-
1
-
-
33645675960
-
Estimating the cost of new drug development: is it really 802 million dollars?
-
Adams CP, Brantner VV. Estimating the cost of new drug development: is it really 802 million dollars?. Health Aff (Millwood). 2006, 25(2):420-428.
-
(2006)
Health Aff (Millwood).
, vol.25
, Issue.2
, pp. 420-428
-
-
Adams, C.P.1
Brantner, V.V.2
-
2
-
-
35148838537
-
Drug-Target Network
-
10.1038/nbt1338, 17921997
-
Yildirim MA, Goh KI, Cusick ME, Barabási AL, Vidal M. Drug-Target Network. Nat. Biotechnol 2007, 25(10):1119-1126. 10.1038/nbt1338, 17921997.
-
(2007)
Nat. Biotechnol
, vol.25
, Issue.10
, pp. 1119-1126
-
-
Yildirim, M.A.1
Goh, K.I.2
Cusick, M.E.3
Barabási, A.L.4
Vidal, M.5
-
3
-
-
27144469033
-
Emergent behavior of growing knowledge about molecular interactions
-
10.1038/nbt1005-1243, 16211067
-
Cokol M, Iossifov I, Weinreb C, Rzhetsky A. Emergent behavior of growing knowledge about molecular interactions. Nat. Biotechnol. 2005, 23:1243-1247. 10.1038/nbt1005-1243, 16211067.
-
(2005)
Nat. Biotechnol.
, vol.23
, pp. 1243-1247
-
-
Cokol, M.1
Iossifov, I.2
Weinreb, C.3
Rzhetsky, A.4
-
4
-
-
4344645978
-
Can the pharmaceutical industry reduce attrition rates?
-
10.1038/nrd1470, 15286737
-
Kola I, Landis J. Can the pharmaceutical industry reduce attrition rates?. Nat. Rev. Drug Discov. 2004, 3(8):711-716. 10.1038/nrd1470, 15286737.
-
(2004)
Nat. Rev. Drug Discov.
, vol.3
, Issue.8
, pp. 711-716
-
-
Kola, I.1
Landis, J.2
-
5
-
-
0030886937
-
Managing the drug discovery/development interface
-
Kennedy T. Managing the drug discovery/development interface. Drug Discovery Today 1997, 2(10):436-444.
-
(1997)
Drug Discovery Today
, vol.2
, Issue.10
, pp. 436-444
-
-
Kennedy, T.1
-
6
-
-
13844276627
-
Target-based drug discovery: is something wrong?
-
10.1016/S1359-6446(04)03316-1, 15718163
-
Sams-Dodd F. Target-based drug discovery: is something wrong?. Drug Discov. Today 2005, 10(2):139-147. 10.1016/S1359-6446(04)03316-1, 15718163.
-
(2005)
Drug Discov. Today
, vol.10
, Issue.2
, pp. 139-147
-
-
Sams-Dodd, F.1
-
7
-
-
8444225024
-
NIH Molecular Libraries Initiative
-
10.1126/science.1105511, 15542455
-
Austin C, Brady L, Insel T, Collins F. NIH Molecular Libraries Initiative. Science 2004, 306(5699):1138-1139. 10.1126/science.1105511, 15542455.
-
(2004)
Science
, vol.306
, Issue.5699
, pp. 1138-1139
-
-
Austin, C.1
Brady, L.2
Insel, T.3
Collins, F.4
-
8
-
-
0141642224
-
The NIH Roadmap
-
10.1126/science.1091867, 14526066
-
Zerhouni E. The NIH Roadmap. Science 2003, 302(5642):63-72. 10.1126/science.1091867, 14526066.
-
(2003)
Science
, vol.302
, Issue.5642
, pp. 63-72
-
-
Zerhouni, E.1
-
9
-
-
25144498379
-
A Human Protein-Protein Interaction Network: A Resource for Annotating the Proteome
-
10.1016/j.cell.2005.08.029, 16169070
-
Stelzl U, et al. A Human Protein-Protein Interaction Network: A Resource for Annotating the Proteome. Cell 2005, 122(6):957-968. 10.1016/j.cell.2005.08.029, 16169070.
-
(2005)
Cell
, vol.122
, Issue.6
, pp. 957-968
-
-
Stelzl, U.1
-
10
-
-
33846048729
-
UniHI: an entry gate to the human protein interactome
-
10.1093/nar/gkl817, 1781159, 17158159
-
Chaurasia G, Iqbal Y, Hanig C, Herzel H, Wanker EE, Futschik ME. UniHI: an entry gate to the human protein interactome. Nucl. Acids Res. 2007, 35:D590-D594. 10.1093/nar/gkl817, 1781159, 17158159.
-
(2007)
Nucl. Acids Res.
, vol.35
-
-
Chaurasia, G.1
Iqbal, Y.2
Hanig, C.3
Herzel, H.4
Wanker, E.E.5
Futschik, M.E.6
-
11
-
-
58149183692
-
UniHI 4: new tools for query, analysis and visualization of the human protein-protein interactome
-
10.1093/nar/gkn841, 2686569, 18984619
-
Chaurasia G, Malhotra S, Russ J, Schnoegl S, Hanig C, Wanker EE, Futschik ME. UniHI 4: new tools for query, analysis and visualization of the human protein-protein interactome. Nucl. Acids Res. 2009, 37:D657-660. 10.1093/nar/gkn841, 2686569, 18984619.
-
(2009)
Nucl. Acids Res.
, vol.37
-
-
Chaurasia, G.1
Malhotra, S.2
Russ, J.3
Schnoegl, S.4
Hanig, C.5
Wanker, E.E.6
Futschik, M.E.7
-
12
-
-
33644876210
-
DrugBank: a comprehensive resource for in silico drug discovery and exploration
-
10.1093/nar/gkj067, 1347430, 16381955
-
Wishart DS, Knox C, Guo AC, Shrivastava S, Hassanali M, Stothard P, Chang Z, Woolsey J. DrugBank: a comprehensive resource for in silico drug discovery and exploration. Nucl. Acids Res. 2006, 34:D668-D672. 10.1093/nar/gkj067, 1347430, 16381955.
-
(2006)
Nucl. Acids Res.
, vol.34
-
-
Wishart, D.S.1
Knox, C.2
Guo, A.C.3
Shrivastava, S.4
Hassanali, M.5
Stothard, P.6
Chang, Z.7
Woolsey, J.8
-
13
-
-
38549151817
-
DrugBank: a knowledgebase for drugs, drug actions and drug targets
-
2238889, 18048412
-
Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M. DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucl. Acids Res. 2008, 36:D901-D906. 2238889, 18048412.
-
(2008)
Nucl. Acids Res.
, vol.36
-
-
Wishart, D.S.1
Knox, C.2
Guo, A.C.3
Cheng, D.4
Shrivastava, S.5
Tzur, D.6
Gautam, B.7
Hassanali, M.8
-
14
-
-
13444266370
-
Online Mendelian Inheritance in Man (OMIM), a knowledgebase of human genes and genetic disorders
-
539987, 15608251
-
Hamosh A, Scott A, Amberger J, Bocchini C, McKusick V. Online Mendelian Inheritance in Man (OMIM), a knowledgebase of human genes and genetic disorders. Nucl. Acids Res. 2005, 33:D514-D5177. 539987, 15608251.
-
(2005)
Nucl. Acids Res.
, vol.33
-
-
Hamosh, A.1
Scott, A.2
Amberger, J.3
Bocchini, C.4
McKusick, V.5
-
15
-
-
34547140875
-
The human disease network
-
10.1073/pnas.0701361104, 1885563, 17502601
-
Goh KI, Cusick ME, Valle D, Childs B, Vidal M, Barabasi AL. The human disease network. Proc. Natl. Acad. Sci. 2007, 104(21):8685-8690. 10.1073/pnas.0701361104, 1885563, 17502601.
-
(2007)
Proc. Natl. Acad. Sci.
, vol.104
, Issue.21
, pp. 8685-8690
-
-
Goh, K.I.1
Cusick, M.E.2
Valle, D.3
Childs, B.4
Vidal, M.5
Barabasi, A.L.6
-
16
-
-
0038483826
-
Emergence of Scaling in Random Networks
-
10.1126/science.286.5439.509, 10521342
-
Barabasi AL, Albert R. Emergence of Scaling in Random Networks. Science 1999, 286(5439):509-512. 10.1126/science.286.5439.509, 10521342.
-
(1999)
Science
, vol.286
, Issue.5439
, pp. 509-512
-
-
Barabasi, A.L.1
Albert, R.2
-
17
-
-
0037199968
-
Hierarchical organization of modularity in metabolic networks
-
10.1126/science.1073374, 12202830
-
Ravasz E, Somera A, Mongru D, Oltvai Z, Barabasi AL. Hierarchical organization of modularity in metabolic networks. Science 2002, 297:1551-1555. 10.1126/science.1073374, 12202830.
-
(2002)
Science
, vol.297
, pp. 1551-1555
-
-
Ravasz, E.1
Somera, A.2
Mongru, D.3
Oltvai, Z.4
Barabasi, A.L.5
-
18
-
-
13444254254
-
The Mouse Genome Database (MGD): from genes to mice-a community resource for mouse biology
-
10.1093/nar/gki498, 540067, 15608240, Mouse Genome Database Group
-
Eppig JT, Bult CJ, Kadin JA, Richardson JE, Blake JA, . Mouse Genome Database Group The Mouse Genome Database (MGD): from genes to mice-a community resource for mouse biology. Nucl. Acids Res 2005, 33:D471-D475. 10.1093/nar/gki498, 540067, 15608240, Mouse Genome Database Group.
-
(2005)
Nucl. Acids Res
, vol.33
-
-
Eppig, J.T.1
Bult, C.J.2
Kadin, J.A.3
Richardson, J.E.4
Blake, J.A.5
-
19
-
-
0033569893
-
Substrate Gating Confers Steroid Specificity to Estrogen Sulfotransferase
-
10.1074/jbc.274.42.30019, 10514486
-
Petrotchenko E, Doerflein M, Kakuta Y, Pedersen L, Negishi M. Substrate Gating Confers Steroid Specificity to Estrogen Sulfotransferase. J. Biol. Chem. 1999, 274(42):30019-30022. 10.1074/jbc.274.42.30019, 10514486.
-
(1999)
J. Biol. Chem.
, vol.274
, Issue.42
, pp. 30019-30022
-
-
Petrotchenko, E.1
Doerflein, M.2
Kakuta, Y.3
Pedersen, L.4
Negishi, M.5
-
20
-
-
20544468698
-
Transcriptional repression of WEE1 by Kruppel-like factor 2 is involved in DNA damage-induced apoptosis
-
10.1038/sj.onc.1208546, 15735666
-
Wang F, Zhu Y, Huang Y, McAvoy S, Johnson W, et al. Transcriptional repression of WEE1 by Kruppel-like factor 2 is involved in DNA damage-induced apoptosis. Oncogene 2005, 24:3875-3885. 10.1038/sj.onc.1208546, 15735666.
-
(2005)
Oncogene
, vol.24
, pp. 3875-3885
-
-
Wang, F.1
Zhu, Y.2
Huang, Y.3
McAvoy, S.4
Johnson, W.5
-
21
-
-
0036490096
-
Regulators of G-Protein Signalling As New Central Nervous System Drug Targets
-
10.1038/nrd747, 12120503
-
Neubig R, Siderovski D. Regulators of G-Protein Signalling As New Central Nervous System Drug Targets. Nat. Rev. Drug Discov. 2002, 1:187-197. 10.1038/nrd747, 12120503.
-
(2002)
Nat. Rev. Drug Discov.
, vol.1
, pp. 187-197
-
-
Neubig, R.1
Siderovski, D.2
-
22
-
-
15544367084
-
RGS Proteins: New Players in the Field of Opioid Signaling and Tolerance Mechanisms
-
10.1213/01.ANE.0000147711.51122.4B, 15781518
-
Xie G, Palmer P. RGS Proteins: New Players in the Field of Opioid Signaling and Tolerance Mechanisms. Anesth. Analg. 2005, 100:1034-1042. 10.1213/01.ANE.0000147711.51122.4B, 15781518.
-
(2005)
Anesth. Analg.
, vol.100
, pp. 1034-1042
-
-
Xie, G.1
Palmer, P.2
-
23
-
-
34247388843
-
Enhancement of SMN2 exon 7 inclusion by antisense oligonucleotides targeting the exon
-
10.1371/journal.pbio.0050073, 1820610, 17355180
-
Hua Y, Vickers T, Baker B, Bennett C, Krainer A. Enhancement of SMN2 exon 7 inclusion by antisense oligonucleotides targeting the exon. PLoS Biol 2007, 5(4):e73. 10.1371/journal.pbio.0050073, 1820610, 17355180.
-
(2007)
PLoS Biol
, vol.5
, Issue.4
-
-
Hua, Y.1
Vickers, T.2
Baker, B.3
Bennett, C.4
Krainer, A.5
-
24
-
-
14944361815
-
RSK4 and PAK5 Are Novel Candidate Genes in Diabetic Rat Kidney and Brain
-
M N, Borlak J. RSK4 and PAK5 Are Novel Candidate Genes in Diabetic Rat Kidney and Brain. Mol. Pharmacol. 2005, 67:604-611.
-
(2005)
Mol. Pharmacol.
, vol.67
, pp. 604-611
-
-
M, N.1
Borlak, J.2
-
25
-
-
59149104834
-
Insights into the Conformational Variability and Regulation of Human Nek2 Kinase
-
10.1016/j.jmb.2008.12.033, 2741569, 19124027
-
Westwood I, Cheary D, Baxter J, Richards M, van Montfort R, Fry A, Bayliss R. Insights into the Conformational Variability and Regulation of Human Nek2 Kinase. J. Mol. Biol. 2009, 386(2):476-485. 10.1016/j.jmb.2008.12.033, 2741569, 19124027.
-
(2009)
J. Mol. Biol.
, vol.386
, Issue.2
, pp. 476-485
-
-
Westwood, I.1
Cheary, D.2
Baxter, J.3
Richards, M.4
van Montfort, R.5
Fry, A.6
Bayliss, R.7
-
26
-
-
67649826155
-
Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin
-
10.1038/nn.2346, 2739046, 19525941
-
Morfini G, You Y, Pollema S, Kaminska A, Liu K, et al. Pathogenic huntingtin inhibits fast axonal transport by activating JNK3 and phosphorylating kinesin. Nat. Neurosci. 2009, 12(7):864-871. 10.1038/nn.2346, 2739046, 19525941.
-
(2009)
Nat. Neurosci.
, vol.12
, Issue.7
, pp. 864-871
-
-
Morfini, G.1
You, Y.2
Pollema, S.3
Kaminska, A.4
Liu, K.5
|