Effects of osmotic stress on the activity of MAPKs and PDGFR-β- mediated signal transduction in NIH-3T3 fibroblasts

American Journal of Physiology - Cell Physiology

Volumn 294, Issue 4, 2008, Pages

  Nielsen, M B ^a   Christensen, S T ^a   Hoffmann, E K ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Mitogen activated protein kinases; Platelet derived growth factor receptor ; Volume sensor

Indexed keywords

JANUS KINASE 1; JANUS KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROTEIN KINASE B;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL MIGRATION; CELL PROLIFERATION; CELL STRAIN 3T3; CELL SWELLING; CELL VOLUME; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; FIBROBLAST; IMMUNOFLUORESCENCE MICROSCOPY; NONHUMAN; OSMOTIC STRESS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; STATISTICAL ANALYSIS; WESTERN BLOTTING;

ANIMALS; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; NIH 3T3 CELLS; OSMOTIC PRESSURE; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA; SIGNAL TRANSDUCTION;

EID: 41949103967     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00134.2007     Document Type: Article

References (79)

1. Alvarez RH, Kantarjian HM, Cortes JE. Biology of platelet-derived growth factor and its involvement in disease. Mayo Clin Proc 81: 1241-1257, 2006.
2. Anbari K, Schultz RM. Effect of sodium and betaine in culture media on development and relative rates of protein synthesis in preimplantation mouse embryos in vitro. Mol Reprod Dev 35: 24-28, 1993.
3. Bildin VN, Wang Z, Iserovich P, Reinach PS. Hypertonicity-induced p38MAPK activation elicits recovery of corneal epithelial cell volume and layer integrity. J Membr Biol 193: 1-13, 2003.
4. Bode JG, Gatsios P, Ludwig S, Rapp UR, Haussinger D, Heinrich PC, Graeve L. The mitogen-activated protein (MAP) kinase p38 and its upstream activator MAP kinase kinase 6 are involved in the activation of signal transducer and activator of transcription by hyperosmolarity. J Biol Chem 274: 30222-30227, 1999.
5. Bortner CD, Cidlowski JA. A necessary role for cell shrinkage in apoptosis. Biochem Pharmacol 56: 1549-1559, 1998.
6. Brunet A, Roux D, Lenormand P, Dowd S, Keyse S, Pouyssegur J. Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry. EMBO J 18: 664-674, 1999.
7. Burg MB. Response of renal inner medullary epithelial cells to osmotic stress. Comp Biochem Physiol A 133: 661-666, 2002.
8. Christensen ST, Guerra C, Wada Y, Valentin T, Angeletti RH, Satir P, Hamasaki T. A regulatory light chain of ciliary outer arm dynein in Tetrahymena thermophila. J Biol Chem 276: 20048-20054, 2001.
9. Chuang SM, Wang IC, Yang JL. Roles of JNK, p38 and ERK mitogen-activated protein kinases in the growth inhibition and apoptosis induced by cadmium. Carcinogenesis 21: 1423-1432, 2000.
10. Coffer PJ, Jin J, Woodgett JR. Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation. Biochem J 335: 1-13, 1998.
11. Copp J, Wiley S, Ward MW, van der GP. Hypertonic shock inhibits growth factor receptor signaling, induces caspase-3 activation, and causes reversible fragmentation of the mitochondrial network. Am J Physiol Cell Physiol 288: C403-C415, 2005.
12. De Nadal E, Alepuz PM, Posas F. Dealing with osmostress through MAP kinase activation. EMBO Rep 3: 735-740, 2002.
13. Dmitrieva NI, Michea LF, Rocha GM, Burg MB. Cell cycle delay and apoptosis in response to osmotic stress. Comp Biochem Physiol A 130: 411-420, 2001.
14. Dubois JM, Rouzaire-Dubois B. The influence of cell volume changes on tumour cell proliferation. Eur Biophys J 33: 227-232, 2004.
15. Duzgun SA, Rasque H, Kito H, Azuma N, Li W, Basson MD, Gahtan V, Dudrick SJ, Sumpio BE. Mitogen-activated protein phosphorylation in endothelial cells exposed to hyperosmolar conditions. J Cell Biochem 76: 567-571, 2000.
16. Ebner HL, Fiechtner B, Pelster B, Krumschnabel G. Extracellular signal regulated MAP-kinase signalling in osmotically stressed trout hepatocytes. Biochim Biophys Acta 1760: 941-950, 2006.
17. Franco R, Lezama R, Ordaz B, Pasantes-Morales H. Epidermal growth factor receptor is activated by hyposmolarity and is an early signal modulating osmolyte efflux pathways in Swiss 3T3 fibroblasts. Pflügers Arch 447: 830-839, 2004.
18. Friis MB, Friborg CR, Schneider L, Nielsen MB, Lambert IH, Christensen ST, Hoffmann EK. Cell shrinkage as a signal to apoptosis in NIH 3T3 fibroblasts. J Physiol 567: 427-443, 2005.
19. Galvez AS, Ulloa JA, Chiong M, Criollo A, Eisner V, Barros LF, Lavandero S. Aldose reductase induced by hyperosmotic stress mediates cardiomyocyte apoptosis: differential effects of sorbitol and mannitol. J Biol Chem 278: 38484-38494, 2003.
20. + exchanger NHE1: relationship to the activation of three MAPK pathways. J Membr Biol 181: 205-214, 2001.
21. + cotransporter in the rectal gland of Squalus acanthias is activated by cell shrinkage. Pflügers Arch 438: 165-176, 1999.
22. + channels channels in Ehrlich ascites tumor cells. Pflügers Arch 438: 263-268, 1999.
23. Hoffmann EK, Dunham PB. Membrane mechanisms and intracellular signalling in cell volume regulation. Int Rev Cytol 161: 173-262, 1995.
24. Hoffmann EK, Nielsen M, Christensen ST. Effects of osmotic stress on the activity of receptor tyrosine kinases and MAP kinases in HIH3T3-fibroblasts (Abstract). Mol Biol Cell 15: 14A, 2004.
25. Hoffmann EK, Pedersen SF. Sensors and signal transduction pathways in vertebrate cell volume regulation. Contrib Nephrol 152: 54-104, 2006.
26. Hoffmann EK, Simonsen LO. Membrane mechanisms in volume and pH regulation in vertebrate cells. Physiol Rev 69: 315-382, 1989.
27. Hoffmann EK, Ussing HH. Membrane mechanisms in volume regulation in vertebrate cells and epithelia. In: Membrane Transport in Biology, edited by Giebisch GH, Schafer JA, Ussing HH, Kristensen P. Berlin, Germany: Springer-Verlag, 1992, p. 317-399.
28. Hohmann S. Osmotic stress signaling and osmoadaptation in yeasts. Microbiol Mol Biol Rev 66: 300-372, 2002.
29. 4 or osmotic swelling in Ehrlich ascites tumor cells. Pflügers Arch 440(2): 283-294, 2000.
30. House SL, Branch K, Newman G, Doetschman T, Schultz JEJ. Cardioprotection induced by cardiac-specific overexpression of fibroblast growth factor-2 is mediated by the MAPK cascade. Am J Physiol Heart Circ Physiol 289: H2167-H2175, 2005.
31. Kim RD, Darling CE, Cerwenka H, Chari RS. Hypoosmotic stress activates p38, ERK 1 and 2, and SAPK/JNK in rat hepatocytes. J Surg Res 90: 58-66, 2000.
32. Kippenberger S, Loitsch S, Guschel M, Muller J, Kaufmann R, Bernd A. Hypotonic stress induces E-cadherin expression in cultured human keratinocytes. FEBS Lett 579: 207-214, 2005.
33. Kodaki T, Woscholski R, Parker PJ. V-Ras activates phosphatidylinositol 3-kinase. Biochem Soc Trans 23: 195S, 1995.
34. + channels induces apoptosis in vascular smooth muscle cells. Am J Physiol Cell Physiol 280: C970-C979, 2001.
35. Lambert IH, Hoffmann EK, Christensen P. Role of prostaglandins and leukotrienes in volume regulation by Ehrlich ascites tumor cells. J Membr Biol 98: 247-256, 1987.
36. Lang F, Busch GL, Ritter M, Völkl H, Waldegger S, Gulbins E, Häussinger D. Functional significance of cell volume regulatory mechanisms. Physiol Rev 78: 247-306, 1998.
37. Lang F, Lepple-Wienhues A, Szabó I, Siemen D, Gulbins E. Cell volume in cell proliferation and apoptotic cell death. In: Cell Volume Regulation, edited by Lang F. Basel, Germany: Karger, 1998, p. 158-168.
38. Lang F, Ritter M, Gamper N, Huber S, Fillon S, Tanneur V, Lepple-Wienhues A, Szabo I, Gulbins E. Cell volume in the regulation of cell proliferation and apoptotic cell death. Cell Physiol Biochem 10: 417-428, 2000.
39. Lang KS, Fillon S, Schneider D, Rammensee HG, Lang F. Stimulation of TNF alpha expression by hyperosmotic stress. Pflügers Arch 443: 798-803, 2002.
40. Lewis A, Di Ciano C, Rotstein OD, Kapus A. Osmotic stress activates Rac and Cdc42 in neutrophils: role in hypertonicity-induced actin polymerization. Am J Physiol Cell Physiol 282: C271-C279, 2002.
41. Lezama R, Diaz-Tellez A, Ramos-Mandujano G, Oropeza L, Pasantes-Morales H. Epidermal growth factor receptor is a common element in the signaling pathways activated by cell volume changes in isosmotic, hyposmotic or hyperosmotic conditions. Neurochem Res 30: 1589-1597, 2005.
42. Liedtke CM, Cole TS. Activation of NKCC1 by hyperosmotic stress in human tracheal epithelial cells involves PKC-delta and ERK. Biochim Biophys Acta 1589: 77-88, 2002.
43. Maeno E, Ishizaki Y, Kanaseki T, Hazama A, Okada Y. Normotonic cell shrinkage because of disordered volume regulation is an early prerequisite to apoptosis. Proc Natl Acad Sci USA 97: 9487-9492, 2000.
44. Maeno E, Shimizu T, Okada Y. Normotonic cell shrinkage induces apoptosis under extracellular low Cl conditions in human lymphoid and epithelial cells. Acta Physiol (Oxf) 187: 217-222, 2006.
45. Marshall CJ. MAP kinase kinase kinase, MAP kinase kinase and MAP kinase. Curr Opin Genet Dev 4: 82-89, 1994.
46. Meier R, Thelen M, Hemmings BA. Inactivation and dephosphorylation of protein kinase Balpha (PKBalpha) promoted by hyperosmotic stress. EMBO J 17: 7294-7303, 1998.
47. Moran J, Hernandez-Pech X, Merchant-Larios H, Pasantes-Morales H. Release of taurine in apoptotic cerebellar granule neurons in culture. Pflúgers Arch 439: 271-277, 2000.
48. Nylandsted J, Gyrd-Hansen M, Danielewicz A, Fehrenbacher N, Lademann U, Hoyer-Hansen M, Weber E, Multhoff G, Rohde M, Jaattela M. Heat shock protein 70 promotes cell survival by inhibiting lysosomal membrane permeabilization. J Exp Med 200: 425-435, 2004.
49. O'Neill WC. Physiological significance of volume-regulatory transporters. Am J Physiol Cell Physiol 276: C995-C1011, 1999.
50. Okada Y, Maeno E, Shimizu T, Dezaki K, Wang J, Morishima S. Receptor-mediated control of regulatory volume decrease (RVD) and apoptotic volume decrease (AVD). J Physiol 532: 3-16, 2001.
51. Ostman A. PDGF receptors-mediators of autocrine tumor growth and regulators of tumor vasculature and stroma. Cytokine Growth Factor Rev 15: 275-286, 2004.
52. Pan Z, Capo-Aponte JE, Zhang F, Wang Z, Pokorny KS, Reinach PS. Differential dependence of regulatory volume decrease behavior in rabbit corneal epithelial cells on MAPK superfamily activation. Exp Eye Res 84: 978-990, 2007.
53. 4 activates MAPK through a Ras-independent but PKCε-dependent pathway in intestinal epithelial cells. J Cell Sci 115: 1883-1893, 2002.
54. Pasantes-Morales H, Lezama RA, Ramos-Mandujano G. Tyrosine kinases and osmolyte fluxes during hyposmotic swelling. Acta Physiol (Oxf) 187: 93-102, 2006.
55. + exchanger, NHE1, differentially regulates mitogen-activated protein kinase subfamilies after osmotic shrinkage in Ehrlich Lettre Ascites cells. Cell Physiol Biochem 20: 735-750, 2007.
56. Pederson SF, Varming C, Christensen ST, Hoffmann EK. Mechanisms of activation of NHE by cell shrinkage and by calyculin A in Ehrlich ascites tumor cells. J Membr Biol 189: 67-81, 2002.
57. Porras A, Zuluaga S, Black E, Valladares A, Alvarez AM, Ambrosino C, Benito M, Nebreda AR. P38 alpha mitogen-activated protein kinase sensitizes cells to apoptosis induced by different stimuli. Mol Biol Cell 15: 922-933, 2004.
58. Qin S, Ding J, Takano T, Yamamura H. Involvement of receptor aggregation and reactive oxygen species in osmotic stress-induced Syk activation in B cells. Biochem Biophys Res Commun 262: 231-236, 1999.
59. Reinehr R, Becker S, Hongen A, Haussinger D. The Src family kinase Yes triggers hyperosmotic activation of the epidermal growth factor receptor and CD95. J Biol Chem 279: 23977-23987, 2004.
60. Reinehr R, Schliess F, Haussinger D. Hyperosmolarity and CD95L trigger CD95/EGF receptor association and tyrosine phosphorylation of CD95 as prerequisites for CD95 membrane trafficking and DISC formation. FASEB J 17: 731-733, 2003.
61. Roger F, Martin PY, Rousselot M, Favre H, Feraille E. Cell shrinkage triggers the activation of mitogen-activated protein kinases by hypertonicity in the rat kidney medullary thick ascending limb of the Henle's loop. Requirement of p38 kinase for the regulatory volume increase response. J Biol Chem 274: 34103-34110, 1999.
62. Rouzaire-Dubois B, Malo M, Milandri JB, Dubois JM. Cell size-proliferation relationship in rat glioma cells. Glia 45: 249-257, 2004.
63. Sadoshima J, Qiu Z, Morgan JP, Izumo S. Tyrosine kinase activation is an immediate and essential step in hypotonic cell swelling-induced ERK activation and c-fos gene expression in cardiac myocytes. EMBO J 15: 5535-5546, 1996.
64. Sarkar D, Su ZZ, Lebedeva IV, Sauane M, Gopalkrishnan RV, Valerie K, Dent P, Fisher PB. mda-7 (IL-24) Mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK. Proc Natl Acad Sci USA 99: 10054-10059, 2002.
65. Schlessinger J. Cell signaling by receptor tyrosine kinases. Cell 103: 211-225, 2000.
66. Schneider L, Clement CA, Teilmann SC, Pazour GJ, Hoffmann EK, Satir P, Christensen ST. PDGFRalphaalpha signaling is regulated through the primary cilium in fibroblasts. Curr Biol 15: 1861-1866, 2005.
67. Sheikh-Hamad D, Gustin MC. MAP kinases and the adaptive response to hypertonicity: functional preservation from yeast to mammals. Am J Physiol Renal Physiol 287: F1102-F1110, 2004.
68. 2+ signalling, protein tyrosine phosphorylation and MAP kinase in regulatory volume decrease. J Physiol 537: 347-362, 2001.
69. --dependent nonselective cation channel, which requires p38 MAPK. J Biol Chem 277: 45776-45784, 2002.
70. Shrode LD, Krump E, Grinstein S. Activation of protein kinases upon volume changes: role in cellular homeostasis. Contrib Nephrol 123: 79-93, 1998.
71. Stutzin A, Hoffmann EK. Swelling-activated ion channels: functional regulation in cell-swelling, proliferation and apoptosis. Acta Physiol (Oxf) 187: 27-42, 2006.
72. Tallquist M, Kazlauskas A. PDGF signaling in cells and mice. Cytokine Growth Factor Rev 15: 205-213, 2004.
73. Terada Y, Inoshita S, Hanada S, Shimamura H, Kuwahara M, Ogawa W, Kasuga M, Sasaki S, Marumo F. Hyperosmolality activates Akt and regulates apoptosis in renal tubular cells. Kidney Int 60: 553-567, 2001.
74. Uhlik MT, Abell AN, Johnson NL, Sun WY, Cuevas BD, Lobel-Rice KE, Horne EA, Dell'Acqua ML, Johnson GL. Rac-MEKK3-MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock. Nat Cell Biol 5: 1104-1110, 2003.
75. Umenishi F, Schrier RW. Hypertonicity-induced aquaporin-1 (AQP1) expression is mediated by the activation of MAPK pathways and hypertonicity-responsive element in the AQP1 gene. J Biol Chem 278: 15765-15770, 2003.
76. Wesselborg S, Bauer MKA, Vogt M, Schmitz ML, Schulze-Osthoff K. Activation of transcription factor NF-kappaB and p38 mitogen-activated protein kinase is mediated by distinct and separate stress effector pathways. J Biol Chem 272: 12422-12429, 1997.
77. Xia Z, Dickens M, Raingeaud J, Davis RJ, Greenberg ME. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270: 1326-1331, 1995.
78. Zhang H, Shi XQ, Hampong M, Blanis L, Pelech S. Stress-induced inhibition of ERK1 and ERK2 by direct interaction with p38 MAP kinase. J Biol Chem 276: 6905-6908, 2001.
79. Zhang Z, Yang XY, Cohen DM. Hypotonicity activates transcription through ERK-dependent and -independent pathways in renal cells. Am J Physiol Cell Physiol 275: C1104-C1112, 1998.