A review of radioprotective plants

International Journal of Green Pharmacy

Volumn 7, Issue 2, 2013, Pages 90-101

  Bhandari, Prasan R ^a  

^a SDM COLLEGE OF MEDICAL SCIENCES AND HOSPITAL   (India)

Author keywords

Plants; radiation toxicity; radioprotection

Indexed keywords

AEGLE MARMELOS EXTRACT; AMARANTUS PANICULATUS EXTRACT; AMIFOSTINE; ANTHOCYANIN; ANTIOXIDANT; AZADIRACHTA INDICA EXTRACT; BETEL EXTRACT; BIOPHYTUM SENSITIVUM EXTRACT; BOERHAAVIA DIFFUSA EXTRACT; CENTELLA ASIATICA EXTRACT; CURCUMIN; CYCLOOXYGENASE 2; EMBLICA OFFICINALIS EXTRACT; GINGER EXTRACT; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HYDROXYL RADICAL; JUSTICIA ADHATODA EXTRACT; MORINGA OLEIFERA EXTRACT; PEPPERMINT; PLANT EXTRACT; PLANT MEDICINAL PRODUCT; PROTEIN KINASE B; RADIOPROTECTIVE AGENT; STAT3 PROTEIN; SUPEROXIDE; SUPEROXIDE DISMUTASE; TINOSPORA CORDIFOLIA EXTRACT; UNCLASSIFIED DRUG; UNINDEXED DRUG; WITHANIA SOMNIFERA EXTRACT;

CANCER RADIOTHERAPY; CELL CYCLE PROGRESSION; CHROMOSOME ABERRATION; CURCUMA LONGA; DISEASE COURSE; DNA DAMAGE; DNA REPAIR; HEMATOPOIETIC STEM CELL; HUMAN; IN VITRO STUDY; IONIZING RADIATION; LIPID PEROXIDATION; LYMPHOCYTE COUNT; MEDICINAL PLANT; NONHUMAN; OCIMUM TENUIFLORUM; RADIATION DOSE; RADIATION EXPOSURE; RADIATION INJURY; RADIATION PROTECTION; RADIOSENSITIVITY; REVIEW; SURVIVAL RATE; SWEET CHERRY; SYZYGIUM CUMINI; UPREGULATION;

EID: 84883627979     PISSN: 09738258     EISSN: 19984103     Source Type: Journal    
DOI: 10.4103/0973-8258.116379     Document Type: Review

References (87)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin 2011;61:69-90.
2. Bray F, Møller B. Predicting the future burden of cancer. Nat Rev Cancer 2006;6:63-74. (Pubitemid 43053652)
3. Oehler C, Dickinson DJ, Broggini-Tenzer A, Hofstetter B, Hollenstein A, Riesterer O, et al. Current concepts for the combined treatment modality of ionizing radiation with anticancer agents. Curr Pharm Des 2007;13:519-35. (Pubitemid 46477755)
4. Kinsella TJ. Radiation oncology: Today and tomorrow. Front Oncol 2011;1:7.
5. Greenberger JS. Radioprotection. In Vivo 2009;23:323-36.
6. Rezvani M. Amelioration of the pathological changes induced by radiotherapy in normal tissues. J Pharm Pharmacol 2008;60:1037-48.
7. C Jagetia G. Radioprotective Potential of Plants and Herbs against the Effects of Ionizing Radiation. J Clin Biochem Nutr 2007;40:74-81. (Pubitemid 46623808)
8. Patt HM, Tyree EB, Straube RL, Smith DE. Cysteine Protection against X Irradiation. Science 1949;110:213-4.
9. Duraković A. Radioprotective agents in medicine. Arh Hig Rada Toksikol 1993;44:331-54. (Pubitemid 24141596)
10. Maisin Jr. Bacq and Alexander Award lecture - Chemical radioprotection: Past, present, and future prospects. Int J Radiat Biol 1998;73:443-50. (Pubitemid 28202118)
11. Cragg GM, Newman DJ, Snader KM. Natural products in drug discovery and development. J Nat Prod 1997;60:52-60. (Pubitemid 27052102)
12. Yuhas JM, Storer JB. Chemoprotection against three modes of radiation death in the mouse. Int J Radiat Biol Relat Stud Phys Chem Med 1969;15:233-7.
13. Brown DQ, Graham WJ 3rd, MacKenzie LJ, Pittock JW 3rd, Shaw LM. Can WR-2721 be improved upon? Pharmacol Ther 1988;39:157-68.
14. Jagetia GC, Baliga MS. Evaluation of the radioprotective effect of the leaf extract of Syzygium cumini (Jamun) in mice exposed to a lethal dose of gamma-irradiation. Nahrung 2003;47:181-5. (Pubitemid 37378700)
15. Jagetia GC, Baliga MS, Malagi KJ, Sethukumar Kamath M. The evaluation of the radioprotective effect of Triphala (an ayurvedic rejuvenating drug) in the mice exposed to gamma-radiation. Phytomedicine 2002;9:99-108. (Pubitemid 34297364)
16. Jagetia GC, Baliga MS, Aruna R, Rajanikant GK, Jain V. Effect of abana (a herbal preparation) on the radiation-induced mortality in mice. J Ethnopharmacol 2003;86:159-65. (Pubitemid 36542870)
17. Weiss JF, Landauer MR, Gunter-Smith PJ, Hanson WR. In: Dubois A, King GL, Livengood DR, editors. Effect of Radioprotective Agents on Survival After Acute Intestinal Radiation Injury. Radiation and the Gastrointestinal Tract. Boca Raton, FL: CRC Press; 1995. p. 183-99.
18. Malaker K. Clinical experience with radioprotectors. In: Bump EA, Malaker K, editors. Radioprotectors: Chemical, Biological and Clinical Perspective. Boca Raton, FL: CRC Press; 1998. p. 373-410.
19. Dai Y, Grant S. Targeting multiple arms of the apoptotic regulatory machinery. Cancer Res 2007;67:2908-11. (Pubitemid 46724822)
20. Gardai SJ, Bratton DL, Ogden CA, Henson PM. Recognition ligands on apoptotic cells: A perspective. J Leukoc Biol 2006;79:896-903. (Pubitemid 44835574)
21. Qiu W, Carson-Walter EB, Liu H, Epperly M, Greenberger JS, Zambetti GP, et al. PUMA regulates intestinal progenitor cell radiosensitivity and gastrointestinal syndrome. Cell Stem Cell 2008;2:576-83. (Pubitemid 351729214)
22. Winters M. Ancient medicine, modern use: Withania somnifera and its potential role in integrative oncology. Altern Med Rev 2006;11:269-77. (Pubitemid 46037128)
23. Hosny Mansour H, Farouk Hafez H. Protective effect of Withania somnifera against radiation-induced hepatotoxicity in rats. Ecotoxicol Environ Saf 2012;80:14-9.
24. Kuttan G. Use of Withania somnifera Dunal as an adjuvant during radiation therapy. Indian J Exp Biol 1996;34:854-6. (Pubitemid 26289496)
25. Baliga MS. Anticancer, chemopreventive and radioprotective potential of black plum (Eugenia jambolana lam.). Asian Pac J Cancer Prev 2011;12:3-15.
26. Goel A, Aggarwal BB. Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs. Nutr Cancer 2010;62:919-30.
27. Jagetia GC. Radioprotection and radiosensitization by curcumin. Adv Exp Med Biol 2007;595:301-20.
28. Nada AS, Hawas AM, Amin Nel-D, Elnashar MM, Abd Elmageed ZY. Radioprotective effect of Curcuma longa extract on γ-irradiation-induced oxidative stress in rats. Can J Physiol Pharmacol 2012;90:415-23.
29. Goel HC, Prem Kumar I, Rana SV. Free radical scavenging and metal chelation by Tinospora cordifolia, a possible role in radioprotection. Indian J Exp Biol 2002;40:727-34. (Pubitemid 34604543)
30. Rao SK, Rao PS, Rao BN. Preliminary investigation of the radiosensitizing activity of guduchi (Tinospora cordifolia) in tumor-bearing mice. Phytother Res 2008;22:1482-9. (Pubitemid 352789618)
31. Goel HC, Prasad J, Singh S, Sagar RK, Agrawala PK, Bala M, et al. Radioprotective potential of an herbal extract of Tinospora cordifolia. J Radiat Res 2004;45:61-8. (Pubitemid 38698650)
32. Monga J, Sharma M, Tailor N, Ganesh N. Antimelanoma and radioprotective activity of alcoholic aqueous extract of different species of Ocimum in C (57) BL mice. Pharm Biol 2011;49:428-36.
33. Joseph LJ, Bhartiya US, Raut YS, Hawaldar RW, Nayak Y, Pawar YP, et al. Radioprotective effect of Ocimum sanctum and amifostine on the salivary gland of rats after therapeutic radioiodine exposure. Cancer Biother Radiopharm 2011;26:737-43.
34. Uma Devi P, Ganasoundari A, Rao BS, Srinivasan KK. In vivo radioprotection by ocimum flavonoids: Survival of mice. Radiat Res 1999;151:74-8. (Pubitemid 29069348)
35. Kumar A, Ram J, Samarth RM, Kumar M. Modulatory influence of Adhatoda vasica Nees leaf extract against gamma irradiation in Swiss albino mice. Phytomedicine 2005;12:285-93. (Pubitemid 40471027)
36. Kumar M, Samarth R, Kumar M, Selvan SR, Saharan B, Kumar A. Protective effect of Adhatoda vascia Nees against radiation-induced damage at cellular, biochemical and chromosomal levels in Swiss albino mice. Evid Based Complement Alternat Med 2007;4:343-50.
37. Maharwal J, Samarth RM, Saini MR. Radiomodulatory influence of Rajgira (Amaranthus paniculatus) leaf extract in Swiss albino mice. Phytother Res 2003;17:1150-4. (Pubitemid 38057170)
38. Krishna A, Kumar A. Evaluation of radioprotective effects of Rajgira (Amaranthus paniculatus) extract in Swiss albino mice. J Radiat Res 2005;46:233-9. (Pubitemid 41190660)
39. Singh SP, Abraham SK, Kesavan PC. Radioprotection of mice following garlic pretreatment. Br J Cancer Suppl 1996;27:S102-4. (Pubitemid 26237939)
40. Sisodia R, Singh S, Mundotiya C, Meghnani E, Srivastava P. Radioprotection of Swiss albino mice by Prunus avium with special reference to hematopoietic system. J Environ Pathol Toxicol Oncol 2011;30:55-70.
41. Singh I, Sharma A, Nunia V, Goyal PK. Radioprotection of Swiss albino mice by Emblica officinalis. Phytother Res 2005;19:444-6. (Pubitemid 41285014)
42. Sharma M, Kumar M. Radioprotection of Swiss albino mice by Myristica fragrans houtt. J Radiat Res 2007;48:135-41. (Pubitemid 46535898)
43. Baliga MS, Bhat HP, Pereira MM, Mathias N, Venkatesh P. Radioprotective effects of Aegle marmelos (L.) Correa (Bael): A concise review. J Altern Complement Med 2010;16:1109-16.
44. Jagetia GC, Venkatesh P. Radioprotection by oral administration of Aegle marmelos (L.) Correa in vivo. J Environ Pathol Toxicol Oncol 2005;24:315-32.
45. Goyal PK, Gehlot P. Radioprotective effects of Aloe vera leaf extract on Swiss albino mice against whole-body gamma irradiation. J Environ Pathol Toxicol Oncol 2009;28:53-61.
46. Bakuridze AD, Nikolaev SM, Berashvili DT, Bakuridze KA, Tsomaia IV. Radio protective drug production from fresh leaves of Aloe arborescens Mill. Georgian Med News 2009;6:80-3.
47. Baliga MS, Rao S. Radioprotective potential of mint: A brief review. J Cancer Res Ther 2010;6:255-62.
48. Samarth RM, Samarth M. Protection against radiation-induced testicular damage in Swiss albino mice by Mentha piperita (Linn.). Basic Clin Pharmacol Toxicol 2009;104:329-34.
49. Samarth RM. Protection against radiation induced hematopoietic damage in bone marrow of Swiss albino mice by Mentha piperita (Linn). J Radiat Res 2007;48:523-8. (Pubitemid 350211129)
50. Bhatia AL, Jain M. Spinacia oleracea L. protects against gamma radiations: A study on glutathione and lipid peroxidation in mouse liver. Phytomedicine 2004;11:607-15. (Pubitemid 40007743)
51. Manu KA, Leyon PV, Kuttan G. Studies on the protective effects of Boerhaavia diffusa L. against gamma radiation induced damage in mice. Integr Cancer Ther 2007;6:381-8. (Pubitemid 350136019)
52. Pereira MM, Haniadka R, Chacko PP, Palatty PL, Baliga MS. Zingiber officinale Roscoe (ginger) as an adjuvant in cancer treatment: A review. J BUON 2011;16:414-24.
53. Baliga MS, Haniadka R, Pereira MM, Thilakchand KR, Rao S, Arora R. Radioprotective effects of Zingiber officinale Roscoe (ginger): Past, present and future. Food Funct 2012;3:714-23.
54. Kumar A, Rao AR, Kimura H. Radiosensitizing effects of neem (Azadirachta indica) oil. Phytother Res 2002;16:74-7. (Pubitemid 34116701)
55. Verma S, Gupta ML, Dutta A, Sankhwar S, Shukla SK, Flora SJ. Modulation of ionizing radiation induced oxidative imbalance by semi-fractionated extract of Piper betle: An in vitro and in vivo assessment. Oxid Med Cell Longev 2010;3:44-52.
56. Sinha M, Das DK, Datta S, Ghosh S, Dey S. Amelioration of ionizing radiation induced lipid peroxidation in mouse liver by Moringa oleifera Lam. leaf extract. Indian J Exp Biol 2012;50:209-15.
57. Sinha M, Das DK, Bhattacharjee S, Majumdar S, Dey S. Leaf extract of Moringa oleifera prevents ionizing radiation-induced oxidative stress in mice. J Med Food 2011;14:1167-72.
58. Guruvayoorappan C, Kuttan G. Protective effect of Biophytum sensitivum (L.) DC on radiation-induced damage in mice. Immunopharmacol Immunotoxicol 2008;30:815-35.
59. Joy J, Nair CK. Protection of DNA and membranes from gamma-radiation induced damages by Centella asiatica. J Pharm Pharmacol 2009;61:941-7.
60. Jagetia GC, Venkatesha VA. Treatment of mice with stem bark extract of Aphanamixis polystachya reduces radiation-induced chromosome damage. Int J Radiat Biol 2006;82:197-209.
61. Thakur I, Devi PU, Bigoniya P. Protection against radiation clastogenecity in mouse bone marrow by Phyllanthus niruri. Indian J Exp Biol 2011;49:704-10.
62. Chawla R, Jaiswal S, Kumar R, Arora R, Sharma RK. Himalayan Bioresource Rhodiola imbricata as a promising radioprotector for nuclear and radiological emergencies. J Pharm Bioallied Sci 2010;2:213-9.
63. Mishra KP, Ganju L, Singh SB. Anti-cellular and immunomodulatory potential of aqueous extract of Rhodiola imbricata rhizome. Immunopharmacol Immunotoxicol 2012;34:513-8.
64. Goel HC, Bala M, Prasad J, Singh S, Agrawala PK, Swahney RC. Radioprotection by Rhodiola imbricata in mice against whole-body lethal irradiation. J Med Food 2006;9:154-60. (Pubitemid 44036103)
65. Lata M, Prasad J, Singh S, Kumar R, Singh L, Chaudhary P, et al. Whole body protection against lethal ionizing radiation in mice by REC-2001: A semi-purified fraction of Podophyllum hexandrum. Phytomedicine 2009;16:47-55.
66. Sharma KV, Sisodia R. Evaluation of the free radical scavenging activity and radioprotective efficacy of Grewia asiatica fruit. J Radiol Prot 2009;29:429-43.
67. Sisodia R, Singh S, Sharma KV, Ahaskar M. Post treatment effect of Grewia asiatica against radiation-induced biochemical alterations in Swiss albino mice. J Environ Pathol Toxicol Oncol 2008;27:113-21. (Pubitemid 351860417)
68. Zhong YH, Han G, Zhou YF, Peng M, Xie CH, Zhou FX, et al. Protection of Angelica sinensis against radiation-induced pulmonary fibrosis in mice. Zhonghua Yu Fang Yi Xue Za Zhi 2007;41:105-9.
69. You WC, Lin WC, Huang JT, Hsieh CC. Indigowood root extract protects hematopoietic cells, reduces tissue damage and modulates inflammatory cytokines after total-body irradiation: Does Indirubin play a role in radioprotection? Phytomedicine 2009;16:1105-11.
70. You WC, Hsieh CC, Huang JT. Effect of extracts from indigowood root (Isatis indigotica Fort.) on immune responses in radiation-induced mucositis. J Altern Complement Med 2009;15:771-8.
71. Benavente-García O, Castillo J, Lorente J, Alcaraz M. Radioprotective effects in vivo of phenolics extracted from Olea europaea L. leaves against X-ray-induced chromosomal damage: Comparative study versus several flavonoids and sulfur-containing compounds. J Med Food 2002;5:125-35. (Pubitemid 35283417)
72. Jindal A, Agrawal A, Goyal PK. Influence of Rosemarinus officinalis extract on radiation-induced intestinal injury in mice. J Environ Pathol Toxicol Oncol 2010;29:169-79.
73. Soyal D, Jindal A, Singh I, Goyal PK. Modulation of radiation-induced biochemical alterations in mice by rosemary (Rosemarinus officinalis) extract. Phytomedicine 2007;14:701-5. (Pubitemid 47419297)
74. Jindal A, Soyal D, Sancheti G, Goyal PK. Radioprotective potential of Rosemarinus officinalis against lethal effects of gamma radiation: A preliminary study. J Environ Pathol Toxicol Oncol 2006;25:633-42.
75. Sancheti G, Goyal PK. Prevention of radiation induced hematological alterations by medicinal plant Rosmarinus officinalis, in mice. Afr J Tradit Complement Altern Med 2006;4:165-72. (Pubitemid 46431955)
76. Adaramoye OA, Okiti OO, Farombi EO. Dried fruit extract from Xylopia aethiopica (Annonaceae) protects Wistar albino rats from adverse effects of whole body radiation. Exp Toxicol Pathol 2011;63:635-43.
77. Adaramoye OA, Popoola BO, Farombi EO. Effects of Xylopia aethiopica (Annonaceae) fruit methanol extract on gamma-radiation-induced oxidative stress in brain of adult male Wistar rats. Acta Biol Hung 2010;61:250-61.
78. Adaramoye OA, Adedara IA, Popoola B, Farombi EO. Extract of Xylopia aethiopica (Annonaceae) protects against gamma-radiation induced testicular damage in Wistar rats. J Basic Clin Physiol Pharmacol 2010;21:295-313.
79. Sureshbabu AV, Barik TK, Namita I, Prem Kumar I. Radioprotective properties of Hippophae rhamnoides (sea buckthorn) extract in vitro. Int J Health Sci (Qassim) 2008;2:45-62.
80. Jagetia GC, Shirwaikar A, Rao SK, Bhilegaonkar PM. Evaluation of the radioprotective effect of Ageratum conyzoides Linn. extract in mice exposed to different doses of gamma radiation. J Pharm Pharmacol 2003;55:1151-8. (Pubitemid 36998657)
81. Eder-Czembirek C, Erovic BM, Czembirek C, Brunner M, Selzer E, Pötter R, et al. Betulinic acid a radiosensitizer in head and neck squamous cell carcinoma cell lines. Strahlenther Onkol 2010;186:143-8.
82. Sheehan J, Ionescu A, Pouratian N, Hamilton DK, Schlesinger D, Oskouian RJ Jr, et al. Use of trans sodium crocetinate for sensitizing glioblastoma multiforme to radiation: Laboratory investigation. J Neurosurg 2008;108:972-8. (Pubitemid 351656846)
83. Kumar B, Kumar A, Pandey BN, Hazra B, Mishra KP. Increased cytotoxicity by the combination of radiation and diospyrin diethylether in fibrosarcoma in culture and in tumor. Int J Radiat Biol 2008;84:429-40. (Pubitemid 351878846)
84. Garg AK, Buchholz TA, Aggarwal BB. Chemosensitization and radiosensitization of tumors by plant polyphenols. Antioxid Redox Signal 2005;7:1630-47. (Pubitemid 41767998)
85. Arora R, Gupta D, Chawla R, Sagar R, Sharma A, Kumar R, et al. Radioprotection by plant products: Present status and future prospects. Phytother Res 2005;19:1-22. (Pubitemid 40444988)
86. Hosseinimehr SJ. Trends in the development of radioprotective agents. Drug Discov Today 2007;12:794-805. (Pubitemid 47539965)
87. Maurya DK, Devasagayam TP, Nair CK. Some novel approaches for radioprotection and the beneficial effect of natural products. Indian J Exp Biol 2006;44:93-114. (Pubitemid 43224071)