Dexmedetomidine versus propofol/midazolam for long-term sedation during mechanical ventilation

Intensive Care Medicine

Volumn 35, Issue 2, 2009, Pages 282-290

  Ruokonen, Esko ^a   Parviainen, Ilkka ^a   Jakob, Stephan M ^b   Nunes, Silvia ^c   Kaukonen, Maija ^d   Shepherd, Stephen T ^e   Sarapohja, Toni ^e   Bratty, J Raymond ^e   Takala, Jukka ^b  

^a KUOPIO UNIVERSITY HOSPITAL   (Finland)

^b UNIVERSITY OF BERN   (Switzerland)

^c TAMPERE UNIVERSITY HOSPITAL   (Finland)

^d HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^e ORION CORPORATION   (Finland)

Author keywords

Conscious sedation; Critical care; Deep sedation; Dexmedetomidine; Intensive care; Mechanical ventilation; Sedatives

Indexed keywords

DEXMEDETOMIDINE; FENTANYL; HYPERTENSIVE FACTOR; INOTROPIC AGENT; MIDAZOLAM; PROPOFOL;

ADULT; AGED; AGITATION; ARTICLE; ARTIFICIAL VENTILATION; BRADYCARDIA; CARDIOTOXICITY; CLINICAL TRIAL; CONFUSION; CONTINUOUS INFUSION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DELIRIUM; DOUBLE BLIND PROCEDURE; DRUG CONTRAINDICATION; DRUG DOSE TITRATION; DRUG INDICATION; DRUG WITHDRAWAL; ENDOTRACHEAL TUBE; FEMALE; HEART ARREST; HUMAN; INTENSIVE CARE UNIT; LOADING DRUG DOSE; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PAIN; PHASE 3 CLINICAL TRIAL; PILOT STUDY; POST HOC ANALYSIS; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; SEDATION; TIME; TREATMENT DURATION; UNSPECIFIED SIDE EFFECT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; DEXMEDETOMIDINE; DOUBLE-BLIND METHOD; FEMALE; HUMANS; HYPNOTICS AND SEDATIVES; INTENSIVE CARE UNITS; MALE; MIDAZOLAM; MIDDLE AGED; PILOT PROJECTS; PROPOFOL; RESPIRATION, ARTIFICIAL; TIME FACTORS; YOUNG ADULT;

EID: 59849087047     PISSN: 03424642     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00134-008-1296-0     Document Type: Article

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