pharmaceutical Press, London 2005, pp. 363-364.
8. Patsalos, P. N., Ann. Clin. Biochem. 1999, 36, 10-19.
9. Sabers, A., Oehman, I., Christensen, J., Tomson, T., Neurology 2003, 61, 570-571.
10. Sidhu, J., Job, S., Singh, S., Philipson, R., Br. J. Clin. Pharmacol. 2006, 61, 191-199.
11. Ohman, I., Vitols, S., Tomson, T., Epilepsia 2000, 41, 709-713.
12. Pennell, P. B., Newport, D. J., Stowe, Z. N., Helmers, S. L., Montgomery, J. Q., Henry, T. R., Neurology 2004, 62, 292-295.
13. Beck, O., Oehman, I., Nordgren, H. K., Ther. Drug Monit. 2006, 28, 603-607.
14. Cheng, C. L., Chou, C. H., Hu, O. Y. P., J. Chromatogr. B 2005, 817, 199-206.
15. Contin, M., Balboni, M., Callegati, E., Candela, C., Albani, F., Riva, R., Baruzzi, A., J. Chromatogr. B 2005, 828, 113-117.
16. Patil, K., Bodhankar, S. L., J. Pharmaceut. Biamed. 2005, 39, 181-186.
17. Franceschi, L., Furlanut, M., Pharmacol. Res. 2005, 51, 297-302.
18. Pucci, V., Bugamelli, F., Baccini, C., Raggi, M. A., Electrophoresis 2005, 26, 935-942.
19. Cooper, J. D. H., Shearsby, N. J., Taylor, J. E., Fook Sheung, C. T. T., J. Chromatogr. B 1997, 702, 227-233.
20. United States Pharmacopeia, 28th Edn., United States Pharmacopeial Convention, Rockville, MD 2005, pp. 2748-2749.
21. Shah, V. P., Midha, K. K., Findlay, J. W. A., John, W. A., Hill, H. M., Hulse, J. D., McGilveray, I. J., McKay, G., Miller, K. J., Patnaik, R. N., Powell, M. L., Tonelli, A., Viswanathan, C. T., Yacobi, A., Pharm. Res. 2000, 17, 1551-1557.
22. Bugamelli, F., Sabbioni, C., Mandrioli, R., Kenndler, E., Albani, F., Raggi, M. A., Anal. Chim. Acta 2002, 472, 1-10.