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Volumn 12, Issue SUPPL.5, 2011, Pages

The BioAssay network and its implications to future therapeutic discovery

Author keywords

[No Author keywords available]

Indexed keywords

BASIC CHEMICALS; BIOLOGICAL DATABASE; BIOLOGICAL NETWORKS; MOLECULAR LIBRARIES; NETWORK BIOLOGY; POTENTIAL DRUG TARGETS; SMALL MOLECULES; TECHNOLOGY DEVELOPMENT;

EID: 79960741740     PISSN: None     EISSN: 14712105     Source Type: Journal    
DOI: 10.1186/1471-2105-12-S5-S1     Document Type: Article
Times cited : (24)

References (26)
  • 1
    • 33645675960 scopus 로고    scopus 로고
    • Estimating the cost of new drug development: is it really 802 million dollars?
    • Adams CP, Brantner VV. Estimating the cost of new drug development: is it really 802 million dollars?. Health Aff (Millwood). 2006, 25(2):420-428.
    • (2006) Health Aff (Millwood). , vol.25 , Issue.2 , pp. 420-428
    • Adams, C.P.1    Brantner, V.V.2
  • 3
    • 27144469033 scopus 로고    scopus 로고
    • Emergent behavior of growing knowledge about molecular interactions
    • 10.1038/nbt1005-1243, 16211067
    • Cokol M, Iossifov I, Weinreb C, Rzhetsky A. Emergent behavior of growing knowledge about molecular interactions. Nat. Biotechnol. 2005, 23:1243-1247. 10.1038/nbt1005-1243, 16211067.
    • (2005) Nat. Biotechnol. , vol.23 , pp. 1243-1247
    • Cokol, M.1    Iossifov, I.2    Weinreb, C.3    Rzhetsky, A.4
  • 4
    • 4344645978 scopus 로고    scopus 로고
    • Can the pharmaceutical industry reduce attrition rates?
    • 10.1038/nrd1470, 15286737
    • Kola I, Landis J. Can the pharmaceutical industry reduce attrition rates?. Nat. Rev. Drug Discov. 2004, 3(8):711-716. 10.1038/nrd1470, 15286737.
    • (2004) Nat. Rev. Drug Discov. , vol.3 , Issue.8 , pp. 711-716
    • Kola, I.1    Landis, J.2
  • 5
    • 0030886937 scopus 로고    scopus 로고
    • Managing the drug discovery/development interface
    • Kennedy T. Managing the drug discovery/development interface. Drug Discovery Today 1997, 2(10):436-444.
    • (1997) Drug Discovery Today , vol.2 , Issue.10 , pp. 436-444
    • Kennedy, T.1
  • 6
    • 13844276627 scopus 로고    scopus 로고
    • Target-based drug discovery: is something wrong?
    • 10.1016/S1359-6446(04)03316-1, 15718163
    • Sams-Dodd F. Target-based drug discovery: is something wrong?. Drug Discov. Today 2005, 10(2):139-147. 10.1016/S1359-6446(04)03316-1, 15718163.
    • (2005) Drug Discov. Today , vol.10 , Issue.2 , pp. 139-147
    • Sams-Dodd, F.1
  • 7
    • 8444225024 scopus 로고    scopus 로고
    • NIH Molecular Libraries Initiative
    • 10.1126/science.1105511, 15542455
    • Austin C, Brady L, Insel T, Collins F. NIH Molecular Libraries Initiative. Science 2004, 306(5699):1138-1139. 10.1126/science.1105511, 15542455.
    • (2004) Science , vol.306 , Issue.5699 , pp. 1138-1139
    • Austin, C.1    Brady, L.2    Insel, T.3    Collins, F.4
  • 8
    • 0141642224 scopus 로고    scopus 로고
    • The NIH Roadmap
    • 10.1126/science.1091867, 14526066
    • Zerhouni E. The NIH Roadmap. Science 2003, 302(5642):63-72. 10.1126/science.1091867, 14526066.
    • (2003) Science , vol.302 , Issue.5642 , pp. 63-72
    • Zerhouni, E.1
  • 9
    • 25144498379 scopus 로고    scopus 로고
    • A Human Protein-Protein Interaction Network: A Resource for Annotating the Proteome
    • 10.1016/j.cell.2005.08.029, 16169070
    • Stelzl U, et al. A Human Protein-Protein Interaction Network: A Resource for Annotating the Proteome. Cell 2005, 122(6):957-968. 10.1016/j.cell.2005.08.029, 16169070.
    • (2005) Cell , vol.122 , Issue.6 , pp. 957-968
    • Stelzl, U.1
  • 11
    • 58149183692 scopus 로고    scopus 로고
    • UniHI 4: new tools for query, analysis and visualization of the human protein-protein interactome
    • 10.1093/nar/gkn841, 2686569, 18984619
    • Chaurasia G, Malhotra S, Russ J, Schnoegl S, Hanig C, Wanker EE, Futschik ME. UniHI 4: new tools for query, analysis and visualization of the human protein-protein interactome. Nucl. Acids Res. 2009, 37:D657-660. 10.1093/nar/gkn841, 2686569, 18984619.
    • (2009) Nucl. Acids Res. , vol.37
    • Chaurasia, G.1    Malhotra, S.2    Russ, J.3    Schnoegl, S.4    Hanig, C.5    Wanker, E.E.6    Futschik, M.E.7
  • 14
    • 13444266370 scopus 로고    scopus 로고
    • Online Mendelian Inheritance in Man (OMIM), a knowledgebase of human genes and genetic disorders
    • 539987, 15608251
    • Hamosh A, Scott A, Amberger J, Bocchini C, McKusick V. Online Mendelian Inheritance in Man (OMIM), a knowledgebase of human genes and genetic disorders. Nucl. Acids Res. 2005, 33:D514-D5177. 539987, 15608251.
    • (2005) Nucl. Acids Res. , vol.33
    • Hamosh, A.1    Scott, A.2    Amberger, J.3    Bocchini, C.4    McKusick, V.5
  • 16
    • 0038483826 scopus 로고    scopus 로고
    • Emergence of Scaling in Random Networks
    • 10.1126/science.286.5439.509, 10521342
    • Barabasi AL, Albert R. Emergence of Scaling in Random Networks. Science 1999, 286(5439):509-512. 10.1126/science.286.5439.509, 10521342.
    • (1999) Science , vol.286 , Issue.5439 , pp. 509-512
    • Barabasi, A.L.1    Albert, R.2
  • 17
    • 0037199968 scopus 로고    scopus 로고
    • Hierarchical organization of modularity in metabolic networks
    • 10.1126/science.1073374, 12202830
    • Ravasz E, Somera A, Mongru D, Oltvai Z, Barabasi AL. Hierarchical organization of modularity in metabolic networks. Science 2002, 297:1551-1555. 10.1126/science.1073374, 12202830.
    • (2002) Science , vol.297 , pp. 1551-1555
    • Ravasz, E.1    Somera, A.2    Mongru, D.3    Oltvai, Z.4    Barabasi, A.L.5
  • 18
    • 13444254254 scopus 로고    scopus 로고
    • The Mouse Genome Database (MGD): from genes to mice-a community resource for mouse biology
    • 10.1093/nar/gki498, 540067, 15608240, Mouse Genome Database Group
    • Eppig JT, Bult CJ, Kadin JA, Richardson JE, Blake JA, . Mouse Genome Database Group The Mouse Genome Database (MGD): from genes to mice-a community resource for mouse biology. Nucl. Acids Res 2005, 33:D471-D475. 10.1093/nar/gki498, 540067, 15608240, Mouse Genome Database Group.
    • (2005) Nucl. Acids Res , vol.33
    • Eppig, J.T.1    Bult, C.J.2    Kadin, J.A.3    Richardson, J.E.4    Blake, J.A.5
  • 19
    • 0033569893 scopus 로고    scopus 로고
    • Substrate Gating Confers Steroid Specificity to Estrogen Sulfotransferase
    • 10.1074/jbc.274.42.30019, 10514486
    • Petrotchenko E, Doerflein M, Kakuta Y, Pedersen L, Negishi M. Substrate Gating Confers Steroid Specificity to Estrogen Sulfotransferase. J. Biol. Chem. 1999, 274(42):30019-30022. 10.1074/jbc.274.42.30019, 10514486.
    • (1999) J. Biol. Chem. , vol.274 , Issue.42 , pp. 30019-30022
    • Petrotchenko, E.1    Doerflein, M.2    Kakuta, Y.3    Pedersen, L.4    Negishi, M.5
  • 20
    • 20544468698 scopus 로고    scopus 로고
    • Transcriptional repression of WEE1 by Kruppel-like factor 2 is involved in DNA damage-induced apoptosis
    • 10.1038/sj.onc.1208546, 15735666
    • Wang F, Zhu Y, Huang Y, McAvoy S, Johnson W, et al. Transcriptional repression of WEE1 by Kruppel-like factor 2 is involved in DNA damage-induced apoptosis. Oncogene 2005, 24:3875-3885. 10.1038/sj.onc.1208546, 15735666.
    • (2005) Oncogene , vol.24 , pp. 3875-3885
    • Wang, F.1    Zhu, Y.2    Huang, Y.3    McAvoy, S.4    Johnson, W.5
  • 21
    • 0036490096 scopus 로고    scopus 로고
    • Regulators of G-Protein Signalling As New Central Nervous System Drug Targets
    • 10.1038/nrd747, 12120503
    • Neubig R, Siderovski D. Regulators of G-Protein Signalling As New Central Nervous System Drug Targets. Nat. Rev. Drug Discov. 2002, 1:187-197. 10.1038/nrd747, 12120503.
    • (2002) Nat. Rev. Drug Discov. , vol.1 , pp. 187-197
    • Neubig, R.1    Siderovski, D.2
  • 22
    • 15544367084 scopus 로고    scopus 로고
    • RGS Proteins: New Players in the Field of Opioid Signaling and Tolerance Mechanisms
    • 10.1213/01.ANE.0000147711.51122.4B, 15781518
    • Xie G, Palmer P. RGS Proteins: New Players in the Field of Opioid Signaling and Tolerance Mechanisms. Anesth. Analg. 2005, 100:1034-1042. 10.1213/01.ANE.0000147711.51122.4B, 15781518.
    • (2005) Anesth. Analg. , vol.100 , pp. 1034-1042
    • Xie, G.1    Palmer, P.2
  • 23
    • 34247388843 scopus 로고    scopus 로고
    • Enhancement of SMN2 exon 7 inclusion by antisense oligonucleotides targeting the exon
    • 10.1371/journal.pbio.0050073, 1820610, 17355180
    • Hua Y, Vickers T, Baker B, Bennett C, Krainer A. Enhancement of SMN2 exon 7 inclusion by antisense oligonucleotides targeting the exon. PLoS Biol 2007, 5(4):e73. 10.1371/journal.pbio.0050073, 1820610, 17355180.
    • (2007) PLoS Biol , vol.5 , Issue.4
    • Hua, Y.1    Vickers, T.2    Baker, B.3    Bennett, C.4    Krainer, A.5
  • 24
    • 14944361815 scopus 로고    scopus 로고
    • RSK4 and PAK5 Are Novel Candidate Genes in Diabetic Rat Kidney and Brain
    • M N, Borlak J. RSK4 and PAK5 Are Novel Candidate Genes in Diabetic Rat Kidney and Brain. Mol. Pharmacol. 2005, 67:604-611.
    • (2005) Mol. Pharmacol. , vol.67 , pp. 604-611
    • M, N.1    Borlak, J.2
  • 25
    • 59149104834 scopus 로고    scopus 로고
    • Insights into the Conformational Variability and Regulation of Human Nek2 Kinase
    • 10.1016/j.jmb.2008.12.033, 2741569, 19124027
    • Westwood I, Cheary D, Baxter J, Richards M, van Montfort R, Fry A, Bayliss R. Insights into the Conformational Variability and Regulation of Human Nek2 Kinase. J. Mol. Biol. 2009, 386(2):476-485. 10.1016/j.jmb.2008.12.033, 2741569, 19124027.
    • (2009) J. Mol. Biol. , vol.386 , Issue.2 , pp. 476-485
    • Westwood, I.1    Cheary, D.2    Baxter, J.3    Richards, M.4    van Montfort, R.5    Fry, A.6    Bayliss, R.7
  • 26
    • 67649826155 scopus 로고    scopus 로고
    • Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin
    • 10.1038/nn.2346, 2739046, 19525941
    • Morfini G, You Y, Pollema S, Kaminska A, Liu K, et al. Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin. Nat. Neurosci. 2009, 12(7):864-871. 10.1038/nn.2346, 2739046, 19525941.
    • (2009) Nat. Neurosci. , vol.12 , Issue.7 , pp. 864-871
    • Morfini, G.1    You, Y.2    Pollema, S.3    Kaminska, A.4    Liu, K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.