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Volumn 58, Issue 2-3, 2004, Pages 85-91

Inhibition of multidrug transporters by verapamil or probenecid does not alter blood-brain barrier penetration of levetiracetam in rats

Author keywords

Epilepsy; Multidrug resistance proteins; P glycoprotein; Probenecid; Verapamil

Indexed keywords

ETIRACETAM; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN; PROBENECID; VERAPAMIL;

EID: 2142773119     PISSN: 09201211     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eplepsyres.2003.12.007     Document Type: Article
Times cited : (91)

References (36)
  • 1
    • 0347033287 scopus 로고    scopus 로고
    • Expression and cellular distribution of multidrug transporter proteins in two major causes of medically intractable epilepsy: Focal cortical dysplasia and glioneuronal tumors
    • Aronica E., Gorter J.A., Jansen G.H., van Veelen C.W., van Rijen P.C., Leenstra S., Ramkema M., Scheffer G.L., Scheper R.J., Troost D. Expression and cellular distribution of multidrug transporter proteins in two major causes of medically intractable epilepsy: focal cortical dysplasia and glioneuronal tumors. Neuroscience. 118:2003;417-429
    • (2003) Neuroscience , vol.118 , pp. 417-429
    • Aronica, E.1    Gorter, J.A.2    Jansen, G.H.3    Van Veelen, C.W.4    Van Rijen, P.C.5    Leenstra, S.6    Ramkema, M.7    Scheffer, G.L.8    Scheper, R.J.9    Troost, D.10
  • 3
    • 0037390579 scopus 로고    scopus 로고
    • Clinical experience of marketed Levetiracetam in an epilepsy clinic-a one year follow up study
    • Betts T., Yarrow H., Greenhill L., Barrett M. Clinical experience of marketed Levetiracetam in an epilepsy clinic-a one year follow up study. Seizure. 12:2003;136-140
    • (2003) Seizure , vol.12 , pp. 136-140
    • Betts, T.1    Yarrow, H.2    Greenhill, L.3    Barrett, M.4
  • 5
    • 0034674901 scopus 로고    scopus 로고
    • A family of drug transporters: The multidrug resistance-associated proteins
    • Borst P., Evers R., Kool M., Wijnholds J. A family of drug transporters: the multidrug resistance-associated proteins. J. Natl. Cancer Inst. 92:2000;1295-1302
    • (2000) J. Natl. Cancer Inst. , vol.92 , pp. 1295-1302
    • Borst, P.1    Evers, R.2    Kool, M.3    Wijnholds, J.4
  • 7
    • 0033756611 scopus 로고    scopus 로고
    • Levetiracetam. a review of its adjunctive use in the management of partial onset seizures
    • Dooley M., Plosker G.L. Levetiracetam. A review of its adjunctive use in the management of partial onset seizures. Drugs. 60:2000;871-893
    • (2000) Drugs , vol.60 , pp. 871-893
    • Dooley, M.1    Plosker, G.L.2
  • 8
    • 0036070539 scopus 로고    scopus 로고
    • Regulation of expression of the multidrug resistance-associated protein 2 (MRP2) and its role in drug disposition
    • Gerk P.M., Vore M. Regulation of expression of the multidrug resistance-associated protein 2 (MRP2) and its role in drug disposition. J. Pharmacol. Exp. Ther. 302:2002;407-415
    • (2002) J. Pharmacol. Exp. Ther. , vol.302 , pp. 407-415
    • Gerk, P.M.1    Vore, M.2
  • 10
    • 0034864144 scopus 로고    scopus 로고
    • Levetiracetam: The preclinical profile of a new class of antiepileptic drugs?
    • Klitgaard H. Levetiracetam: the preclinical profile of a new class of antiepileptic drugs? Epilepsia. 42(Suppl. 4):2001;13-18
    • (2001) Epilepsia , vol.42 , Issue.SUPPL. 4 , pp. 13-18
    • Klitgaard, H.1
  • 11
    • 0035212257 scopus 로고    scopus 로고
    • Drug transporters in the central nervous system: Brain barriers and brain parenchyma considerations
    • Lee G., Dallas S., Hong M., Bendayan R. Drug transporters in the central nervous system: brain barriers and brain parenchyma considerations. Pharmacol. Rev. 53:2001;569-596
    • (2001) Pharmacol. Rev. , vol.53 , pp. 569-596
    • Lee, G.1    Dallas, S.2    Hong, M.3    Bendayan, R.4
  • 12
    • 0003346794 scopus 로고    scopus 로고
    • Levetiracetam: Clinical use
    • Levy, R.H., Mattson, R.H., Meldrum, B.S., Perucca, E. (Eds.), Lippincott Williams & Wilkins, Philadelphia
    • Leppik, I.E., 2002. Levetiracetam: clinical use. In: Levy, R.H., Mattson, R.H., Meldrum, B.S., Perucca, E. (Eds.), Antiepileptic Drugs. Fifth edition, Lippincott Williams & Wilkins, Philadelphia, pp. 433-441.
    • (2002) Antiepileptic Drugs. Fifth Edition , pp. 433-441
    • Leppik, I.E.1
  • 13
    • 0036109602 scopus 로고    scopus 로고
    • Animal models of drug-resistant epilepsy
    • (discussion 159-6)
    • Löscher W. Animal models of drug-resistant epilepsy. Novartis. Found. Symp. 243:2002a;149-159. (discussion 159-6)
    • (2002) Novartis. Found. Symp. , vol.243 , pp. 149-159
    • Löscher, W.1
  • 14
    • 0036499726 scopus 로고    scopus 로고
    • Current status and future directions in the pharmacotherapy of epilepsy
    • Löscher W. Current status and future directions in the pharmacotherapy of epilepsy. Trends Pharmacol. Sci. 23:2002;113-118
    • (2002) Trends Pharmacol. Sci. , vol.23 , pp. 113-118
    • Löscher, W.1
  • 15
    • 0021267961 scopus 로고
    • Kinetics of penetration of common antiepileptics drugs into cerebrospinal fluid
    • Löscher W., Frey H.-H. Kinetics of penetration of common antiepileptics drugs into cerebrospinal fluid. Epilepsia. 25:1984;346-352
    • (1984) Epilepsia , vol.25 , pp. 346-352
    • Löscher, W.1    Frey, H.-H.2
  • 16
    • 0027410987 scopus 로고
    • Profile of ucb L059, a novel anticonvulsant drug, in models of partial and generalized epilepsy in mice and rats
    • Löscher W., Hönack D. Profile of ucb L059, a novel anticonvulsant drug, in models of partial and generalized epilepsy in mice and rats. Eur. J. Pharmacol. 232:1993;147-158
    • (1993) Eur. J. Pharmacol. , vol.232 , pp. 147-158
    • Löscher, W.1    Hönack, D.2
  • 17
    • 0036128985 scopus 로고    scopus 로고
    • Role of multidrug transporters in pharmacoresistance to antiepileptic drugs
    • Löscher W., Potschka H. Role of multidrug transporters in pharmacoresistance to antiepileptic drugs. J. Pharmacol. Exp. Ther. 301:2002;7-14
    • (2002) J. Pharmacol. Exp. Ther. , vol.301 , pp. 7-14
    • Löscher, W.1    Potschka, H.2
  • 18
    • 0036342414 scopus 로고    scopus 로고
    • New horizons in the development of antiepileptic drugs
    • Löscher W., Schmidt D. New horizons in the development of antiepileptic drugs. Epilepsy Res. 50:2002;3-16
    • (2002) Epilepsy Res. , vol.50 , pp. 3-16
    • Löscher, W.1    Schmidt, D.2
  • 19
    • 0034077338 scopus 로고    scopus 로고
    • Theoretical calculation and prediction of P-glycoprotein-interacting drugs using MolSurf parametrization and PLS statistics
    • Osterberg T., Norinder U. Theoretical calculation and prediction of P-glycoprotein-interacting drugs using MolSurf parametrization and PLS statistics. Eur. J. Pharm. Sci. 10:2000;295-303
    • (2000) Eur. J. Pharm. Sci. , vol.10 , pp. 295-303
    • Osterberg, T.1    Norinder, U.2
  • 20
    • 2142831652 scopus 로고    scopus 로고
    • Levetiracetam: Chemistry, biotransformation, pharmacokinetics, and drug interactions
    • Levy, R.H., Mattson, R.H., Meldrum, B.S., Perucca, E. (Eds.), Lippincott Williams & Wilkins, Philadelphia
    • Patsalos, P.N., 2002. Levetiracetam: chemistry, biotransformation, pharmacokinetics, and drug interactions. In: Levy, R.H., Mattson, R.H., Meldrum, B.S., Perucca, E. (Eds.), Antiepileptic Drugs. Fifth Edition, Lippincott Williams & Wilkins, Philadelphia, pp. 428-432.
    • (2002) Antiepileptic Drugs. Fifth Edition , pp. 428-432
    • Patsalos, P.N.1
  • 21
    • 0035900333 scopus 로고    scopus 로고
    • P-Glycoprotein and multidrug resistance-associated protein are involved in the regulation of extracellular levels of the major antiepileptic drug carbamazepine in the brain
    • Potschka H., Fedrowitz M., Löscher W. P-Glycoprotein and multidrug resistance-associated protein are involved in the regulation of extracellular levels of the major antiepileptic drug carbamazepine in the brain. Neuroreport. 12:2001;3557-3560
    • (2001) Neuroreport , vol.12 , pp. 3557-3560
    • Potschka, H.1    Fedrowitz, M.2    Löscher, W.3
  • 22
    • 0037178642 scopus 로고    scopus 로고
    • P-glycoprotein-mediated efflux of phenobarbital, lamotrigine, and felbamate at the blood-brain barrier: Evidence from microdialysis experiments in rats
    • Potschka H., Fedrowitz M., Löscher W. P-glycoprotein-mediated efflux of phenobarbital, lamotrigine, and felbamate at the blood-brain barrier: evidence from microdialysis experiments in rats. Neurosci. Lett. 327:2002;173-176
    • (2002) Neurosci. Lett. , vol.327 , pp. 173-176
    • Potschka, H.1    Fedrowitz, M.2    Löscher, W.3
  • 23
    • 0037665280 scopus 로고    scopus 로고
    • Multidrug resistance protein MRP2 contributes to blood- brain barrier function and restricts antiepileptic drug activity
    • Potschka H., Fedrowitz M., Löscher W. Multidrug resistance protein MRP2 contributes to blood- brain barrier function and restricts antiepileptic drug activity. J. Pharmacol. Exp. Ther. 306:2003;124-131
    • (2003) J. Pharmacol. Exp. Ther. , vol.306 , pp. 124-131
    • Potschka, H.1    Fedrowitz, M.2    Löscher, W.3
  • 24
    • 0035828178 scopus 로고    scopus 로고
    • Multidrug resistance-associated protein is involved in the regulation of extracellular levels of phenytoin in the brain
    • Potschka H., Löscher W. Multidrug resistance-associated protein is involved in the regulation of extracellular levels of phenytoin in the brain. Neuroreport. 12:2001a;2387-2389
    • (2001) Neuroreport , vol.12 , pp. 2387-2389
    • Potschka, H.1    Löscher, W.2
  • 25
    • 0035167174 scopus 로고    scopus 로고
    • In vivo evidence for P-glycoprotein-mediated transport of phenytoin at the blood-brain barrier of rats
    • Potschka H., Löscher W. In vivo evidence for P-glycoprotein-mediated transport of phenytoin at the blood-brain barrier of rats. Epilepsia. 42:2001;1231-1240
    • (2001) Epilepsia , vol.42 , pp. 1231-1240
    • Potschka, H.1    Löscher, W.2
  • 27
    • 0036111476 scopus 로고    scopus 로고
    • Drug resistance molecules: Lessons from oncology
    • Scheffer G.L., Scheper R.J. Drug resistance molecules: lessons from oncology. Novartis. Found. Symp. 243:2002;19-31
    • (2002) Novartis. Found. Symp. , vol.243 , pp. 19-31
    • Scheffer, G.L.1    Scheper, R.J.2
  • 28
    • 0031962285 scopus 로고    scopus 로고
    • How does P-glycoprotein recognize its substrates?
    • Seelig A. How does P-glycoprotein recognize its substrates? Int. J. Clin. Pharmacol. Ther. 36:1998;50-54
    • (1998) Int. J. Clin. Pharmacol. Ther. , vol.36 , pp. 50-54
    • Seelig, A.1
  • 29
    • 0034055630 scopus 로고    scopus 로고
    • Substrate recognition by P-glycoprotein and the multidrug resistance-associated protein MRP1: A comparison
    • Seelig A., Blatter X.L., Wohnsland F. Substrate recognition by P-glycoprotein and the multidrug resistance-associated protein MRP1: a comparison. Int. J. Clin. Pharmacol. Ther. 38:2000;111-121
    • (2000) Int. J. Clin. Pharmacol. Ther. , vol.38 , pp. 111-121
    • Seelig, A.1    Blatter, X.L.2    Wohnsland, F.3
  • 31
    • 0033250545 scopus 로고    scopus 로고
    • Multidrug-resistance transporters
    • Silverman J.A. Multidrug-resistance transporters. Pharm. Biotechnol. 12:1999;353-386
    • (1999) Pharm. Biotechnol. , vol.12 , pp. 353-386
    • Silverman, J.A.1
  • 32
    • 12144285671 scopus 로고    scopus 로고
    • Drug resistance in epilepsy: Not futile, but complex?
    • Sisodiya S. Drug resistance in epilepsy: not futile, but complex? Lancet Neurol. 2:2003;331
    • (2003) Lancet Neurol. , vol.2 , pp. 331
    • Sisodiya, S.1
  • 33
    • 0036156280 scopus 로고    scopus 로고
    • Drug resistance in epilepsy: Expression of drug resistance proteins in common causes of refractory epilepsy
    • Sisodiya S.M., Lin W.-R., Harding B.N., Squier M.V., Keir G., Thom M. Drug resistance in epilepsy: expression of drug resistance proteins in common causes of refractory epilepsy. Brain. 125:2002;22-31
    • (2002) Brain , vol.125 , pp. 22-31
    • Sisodiya, S.M.1    Lin, W.-R.2    Harding, B.N.3    Squier, M.V.4    Keir, G.5    Thom, M.6
  • 34
    • 0037204543 scopus 로고    scopus 로고
    • Progress in understanding the structure-activity relationships of P-glycoprotein
    • Stouch T.R., Gudmundsson O. Progress in understanding the structure-activity relationships of P-glycoprotein. Adv. Drug Deliv. Rev. 54:2002;315-328
    • (2002) Adv. Drug Deliv. Rev. , vol.54 , pp. 315-328
    • Stouch, T.R.1    Gudmundsson, O.2
  • 36
    • 0034892646 scopus 로고    scopus 로고
    • A microdialysis study of the novel antiepileptic drug levetiracetam: Extracellular pharmacokinetics and effect on taurine in rat brain
    • Tong X., Patsalos P.N. A microdialysis study of the novel antiepileptic drug levetiracetam: extracellular pharmacokinetics and effect on taurine in rat brain. Br. J. Pharmacol. 133:2001;867-874
    • (2001) Br. J. Pharmacol. , vol.133 , pp. 867-874
    • Tong, X.1    Patsalos, P.N.2


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