A randomized trial of intermittent lorazepam versus propofol with daily interruption in mechanically ventilated patients

Critical Care Medicine

Volumn 34, Issue 5, 2006, Pages 1326-1332

  Carson, Shannon S ^a,g   Kress, John P ^b   Rodgers, Jo Ellen ^c   Vinayak, Ajeet ^d   Campbell Bright, Stacy ^c   Levitt, Joseph ^e   Bourdet, Sharya ^c   Ivanova, Anastasia ^a   Henderson, Ashley G ^a   Pohlman, Anne ^b   Chang, Lydia ^f   Rich, Preston B ^a   Hall, Jesse ^b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

^c University of North Carolina   (United States)

^d UNIVERSITY OF VIRGINIA   (United States)

^e STANFORD UNIVERSITY MEDICAL CENTER   (United States)

^f UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE   (United States)

^g UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Conscious sedation; Intensive care units; Mechanical ventilator weaning; Respiratory failure

Indexed keywords

BENZODIAZEPINE DERIVATIVE; DIALUDID; FENTANYL; HALOPERIDOL; HYDROMORPHONE; LORAZEPAM; MIDAZOLAM; MORPHINE SULFATE; OPIATE; PROPOFOL; SEDATIVE AGENT; HYPNOTIC SEDATIVE AGENT;

ABSENCE OF SIDE EFFECTS; ADULT; ARTICLE; ARTIFICIAL VENTILATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG INTERMITTENT THERAPY; FEMALE; HOSPITALIZATION; HUMAN; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; OPEN STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY FAILURE; SEDATION; SURVIVAL; COMPARATIVE STUDY; DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; LENGTH OF STAY; MIDDLE AGED; MULTICENTER STUDY;

DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMANS; HYPNOTICS AND SEDATIVES; INFUSIONS, INTRAVENOUS; INTENSIVE CARE UNITS; LENGTH OF STAY; LORAZEPAM; MALE; MIDDLE AGED; PROPOFOL; RESPIRATION, ARTIFICIAL; VENTILATOR WEANING;

EID: 33646571863     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000215513.63207.7F     Document Type: Article

References (38)

1. Ostermann ME, Keenan SP, Seiferling RA, et al: Sedation in the intensive care unit: A systematic review. JAMA 2000; 283:1451-1459
2. Gehlbach BK, Kress JP: Sedation in the intensive care unit. Curr Opin Crit Care 2002; 8:290-298
3. Brook AD, Ahrens TS, Schaiff R, et al: Effect of a nursing-implemented sedation protocol on the duration of mechanical ventilation. Intensive Care Med 1999; 27:2609-2615
4. Jonghe BD, Bastuji-Garin S, Fangio P, et al: Sedation algorithm in critically ill patients without acute brain injury. Crit Care Med 2005; 33:120-127
5. Kress JP, Pohlman AS, O'Connor MF, et al: Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. N Engl J Med 2000; 342:1471-1477
6. Izurieta R, Rabatin JT: Sedation during mechanical ventilation: A systematic review. Crit Care Med 2002; 30:2644-2648
7. Jacobi J, Fraser GL, Coursin DB, et al: Clinical practice guidelines for the sustained use of sedatives and analgesics in the critically ill adult. Crit Care Med 2002; 30:119-141
8. Swart E, van Schijndel RJM, van Loenen AC, et al: Continuous infusion of lorazepam versus midazolam in patients in the intensive care unit: Sedation with lorazepam is easier to manage and is more cost effective. Crit Care Med 1999; 27:1461-1465
9. Pohlman AS, Simpson KP, Hall JB: Continuous intravenous infusions of lorazepam versus midazolam for sedation during mechanical ventilatory support: A prospective, randomized study. Crit Care Med 1994; 22:1241-1247
10. de Wit M, Epstein SK, Greenblatt DJ: Comparison of lorazepam and sedation levels in patients managed with continuous intravenous infusions versus bolus therapy. Am J Respir Crit Care Med 2003; 167:A969
11. McCollam JS, O'Neil MG, Norcross ED, et al: Continuous infusions of lorazepam, midazolam, and propofol for sedation of the critically ill surgery trauma patient: A prospective, randomized comparison. Crit Care Med 1999; 27:2454-2458
12. Weinbroum AA, Halpern P, Rudick V, et al: Midazolam versus propofol for long-term sedation in the ICU: A randomized prospective comparison. Intensive Care Med 1997; 23:1258-1263
13. Sanchez-Izquierdo-Riera JA, Caballero-Cubedo RE, Perez-Vela JL, et al: Propofol versus midazolam: Safety and efficacy for sedating the severe trauma patient. Anesth Analg 1998; 86:1219-1224
14. Sandiumenge Camps A, Sanchez-Izquierdo-Riera JA, Toral Vazquez D, et al: Midazolam and 2% propofol in long-term sedation of traumatized critically ill patients: Efficacy and safety comparison. Crit Care Med 2000; 28:3612-3619
15. Kress JP, O'Connor MF, Pohlman AS, et al: Sedation of critically ill patients during mechanical ventilation: A comparison of propofol and midazolam. Am J Respir Crit Care Med 1996; 153:1012-1018
16. Barrientos-Vega R, Mar Sanchez-Soria M, Morales-Garcia C, et al: Prolonged sedation of critically ill patients with midazolam or propofol: Impact on weaning and costs. Crit Care Med 1997; 25:33-40
17. Costa J, Cabre L, Molina R, et al: Cost of ICU sedation. Clin Intensive Care 1994; 5:17-21
18. Carrasco G, Molina R, Costa J, et al: Propofol vs midazolam in short-, medium-, and long-term sedation of critically ill patients. Chest 1993; 103:557-564
19. Aitkenhead AR, Pepperman ML, Willatts SM, et al: Comparison of propofol and midazolam for sedation in critically ill patients. Lancet 1989; 2:704-709
20. Sessler CN: Wake up and breathe. Crit Care Med 2004; 32:1413-1414
21. Herr DL, Kelly K, Hall JB, et al: Safety and efficacy of propofol with EDTA when used for sedation of surgical intensive care unit patients. Intensive Care Med 2000; 26:S452-S462
22. Ramsay MA, Savege TM, Simpson BR, et al: Controlled sedation with alphaxalone-alphadolone. BMJ 1974; 2:656-659
23. Ely EW, Baker AM, Dunagan DP, et al: Effect on the duration of mechanical ventilation of identifying patients capable of breathing spontaneously. N Engl J Med 1996; 335:1864-1869
24. Knaus WA, Draper EA, Wagner DP, et al: APACHE II: A severity of disease classification system. Crit Care Med 1986; 311:818-829
25. Vincent JL, Moreno R, Takala J, et al: The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med 1996; 22:707-710
26. Bailie GR, Cockshott ID, Douglas EJ, et al: Pharmacokinetics of propofol during and after long term continuous infusion for maintenance of sedation in ICU patients. Br J Anaesth 1992; 68:486-491
27. Albanese JC, Martin C, Lacarelle B, et al: Pharmacokinetics of long-term propofol infusion used for sedation in ICU patients. Anesthesiology 1990; 73:214-217
28. Greenblatt DJ: Clinical pharmacokinetics of oxazepam and lorazepam. Clin Pharmacokinet 1981; 6:89-105
29. Miller LG: Chronic benzodiazepine administration: From the patient to the gene. J Clin Pharmacol 1991; 31:492-495
30. Guentert TW: Time-dependence in benzodiazepine pharmacokinetics. Mechanisms and clinical significance. Clin Pharmacokinet 1984; 9:203-210
31. Sivam SP, Ho IK: GABA in morphine analgesia and tolerance. Life Sci 1985; 37:199-208
32. Ely EW, Shintani A, Truman B, et al: Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit. JAMA 2004; 291:1753-1762
33. Sessler CN, Gosnell MS, Grap MJ, et al: The Richmond Agitation-Sedation Scale. Validity and reliability in adult intensive care unit patients. Am J Respir Crit Care Med 2002; 166:1338-1344
34. Ely EW, Inouye SK, Bernard GR, et al: Delirium in mechanically ventilated patients. Validity and reliability of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU). JAMA 2001; 286:2703-2710
35. Cernaianu AC, DelRossi AJ, Flum DR, et al: Lorazepam and midazolam in the intensive care unit: A randomized, prospective, multicenter study of hemodynamics, oxygen transport, efficacy, and cost. Crit Care Med 1996; 24:222-228
36. Kollef MH, Levy NT, Ahrens TS, et al: The use of continuous IV sedation is associated with prolongation of mechanical ventilation. Chest 1998; 114:541-548
37. Schweickert WD, Gehlbach BK, Pohlman AS, et al: Daily interruption of sedative infusions and complications of critical illness in mechanically ventilated patients. Crit Care Med 2004; 32:1272-1276
38. Chastre J, Fagon JY: Ventilator-associated pneumonia. Am J Respir Crit Care Med 2002; 165:867-903