Necrosis versus apoptosis in acetaminophen-induced hepatotoxicity

Hepatology

Volumn 53, Issue 3, 2011, Pages 1070-

  Schulze Osthoff, Klaus ^a   Bantel, Heike ^b  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 9; CHEMOKINE RECEPTOR CXCR2; CYTOCHROME P450; DIMETHYL SULFOXIDE; PARACETAMOL;

APOPTOSIS; CELL DEATH; DISEASE COURSE; DNA FRAGMENTATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME INHIBITION; HUMAN; LETTER; LIVER MITOCHONDRION; LIVER NECROSIS; LIVER TOXICITY; NICK END LABELING; NONHUMAN; PREDICTIVE VALUE; PRIORITY JOURNAL; TOXIC HEPATITIS;

ACETAMINOPHEN; ANIMALS; APOPTOSIS; DRUG-INDUCED LIVER INJURY; LIVER FAILURE, ACUTE; MICE; NECROSIS;

EID: 79952205029     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.24027     Document Type: Letter

References (10)

1. Hu B, Colletti LM. CXC receptor-2 knockout genotype increases X-linked inhibitor of apoptosis protein and protects mice from acetaminophen hepatotoxicity. HEPATOLOGY 2010; 52: 691-702.
2. Jaeschke H, Bajt ML. Intracellular signaling mechanisms of acetaminophen-induced liver cell death. Toxicol Sci 2006; 89: 31-41.
3. Malhi H, Gores GJ. Cellular and molecular mechanisms of liver injury. Gastroenterology 2008; 134: 1641-1654.
4. Volkmann X, Anstaett M, Hadem J, Stiefel P, Bahr MJ, Lehner F, et al. Caspase activation is associated with spontaneous recovery from acute liver failure. HEPATOLOGY 2008; 47: 1624-1633.
5. Hofer S, Brenner T, Bopp C, Steppan J, Lichtenstern C, Weitz J, et al. Cell death serum biomarkers are early predictors for survival in severe septic patients with hepatic dysfunction. Crit Care 2009; 13: R93.
6. Bechmann LP, Marquitan G, Jochum C, Saner F, Gerken G, Canbay A. Apoptosis versus necrosis rate as a predictor in acute liver failure following acetaminophen intoxication compared with acute-on-chronic liver failure. Liver Int 2008; 28: 713-716.
7. Leist M, Single B, Castoldi AF, Kuhnle S, Nicotera P. Intracellular adenosine triphosphate (ATP) concentration: a switch in the decision between apoptosis and necrosis. J Exp Med 1997; 185: 1481-1486.
8. Bernal W, Donaldson N, Wyncoll D, Wendon J. Blood lactate as an early predictor of outcome in paracetamol-induced acute liver failure: a cohort study. Lancet 2002; 359: 558-563.
9. Yu ZW, Quinn PJ. Dimethyl sulphoxide: a review of its applications in cell biology. Biosci Rep 1994; 14: 259-281.
10. Wolf BB, Goldstein JC, Stennicke HR, Beere H, Amarante-Mendes GP, Salvesen GS, et al. Calpain functions in a caspase-independent manner to promote apoptosis-like events during platelet activation. Blood 1999; 94: 1683-1692.