Modulation of ionizing radiation induced oxidative imbalance by semi-fractionated extract of Piper betle: An in vitro and in vivo assessment

Oxidative Medicine and Cellular Longevity

Volumn 3, Issue 1, 2010, Pages 44-52

  Verma, Savita ^a   Gupta, Manju Lata ^a   Dutta, Ajaswrata ^a   Sankhwar, Sanghmitra ^a   Shukla, Sandeep Kumar ^a   Flora, Swaran J S ^b  

^a INSTITUTE OF NUCLEAR MEDICINE AND ALLIED SCIENCES   (India)

^b DEFENCE RESEARCH AND DEVELOPMENT ESTABLISHMENT   (India)

Author keywords

Glutathione; Ionizing radiation; Lipid peroxidation; Oxidative stress; Piper betle

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; BETEL EXTRACT; GLUTATHIONE; LIPID; METAL CHELATE; SCAVENGER; SUPEROXIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; AQUEOUS SOLUTION; ARTICLE; BODY WEIGHT; CANCER RADIOTHERAPY; CHELATION; CONTROLLED STUDY; DRUG EFFICACY; ENZYME INHIBITION; FEMALE; FERRIC REDUCING ANTIOXIDANT PROPERTY; IN VITRO STUDY; IN VIVO STUDY; IONIZING RADIATION; LIPID PEROXIDATION; MICRONUCLEUS; MOUSE; NONHUMAN; OXIDATIVE STRESS; PIPER BETLE; PLASMA; RADIATION DOSE; RADIATION DOSE FRACTIONATION; RADIATION EXPOSURE; SCAVENGING SYSTEM; THYMUS; TISSUE INJURY;

MUS; PIPER BETLE;

EID: 77953472092     PISSN: 19420900     EISSN: 19420994     Source Type: Journal    
DOI: 10.4161/oxim.3.1.10349     Document Type: Article

References (36)

1. Hosseinimehr SJ. Trends in the development of radioprotective agents. Drug Discov Today 2007; 12:794-805.
2. Jagetia GC. Radioprotective potential of plants and herbs against the effects of ionizing radiation. J Clin Biochem Nutr 2007; 40:74-81.
3. Ozsachin M, Betz M, Matzinger O, Bron L, Luthi F, Pasche P, et al. Feasibility and efficacy of subcutaneous amifostine therapy in patients with head and neck cancer treated with curative accelerated concomitant-boost radiation therapy. Arch Otolaryngol Head Neck Surg 2006; 132:141-5.
4. Adhikary P, Banerji J, Chowdhury D, Das AK, Deb CC, Mukherjee SR, Chatterjee A. Antifertility effect of Piper betle Linn. extract on overy and testis of albino rats. Ind J Exp Biol 1989; 27:868-70.
5. Choudhury D, Kale RK. Antioxidant and nontoxic properties of Piper betle leaf extract: in-vitro and in-vivo studies. Phytother Res 2002; 16:461-6.
6. Sankaranarayanan K. Estimation of the genetic risks of exposure to ionizing radiation in human: Current status and emerging perspectives. J Radiat Res 2006; 47:57-66.
7. Gems D, Partridge L. Stress-response hormesis and aging: that which does not kill us makes us stronger. Cell Metab 2008; 7:200-3.
8. Nikola G. Anti-ageing and ageing factors in life: The role of free radicals. Radiat Phys Chem 2007; 76:1577-86.
9. Chatterjee A, Pakrashi SC. In: Treatise of Indian Medicinal Plants, CSIR Publication New Delhi 1995; 1:26-35.
10. Prabhu MS, Platel K, Saraswhati G, Srinivasan K. Effect of orally administered betel leaf (Piper betle Linn.) on digestive enzymes of pancreas and intestinal mucosa and on the bile production in rats. Ind J Exp Biol 1995; 33:752-6.
11. Saravanan R, Prakasam A, Ramesh B, Pugalendi KV. Influence of Piper betle on hepatic marker enzymes and tissue antioxidant status in ethanol treated Wister rats. J Med Food 2002; 5:197-204.
12. Kanjwani DG, Marathe TP, Chiplunkar SV, Sathaye SS. Evaluation of immunomodulatory activity of methanolic extract of Piper. Scand J Immunol 2008; 67:589-93.
13. Bhattacharya S, Subramanian M, Roychowdhury S, Bauri KA, Kamat JP, Chattopadhyay S, Bandyopadhyay SK. Radioprotective property of the ethanolic extract of Piper betel leaf. J Radiat Res 2005; 46:165-71.
14. Dasgupta N, Bratati De. Antioxidant activity of Piper betle L. leaf extract in vitro. Food Chem 2004; 88:219-24.
15. Patel JM. A review of potential health benefits of flavonoids. Lethbridge Undergrad Res J 2008; 3.
16. Agbor Gabriel A, Vinson Joe A, Oben Julius E, Ngogang Jeanne Y. In vitro antioxidant activity of three Piper species. J Herb Pharmacother 2007; 7:49-64.
17. Flora SJS. Structural, chemical and biological aspects of antioxidants for strategies against metal and metalloid exposure. Oxid Med Cell Longev 2009; 3:191-206.
18. Flora SJS, Chouhan S, Kannan GM, Mittal M, Swarnakar H. Combined administration of taurine and monoisoamyl DMSA protects arsenic induced oxidative injury in rats. Oxid Med Cell Longev 2008; 1:39-45.
19. Amonkar AJ, Nagabhushan M, D'Souza AV, Bhide SV. Hydroxychavicol: a new phenolic antimutagen from Betel leaf. Fd Chem Toxicol 1986; 24:1321-4.
20. Sisodia R, Yadav RK, Sharma KV, Bhatia AL. Spinacia oleracea modulates radiation-induced biochemical changes in mice testis. Ind J Pharmaceut Sci 2008; 70:320-6.
21. Gupta ML, Sankhwar S, Verma S, Devi M, Samanta N, Agrawala PK, et al. Whole body protection to lethally irradiated mice by oral administration of semipurified fraction of Podophyllum hexandrum and post irradiation treatment of Picrorhiza kurroa. Tokai J Exp Clin Med 2008; 33:6-12.
22. Goel HC, Agrawala PK, Pathania V, Malhotra N. Immunomodulatory and cytoprotective role of RP-1 in γ-radiated mice. Mol Cell Biochem 2003; 254:73-81.
23. Dlugosz A, Lembas-Bogaczyk J, Lamer-Zarawska E. Antoxid increases ferric reducing antioxidant power (FRAP) even stronger than vitamin C. Acta Pol Pharm 2006; 63:446-8.
24. Bhartiya US, Raut YS, Joseph LJ, Hawaldar RW, Rao BS. Evaluation of the radioprotective effect of turmeric extract and vitamin E in mice exposed to therapeutic dose of radioiodine. Ind J Clin Biochem 2008; 32:382-6.
25. Hosseinimehr SJ, Nemati A. Radioprotective effects of hesperidin against gamma irradiation in mouse bone marrow cells. Br J Radiol 2006; 79:415-8.
26. McDonald S, Prenzler PD, Autolovich M, Robards K. Phenolic content and antioxidant activity of olive extracts. Food Chem 2000; 73:73-84.
27. Zhishen J, Mengcheng T, Jianming W. The determination of flavonoid content in mulberry and their scavenging effects on superoxide radicals. Fd Chem 1999; 64:555-9.
28. Koleva II, Van Beek TA, Linssen JPH, de Groot A, Evstatieva LN. Screening of plants extracts for antioxidant activity: a comparative study on three testing methods. Phytochem Anal 2002; 13:8-17.
29. Govindrarajan R, Vijayakumar M, Rawat AKS, Mehrotra S. Free radical scavenging potential of Picrorhiza kurrooa Royle ex Benth. Ind J Exp Biol 2003; 41:875-9.
30. Benzie IIF, Strain JJ. The ferric reducing ability of plasma (FRAP) as a measure of antioxidant power: the FRAP assay. Anal Biochem 1996; 239:70-6.
31. Oyaizu M. Anti-oxidative activity of browning products of glucosamine fractionated by organic solvent and thin layer chromatography. Nippon Shokuhin Kogyo Gakkaishi 1986; 35:771-5.
32. John A, Steven DA. Microsomal lipid peroxidation. Methods Enzymol 1984; 30:302-8.
33. Beuege JA, Aust SD. Microsomal lipid peroxidation. Methods Enzymol 1978; 30:302-10.
34. Beutler EUR. Reduced glutathione-GSH, u: Beutler E. (ur.) Red cell metabolism: A manual of biochemical methods, New York: Grane and Straton 1975.
35. Chaubey RC, Bhilwade HN, Joshi BN, Chauhan PS. Studies on migration of micronucleated erythrocytes from bone marrow to the peripheral blood in irradiated swiss mice. Int J Radiat Biol 1993; 63:239-45.
36. Bradford M. A rapid and sensitive method for the quantitation of microgram quatities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72:248-54.