Propofol associated with a shorter duration of mechanical ventilation than scheduled intermittent lorazepam: A database analysis using Project IMPACT

Annals of Pharmacotherapy

Volumn 41, Issue 12, 2007, Pages 1986-1991

  Fong, Jeffrey J ^a   Kanji, Salmaan ^b,c   Dasta, Joseph F ^d,e   Garpestad, Erik ^f   Devlin, John W ^a,f  

^a NORTHEASTERN UNIVERSITY   (United States)

^b UNIVERSITY OF OTTAWA   (Canada)

^c OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^d UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^e OHIO STATE UNIVERSITY   (United States)

^f TUFTS MEDICAL CENTER   (United States)

Author keywords

Critical care; Lorazepam; Propofol; Sedation

Indexed keywords

LORAZEPAM; PROPOFOL;

ARTICLE; ARTIFICIAL VENTILATION; CONTINUOUS INFUSION; CONTROLLED STUDY; DATA ANALYSIS; DRUG DOSE REGIMEN; DRUG INTERMITTENT THERAPY; DRUG UTILIZATION; FEMALE; HUMAN; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SEDATION;

ANESTHETICS, INTRAVENOUS; DATABASES, FACTUAL; FEMALE; HUMANS; HYPNOTICS AND SEDATIVES; INTENSIVE CARE UNITS; LORAZEPAM; MALE; PROPOFOL; RESPIRATION, ARTIFICIAL;

EID: 36849065665     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1345/aph.1K296     Document Type: Article

References (32)

1. Jacobi J, Fraser GL, Coursin DB, et al. Clinical practice guidelines for the sustained use of sedatives and analgesics in the critically ill adult. Crit Care Med 2002;30:119-41.
2. Brook AD, Ahrens TS, Schaiff R, et al. Effect of a nursing-implemented sedation protocol on the duration of mechanical ventilation. Crit Care Med 1999;27:2609-15.
3. Fraser GL, Riker RR. Comfort without coma: changing sedation practices. Crit Care Med 2007;35:635-7.
4. Kollef MH, Levy NT, Ahrens TS, Schaiff R, Prentice D, Sherman G. The use of continuous I.V. sedation is associated with prolongation of mechanical ventilation. Chest 1998;114:541-8.
5. Kress JP, Pohlman AS, O'Connor MF, Hall JB. Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. N Engl J Med 2000;342:1471-7.
6. Barrientos-Vega R, Mar Sanchez-Soria M, Morales-Garcia C, Robas-Gomez A, Cuena-Boy R, Ayensa-Rincon A. Prolonged sedation of critically ill patients with midazolam or propofol: impact on weaning and costs. Crit Care Med 1997;25:33-40.
7. Carrasco G, Molina R, Costa J, Soler JM, Cabre L, Propofol vs midazolam in short-, medium-, and long-term sedation of critically ill patients. A cost-benefit analysis. Chest 1993;103:557-64.
8. Chamorro C, de Latorre FJ, Montero A, et al. Comparative study of propofol versus midazolam in the sedation of critically ill patients: results of a prospective, randomized, multicenter trial. Crit Care Med 1996;24:932-9.
9. Sanchez-Izquierdo-Riera JA, Caballero-Cubedo RE, Perez-Vela JL, Ambros-Checa A, Cantalapiedra-Santiago JA, Alted-Lopez E. Propofol versus midazolam: safety and efficacy for sedating the severe trauma patient. Anesth Analg 1998;86:1219-24.
10. Weinbroum AA, Halpern P, Rudick V, Sorkine P, Freedman M, Geller E. Midazolam versus propofol for long-term sedation in the ICU: a randomized prospective comparison. Intensive Care Med 1997;23:1258-63.
11. Carson SS, Kress JP, Rodgers JE, et al. A randomized trial of intermittent lorazepam versus propofol with daily interruption in mechanically ventilated patients. Crit Care Med 2006;34:1326-32.
12. Devlin JW, Fong JJ, Schumaker GL. Identifying factors that could account for differences in duration of mechanical ventilation between intermittent lorazepam- and propofol-treated patients. Crit Care Med 2006;34:3063-4; author reply 3064.
13. Devlin JW, Tanios MA, Epstein SK. Intensive care unit sedation: waking up clinicians to the gap between research and practice. Crit Care Med 2006;34:556-7.
14. Van den Berghe G, Wilmer A, Hermans G, et al. Intensive insulin therapy in the medical ICO. N Engl J Med 2006;354:449-61.
15. van den Berghe G, Wouters P, Weekers F, et al. Intensive insulin therapy in the critically ill patients. N Engl J Med 2001;345:1359-67.
16. Dasta JF, Kane-Gill SL, Durtschi AJ. Comparing dexmedetomidine prescribing patterns and safety in the naturalistic setting versus published data. Ann Pharmacother 2004;38:1130-5. DOI 10.1345/aph.1D615
17. Kane-Gill SL, Feng Y, Bobek MB, Bies RR, Pruchnicki MC, Dasta JF. Administration of enoxaparin by continuous infusion in a naturalistic setting: analysis of renal function and safety. J Clin Pharm Ther 2005;30:207-13.
18. Riker RR, Fraser GL. Daily interruption of sedative infusions in critically ill patients. N Engl J Med 2000;343:814; author reply 814-5.
19. Riker RR, Picard JT, Fraser GL. Prospective evaluation of the Sedation-Agitation Scale for adult critically ill patients. Crit Care Med 1999;27:1325-9.
20. Cook SF, Visscher WA, Hobbs CL, Williams RL. Project IMPACT: results from a pilot validity study of a new observational database. Crit Care Med 2002;30:2765-70.
21. Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: a severity of disease classification system. Crit Care Med 1985;13:818-29.
22. Kress JP, Hall JB. Sedation in the mechanically ventilated patient. Crit Care Med 2006;34:2541-6.
23. Steg PG, Lopez-Sendon J, Lopez de Sa E, et al. External validity of clinical trials in acute myocardial infarction. Arch Intern Med 2007;167:68-73.
24. Bailie GR, Cockshott ID,Douglas EJ, Bowles BJ. Pharmacokinetics of propofol during and after long-term continuous infusion for maintenance of sedation in ICU patients. Br J Anaesth 1992;68:486-91.
25. de Wit M, Best AM, Epstein SK, Greenblatt DJ. Lorazepam concentrations, pharmacokinetics and pharmacodynamics in a cohort of mechanically ventilated ICU patients. Im J Clin Pharmacol Ther 2006;44:466-73.
26. Concato J, Feinstein AR, Holford TR. The risk of determining risk with multivariable models. Ann Intern Med 1993;118:201-10.
27. Nasraway SA Jr, Albert M, Donnelly AM, Ruthazer R, Shikora SA, Saltzman E. Morbid obesity is an independent determinant of death among surgical critically ill patients. Crit Care Med 2006;34:964-70.
28. Rapoport J, Teres D, Steingrub J, Higgins T, McGee W, Lemeshow S. Patient characteristics and ICU organizational factors that influence frequency of pulmonary artery catheterization. JAMA 2000;283:2559-67.
29. Devlin JW, Holbrook AM, Fuller HD. The effect of ICU sedation guidelines and pharmacist interventions on clinical outcomes and drug cost. Ann Pharmacother 1997;31:689-95.
30. Connors AF Jr. Pitfalls in estimating the effect of interventions in the critically ill using observational study designs. Crit Care Med 2001;29:1283-4.
31. Thomason JW, Shintani A, Peterson JF, Pun BT, Jackson JC, Ely EW. Intensive care unit delirium is an independent predictor of longer hospital stay: a prospective analysis of 261 non-ventilated patients. Crit Care 2005;9:R375-81.
32. Cook D, Heyland D, Marshall J. On the need for observational studies to design and interpret randomized trials in ICU patients: a case study in stress ulcer prophylaxis. Intensive Care Med 2001;27:347-54.