Studies on the protective effects of Boerhaavia diffusa L. against gamma radiation-induced damage in mice

Integrative Cancer Therapies

Volumn 6, Issue 4, 2007, Pages 381-388

  Manu, K A ^a   Leyon, P V ^a   Kuttan, Girija ^a  

^a AMALA CANCER RESEARCH CENTRE   (India)

Author keywords

esterase; Alkaline phosphatase; B. diffusa; Glutamate pyruvate transferase; Immunomodulation; Lipid peroxidation; Oxidative stress; Radioprotectors; Reduced glutathione

Indexed keywords

ALANINE AMINOTRANSFERASE; ALCOHOL; ALKALINE PHOSPHATASE; BOERHAAVIA DIFFUSA EXTRACT; DNA; GLUTATHIONE; PLANT EXTRACT; UNCLASSIFIED DRUG;

AGAR GEL ELECTROPHORESIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MARROW; CELL MATURATION; CLINICAL STUDY; CONTROLLED STUDY; DNA DAMAGE; DRUG EFFECT; GAMMA RADIATION; IN VIVO STUDY; LEUKOCYTE COUNT; LIPID PEROXIDATION; LIVER TOXICITY; MALE; MONOCYTE; MOUSE; NONHUMAN; NYCTAGINACEAE; PRIORITY JOURNAL; RADIATION DOSE; SUSTAINED RELEASE PREPARATION; WHOLE BODY RADIATION;

ALKALINE PHOSPHATASE; ANIMALS; BONE MARROW; BONE MARROW CELLS; DNA DAMAGE; ESTERASES; GAMMA RAYS; GLUTATHIONE; INTESTINAL MUCOSA; LEUKOCYTE COUNT; LEUKOCYTES; LIPID PEROXIDATION; LIPID PEROXIDES; LIVER; MALE; MICE; NYCTAGINACEAE; OXIDATIVE STRESS; PHYTOTHERAPY; PLANT EXTRACTS; RADIATION INJURIES, EXPERIMENTAL; RADIATION-PROTECTIVE AGENTS; TRANSAMINASES; WHOLE-BODY IRRADIATION;

EID: 36248978668     PISSN: 15347354     EISSN: 1552695X     Source Type: Journal    
DOI: 10.1177/1534735407309743     Document Type: Article

References (37)

1. Thalmeier K., Meissner P., Reisbach G., et al. Constitutive and modulated cytokine expression in two permanent human bone marrow stromal cell lines. Exp Hematol. 1996 ; 24: 1-10.
2. Yarmonenko SP Changes in gastrointestinal renewal system. In: Yarmonenko SP, ed. Radiobiology of Humans and Animals. Moscow, Russia: Mir Publishers ; 1998: 130-137.
3. Nair CKK, Parida, DK, Nomura T. Radioprotectors in radiotherapy. J Radiat Res. 2001 ; 42: 21-37.
4. Von Sonnlag C. The Chemical Basis of Radiation Biology. London: Francis & Taylor ; 1987.
5. Spotheim-Maurizot M., Garnier F., Sabattier R., Charlier M. Metal ions protect DNA against strand breakage induced by fast neutrons. Int J Radiat Biol. 1992 ; 62: 659-666.
6. Agrawal A., Kale RK Radiation induced peroxidative damage: mechanism and significance. Ind J Exp Biol. 2001 ; 39: 291-309.
7. Pandey BN, Mishra KP Fluorescence and ESR studies on membrane oxidative damage by γ-radiation. Appl Magn Reson. 2000 ; 18: 483-492.
8. Mittal A., Pathania V., Agrawala PK, Prasad J., Singh S., Goel HC Influence of Podophyllum hexandrum on endogenous antioxidant defense system in mice: possible role in radioprotection. J Ethnopharmacol. 2001 ; 76: 253-262.
9. Miura Y., Anzai K., Ueda J., Ozawa T. Novel approach to in vivo screening for radioprotective activity in whole mice: in vivo electron spin resonance study probing the redox reaction of nitroxyl. J Radiat Res. 2000 ; 41: 103-111.
10. Maisin JR, Albert C., Henry A. Reduction of short term radiation lethality by biological response modifiers given alone or in association with other chemical protectors. Radiat Res. 1993 ; 135: 332-337.
11. Hiruma-Lima CA, Gracioso JS, Bighetti EJ, Germonsen RL, SouzaBrito AR The juice of fresh leaves of Boerhaavia diffusa L. (Nyctaginaceae) markedly reduces pain in mice. J Ethnopharmacol. 2000 ; 71: 267-274.
12. Mungantiwar AA, Nair AM, Shinde UA, et al. Studies on the immunomodulatory effects of Boerhaavia diffusa alkaloidal fraction. J Ethnopharmacol. 1999 ; 65: 125-131.
13. Rawat AK, Mehrotra S., Tripathi SC, Shome U. Hepatoprotective activity of Boerhaavia diffusa L. roots: a popular Indian ethnomedicine. J Ethnopharmacol. 1997 ; 51: 61-66.
14. Chandan BK, Sharma AK, Anand KK Boerhaavia diffusa: a study of its hepatoprotective activity. J Ethnopharmacol. 1991 ; 31: 299-307.
15. Mehrotra S., Singh VK, Agarwal SS, Maurya R., Srimal RC Antilymphoproliferative activity of ethanolic extract of Boerhaavia diffusa roots. Exp Mol Pathol. 2002 ; 72: 236-242.
16. Ene Obong EE, Amadi OC Contribution to the cytological effects of medicinal plants: I. The mitodepressive effects of water extracts of Boerhaavia diffusa and Vernonia amygdalina on Allium cepa root tip mitosis. Cytologia. 1987 ; 52: 469-474.
17. Cheesbrough M., MacArthur J. A Laboratory Manual for Rural Tropical Hospitals. London: Churchill Livingstone ; 1976.
18. Drabkin DS, Austin JH Spectrophotometric constants for common hemoglobin derivatives in human dog and rabbit blood. J Biol Chem. 1932 ; 98: 719-733.
19. King EJ, Armstrong AR Methods of King and Armstrong. In: Varley H, Gowenlock AH, Bell M, eds. Practical Clinical Biochemistry. 5 th ed. London: Heinemann ; 1980: 897.
20. Bergmeyer HO, Bernt E. Calorimetric method for aspartate and alkaline aminotransferases. In: Varley H, Gowenlock AH, Bell M, eds. Practical Clinical Biochemistry. 5 th ed. London: Heinemann ; 1980: 741-742.
21. Ohkawa H., Ohishi N., Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1979 ; 95: 351-358.
22. Moron MA, Depierre JW, Mannervick B. Levels of glutathione reductase and glutathione-S-transferase activities in rat lung and liver. Biochim Biophys Acta. 1979 ; 582: 67-68.
23. Bancroft JD, Cook HF A Manual of Histologic Technique. London: Churchill Livingston ; 1984.
24. Kalechman Y., Albeck M., Oran M., et al. Radioprotective effects of the immunomodulator AS101. J Immunol. 1990 ; 145: 1512-1517.
25. Neta R., Vogel SN, Oppenhein JJ, Douohas SD Cytokines in radioprotection: comparison of radioprotective effects of IL-1 to IL-2, GM-CSF and IFN-gamma. Lymphokine Res. 1986 ; 5: 103-110.
26. Swartz GN, Neta R., Vigneulle RM, Patchen ML, MacVittie TJ Recovery of hematopoietic colony forming cells in irradiated mice pre-treated with interleukin (IL-1). Exp Hematol. 1988 ; 16: 752-755.
27. Fridovich I. The biology of oxygen radicals. Science. 1978 ; 201: 875-880.
28. Samarnath RM, Kumar A. Mentha piperita leaf extract provides protection against radiation induced chromosomal damage in bone marrow of mice. Ind J Exp Biol. 2003 ; 41: 229-237.
29. Halliwell B., Gutteridge JMC. Free Radicals in Biology and Medicine. 3 rd ed. Oxford, UK: Oxford Science Publications ; 2000.
30. Molander DW, Wroblewski F., La Due JS Transaminase compared with cholinesterase and alkaline phosphatase an index of hepatocellular integrity. Clin Res Proc. 1955 ; 3: 20-24.
31. Zimmerman HJ, Seef LB Enzymes in hepatic disease. In: Goodly EL, ed. Diagnostic Enzymology. Philadelphia: Lea & Febiger ; 1970.
32. Gracy RW, Talent JM, Kong Y., Conard CC Reactive oxygen species: the unavoidable environmental insult? Mut Res. 1999 ; 428: 17-22.
33. Sridharan S., Syamaladevi LC Protective effect of N-acetylcysteine against gamma ray induced damage in rats: biochemical evaluations. Ind J Exp Biol. 2002 ; 40: 181-186.
34. Bump EA, Brown JM Role of glutathione in the radiation response of mammalian cells in vitro and in vivo. Pharmacol Ther. 1990 ; 47: 117-136.
35. Sreekanth KS, Sabu MC, Varghese L., Manesh C., Kuttan G., Kuttan R. Antioxidant activity of Smoke Shield in vitro and in vivo. J Pharm Pharmacol. 2003 ; 55: 847-853.
36. Bisht KS, Prabhu S., Uma Devi P. Modification of radiation induced damages in mouse intestine by WR-2721. Ind J Expt Biol. 2000 ; 38: 669-674.
37. Belli M., Sapora O., Tabocchini MA Molecular targets in cellular response to ionizing radiation and implications in space radiation protection. J Radiat Res. 2002 ; 43: 13-19.