Mannose-Binding Lectin Inhibits Monocyte Proliferation through Transforming Growth Factor-β1 and p38 Signaling Pathways

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  Wang, Yan ^a,b   Chen, A De ^a   Lei, Yan Mei ^a   Shan, Gui Qiu ^a   Zhang, Li Yun ^a   Lu, Xiao ^a   Chen, Zheng Liang ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b GUANGDONG MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 [4 (1,3 BENZODIOXOL 5 YL) 5 (2 PYRIDINYL) 1H IMIDAZOL 2 YL]BENZAMIDE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CASPASE 3; CYCLIN D1; CYCLIN D3; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE INHIBITOR 1; MANNOSE BINDING LECTIN; SYNAPTOPHYSIN; TRANSFORMING GROWTH FACTOR BETA1;

ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; MONOCYTE; PHARMACOLOGICAL BLOCKING; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; UPREGULATION;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CASPASE 3; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; G1 PHASE CELL CYCLE CHECKPOINTS; GENE EXPRESSION REGULATION; HUMANS; IMIDAZOLES; MANNOSE-BINDING LECTIN; MAP KINASE SIGNALING SYSTEM; MONOCYTES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN BINDING; PYRIDINES; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84883606852     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0072505     Document Type: Article

References (39)

1. Eikelenboom P, van Exel E, Veerhuis R, Rozemuller AJ, van Gool WA, et al. (2012) Innate immunity and the etiology of late-onset Alzheimer's disease. Neurodegener Dis 10: 271-273.
2. Deretic V, (2009) Links between autophagy, innate immunity, inflammation and Crohn's disease. Dig Dis 27: 246-251.
3. Pardee AB, (1989) G1 events and regulation of cell proliferation. Science 246: 603-608.
4. Parihar A, Eubank TD, Doseff AI, (2010) Monocytes and macrophages regulate immunity through dynamic networks of survival and cell death. J Innate Immun 2: 204-215.
5. Heitzeneder S, Seidel M, Forster-Waldl E, Heitger A, (2012) Mannan-binding lectin deficiency - Good news, bad news, doesn't matter? Clin Immunol 143: 22-38.
6. Fraser IP, Koziel H, Ezekowitz RA, (1998) The serum mannose-binding protein and the macrophage mannose receptor are pattern recognition molecules that link innate and adaptive immunity. Semin Immunol 10: 363-372.
7. Pradhan V, Surve P, Ghosh K, (2010) Mannose binding lectin (MBL) in autoimmunity and its role in systemic lupus erythematosus (SLE). J Assoc Physicians India 58: 688-690.
8. Witte CE, Archer KA, Rae CS, Sauer JD, Woodward JJ, et al. (2012) Innate immune pathways triggered by Listeria monocytogenes and their role in the induction of cell-mediated immunity. Adv Immunol 113: 135-156.
9. Pasare C, Medzhitov R, (2004) Toll-like receptors: linking innate and adaptive immunity. Microbes Infect 6: 1382-1387.
10. Fraser DA, Tenner AJ, (2010) Innate immune proteins C1q and mannan-binding lectin enhance clearance of atherogenic lipoproteins by human monocytes and macrophages. J Immunol 185: 3932-3939.
11. Wang M, Zhang Y, Chen Y, Zhang L, Lu X, et al. (2011) Mannan-binding lectin regulates dendritic cell maturation and cytokine production induced by lipopolysaccharide. BMC Immunol 12: 1.
12. Takahashi K, Gordon J, Liu H, Sastry KN, Epstein JE, et al. (2002) Lack of mannose-binding lectin-A enhances survival in a mouse model of acute septic peritonitis. Microbes Infect 4: 773-784.
13. MacDonald SL, Downing I, Atkinson AP, Gallagher RC, Turner ML, et al. (2010) Dendritic cells previously exposed to mannan-binding lectin enhance cytokine production in allogeneic mononuclear cell cultures. Hum Immunol 71: 1077-1083.
14. Tan SM, Chung MC, Kon OL, Thiel S, Lee SH, et al. (1996) Improvements on the purification of mannan-binding lectin and demonstration of its Ca(2+)-independent association with a C1s-like serine protease. Biochem J 319 (Pt 2): 329-332.
15. Dumestre-Perard C, Ponard D, Arlaud GJ, Monnier N, Sim RB, et al. (2002) Evaluation and clinical interest of mannan binding lectin function in human plasma. Mol Immunol 39: 465-473.
16. Downing I, MacDonald SL, Turner ML, Kilpatrick DC, (2005) Detection of an autologous ligand for mannan-binding lectin on human B lymphocytes. Scand J Immunol 62: 507-514.
17. MacDonald SL, Downing I, Turner M, Kilpatrick DC, (2008) Is mannan-binding lectin (MBL) detectable on monocytes and monocyte-derived immature dendritic cells? Biochem Soc Trans 36: 1497-1500.
18. Wang M, Chen Y, Zhang Y, Zhang L, Lu X, et al. (2011) Mannan-binding lectin directly interacts with Toll-like receptor 4 and suppresses lipopolysaccharide-induced inflammatory cytokine secretion from THP-1 cells. Cell Mol Immunol 8: 265-275.
19. Truong LN, Wu X, (2011) Prevention of DNA re-replication in eukaryotic cells. J Mol Cell Biol 3: 13-22.
20. Nigg EA, (1995) Cyclin-dependent protein kinases: key regulators of the eukaryotic cell cycle. Bioessays 17: 471-480.
21. Owa T, Yoshino H, Yoshimatsu K, Nagasu T, (2001) Cell cycle regulation in the G1 phase: a promising target for the development of new chemotherapeutic anticancer agents. Curr Med Chem 8: 1487-1503.
22. Sherr CJ, Roberts JM, (1995) Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev 9: 1149-1163.
23. Martin-Caballero J, Flores JM, Garcia-Palencia P, Collado M, Serrano M, (2004) Different cooperating effect of p21 or p27 deficiency in combination with INK4a/ARF deletion in mice. Oncogene 23: 8231-8237.
24. Yao G, Yang L, Hu Y, Liang J, Hou Y, (2006) Nonylphenol-induced thymocyte apoptosis involved caspase-3 activation and mitochondrial depolarization. Mol Immunol 43: 915-926.
25. Gasser O, Schifferli JA, (2004) Activated polymorphonuclear neutrophils disseminate anti-inflammatory microparticles by ectocytosis. Blood 104: 2543-2548.
26. Yingling JM, Blanchard KL, Sawyer JS, (2004) Development of TGF-beta signalling inhibitors for cancer therapy. Nat Rev Drug Discov 3: 1011-1022.
27. Halder SK, Beauchamp RD, Datta PK, (2005) A specific inhibitor of TGF-beta receptor kinase, SB-431542, as a potent antitumor agent for human cancers. Neoplasia 7: 509-521.
28. Meloche S, Pouyssegur J, (2007) The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition. Oncogene 26: 3227-3239.
29. Crawley JB, Rawlinson L, Lali FV, Page TH, Saklatvala J, et al. (1997) T cell proliferation in response to interleukins 2 and 7 requires p38MAP kinase activation. J Biol Chem 272: 15023-15027.
30. Ma Y, Uemura K, Oka S, Kozutsumi Y, Kawasaki N, et al. (1999) Antitumor activity of mannan-binding protein in vivo as revealed by a virus expression system: mannan-binding proteindependent cell-mediated cytotoxicity. Proc Natl Acad Sci U S A 96: 371-375.
31. Hong Q, Sze CI, Lin SR, Lee MH, He RY, et al. (2009) Complement C1q activates tumor suppressor WWOX to induce apoptosis in prostate cancer cells. PLoS One 4: e5755.
32. Farber K, Cheung G, Mitchell D, Wallis R, Weihe E, et al. (2009) C1q, the recognition subcomponent of the classical pathway of complement, drives microglial activation. J Neurosci Res 87: 644-652.
33. Thery C, Boussac M, Veron P, Ricciardi-Castagnoli P, Raposo G, et al. (2001) Proteomic analysis of dendritic cell-derived exosomes: a secreted subcellular compartment distinct from apoptotic vesicles. J Immunol 166: 7309-7318.
34. Linker R, Gold R, Luhder F, (2009) Function of neurotrophic factors beyond the nervous system: inflammation and autoimmune demyelination. Crit Rev Immunol 29: 43-68.
35. Savill J, Dransfield I, Gregory C, Haslett C, (2002) A blast from the past: clearance of apoptotic cells regulates immune responses. Nat Rev Immunol 2: 965-975.
36. Turner MW, Hamvas RM, (2000) Mannose-binding lectin: structure, function, genetics and disease associations. Rev Immunogenet 2: 305-322.
37. Thiel S, Holmskov U, Hviid L, Laursen SB, Jensenius JC, (1992) The concentration of the C-type lectin, mannan-binding protein, in human plasma increases during an acute phase response. Clin Exp Immunol 90: 31-35.
38. Schafranski MD, Stier A, Nisihara R, Messias-Reason IJ, (2004) Significantly increased levels of mannose-binding lectin (MBL) in rheumatic heart disease: a beneficial role for MBL deficiency. Clin Exp Immunol 138: 521-525.
39. Hansen TK, Thiel S, Knudsen ST, Gravholt CH, Christiansen JS, et al. (2003) Elevated levels of mannan-binding lectin in patients with type 1 diabetes. J Clin Endocrinol Metab 88: 4857-4861.